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Childhood Astrocytoma

MedGen UID:
898003
•Concept ID:
C4086152
•
Neoplastic Process

Definition

An astrocytoma that occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Astrocytoma

Professional guidelines

PubMed

Clinical Features, Treatment and Outcome of Childhood Glial Tumors.
Kara B, Ertan K, Karabagli P, Karabagli H, Yavas G, Caglayan AO, Koksal Y
Turk Neurosurg 2022;32(1):135-142. doi: 10.5137/1019-5149.JTN.34801-21.2. PMID: 34751424
Childhood brain tumors: current management, biological insights, and future directions.
Pollack IF, Agnihotri S, Broniscer A
J Neurosurg Pediatr 2019 Mar 1;23(3):261-273. doi: 10.3171/2018.10.PEDS18377. PMID: 30835699Free PMC Article
Diagnosis and management of brain and spinal cord tumors in the neonate.
Hwang SW, Su JM, Jea A
Semin Fetal Neonatal Med 2012 Aug;17(4):202-206. Epub 2012 Mar 30 doi: 10.1016/j.siny.2012.03.001. PMID: 22465555

Recent clinical studies

Etiology

Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
Foss-Skiftesvik J, Li S, Rosenbaum A, Hagen CM, Stoltze UK, Ljungqvist S, Hjalmars U, Schmiegelow K, Morimoto L, de Smith AJ, Mathiasen R, Metayer C, Hougaard D, Melin B, Walsh KM, Bybjerg-Grauholm J, Dahlin AM, Wiemels JL
Neuro Oncol 2023 Sep 5;25(9):1709-1720. doi: 10.1093/neuonc/noad042. PMID: 36810956Free PMC Article
Neuropsychological and socioeconomic outcomes in adult survivors of pediatric low-grade glioma.
Ris MD, Leisenring WM, Goodman P, Di C, Noll J, Levy W, Robison LL, Armstrong GT
Cancer 2019 Sep 1;125(17):3050-3058. Epub 2019 Jun 24 doi: 10.1002/cncr.32186. PMID: 31231797Free PMC Article
Adverse medical events associated with childhood cerebellar astrocytomas and medulloblastomas: natural history and relation to very long-term neurobehavioral outcome.
Roncadin C, Dennis M, Greenberg ML, Spiegler BJ
Childs Nerv Syst 2008 Sep;24(9):995-1002; discussion 1003. Epub 2008 Jun 25 doi: 10.1007/s00381-008-0658-9. PMID: 18581121
Parental occupation and childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1992 Feb 15;52(4):782-6. PMID: 1737337
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1990 May 1;50(9):2608-12. PMID: 2328486

Diagnosis

Neuropsychological and socioeconomic outcomes in adult survivors of pediatric low-grade glioma.
Ris MD, Leisenring WM, Goodman P, Di C, Noll J, Levy W, Robison LL, Armstrong GT
Cancer 2019 Sep 1;125(17):3050-3058. Epub 2019 Jun 24 doi: 10.1002/cncr.32186. PMID: 31231797Free PMC Article
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.
Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJ
Clin Cancer Res 2013 Dec 15;19(24):6716-29. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-0842. PMID: 24132923Free PMC Article
Adverse medical events associated with childhood cerebellar astrocytomas and medulloblastomas: natural history and relation to very long-term neurobehavioral outcome.
Roncadin C, Dennis M, Greenberg ML, Spiegler BJ
Childs Nerv Syst 2008 Sep;24(9):995-1002; discussion 1003. Epub 2008 Jun 25 doi: 10.1007/s00381-008-0658-9. PMID: 18581121
Parental occupation and childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1992 Feb 15;52(4):782-6. PMID: 1737337
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1990 May 1;50(9):2608-12. PMID: 2328486

Therapy

Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma.
Studebaker A, Bondra K, Seum S, Shen C, Phelps DA, Chronowski C, Leasure J, Smith PD, Kurmasheva RT, Mo X, Fouladi M, Houghton PJ
Pediatr Blood Cancer 2015 Oct;62(10):1768-74. Epub 2015 May 15 doi: 10.1002/pbc.25579. PMID: 25981859Free PMC Article
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.
Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJ
Clin Cancer Res 2013 Dec 15;19(24):6716-29. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-0842. PMID: 24132923Free PMC Article
Family history of cancer and seizures in young children with brain tumors: a report from the Childrens Cancer Group (United States and Canada).
Kuijten RR, Strom SS, Rorke LB, Boesel CP, Buckley JD, Meadows AT, Bunin GR
Cancer Causes Control 1993 Sep;4(5):455-64. doi: 10.1007/BF00050865. PMID: 8218878
Parental occupation and childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1992 Feb 15;52(4):782-6. PMID: 1737337
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1990 May 1;50(9):2608-12. PMID: 2328486

Prognosis

Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
Foss-Skiftesvik J, Li S, Rosenbaum A, Hagen CM, Stoltze UK, Ljungqvist S, Hjalmars U, Schmiegelow K, Morimoto L, de Smith AJ, Mathiasen R, Metayer C, Hougaard D, Melin B, Walsh KM, Bybjerg-Grauholm J, Dahlin AM, Wiemels JL
Neuro Oncol 2023 Sep 5;25(9):1709-1720. doi: 10.1093/neuonc/noad042. PMID: 36810956Free PMC Article
Adverse medical events associated with childhood cerebellar astrocytomas and medulloblastomas: natural history and relation to very long-term neurobehavioral outcome.
Roncadin C, Dennis M, Greenberg ML, Spiegler BJ
Childs Nerv Syst 2008 Sep;24(9):995-1002; discussion 1003. Epub 2008 Jun 25 doi: 10.1007/s00381-008-0658-9. PMID: 18581121
Increased incidence rates but no space-time clustering of childhood astrocytoma in Sweden, 1973-1992: a population-based study of pediatric brain tumors.
Hjalmars U, Kulldorff M, Wahlqvist Y, Lannering B
Cancer 1999 May 1;85(9):2077-90. PMID: 10223251
Immunohistochemical detection of p53 protein expression in various childhood astrocytoma subtypes: significance in tumor progression.
Bodey B, Gröger AM, Bodey B Jr, Siegel SE, Kaiser HE
Anticancer Res 1997 Mar-Apr;17(2A):1187-94. PMID: 9137469
Family history of cancer and seizures in young children with brain tumors: a report from the Childrens Cancer Group (United States and Canada).
Kuijten RR, Strom SS, Rorke LB, Boesel CP, Buckley JD, Meadows AT, Bunin GR
Cancer Causes Control 1993 Sep;4(5):455-64. doi: 10.1007/BF00050865. PMID: 8218878

Clinical prediction guides

Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.
Foss-Skiftesvik J, Li S, Rosenbaum A, Hagen CM, Stoltze UK, Ljungqvist S, Hjalmars U, Schmiegelow K, Morimoto L, de Smith AJ, Mathiasen R, Metayer C, Hougaard D, Melin B, Walsh KM, Bybjerg-Grauholm J, Dahlin AM, Wiemels JL
Neuro Oncol 2023 Sep 5;25(9):1709-1720. doi: 10.1093/neuonc/noad042. PMID: 36810956Free PMC Article
Neuropsychological and socioeconomic outcomes in adult survivors of pediatric low-grade glioma.
Ris MD, Leisenring WM, Goodman P, Di C, Noll J, Levy W, Robison LL, Armstrong GT
Cancer 2019 Sep 1;125(17):3050-3058. Epub 2019 Jun 24 doi: 10.1002/cncr.32186. PMID: 31231797Free PMC Article
Adverse medical events associated with childhood cerebellar astrocytomas and medulloblastomas: natural history and relation to very long-term neurobehavioral outcome.
Roncadin C, Dennis M, Greenberg ML, Spiegler BJ
Childs Nerv Syst 2008 Sep;24(9):995-1002; discussion 1003. Epub 2008 Jun 25 doi: 10.1007/s00381-008-0658-9. PMID: 18581121
Parental occupation and childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1992 Feb 15;52(4):782-6. PMID: 1737337
Gestational and familial risk factors for childhood astrocytoma: results of a case-control study.
Kuijten RR, Bunin GR, Nass CC, Meadows AT
Cancer Res 1990 May 1;50(9):2608-12. PMID: 2328486

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