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Abnormal circulating C-peptide concentration

MedGen UID:
898382
•Concept ID:
C4280765
•
Finding
Synonyms: Abnormal C peptide level; Abnormal C-peptide level
 
HPO: HP:0030794

Definition

An anomalous circulating concentration of the connecting (C) peptide, which links the insulin A and B chains in proinsulin, providing thereby a means to promote their efficient folding and assembly in the endoplasmic reticulum during insulin biosynthesis. After cleavage of proinsulin, C-peptide is stored with insulin in the soluble phase of the secretory granules and is subsequently released in equimolar amounts with insulin, providing a useful independent indicator of insulin secretion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating C-peptide concentration

Recent clinical studies

Etiology

Associations of cord blood meta-inflammation and vitamin D with neurodevelopmental delay: A prospective birth cohort study in China.
Wang P, Wu L, Yin WJ, Tao RX, Zhang Y, Li PP, Jiang XM, Shao ZY, Zhu P
Front Immunol 2022;13:1078340. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1078340. PMID: 36685522Free PMC Article
Reduced circulating stem cells associate with excess fasting and post-load NEFA exposure in healthy adults with normal glucose tolerance.
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
The relationships of irisin with bone mineral density and body composition in PCOS patients.
Gao S, Cheng Y, Zhao L, Chen Y, Liu Y
Diabetes Metab Res Rev 2016 May;32(4):421-8. Epub 2016 Jan 8 doi: 10.1002/dmrr.2767. PMID: 26589554
Augmentation of alimentary insulin secretion despite similar gastric inhibitory peptide (GIP) responses in juvenile obesity.
Heptulla RA, Tamborlane WV, Cavaghan M, Bronson M, Limb C, Ma YZ, Sherwin RS, Caprio S
Pediatr Res 2000 May;47(5):628-33. doi: 10.1203/00006450-200005000-00012. PMID: 10813588
Insulin-like growth-factor-binding protein 3 is decreased in early-stage operable pre-menopausal breast cancer.
Bruning PF, Van Doorn J, Bonfrèr JM, Van Noord PA, Korse CM, Linders TC, Hart AA
Int J Cancer 1995 Jul 28;62(3):266-70. doi: 10.1002/ijc.2910620306. PMID: 7543079

Diagnosis

Associations of cord blood meta-inflammation and vitamin D with neurodevelopmental delay: A prospective birth cohort study in China.
Wang P, Wu L, Yin WJ, Tao RX, Zhang Y, Li PP, Jiang XM, Shao ZY, Zhu P
Front Immunol 2022;13:1078340. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1078340. PMID: 36685522Free PMC Article
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity.
Kunz HE, Hart CR, Gries KJ, Parvizi M, Laurenti M, Dalla Man C, Moore N, Zhang X, Ryan Z, Polley EC, Jensen MD, Vella A, Lanza IR
Am J Physiol Endocrinol Metab 2021 Jul 1;321(1):E105-E121. Epub 2021 May 17 doi: 10.1152/ajpendo.00070.2021. PMID: 33998291Free PMC Article
Reduced circulating stem cells associate with excess fasting and post-load NEFA exposure in healthy adults with normal glucose tolerance.
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Deficiency of total and nonglycosylated amylin in plasma characterizes subjects with impaired glucose tolerance and type 2 diabetes.
Mäkimattila S, Fineman MS, Yki-Järvinen H
J Clin Endocrinol Metab 2000 Aug;85(8):2822-7. doi: 10.1210/jcem.85.8.6721. PMID: 10946889
Mutant insulin syndromes.
Vinik A, Bell G
Horm Metab Res 1988 Jan;20(1):1-10. doi: 10.1055/s-2007-1010736. PMID: 3286444

Therapy

Reduced circulating stem cells associate with excess fasting and post-load NEFA exposure in healthy adults with normal glucose tolerance.
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Insulin effect on serum potassium and auto-inhibition of insulin secretion is intact in a patient with leprechaunism despite severe impairment of substrates metabolism.
Luzi L, Zoppini G, Targher G, Battezzati A, Muggeo M, Bonora E
Diabetes Metab Res Rev 2008 Mar-Apr;24(3):205-10. doi: 10.1002/dmrr.771. PMID: 17968975
Augmentation of alimentary insulin secretion despite similar gastric inhibitory peptide (GIP) responses in juvenile obesity.
Heptulla RA, Tamborlane WV, Cavaghan M, Bronson M, Limb C, Ma YZ, Sherwin RS, Caprio S
Pediatr Res 2000 May;47(5):628-33. doi: 10.1203/00006450-200005000-00012. PMID: 10813588
Glucose metabolism and insulin secretion in infants with symptomatic ventricular septal defect.
Lundell KH, Sabel KG, Eriksson BO, Mellgren G
Acta Paediatr Scand 1989 Jul;78(4):620-6. doi: 10.1111/j.1651-2227.1989.tb17947.x. PMID: 2675533
Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions.
Bolli GB, Tsalikian E, Haymond MW, Cryer PE, Gerich JE
J Clin Invest 1984 Jun;73(6):1532-41. doi: 10.1172/JCI111359. PMID: 6373827Free PMC Article

Prognosis

Reduced circulating stem cells associate with excess fasting and post-load NEFA exposure in healthy adults with normal glucose tolerance.
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
The relationships of irisin with bone mineral density and body composition in PCOS patients.
Gao S, Cheng Y, Zhao L, Chen Y, Liu Y
Diabetes Metab Res Rev 2016 May;32(4):421-8. Epub 2016 Jan 8 doi: 10.1002/dmrr.2767. PMID: 26589554

Clinical prediction guides

Associations of cord blood meta-inflammation and vitamin D with neurodevelopmental delay: A prospective birth cohort study in China.
Wang P, Wu L, Yin WJ, Tao RX, Zhang Y, Li PP, Jiang XM, Shao ZY, Zhu P
Front Immunol 2022;13:1078340. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1078340. PMID: 36685522Free PMC Article
Reduced circulating stem cells associate with excess fasting and post-load NEFA exposure in healthy adults with normal glucose tolerance.
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Plasma islet amyloid polypeptide (Amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients.
Sanke T, Hanabusa T, Nakano Y, Oki C, Okai K, Nishimura S, Kondo M, Nanjo K
Diabetologia 1991 Feb;34(2):129-32. doi: 10.1007/BF00500385. PMID: 2065848
Impaired glucose tolerance is characterized by multiple abnormalities in the regulation of intermediary metabolism.
Krentz AJ, Singh BM, Nattrass M
Diabet Med 1991 Nov;8(9):848-54. doi: 10.1111/j.1464-5491.1991.tb02123.x. PMID: 1837511

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