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Abnormal circulating C-peptide concentration

MedGen UID:
898382
Concept ID:
C4280765
Finding
Synonyms: Abnormal C peptide level; Abnormal C-peptide level
 
HPO: HP:0030794

Definition

An anomalous circulating concentration of the connecting (C) peptide, which links the insulin A and B chains in proinsulin, providing thereby a means to promote their efficient folding and assembly in the endoplasmic reticulum during insulin biosynthesis. After cleavage of proinsulin, C-peptide is stored with insulin in the soluble phase of the secretory granules and is subsequently released in equimolar amounts with insulin, providing a useful independent indicator of insulin secretion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating C-peptide concentration

Recent clinical studies

Etiology

Wang P, Wu L, Yin WJ, Tao RX, Zhang Y, Li PP, Jiang XM, Shao ZY, Zhu P
Front Immunol 2022;13:1078340. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1078340. PMID: 36685522Free PMC Article
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Gao S, Cheng Y, Zhao L, Chen Y, Liu Y
Diabetes Metab Res Rev 2016 May;32(4):421-8. Epub 2016 Jan 8 doi: 10.1002/dmrr.2767. PMID: 26589554
Heptulla RA, Tamborlane WV, Cavaghan M, Bronson M, Limb C, Ma YZ, Sherwin RS, Caprio S
Pediatr Res 2000 May;47(5):628-33. doi: 10.1203/00006450-200005000-00012. PMID: 10813588
Bruning PF, Van Doorn J, Bonfrèr JM, Van Noord PA, Korse CM, Linders TC, Hart AA
Int J Cancer 1995 Jul 28;62(3):266-70. doi: 10.1002/ijc.2910620306. PMID: 7543079

Diagnosis

Wang P, Wu L, Yin WJ, Tao RX, Zhang Y, Li PP, Jiang XM, Shao ZY, Zhu P
Front Immunol 2022;13:1078340. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1078340. PMID: 36685522Free PMC Article
Kunz HE, Hart CR, Gries KJ, Parvizi M, Laurenti M, Dalla Man C, Moore N, Zhang X, Ryan Z, Polley EC, Jensen MD, Vella A, Lanza IR
Am J Physiol Endocrinol Metab 2021 Jul 1;321(1):E105-E121. Epub 2021 May 17 doi: 10.1152/ajpendo.00070.2021. PMID: 33998291Free PMC Article
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Mäkimattila S, Fineman MS, Yki-Järvinen H
J Clin Endocrinol Metab 2000 Aug;85(8):2822-7. doi: 10.1210/jcem.85.8.6721. PMID: 10946889
Vinik A, Bell G
Horm Metab Res 1988 Jan;20(1):1-10. doi: 10.1055/s-2007-1010736. PMID: 3286444

Therapy

Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Luzi L, Zoppini G, Targher G, Battezzati A, Muggeo M, Bonora E
Diabetes Metab Res Rev 2008 Mar-Apr;24(3):205-10. doi: 10.1002/dmrr.771. PMID: 17968975
Heptulla RA, Tamborlane WV, Cavaghan M, Bronson M, Limb C, Ma YZ, Sherwin RS, Caprio S
Pediatr Res 2000 May;47(5):628-33. doi: 10.1203/00006450-200005000-00012. PMID: 10813588
Lundell KH, Sabel KG, Eriksson BO, Mellgren G
Acta Paediatr Scand 1989 Jul;78(4):620-6. doi: 10.1111/j.1651-2227.1989.tb17947.x. PMID: 2675533
Bolli GB, Tsalikian E, Haymond MW, Cryer PE, Gerich JE
J Clin Invest 1984 Jun;73(6):1532-41. doi: 10.1172/JCI111359. PMID: 6373827Free PMC Article

Prognosis

Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Gao S, Cheng Y, Zhao L, Chen Y, Liu Y
Diabetes Metab Res Rev 2016 May;32(4):421-8. Epub 2016 Jan 8 doi: 10.1002/dmrr.2767. PMID: 26589554

Clinical prediction guides

Wang P, Wu L, Yin WJ, Tao RX, Zhang Y, Li PP, Jiang XM, Shao ZY, Zhu P
Front Immunol 2022;13:1078340. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1078340. PMID: 36685522Free PMC Article
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Sanke T, Hanabusa T, Nakano Y, Oki C, Okai K, Nishimura S, Kondo M, Nanjo K
Diabetologia 1991 Feb;34(2):129-32. doi: 10.1007/BF00500385. PMID: 2065848
Krentz AJ, Singh BM, Nattrass M
Diabet Med 1991 Nov;8(9):848-54. doi: 10.1111/j.1464-5491.1991.tb02123.x. PMID: 1837511

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