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Prolonged euglobulin clot lysis time

MedGen UID:
898698
Concept ID:
C4280705
Finding
HPO: HP:0040243

Definition

Abnormally increased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProlonged euglobulin clot lysis time

Professional guidelines

PubMed

Mazur P, Sokołowski G, Hubalewska-Dydejczyk A, Płaczkiewicz-Jankowska E, Undas A
Thromb Res 2014 Aug;134(2):510-7. Epub 2014 Jun 6 doi: 10.1016/j.thromres.2014.05.041. PMID: 24962680
Neergaard-Petersen S, Ajjan R, Hvas AM, Hess K, Larsen SB, Kristensen SD, Grove EL
PLoS One 2013;8(8):e71150. Epub 2013 Aug 19 doi: 10.1371/journal.pone.0071150. PMID: 23976993Free PMC Article

Recent clinical studies

Etiology

Natesirinilkul R, Sasanakul W, Chuansumrit A, Kadegasem P, Visudtibhan A, Wongwerawattanakoon P, Sirachainan N
J Stroke Cerebrovasc Dis 2014 Nov-Dec;23(10):2566-2572. Epub 2014 Oct 3 doi: 10.1016/j.jstrokecerebrovasdis.2014.05.025. PMID: 25284719
Vucković BA, Djerić MJ, Ilić TA, Canak VB, Kojić-Damjanov SLj, Zarkov MG, Cabarkapa VS
Srp Arh Celok Lek 2010 Jan;138 Suppl 1:12-7. doi: 10.2298/sarh10s1012v. PMID: 20229676
Malyszko J, Malyszko JS, Hryszko T, Mysliwiec M
Transplant Proc 2006 Jan-Feb;38(1):105-7. doi: 10.1016/j.transproceed.2005.11.072. PMID: 16504676
Malyszko J, Malyszko JS, Hryszko T, Brzosko S, Lebkowska U, Mysliwiec M
Transpl Int 2005 Feb;18(2):256-9. doi: 10.1111/j.1432-2277.2004.00027.x. PMID: 15691280
Salobir B, Sabovic M, Peternel P, Stegnar M
Pathophysiol Haemost Thromb 2003 Mar-Apr;33(2):96-101. doi: 10.1159/000073853. PMID: 14624051

Diagnosis

Natesirinilkul R, Sasanakul W, Chuansumrit A, Kadegasem P, Visudtibhan A, Wongwerawattanakoon P, Sirachainan N
J Stroke Cerebrovasc Dis 2014 Nov-Dec;23(10):2566-2572. Epub 2014 Oct 3 doi: 10.1016/j.jstrokecerebrovasdis.2014.05.025. PMID: 25284719
Borawski J, Myśliwiec M
Clin Appl Thromb Hemost 2001 Oct;7(4):296-9. doi: 10.1177/107602960100700408. PMID: 11697712

Therapy

Malyszko J, Malyszko JS, Hryszko T, Mysliwiec M
Transplant Proc 2006 Jan-Feb;38(1):105-7. doi: 10.1016/j.transproceed.2005.11.072. PMID: 16504676
Malyszko J, Malyszko JS, Hryszko T, Brzosko S, Lebkowska U, Mysliwiec M
Transpl Int 2005 Feb;18(2):256-9. doi: 10.1111/j.1432-2277.2004.00027.x. PMID: 15691280
Salobir B, Sabovic M, Peternel P, Stegnar M
Pathophysiol Haemost Thromb 2003 Mar-Apr;33(2):96-101. doi: 10.1159/000073853. PMID: 14624051
Rüegg M
Pharmacology 1976;14(6):522-36. doi: 10.1159/000136637. PMID: 1019226

Prognosis

Malyszko J, Malyszko JS, Hryszko T, Brzosko S, Lebkowska U, Mysliwiec M
Transpl Int 2005 Feb;18(2):256-9. doi: 10.1111/j.1432-2277.2004.00027.x. PMID: 15691280
Salobir B, Sabovic M, Peternel P, Stegnar M
Pathophysiol Haemost Thromb 2003 Mar-Apr;33(2):96-101. doi: 10.1159/000073853. PMID: 14624051

Clinical prediction guides

Malyszko J, Malyszko JS, Hryszko T, Mysliwiec M
Transplant Proc 2006 Jan-Feb;38(1):105-7. doi: 10.1016/j.transproceed.2005.11.072. PMID: 16504676
Malyszko J, Malyszko JS, Hryszko T, Brzosko S, Lebkowska U, Mysliwiec M
Transpl Int 2005 Feb;18(2):256-9. doi: 10.1111/j.1432-2277.2004.00027.x. PMID: 15691280
Salobir B, Sabovic M, Peternel P, Stegnar M
Pathophysiol Haemost Thromb 2003 Mar-Apr;33(2):96-101. doi: 10.1159/000073853. PMID: 14624051
Akinsete I, Uyanwah PO
Afr J Med Med Sci 1989 Jun;18(2):89-93. PMID: 2474240

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