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Invasive fungal infection

MedGen UID:
899732
Concept ID:
C1262313
Disease or Syndrome
Synonyms: Disseminated Fungal Infection; Disseminated Fungal Infections; Fungal Infection, Disseminated; Fungal Infection, Invasive; Infection, Disseminated Fungal; Infection, Invasive Fungal; Invasive Fungal Infection; Invasive Fungal Infections; Invasive Mycoses; Mycoses, Invasive
SNOMED CT: Invasive fungal infection (12391000132109); Invasive mycosis (12391000132109); Invasive fungal disease (12391000132109)
 
HPO: HP:0020101

Definition

Fungal infection characterized by invasion of host tissues. [from HPO]

Professional guidelines

PubMed

Chang CC, Harrison TS, Bicanic TA, Chayakulkeeree M, Sorrell TC, Warris A, Hagen F, Spec A, Oladele R, Govender NP, Chen SC, Mody CH, Groll AH, Chen YC, Lionakis MS, Alanio A, Castañeda E, Lizarazo J, Vidal JE, Takazono T, Hoenigl M, Alffenaar JW, Gangneux JP, Soman R, Zhu LP, Bonifaz A, Jarvis JN, Day JN, Klimko N, Salmanton-García J, Jouvion G, Meya DB, Lawrence D, Rahn S, Bongomin F, McMullan BJ, Sprute R, Nyazika TK, Beardsley J, Carlesse F, Heath CH, Ayanlowo OO, Mashedi OM, Queiroz-Telles Filho F, Hosseinipour MC, Patel AK, Temfack E, Singh N, Cornely OA, Boulware DR, Lortholary O, Pappas PG, Perfect JR
Lancet Infect Dis 2024 Aug;24(8):e495-e512. Epub 2024 Feb 9 doi: 10.1016/S1473-3099(23)00731-4. PMID: 38346436Free PMC Article
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767
Mellinghoff SC, Panse J, Alakel N, Behre G, Buchheidt D, Christopeit M, Hasenkamp J, Kiehl M, Koldehoff M, Krause SW, Lehners N, von Lilienfeld-Toal M, Löhnert AY, Maschmeyer G, Teschner D, Ullmann AJ, Penack O, Ruhnke M, Mayer K, Ostermann H, Wolf HH, Cornely OA
Ann Hematol 2018 Feb;97(2):197-207. Epub 2017 Dec 7 doi: 10.1007/s00277-017-3196-2. PMID: 29218389Free PMC Article

Recent clinical studies

Etiology

Puerta-Alcalde P, Monzó-Gallo P, Aguilar-Guisado M, Ramos JC, Laporte-Amargós J, Machado M, Martin-Davila P, Franch-Sarto M, Sánchez-Romero I, Badiola J, Gómez L, Ruiz-Camps I, Yáñez L, Vázquez L, Chumbita M, Marco F, Soriano A, González P, Fernández-Cruz A, Batlle M, Fortún J, Guinea J, Gudiol C, García J, Ruiz Pérez de Pipaón M, Alastruey-Izquierdo A, Garcia-Vidal C
J Infect 2023 Jul;87(1):46-53. Epub 2023 May 16 doi: 10.1016/j.jinf.2023.05.005. PMID: 37201859
Fernández Ávila DC, Diehl M, Degrave AM, Buttazzoni M, Pereira T, Aguirre MA, Basquiera AL, Scolnik M
Reumatismo 2021 Apr 19;73(1):44-47. doi: 10.4081/reumatismo.2021.1368. PMID: 33874646
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
Skiada A, Petrikkos G
Skinmed 2013 May-Jun;11(3):155-9; quiz 159-60. PMID: 23930354

Diagnosis

Puerta-Alcalde P, Monzó-Gallo P, Aguilar-Guisado M, Ramos JC, Laporte-Amargós J, Machado M, Martin-Davila P, Franch-Sarto M, Sánchez-Romero I, Badiola J, Gómez L, Ruiz-Camps I, Yáñez L, Vázquez L, Chumbita M, Marco F, Soriano A, González P, Fernández-Cruz A, Batlle M, Fortún J, Guinea J, Gudiol C, García J, Ruiz Pérez de Pipaón M, Alastruey-Izquierdo A, Garcia-Vidal C
J Infect 2023 Jul;87(1):46-53. Epub 2023 May 16 doi: 10.1016/j.jinf.2023.05.005. PMID: 37201859
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
Gonzalez-Lara MF, Ostrosky-Zeichner L
Semin Respir Crit Care Med 2020 Feb;41(1):3-12. Epub 2020 Jan 30 doi: 10.1055/s-0040-1701215. PMID: 32000280
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article

Therapy

Vergidis P, Sendi P, Alkhateeb HB, Nguyen MH
Clin Microbiol Infect 2024 Jun;30(6):755-761. Epub 2024 Jan 28 doi: 10.1016/j.cmi.2024.01.015. PMID: 38286175
Sprute R, Nacov JA, Neofytos D, Oliverio M, Prattes J, Reinhold I, Cornely OA, Stemler J
Mol Aspects Med 2023 Aug;92:101190. Epub 2023 May 17 doi: 10.1016/j.mam.2023.101190. PMID: 37207579
El-Baba F, Gao Y, Soubani AO
Am J Med 2020 Jun;133(6):668-674. Epub 2020 Mar 30 doi: 10.1016/j.amjmed.2020.02.025. PMID: 32240631
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
Peyton LR, Gallagher S, Hashemzadeh M
Drugs Today (Barc) 2015 Dec;51(12):705-18. doi: 10.1358/dot.2015.51.12.2421058. PMID: 26798851

Prognosis

Vergidis P, Sendi P, Alkhateeb HB, Nguyen MH
Clin Microbiol Infect 2024 Jun;30(6):755-761. Epub 2024 Jan 28 doi: 10.1016/j.cmi.2024.01.015. PMID: 38286175
Gushiken AC, Saharia KK, Baddley JW
Infect Dis Clin North Am 2021 Jun;35(2):493-514. doi: 10.1016/j.idc.2021.03.012. PMID: 34016288
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article
Husain S, Camargo JF
Clin Transplant 2019 Sep;33(9):e13544. Epub 2019 Apr 23 doi: 10.1111/ctr.13544. PMID: 30900296
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article

Clinical prediction guides

Fontana L, Perlin DS, Zhao Y, Noble BN, Lewis JS, Strasfeld L, Hakki M
Clin Infect Dis 2020 Feb 14;70(5):723-730. doi: 10.1093/cid/ciz282. PMID: 30958538Free PMC Article
John J, Loo A, Mazur S, Walsh TJ
Expert Opin Drug Metab Toxicol 2019 Nov;15(11):881-895. Epub 2019 Oct 30 doi: 10.1080/17425255.2019.1671971. PMID: 31550939
Azoulay E, Mokart D, Kouatchet A, Demoule A, Lemiale V
Lancet Respir Med 2019 Feb;7(2):173-186. Epub 2018 Dec 7 doi: 10.1016/S2213-2600(18)30345-X. PMID: 30529232Free PMC Article
Timsit JF, Azoulay E, Schwebel C, Charles PE, Cornet M, Souweine B, Klouche K, Jaber S, Trouillet JL, Bruneel F, Argaud L, Cousson J, Meziani F, Gruson D, Paris A, Darmon M, Garrouste-Orgeas M, Navellou JC, Foucrier A, Allaouchiche B, Das V, Gangneux JP, Ruckly S, Maubon D, Jullien V, Wolff M; EMPIRICUS Trial Group
JAMA 2016 Oct 18;316(15):1555-1564. doi: 10.1001/jama.2016.14655. PMID: 27706483
May RC, Stone NR, Wiesner DL, Bicanic T, Nielsen K
Nat Rev Microbiol 2016 Feb;14(2):106-17. Epub 2015 Dec 21 doi: 10.1038/nrmicro.2015.6. PMID: 26685750Free PMC Article

Recent systematic reviews

Domingos EL, Vilhena RO, Santos JMMF, Fachi MM, Böger B, Adam LM, Tonin FS, Pontarolo R
Int J Antimicrob Agents 2022 Aug;60(2):106614. Epub 2022 Jun 9 doi: 10.1016/j.ijantimicag.2022.106614. PMID: 35691603
Lahmer T, Peçanha-Pietrobom PM, Schmid RM, Colombo AL
Mycoses 2022 Feb;65(2):140-151. Epub 2021 Dec 8 doi: 10.1111/myc.13403. PMID: 34837414
Bassetti M, Garnacho-Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, Chakrabarti A, Kett D, Leon C, Ostrosky-Zeichner L, Sanguinetti M, Timsit JF, Richardson MD, Shorr A, Cornely OA
Intensive Care Med 2017 Sep;43(9):1225-1238. Epub 2017 Mar 2 doi: 10.1007/s00134-017-4731-2. PMID: 28255613
Steimbach LM, Tonin FS, Virtuoso S, Borba HH, Sanches AC, Wiens A, Fernandez-Llimós F, Pontarolo R
Mycoses 2017 Mar;60(3):146-154. Epub 2016 Nov 22 doi: 10.1111/myc.12585. PMID: 27878878
Clerihew L, McGuire W
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD003953. doi: 10.1002/14651858.CD003953.pub3. PMID: 22696338Free PMC Article

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