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Abnormal lymphocyte apoptosis

MedGen UID:
900183
•Concept ID:
C4280725
•
Finding
HPO: HP:0030886

Definition

A anomaly in the rate of programmed cell death (apoptosis) in lymphocytes. [from HPO]

Professional guidelines

PubMed

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Recent clinical studies

Etiology

Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.
Sneller MC, Wang J, Dale JK, Strober W, Middelton LA, Choi Y, Fleisher TA, Lim MS, Jaffe ES, Puck JM, Lenardo MJ, Straus SE
Blood 1997 Feb 15;89(4):1341-8. PMID: 9028957

Diagnosis

Autoimmune Lymphoproliferative Syndrome with Red Cell Aplasia.
Meena KR, Bisht S, Tamaria KC
Indian J Pediatr 2015 Dec;82(12):1172-4. Epub 2015 May 15 doi: 10.1007/s12098-015-1779-2. PMID: 25972287
ALPS: an autoimmune human lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.
Puck JM, Sneller MC
Semin Immunol 1997 Feb;9(1):77-84. doi: 10.1006/smim.1996.0056. PMID: 9106310

Therapy

Autoimmune Lymphoproliferative Syndrome with Red Cell Aplasia.
Meena KR, Bisht S, Tamaria KC
Indian J Pediatr 2015 Dec;82(12):1172-4. Epub 2015 May 15 doi: 10.1007/s12098-015-1779-2. PMID: 25972287

Prognosis

Clincal, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.
Sneller MC, Wang J, Dale JK, Strober W, Middelton LA, Choi Y, Fleisher TA, Lim MS, Jaffe ES, Puck JM, Lenardo MJ, Straus SE
Blood 1997 Feb 15;89(4):1341-8. PMID: 9028957

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