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Childhood Mixed Germ Cell Tumor

MedGen UID:
900715
Concept ID:
C4086164
Neoplastic Process

Definition

A mixed germ cell tumor occurring in children. [from NCI]

Professional guidelines

PubMed

Brown S, Chowdhury T, Collin M, Grundy RG, Howell L, Ramanujachar R, Rees H, Vora A, Gray JC, Bate J
Pediatr Blood Cancer 2023 Mar;70(3):e30159. Epub 2022 Dec 24 doi: 10.1002/pbc.30159. PMID: 36565277
Yeo KK, Nagabushan S, Dhall G, Abdelbaki MS
Neoplasia 2023 Feb;36:100860. Epub 2022 Dec 13 doi: 10.1016/j.neo.2022.100860. PMID: 36521378Free PMC Article
Lober RM
Minerva Pediatr 2013 Apr;65(2):149-65. PMID: 23612260

Recent clinical studies

Etiology

Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Menyhárt O, Giangaspero F, Győrffy B
J Hematol Oncol 2019 Mar 15;12(1):29. doi: 10.1186/s13045-019-0712-y. PMID: 30876441Free PMC Article
Abacı A, Çatlı G, Berberoğlu M
J Pediatr Endocrinol Metab 2015 Sep;28(9-10):1019-27. doi: 10.1515/jpem-2014-0522. PMID: 25879315
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Cuccia V, Rodríguez F, Palma F, Zuccaro G
Childs Nerv Syst 2006 Jun;22(6):577-85. Epub 2006 Mar 23 doi: 10.1007/s00381-006-0095-6. PMID: 16555075

Diagnosis

Cordani R, Veneruso M, Napoli F, Milanaccio C, Verrico A, Consales A, Cataldi M, Fava D, Di Iorgi N, Maghnie M, Mancardi MM, Nobili L
J Neurol 2021 Nov;268(11):4362-4369. Epub 2021 Sep 14 doi: 10.1007/s00415-021-10794-1. PMID: 34522989Free PMC Article
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Menyhárt O, Giangaspero F, Győrffy B
J Hematol Oncol 2019 Mar 15;12(1):29. doi: 10.1186/s13045-019-0712-y. PMID: 30876441Free PMC Article
Abacı A, Çatlı G, Berberoğlu M
J Pediatr Endocrinol Metab 2015 Sep;28(9-10):1019-27. doi: 10.1515/jpem-2014-0522. PMID: 25879315
Dehner LP
Mod Pathol 1998 Jul;11(7):669-85. PMID: 9688189

Therapy

Hall C, Hansen J, von Ehrenstein OS, He D, Olsen J, Ritz B, Heck JE
Int Arch Occup Environ Health 2020 Jul;93(5):659-668. Epub 2020 Feb 5 doi: 10.1007/s00420-020-01524-7. PMID: 32025796Free PMC Article
Burzynski SR
Paediatr Drugs 2006;8(3):167-78. doi: 10.2165/00148581-200608030-00003. PMID: 16774296
Cuccia V, Rodríguez F, Palma F, Zuccaro G
Childs Nerv Syst 2006 Jun;22(6):577-85. Epub 2006 Mar 23 doi: 10.1007/s00381-006-0095-6. PMID: 16555075
McDaid C, Hartley S, Bagnall AM, Ritchie G, Light K, Riemsma R
Health Technol Assess 2005 Dec;9(48):iii, ix-x, 1-145. doi: 10.3310/hta9480. PMID: 16336843
Terenziani M, Massimino M, Casanova M, Cefalo G, Ferrari A, Luksch R, Spreafico F, Polastri D, Fontanelli R, Piva L, Fossati-Bellani F
Gynecol Oncol 2001 Jun;81(3):436-40. doi: 10.1006/gyno.2001.6177. PMID: 11371135

Prognosis

Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Menyhárt O, Giangaspero F, Győrffy B
J Hematol Oncol 2019 Mar 15;12(1):29. doi: 10.1186/s13045-019-0712-y. PMID: 30876441Free PMC Article
Abacı A, Çatlı G, Berberoğlu M
J Pediatr Endocrinol Metab 2015 Sep;28(9-10):1019-27. doi: 10.1515/jpem-2014-0522. PMID: 25879315
Cuccia V, Rodríguez F, Palma F, Zuccaro G
Childs Nerv Syst 2006 Jun;22(6):577-85. Epub 2006 Mar 23 doi: 10.1007/s00381-006-0095-6. PMID: 16555075

Clinical prediction guides

Schraw JM, Sok P, Desrosiers TA, Janitz AE, Langlois PH, Canfield MA, Frazier AL, Plon SE, Lupo PJ, Poynter JN
Cancer 2023 Oct 15;129(20):3300-3308. Epub 2023 Jun 27 doi: 10.1002/cncr.34906. PMID: 37366624
Greimelmaier K, Calaminus G, Kristiansen G, Vokuhl C, Klapper W
Pediatr Blood Cancer 2019 Aug;66(8):e27777. Epub 2019 May 2 doi: 10.1002/pbc.27777. PMID: 31045322
Abacı A, Çatlı G, Berberoğlu M
J Pediatr Endocrinol Metab 2015 Sep;28(9-10):1019-27. doi: 10.1515/jpem-2014-0522. PMID: 25879315
De Backer A, Madern GC, Oosterhuis JW, Hakvoort-Cammel FG, Hazebroek FW
Pediatr Blood Cancer 2006 Apr;46(4):459-64. doi: 10.1002/pbc.20633. PMID: 16206211
McDaid C, Hartley S, Bagnall AM, Ritchie G, Light K, Riemsma R
Health Technol Assess 2005 Dec;9(48):iii, ix-x, 1-145. doi: 10.3310/hta9480. PMID: 16336843

Recent systematic reviews

Kreis C, Doessegger E, Lupatsch JE, Spycher BD
Eur J Epidemiol 2019 Jan;34(1):9-21. Epub 2018 Nov 16 doi: 10.1007/s10654-018-0456-y. PMID: 30446850Free PMC Article
McDaid C, Hartley S, Bagnall AM, Ritchie G, Light K, Riemsma R
Health Technol Assess 2005 Dec;9(48):iii, ix-x, 1-145. doi: 10.3310/hta9480. PMID: 16336843

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