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Childhood Ganglioneuroblastoma

MedGen UID:
901150
•Concept ID:
C4086158
•
Neoplastic Process

Definition

A ganglioneuroblastoma that occurs during childhood. [from NCI]

Professional guidelines

PubMed

Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Early Detection and Treatment of Neuroblastic Tumor with Opsoclonus-Myoclonus Syndrome Improve Neurological Outcome: A Review of Five Cases at a Single Institution in Japan.
Takama Y, Yoneda A, Nakamura T, Nakaoka T, Higashio A, Santo K, Kuki I, Kawawaki H, Tomiwa K, Hara J
Eur J Pediatr Surg 2016 Feb;26(1):54-9. Epub 2015 Sep 26 doi: 10.1055/s-0035-1564714. PMID: 26409265

Recent clinical studies

Etiology

Ganglioneuroblastoma in a Child With Neurofibromatosis Type 1: A Case Report and Literature Review.
Okonta VN, Majlessipour F, Baca NM
J Pediatr Hematol Oncol 2023 Jan 1;45(1):e131-e134. Epub 2022 Apr 6 doi: 10.1097/MPH.0000000000002461. PMID: 35398860
Exploring the prognosis of neuroblastoma in adolescents and adults: a case series and literature review.
Jin QY, Du SB, Yuan XJ
Neoplasma 2022 Mar;69(2):464-473. Epub 2022 Jan 25 doi: 10.4149/neo_2021_210325N399. PMID: 35068159
Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
The ganglioside G(D2) as a circulating tumor biomarker for neuroblastoma.
Balis FM, Busch CM, Desai AV, Hibbitts E, Naranjo A, Bagatell R, Irwin M, Fox E
Pediatr Blood Cancer 2020 Jan;67(1):e28031. Epub 2019 Oct 14 doi: 10.1002/pbc.28031. PMID: 31612589Free PMC Article
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article

Diagnosis

Exploring the prognosis of neuroblastoma in adolescents and adults: a case series and literature review.
Jin QY, Du SB, Yuan XJ
Neoplasma 2022 Mar;69(2):464-473. Epub 2022 Jan 25 doi: 10.4149/neo_2021_210325N399. PMID: 35068159
Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
The ganglioside G(D2) as a circulating tumor biomarker for neuroblastoma.
Balis FM, Busch CM, Desai AV, Hibbitts E, Naranjo A, Bagatell R, Irwin M, Fox E
Pediatr Blood Cancer 2020 Jan;67(1):e28031. Epub 2019 Oct 14 doi: 10.1002/pbc.28031. PMID: 31612589Free PMC Article
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Neuroectodermal and neuroendocrine tumors principally seen in children.
Parham DM
Am J Clin Pathol 2001 Jun;115 Suppl:S113-28. doi: 10.1309/2A98-GPDN-EN87-5J0L. PMID: 11993686

Therapy

Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors.
Tao T, Shi H, Wang M, Perez-Atayde AR, London WB, Gutierrez A, Lemos B, Durbin AD, Look AT
J Exp Med 2020 Oct 5;217(10) doi: 10.1084/jem.20191871. PMID: 32728700Free PMC Article
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Thoracic neuroblastic tumors in childhood.
Demir HA, Yalçin B, Büyükpamukçu N, Kale G, Varan A, Akyüz C, Kutluk T, Büyükpamukçu M
Pediatr Blood Cancer 2010 Jul 1;54(7):885-9. doi: 10.1002/pbc.22405. PMID: 20049935
Second neoplasms in pediatric patients treated for cancer: a center's 30-year experience.
Cağlar K, Varan A, Akyüz C, Selek U, Kutluk T, Yalçin B, Atahan IL, Büyükpamukçu M
J Pediatr Hematol Oncol 2006 Jun;28(6):374-8. doi: 10.1097/00043426-200606000-00010. PMID: 16794506
Pineal region tumors of childhood.
Packer RJ, Sutton LN, Rosenstock JG, Rorke LB, Bilaniuk LT, Zimmerman RA, Littman PA, Bruce DA, Schut L
Pediatrics 1984 Jul;74(1):97-102. PMID: 6739222

Prognosis

Single-cell transcriptome sequencing reveals tumor heterogeneity in family neuroblastoma.
Zhang Y, Ma Y, Liu Q, Du Y, Peng L, Zhou J, Zhao Z, Li C, Wang S
Front Immunol 2023;14:1197773. Epub 2023 Sep 18 doi: 10.3389/fimmu.2023.1197773. PMID: 37790931Free PMC Article
Exploring the prognosis of neuroblastoma in adolescents and adults: a case series and literature review.
Jin QY, Du SB, Yuan XJ
Neoplasma 2022 Mar;69(2):464-473. Epub 2022 Jan 25 doi: 10.4149/neo_2021_210325N399. PMID: 35068159
The ganglioside G(D2) as a circulating tumor biomarker for neuroblastoma.
Balis FM, Busch CM, Desai AV, Hibbitts E, Naranjo A, Bagatell R, Irwin M, Fox E
Pediatr Blood Cancer 2020 Jan;67(1):e28031. Epub 2019 Oct 14 doi: 10.1002/pbc.28031. PMID: 31612589Free PMC Article
Renal and adrenal tumours in children.
McHugh K
Cancer Imaging 2007 Mar 5;7(1):41-51. doi: 10.1102/1470-7330.2007.0007. PMID: 17339140Free PMC Article
Ganglioneuroblastoma in adults.
Kilton LJ, Aschenbrener C, Burns CP
Cancer 1976 Feb;37(2):974-83. doi: 10.1002/1097-0142(197602)37:2<974::aid-cncr2820370254>3.0.co;2-g. PMID: 1253121

Clinical prediction guides

Ganglioneuroblastoma in a Child With Neurofibromatosis Type 1: A Case Report and Literature Review.
Okonta VN, Majlessipour F, Baca NM
J Pediatr Hematol Oncol 2023 Jan 1;45(1):e131-e134. Epub 2022 Apr 6 doi: 10.1097/MPH.0000000000002461. PMID: 35398860
Expression of BARD1 β Isoform in Selected Pediatric Tumors.
Jasiak A, Krawczyńska N, Iliszko M, Czarnota K, Buczkowski K, Stefanowicz J, Adamkiewicz-Drożyńska E, Cichosz G, Iżycka-Świeszewska E
Genes (Basel) 2021 Jan 26;12(2) doi: 10.3390/genes12020168. PMID: 33530592Free PMC Article
The ganglioside G(D2) as a circulating tumor biomarker for neuroblastoma.
Balis FM, Busch CM, Desai AV, Hibbitts E, Naranjo A, Bagatell R, Irwin M, Fox E
Pediatr Blood Cancer 2020 Jan;67(1):e28031. Epub 2019 Oct 14 doi: 10.1002/pbc.28031. PMID: 31612589Free PMC Article
Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B
BMC Cancer 2016 Jul 27;16:542. doi: 10.1186/s12885-016-2513-9. PMID: 27465021Free PMC Article
Cyclin D1 in pediatric neuroblastic tumors: A microarray analysis.
Fagone P, Nicoletti F, Vecchio GM, Parenti R, Magro G
Acta Histochem 2015 Oct;117(8):820-3. Epub 2015 Oct 25 doi: 10.1016/j.acthis.2015.10.002. PMID: 26510683

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