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Childhood Choriocarcinoma

MedGen UID:
901410
•Concept ID:
C4086155
•
Neoplastic Process

Definition

A choriocarcinoma occurring in children. [from NCI]

Professional guidelines

PubMed

Malignant germ cell tumors: clinical characteristics, treatment, and outcome. A report from the study group for Pediatric Solid Malignant Tumors in the Kyushu Area, Japan.
Suita S, Shono K, Tajiri T, Takamatsu T, Mizote H, Nagasaki A, Inomata Y, Hara T, Okamura J, Miyazaki S, Kawakami K, Eguchi H, Tsuneyoshi M; Committee for Pediatric Solid Malignant Tumors in the Kyushu Area
J Pediatr Surg 2002 Dec;37(12):1703-6. doi: 10.1053/jpsu.2002.36700. PMID: 12483635
Progress in the systemic treatment of cancer. Concepts, trials, drugs, and biologics.
Carbone PP
Cancer 1990 Feb 1;65(3 Suppl):625-33. doi: 10.1002/1097-0142(19900201)65:3+<625::aid-cncr2820651305>3.0.co;2-y. PMID: 2302652
Management of primary intracranial germ cell tumors of childhood.
Allen JC
Pediatr Neurosci 1987;13(3):152-7. doi: 10.1159/000120321. PMID: 2841657

Recent clinical studies

Etiology

Palmitate induces integrated stress response and lipoapoptosis in trophoblasts.
Sahoo PK, Krishnamoorthy C, Wood JR, Hanson C, Anderson-Berry A, Mott JL, Natarajan SK
Cell Death Dis 2024 Jan 11;15(1):31. doi: 10.1038/s41419-023-06415-6. PMID: 38212315Free PMC Article
Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor.
Chiofalo B, Palmara V, Laganà AS, Triolo O, Vitale SG, Conway F, Santoro G
Curr Treat Options Oncol 2017 Aug 24;18(10):58. doi: 10.1007/s11864-017-0502-0. PMID: 28840513
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Pelvic neoplasms in children.
Groff DB
J Surg Oncol 2001 May;77(1):65-71. doi: 10.1002/jso.1068. PMID: 11344486
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164

Diagnosis

Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor.
Chiofalo B, Palmara V, Laganà AS, Triolo O, Vitale SG, Conway F, Santoro G
Curr Treat Options Oncol 2017 Aug 24;18(10):58. doi: 10.1007/s11864-017-0502-0. PMID: 28840513
Pelvic neoplasms in children.
Groff DB
J Surg Oncol 2001 May;77(1):65-71. doi: 10.1002/jso.1068. PMID: 11344486
Diagnostic value of alpha 1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood.
Schneider DT, Calaminus G, Göbel U
Pediatr Hematol Oncol 2001 Jan-Feb;18(1):11-26. doi: 10.1080/088800101750059828. PMID: 11205836
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164
Gonadal and extragonadal germ cell neoplasia of childhood.
Dehner LP
Hum Pathol 1983 Jun;14(6):493-511. doi: 10.1016/s0046-8177(83)80004-5. PMID: 6343221

Therapy

Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor.
Chiofalo B, Palmara V, Laganà AS, Triolo O, Vitale SG, Conway F, Santoro G
Curr Treat Options Oncol 2017 Aug 24;18(10):58. doi: 10.1007/s11864-017-0502-0. PMID: 28840513
Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential.
Savage P
BMC Cancer 2015 Jan 21;15:11. doi: 10.1186/s12885-015-1006-6. PMID: 25605631Free PMC Article
Of leaves and butterflies: how methotrexate came to be the savior of women.
Skubisz MM, Tong S
Obstet Gynecol 2011 Nov;118(5):1169-1173. doi: 10.1097/AOG.0b013e31822fcc0d. PMID: 22015888
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164
Management of primary intracranial germ cell tumors of childhood.
Allen JC
Pediatr Neurosci 1987;13(3):152-7. doi: 10.1159/000120321. PMID: 2841657

Prognosis

Fertility Sparing Strategies in Patients Affected by Placental Site Trophoblastic Tumor.
Chiofalo B, Palmara V, Laganà AS, Triolo O, Vitale SG, Conway F, Santoro G
Curr Treat Options Oncol 2017 Aug 24;18(10):58. doi: 10.1007/s11864-017-0502-0. PMID: 28840513
Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside.
Santoro G, Laganà AS, Micali A, Barresi V, Giacobbe V, Palmara V
Arch Gynecol Obstet 2017 Jan;295(1):173-187. Epub 2016 Aug 22 doi: 10.1007/s00404-016-4182-y. PMID: 27549089
Management of primary intracranial germ cell tumors of childhood.
Allen JC
Pediatr Neurosci 1987;13(3):152-7. doi: 10.1159/000120321. PMID: 2841657
Germinal testicular tumors in childhood. Report of observations and literature review.
Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238
Gonadal and extragonadal germ cell neoplasia of childhood.
Dehner LP
Hum Pathol 1983 Jun;14(6):493-511. doi: 10.1016/s0046-8177(83)80004-5. PMID: 6343221

Clinical prediction guides

Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential.
Savage P
BMC Cancer 2015 Jan 21;15:11. doi: 10.1186/s12885-015-1006-6. PMID: 25605631Free PMC Article
Mediastinal germ cell tumors: clinical aspects and outcomes in 7 children.
De Backer A, Madern GC, Hakvoort-Cammel FG, Oosterhuis JW, Hazebroek FW
Eur J Pediatr Surg 2006 Oct;16(5):318-22. doi: 10.1055/s-2006-924647. PMID: 17160775
Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols.
Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ, Harms D, Göbel U
Pediatr Blood Cancer 2004 Feb;42(2):169-75. doi: 10.1002/pbc.10321. PMID: 14752882
Chlorambucil-induced seizures.
Salloum E, Khan KK, Cooper DL
Cancer 1997 Mar 1;79(5):1009-13. doi: 10.1002/(sici)1097-0142(19970301)79:5<1009::aid-cncr18>3.0.co;2-5. PMID: 9041164
Germinal testicular tumors in childhood. Report of observations and literature review.
Weissbach L, Altwein JE, Stiens R
Eur Urol 1984;10(2):73-85. doi: 10.1159/000463762. PMID: 6368238

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