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Reduced prothrombin antigen

MedGen UID:
901989
Concept ID:
C4280698
Finding
HPO: HP:0040250

Definition

Reduced prothrombin antigen as measured by ELISA assay. Prothrombin is a vitamin K-dependent coagulation factor that is proteolytically cleaved to form thrombin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced prothrombin antigen

Conditions with this feature

Vitamin K-dependent clotting factors, combined deficiency of, type 2
MedGen UID:
334505
Concept ID:
C1843832
Disease or Syndrome
Deficiency of all vitamin K-dependent clotting factors leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Familial multiple coagulation factor deficiency is rare. Clinical symptoms of the disease include episodes of intracranial hemorrhage in the first weeks of life, sometimes leading to a fatal outcome (Fregin et al., 2002). For a general phenotypic description and a discussion of genetic heterogeneity of combined deficiency of vitamin K-dependent clotting factors, see VKCFD1 (277450).

Professional guidelines

PubMed

Ha I, Chung JW, Jang ES, Jeong SH, Kim JW
J Gastroenterol Hepatol 2020 Oct;35(10):1774-1781. Epub 2020 Mar 20 doi: 10.1111/jgh.15031. PMID: 32154938
Verhaz A
Srp Arh Celok Lek 2014 Nov-Dec;142(11-12):703-7. doi: 10.2298/sarh1412703v. PMID: 25731000
Hunault M, Bauer KA
Semin Thromb Hemost 2000;26(4):401-5. doi: 10.1055/s-2000-8459. PMID: 11092215

Recent clinical studies

Etiology

Zhan J, Wang J, Zhang Z, Xue R, Jiang S, Liu J, Liu Y, Zhu L, Xia J, Yan X, Ding W, Zhu C, Qiu Y, Li J, Huang R, Wu C
Virulence 2023 Dec;14(1):2268497. Epub 2023 Nov 8 doi: 10.1080/21505594.2023.2268497. PMID: 37938933Free PMC Article
Natorska J, Corral J, de la Morena-Barrio ME, Bravo-Pérez C, Bagoly Z, Bereczky Z, Treliński J, Witkowski M, Klajmon A, Undas A, Ząbczyk M
Thromb Haemost 2023 Sep;123(9):880-891. Epub 2023 May 18 doi: 10.1055/s-0043-1768712. PMID: 37201530Free PMC Article
Elbagir S, Diaz-Gallo LM, Grosso G, Zickert A, Gunnarsson I, Mahler M, Svenungsson E, Rönnelid J
Rheumatology (Oxford) 2023 Feb 1;62(2):924-933. doi: 10.1093/rheumatology/keac327. PMID: 35642868Free PMC Article
Zhong C, Zhang L, Chen L, Deng L, Li R
J Thromb Haemost 2017 Jan;15(1):122-130. Epub 2016 Dec 24 doi: 10.1111/jth.13561. PMID: 27813324
Ye XG, Su QM
World J Gastroenterol 2013 Oct 21;19(39):6665-78. doi: 10.3748/wjg.v19.i39.6665. PMID: 24151397Free PMC Article

Diagnosis

Zhan J, Wang J, Zhang Z, Xue R, Jiang S, Liu J, Liu Y, Zhu L, Xia J, Yan X, Ding W, Zhu C, Qiu Y, Li J, Huang R, Wu C
Virulence 2023 Dec;14(1):2268497. Epub 2023 Nov 8 doi: 10.1080/21505594.2023.2268497. PMID: 37938933Free PMC Article
Su K, Jin Y, Miao Z, Cheng X, Yang L, Wang M
Hematology 2017 Jul;22(6):380-385. Epub 2017 Feb 14 doi: 10.1080/10245332.2017.1287332. PMID: 28196451
Ye XG, Su QM
World J Gastroenterol 2013 Oct 21;19(39):6665-78. doi: 10.3748/wjg.v19.i39.6665. PMID: 24151397Free PMC Article
Lockwood CJ, Rand JH
Obstet Gynecol Surv 1994 Jun;49(6):432-41. doi: 10.1097/00006254-199406000-00026. PMID: 7522311
Adler M, Gavaler JS, Duquesnoy R, Fung JJ, Svanas G, Starzl TE, van Thiel DH
Ann Surg 1988 Aug;208(2):196-202. doi: 10.1097/00000658-198808000-00011. PMID: 3041926Free PMC Article

Therapy

Zhan J, Wang J, Zhang Z, Xue R, Jiang S, Liu J, Liu Y, Zhu L, Xia J, Yan X, Ding W, Zhu C, Qiu Y, Li J, Huang R, Wu C
Virulence 2023 Dec;14(1):2268497. Epub 2023 Nov 8 doi: 10.1080/21505594.2023.2268497. PMID: 37938933Free PMC Article
Christersson C, Wallentin L, Andersson U, Alexander JH, Alings M, De Caterina R, Gersh BJ, Granger CB, Halvorsen S, Hanna M, Huber K, Hylek EM, Lopes RD, Oh BH, Siegbahn A
Heart 2019 Feb;105(3):235-242. Epub 2018 Sep 12 doi: 10.1136/heartjnl-2018-313351. PMID: 30209126Free PMC Article
Zhong C, Zhang L, Chen L, Deng L, Li R
J Thromb Haemost 2017 Jan;15(1):122-130. Epub 2016 Dec 24 doi: 10.1111/jth.13561. PMID: 27813324
Liu L, Ling J, Ma Z, Yuan Q, Pan J, Yang H
Mol Med Rep 2015 Apr;11(4):3015-20. Epub 2014 Dec 3 doi: 10.3892/mmr.2014.3041. PMID: 25482054
Ye XG, Su QM
World J Gastroenterol 2013 Oct 21;19(39):6665-78. doi: 10.3748/wjg.v19.i39.6665. PMID: 24151397Free PMC Article

Prognosis

Zhan J, Wang J, Zhang Z, Xue R, Jiang S, Liu J, Liu Y, Zhu L, Xia J, Yan X, Ding W, Zhu C, Qiu Y, Li J, Huang R, Wu C
Virulence 2023 Dec;14(1):2268497. Epub 2023 Nov 8 doi: 10.1080/21505594.2023.2268497. PMID: 37938933Free PMC Article
Roberts JC, Javed MJ, Lundy MK, Burns RM, Wang H, Tarantino MD
J Thromb Haemost 2022 Aug;20(8):1797-1807. Epub 2022 May 22 doi: 10.1111/jth.15755. PMID: 35524764Free PMC Article
Navone SE, Guarnaccia L, Locatelli M, Rampini P, Caroli M, La Verde N, Gaudino C, Bettinardi N, Riboni L, Marfia G, Campanella R
World Neurosurg 2019 Jan;121:e621-e629. Epub 2018 Oct 3 doi: 10.1016/j.wneu.2018.09.177. PMID: 30292037
Liu L, Ling J, Ma Z, Yuan Q, Pan J, Yang H
Mol Med Rep 2015 Apr;11(4):3015-20. Epub 2014 Dec 3 doi: 10.3892/mmr.2014.3041. PMID: 25482054
Puccetti L, Bruni F, Pasqui AL, Pastorelli M, Bova G, Cercignani M, Palazzuoli A, Auteri A
Ital Heart J 2002 Oct;3(10):579-86. PMID: 12478815

Clinical prediction guides

Zhan J, Wang J, Zhang Z, Xue R, Jiang S, Liu J, Liu Y, Zhu L, Xia J, Yan X, Ding W, Zhu C, Qiu Y, Li J, Huang R, Wu C
Virulence 2023 Dec;14(1):2268497. Epub 2023 Nov 8 doi: 10.1080/21505594.2023.2268497. PMID: 37938933Free PMC Article
Zhong C, Zhang L, Chen L, Deng L, Li R
J Thromb Haemost 2017 Jan;15(1):122-130. Epub 2016 Dec 24 doi: 10.1111/jth.13561. PMID: 27813324
Liu L, Ling J, Ma Z, Yuan Q, Pan J, Yang H
Mol Med Rep 2015 Apr;11(4):3015-20. Epub 2014 Dec 3 doi: 10.3892/mmr.2014.3041. PMID: 25482054
Ye XG, Su QM
World J Gastroenterol 2013 Oct 21;19(39):6665-78. doi: 10.3748/wjg.v19.i39.6665. PMID: 24151397Free PMC Article
Coppola L, Guastafierro S, Verrazzo G, Coppola A, De Lucia D, Tirelli A
Arch Pathol Lab Med 2002 Jul;126(7):842-5. doi: 10.5858/2002-126-0842-CIIMPA. PMID: 12088455

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