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Pigmentary Change in Skin

MedGen UID:: 902740
•Concept ID:: C4086744
•: Finding

Synonym:

Pigmentary Change of Skin

Definition

Abnormal skin pigmentation. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPigmentary Change in Skin

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Site or System
    - Integumentary system finding
      - Pigmentary Change in Skin
        Depigmentation
        Hyperpigmentation of the skin
        Acromelanosis
        Carney complex
        Carney complex type 2
        Carney complex, type 1
        Carney complex - trismus - pseudocamptodactyly syndrome
        Dermatopathia pigmentosa reticularis
        Dowling-Degos disease
        Dowling-Degos disease 1
        Dowling-Degos disease 2
        Dowling-degos disease 3
        Dowling-Degos disease 4
        Dyschromatosis universalis hereditaria
        Dyskeratosis congenita
        Autosomal recessive dyskeratosis congenita
        Autosomal recessive dyskeratosis congenita 4
        Dyskeratosis congenita, autosomal dominant 1
        Dyskeratosis congenita, autosomal dominant 2
        Dyskeratosis congenita, autosomal dominant 3
        Dyskeratosis congenita, autosomal dominant 6
        Dyskeratosis congenita, autosomal recessive 1
        Dyskeratosis congenita, autosomal recessive 2
        Dyskeratosis congenita, autosomal recessive 3
        Dyskeratosis congenita, autosomal recessive 5
        Dyskeratosis congenita, autosomal recessive 6
        Dyskeratosis congenita, X-linked
        Revesz syndrome
        Extrasystoles-short stature-hyperpigmentation-microcephaly syndrome
        Familial generalized lentiginosis
        Familial progressive hyperpigmentation
        Fanconi anemia
        Fanconi anemia complementation group A
        Fanconi anemia complementation group B
        Fanconi anemia complementation group C
        Fanconi anemia complementation group D1
        Fanconi anemia complementation group D2
        Fanconi anemia complementation group E
        Fanconi anemia complementation group F
        Fanconi anemia complementation group G
        Fanconi anemia complementation group I
        Fanconi anemia complementation group J
        Fanconi anemia complementation group L
        Fanconi anemia complementation group N
        Fanconi anemia complementation group O
        Fanconi anemia complementation group P
        Fanconi anemia, complementation group M
        Gastrocutaneous syndrome
        Generalized hyperpigmentation
        Generalized bronze hyperpigmentation
        Generalized reticulate brown pigmentation
        H syndrome
        Hyperkeratosis-hyperpigmentation syndrome
        Hyperpigmentation in sun-exposed areas
        Freckles in sun-exposed areas
        Hypertrichotic hyperpigmented patch
        Intrauterine growth restriction-congenital multiple café-au-lait macules-increased sister chromatid exchange syndrome
        Irregular hyperpigmentation
        Forehead hyperpigmentation
        Hyperpigmentation of eyelid
        Hyperpigmented streaks
        Irregular hyperpigmentation of back
        Linear hyperpigmentation
        Progressive reticulate hyperpigmentation
        Reticular hyperpigmentation
        Spotty hyperpigmentation
        Legius syndrome
        Leukonychia totalis-acanthosis-nigricans-like lesions-abnormal hair syndrome
        Linear and whorled nevoid hypermelanosis
        McCune-Albright syndrome
        Melanosis
        Acanthosis nigricans
        Lentigo
        Melasma
        Moynahan syndrome
        Naegeli-Franceschetti-Jadassohn syndrome
        Nail and teeth abnormalities-marginal palmoplantar keratoderma-oral hyperpigmentation syndrome
        Neuroectodermal melanolysosomal disease
        Neurofibromatosis type 6
        Neurofibromatosis, type 1
        Chromosome 17q11.2 deletion syndrome, 1.4Mb
        Neurofibromatosis type 1 due to NF1 mutation or intragenic deletion
        Neurofibromatosis Type 1 with Inoperable, Progressive, Symptomatic Plexiform Neurofibromas
        Recurrent Neurofibromatosis Type 1
        Refractory Neurofibromatosis Type 1
        Neurofibromatosis-Noonan syndrome
        Noonan syndrome with multiple lentigines
        LEOPARD syndrome 1
        LEOPARD syndrome 2
        LEOPARD syndrome 3
        Osteopathia striata-pigmentary dermopathy-white forelock syndrome
        Peutz-Jeghers syndrome
        Port-wine stain with oculocutaneous melanosis
        Phakomatosis cesioflammea
        Phakomatosis cesiomarmorata
        Phakomatosis spilorosea
        Pretibial hyperpigmentation
        Progressive hyperpigmentation
        Reticulate acropigmentation of Kitamura
        Schwannomatosis
        Severe growth deficiency-strabismus-extensive dermal melanocytosis-intellectual disability syndrome
        Symmetrical dyschromatosis of extremities
        Terminal osseous dysplasia-pigmentary defects syndrome
        Hypopigmentation of the skin
        Absent skin pigmentation
        Absent pigmentation of chest
        Absent pigmentation of the abdomen
        Absent pigmentation of the limbs
        Albinism
        Chédiak-Higashi syndrome
        Ocular albinism
        Ocular albinism, type I
        Oculocutaneous albinism
        Piebaldism
        Albinism-hearing loss syndrome
        Confetti hypopigmentation pattern of lower leg skin
        Deaf blind hypopigmentation syndrome, Yemenite type
        Generalized hypopigmentation
        Hypopigmented streaks
        Mediosternal, longitudinal streak of hypopigmentation
        Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies
        Mixed hypo- and hyperpigmentation of the skin
        Areas of hypopigmentation and hyperpigmentation that do not follow Blaschko lines
        Axillary and groin hyperpigmentation and hypopigmentation
        Increased groin pigmentation with raindrop depigmentation
        Patchy hypo- and hyperpigmentation
        Partial albinism
        PCWH syndrome
        Piebald trait-neurologic defects syndrome
        Tietz syndrome
        Vici syndrome
        Vitiligo
        Progressive vitiligo
        Waardenburg syndrome
        Waardenburg syndrome type 1
        Waardenburg syndrome type 2
        Waardenburg syndrome type 3
        Waardenburg syndrome type 4A
        Waardenburg-Shah syndrome
        Waardenburg syndrome type 4B
        Waardenburg syndrome type 4C

Professional guidelines

PubMed

Characteristics and management of Asian skin.

Chan IL, Cohen S, da Cunha MG, Maluf LC
Int J Dermatol 2019 Feb;58(2):131-143. Epub 2018 Jul 24 doi: 10.1111/ijd.14153. PMID: 30039861

Cutaneous lupus erythematosus: issues in diagnosis and treatment.

Walling HW, Sontheimer RD
Am J Clin Dermatol 2009;10(6):365-81. doi: 10.2165/11310780-000000000-00000. PMID: 19824738

Skin ageing and its treatment.

Baumann L
J Pathol 2007 Jan;211(2):241-51. doi: 10.1002/path.2098. PMID: 17200942

See all (69)

Recent clinical studies

Etiology

Efficacy of fractional laser, radiofrequency and IPL rejuvenation of periorbital region.

Kołodziejczak A, Rotsztejn H
Lasers Med Sci 2022 Mar;37(2):895-903. Epub 2021 May 14 doi: 10.1007/s10103-021-03329-7. PMID: 33988812 Free PMC Article

Characteristics and management of Asian skin.

Chan IL, Cohen S, da Cunha MG, Maluf LC
Int J Dermatol 2019 Feb;58(2):131-143. Epub 2018 Jul 24 doi: 10.1111/ijd.14153. PMID: 30039861

UV radiation and the skin.

D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T
Int J Mol Sci 2013 Jun 7;14(6):12222-48. doi: 10.3390/ijms140612222. PMID: 23749111 Free PMC Article

Ethnic skin disorders overview.

Halder RM, Nootheti PK
J Am Acad Dermatol 2003 Jun;48(6 Suppl):S143-8. doi: 10.1067/mjd.2003.274. PMID: 12789168

Chemical face peels.

Matarasso SL, Glogau RG
Dermatol Clin 1991 Jan;9(1):131-50. PMID: 2022090

See all (226)

Diagnosis

Ultraviolet imaging in dermatology.

Mojeski JA, Almashali M, Jowdy P, Fitzgerald ME, Brady KL, Zeitouni NC, Colegio OR, Paragh G
Photodiagnosis Photodyn Ther 2020 Jun;30:101743. Epub 2020 Mar 18 doi: 10.1016/j.pdpdt.2020.101743. PMID: 32198019

Pigmentation Disorders in the Elderly.

Armenta AM, Henkel ED, Ahmed AM
Drugs Aging 2019 Mar;36(3):235-245. doi: 10.1007/s40266-018-00633-w. PMID: 30637685

UV radiation and the skin.

D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T
Int J Mol Sci 2013 Jun 7;14(6):12222-48. doi: 10.3390/ijms140612222. PMID: 23749111 Free PMC Article

Cutaneous lupus erythematosus: issues in diagnosis and treatment.

Walling HW, Sontheimer RD
Am J Clin Dermatol 2009;10(6):365-81. doi: 10.2165/11310780-000000000-00000. PMID: 19824738

Pigmentary diseases.

Kim NY, Pandya AG
Med Clin North Am 1998 Sep;82(5):1185-207. doi: 10.1016/s0025-7125(05)70410-7. PMID: 9769800

See all (190)

Therapy

Characteristics and management of Asian skin.

Chan IL, Cohen S, da Cunha MG, Maluf LC
Int J Dermatol 2019 Feb;58(2):131-143. Epub 2018 Jul 24 doi: 10.1111/ijd.14153. PMID: 30039861

Photoaging.

Sjerobabski Masnec I, Poduje S
Coll Antropol 2008 Oct;32 Suppl 2:177-80. PMID: 19140280

Skin ageing and its treatment.

Baumann L
J Pathol 2007 Jan;211(2):241-51. doi: 10.1002/path.2098. PMID: 17200942

Photoaging in Asians.

Chung JH
Photodermatol Photoimmunol Photomed 2003 Jun;19(3):109-21. doi: 10.1034/j.1600-0781.2003.00027.x. PMID: 12914595

Chemical face peels.

Matarasso SL, Glogau RG
Dermatol Clin 1991 Jan;9(1):131-50. PMID: 2022090

See all (267)

Prognosis

Clinical and biological impact of the exposome on the skin.

Passeron T, Krutmann J, Andersen ML, Katta R, Zouboulis CC
J Eur Acad Dermatol Venereol 2020 Jul;34 Suppl 4:4-25. doi: 10.1111/jdv.16614. PMID: 32677068

Pigmentation Disorders in the Elderly.

Armenta AM, Henkel ED, Ahmed AM
Drugs Aging 2019 Mar;36(3):235-245. doi: 10.1007/s40266-018-00633-w. PMID: 30637685

Pigmentary changes in patients treated with targeted anticancer agents: A systematic review and meta-analysis.

Dai J, Belum VR, Wu S, Sibaud V, Lacouture ME
J Am Acad Dermatol 2017 Nov;77(5):902-910.e2. Epub 2017 Sep 14 doi: 10.1016/j.jaad.2017.06.044. PMID: 28918974 Free PMC Article

Skin ageing and its treatment.

Baumann L
J Pathol 2007 Jan;211(2):241-51. doi: 10.1002/path.2098. PMID: 17200942

Jellyfish envenomation syndromes updated.

Burnett JW, Calton GJ
Ann Emerg Med 1987 Sep;16(9):1000-5. doi: 10.1016/s0196-0644(87)80748-5. PMID: 2888425

See all (89)

Clinical prediction guides

Efficacy of fractional laser, radiofrequency and IPL rejuvenation of periorbital region.

Kołodziejczak A, Rotsztejn H
Lasers Med Sci 2022 Mar;37(2):895-903. Epub 2021 May 14 doi: 10.1007/s10103-021-03329-7. PMID: 33988812 Free PMC Article

Characteristics and management of Asian skin.

Chan IL, Cohen S, da Cunha MG, Maluf LC
Int J Dermatol 2019 Feb;58(2):131-143. Epub 2018 Jul 24 doi: 10.1111/ijd.14153. PMID: 30039861

Dermal fillers: pathophysiology, prevention and treatment of complications.

Chiang YZ, Pierone G, Al-Niaimi F
J Eur Acad Dermatol Venereol 2017 Mar;31(3):405-413. Epub 2016 Oct 28 doi: 10.1111/jdv.13977. PMID: 27662522

Neuroendocrinology of the skin.

Slominski A, Wortsman J
Endocr Rev 2000 Oct;21(5):457-87. doi: 10.1210/edrv.21.5.0410. PMID: 11041445

Jellyfish envenomation syndromes updated.

Burnett JW, Calton GJ
Ann Emerg Med 1987 Sep;16(9):1000-5. doi: 10.1016/s0196-0644(87)80748-5. PMID: 2888425

See all (208)

Recent systematic reviews

Laser Treatment Monitoring with Reflectance Confocal Microscopy.

Guida S, Longo C, Amato S, Rossi AM, Manfredini M, Ciardo S, Spadafora M, Nisticò SP, Mercuri SR, Rongioletti F, Zerbinati N, Pellacani G
Medicina (Kaunas) 2023 May 28;59(6) doi: 10.3390/medicina59061039. PMID: 37374244 Free PMC Article

Prevalence of Chronic Kidney Disease, Its Risk Factors and Outcome in Nepal: A Systematic Review and Meta-analysis.

Shrestha DB, Budhathoki P, Sedhai YR, Baniya R, Gaire S, Adhikari Y, Marasini A, Bhandari S, Sedhain A
J Nepal Health Res Counc 2021 Sep 6;19(2):230-238. doi: 10.33314/jnhrc.v19i2.3302. PMID: 34601509

Treatment Modalities for Cherry Angiomas: A Systematic Review.

Buslach N, Foulad DP, Saedi N, Mesinkovska NA
Dermatol Surg 2020 Dec;46(12):1691-1697. doi: 10.1097/DSS.0000000000002791. PMID: 33252464

Pigmentary changes in patients treated with targeted anticancer agents: A systematic review and meta-analysis.

Dai J, Belum VR, Wu S, Sibaud V, Lacouture ME
J Am Acad Dermatol 2017 Nov;77(5):902-910.e2. Epub 2017 Sep 14 doi: 10.1016/j.jaad.2017.06.044. PMID: 28918974 Free PMC Article

Mosaic Neurofibromatosis Type 1: A Systematic Review.

García-Romero MT, Parkin P, Lara-Corrales I
Pediatr Dermatol 2016 Jan-Feb;33(1):9-17. Epub 2015 Sep 4 doi: 10.1111/pde.12673. PMID: 26338194

See all (6)

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Pigmentary Change in Skin

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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