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Breast Cancer Lymphedemas

MedGen UID:
904196
•Concept ID:
C4277512
•
Disease or Syndrome
Synonyms: Breast Cancer Lymphedema; Breast Cancer Related Arm Lymphedema; Breast Cancer Related Lymphedema; Breast Cancer Treatment Related Lymphedema; Breast Cancer Treatment-Related Lymphedema; Breast Cancer-Related Arm Lymphedema; Lymphedema, Breast Cancer

Definition

Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical treatment (e.g., MASTECTOMY) or radiation treatment of breast cancer. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Cancer Lymphedemas

Professional guidelines

PubMed

Breast Surgery: Management of Postoperative Complications Following Operations for Breast Cancer.
Al-Hilli Z, Wilkerson A
Surg Clin North Am 2021 Oct;101(5):845-863. Epub 2021 Aug 7 doi: 10.1016/j.suc.2021.06.014. PMID: 34537147
Long-Term Effects of Breast Cancer Surgery, Treatment, and Survivor Care.
Lovelace DL, McDaniel LR, Golden D
J Midwifery Womens Health 2019 Nov;64(6):713-724. Epub 2019 Jul 19 doi: 10.1111/jmwh.13012. PMID: 31322834
Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment.
Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D, Zick SM, Boyce LM, Tripathy D
CA Cancer J Clin 2017 May 6;67(3):194-232. Epub 2017 Apr 24 doi: 10.3322/caac.21397. PMID: 28436999Free PMC Article

Recent clinical studies

Etiology

Prospective Surveillance for Breast Cancer-Related Arm Lymphedema: A Systematic Review and Meta-Analysis.
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
Manual lymphatic drainage treatment for lymphedema: a systematic review of the literature.
Thompson B, Gaitatzis K, Janse de Jonge X, Blackwell R, Koelmeyer LA
J Cancer Surviv 2021 Apr;15(2):244-258. Epub 2020 Aug 15 doi: 10.1007/s11764-020-00928-1. PMID: 32803533
Efficacy and efficiency of a new therapeutic approach based on activity-oriented proprioceptive antiedema therapy (TAPA) for edema reduction and improved occupational performance in the rehabilitation of breast cancer-related arm lymphedema in women: a controlled, randomized clinical trial.
Muñoz-Alcaraz MN, Pérula-de-Torres LÁ, Serrano-Merino J, Jiménez-Vílchez AJ, Olmo-Carmona MV, Muñoz-García MT, Bartolomé-Moreno C, Oliván-Blázquez B, Magallón-Botaya R
BMC Cancer 2020 Nov 9;20(1):1074. doi: 10.1186/s12885-020-07558-x. PMID: 33167921Free PMC Article
Breast Cancer-Related Lymphedema: Risk Factors, Screening, Management, and the Impact of Locoregional Treatment.
McLaughlin SA, Brunelle CL, Taghian A
J Clin Oncol 2020 Jul 10;38(20):2341-2350. Epub 2020 May 22 doi: 10.1200/JCO.19.02896. PMID: 32442064Free PMC Article
Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.
Hasenoehrl T, Palma S, Ramazanova D, Kölbl H, Dorner TE, Keilani M, Crevenna R
Support Care Cancer 2020 Aug;28(8):3593-3603. Epub 2020 May 15 doi: 10.1007/s00520-020-05521-x. PMID: 32415386Free PMC Article

Diagnosis

Advances in the prevention and treatment of breast cancer-related lymphedema.
Donahue PMC, MacKenzie A, Filipovic A, Koelmeyer L
Breast Cancer Res Treat 2023 Jul;200(1):1-14. Epub 2023 Apr 27 doi: 10.1007/s10549-023-06947-7. PMID: 37103598Free PMC Article
Effect of exercise mode on physical function and quality of life in breast cancer-related lymphedema: a randomized trial.
Basha MA, Aboelnour NH, Alsharidah AS, Kamel FH
Support Care Cancer 2022 Mar;30(3):2101-2110. Epub 2021 Oct 20 doi: 10.1007/s00520-021-06559-1. PMID: 34669036
Diagnosis, treatment and quality of life in patients with cancer-related lymphedema.
Kalemikerakis I, Evaggelakou A, Kavga A, Vastardi M, Konstantinidis T, Govina O
J BUON 2021 Sep-Oct;26(5):1735-1741. PMID: 34761576
Lymphedema after Breast Cancer Treatment.
Rockson SG
N Engl J Med 2018 Nov 15;379(20):1937-1944. doi: 10.1056/NEJMcp1803290. PMID: 30428297
Effects of Kinesio Taping on breast cancer-related lymphedema: A meta-analysis in clinical trials.
Kasawara KT, Mapa JMR, Ferreira V, Added MAN, Shiwa SR, Carvas N Jr, Batista PA
Physiother Theory Pract 2018 May;34(5):337-345. Epub 2018 Jan 8 doi: 10.1080/09593985.2017.1419522. PMID: 29308967

Therapy

Prospective Surveillance for Breast Cancer-Related Arm Lymphedema: A Systematic Review and Meta-Analysis.
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
Manual lymphatic drainage for lymphedema in patients after breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
Liang M, Chen Q, Peng K, Deng L, He L, Hou Y, Zhang Y, Guo J, Mei Z, Li L
Medicine (Baltimore) 2020 Dec 4;99(49):e23192. doi: 10.1097/MD.0000000000023192. PMID: 33285693Free PMC Article
Efficacy and efficiency of a new therapeutic approach based on activity-oriented proprioceptive antiedema therapy (TAPA) for edema reduction and improved occupational performance in the rehabilitation of breast cancer-related arm lymphedema in women: a controlled, randomized clinical trial.
Muñoz-Alcaraz MN, Pérula-de-Torres LÁ, Serrano-Merino J, Jiménez-Vílchez AJ, Olmo-Carmona MV, Muñoz-García MT, Bartolomé-Moreno C, Oliván-Blázquez B, Magallón-Botaya R
BMC Cancer 2020 Nov 9;20(1):1074. doi: 10.1186/s12885-020-07558-x. PMID: 33167921Free PMC Article
Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.
Hasenoehrl T, Palma S, Ramazanova D, Kölbl H, Dorner TE, Keilani M, Crevenna R
Support Care Cancer 2020 Aug;28(8):3593-3603. Epub 2020 May 15 doi: 10.1007/s00520-020-05521-x. PMID: 32415386Free PMC Article
Effects of a 12-week resistance and aerobic exercise program on muscular strength and quality of life in breast cancer survivors: Study protocol for the EFICAN randomized controlled trial.
Soriano-Maldonado A, Carrera-Ruiz Á, Díez-Fernández DM, Esteban-Simón A, Maldonado-Quesada M, Moreno-Poza N, García-Martínez MDM, Alcaraz-García C, Vázquez-Sousa R, Moreno-Martos H, Toro-de-Federico A, Hachem-Salas N, Artés-Rodríguez E, Rodríguez-Pérez MA, Casimiro-Andújar AJ
Medicine (Baltimore) 2019 Nov;98(44):e17625. doi: 10.1097/MD.0000000000017625. PMID: 31689771Free PMC Article

Prognosis

Prediction models for breast cancer-related lymphedema: a systematic review and critical appraisal.
Lin Q, Yang T, Yongmei J, Die YM
Syst Rev 2022 Oct 13;11(1):217. doi: 10.1186/s13643-022-02084-2. PMID: 36229876Free PMC Article
Comparing hypofractionated to conventional fractionated radiotherapy in postmastectomy breast cancer: a meta-analysis and systematic review.
Liu L, Yang Y, Guo Q, Ren B, Peng Q, Zou L, Zhu Y, Tian Y
Radiat Oncol 2020 Jan 17;15(1):17. doi: 10.1186/s13014-020-1463-1. PMID: 31952507Free PMC Article
Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection.
Cho Y, Do J, Jung S, Kwon O, Jeon JY
Support Care Cancer 2016 May;24(5):2047-2057. Epub 2015 Nov 5 doi: 10.1007/s00520-015-3005-1. PMID: 26542271
Regional Nodal Irradiation in Early-Stage Breast Cancer.
Whelan TJ, Olivotto IA, Parulekar WR, Ackerman I, Chua BH, Nabid A, Vallis KA, White JR, Rousseau P, Fortin A, Pierce LJ, Manchul L, Chafe S, Nolan MC, Craighead P, Bowen J, McCready DR, Pritchard KI, Gelmon K, Murray Y, Chapman JA, Chen BE, Levine MN; MA.20 Study Investigators
N Engl J Med 2015 Jul 23;373(4):307-16. doi: 10.1056/NEJMoa1415340. PMID: 26200977Free PMC Article
Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis.
DiSipio T, Rye S, Newman B, Hayes S
Lancet Oncol 2013 May;14(6):500-15. Epub 2013 Mar 27 doi: 10.1016/S1470-2045(13)70076-7. PMID: 23540561

Clinical prediction guides

Prediction models for breast cancer-related lymphedema: a systematic review and critical appraisal.
Lin Q, Yang T, Yongmei J, Die YM
Syst Rev 2022 Oct 13;11(1):217. doi: 10.1186/s13643-022-02084-2. PMID: 36229876Free PMC Article
Prospective Surveillance for Breast Cancer-Related Arm Lymphedema: A Systematic Review and Meta-Analysis.
Rafn BS, Christensen J, Larsen A, Bloomquist K
J Clin Oncol 2022 Mar 20;40(9):1009-1026. Epub 2022 Jan 25 doi: 10.1200/JCO.21.01681. PMID: 35077194
Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.
Hasenoehrl T, Palma S, Ramazanova D, Kölbl H, Dorner TE, Keilani M, Crevenna R
Support Care Cancer 2020 Aug;28(8):3593-3603. Epub 2020 May 15 doi: 10.1007/s00520-020-05521-x. PMID: 32415386Free PMC Article
Effects of Kinesio Taping on breast cancer-related lymphedema: A meta-analysis in clinical trials.
Kasawara KT, Mapa JMR, Ferreira V, Added MAN, Shiwa SR, Carvas N Jr, Batista PA
Physiother Theory Pract 2018 May;34(5):337-345. Epub 2018 Jan 8 doi: 10.1080/09593985.2017.1419522. PMID: 29308967
Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection.
Cho Y, Do J, Jung S, Kwon O, Jeon JY
Support Care Cancer 2016 May;24(5):2047-2057. Epub 2015 Nov 5 doi: 10.1007/s00520-015-3005-1. PMID: 26542271

Recent systematic reviews

Manual lymphatic drainage treatment for lymphedema: a systematic review of the literature.
Thompson B, Gaitatzis K, Janse de Jonge X, Blackwell R, Koelmeyer LA
J Cancer Surviv 2021 Apr;15(2):244-258. Epub 2020 Aug 15 doi: 10.1007/s11764-020-00928-1. PMID: 32803533
Manual lymphatic drainage for lymphedema in patients after breast cancer surgery: A systematic review and meta-analysis of randomized controlled trials.
Liang M, Chen Q, Peng K, Deng L, He L, Hou Y, Zhang Y, Guo J, Mei Z, Li L
Medicine (Baltimore) 2020 Dec 4;99(49):e23192. doi: 10.1097/MD.0000000000023192. PMID: 33285693Free PMC Article
Resistance exercise and breast cancer-related lymphedema-a systematic review update and meta-analysis.
Hasenoehrl T, Palma S, Ramazanova D, Kölbl H, Dorner TE, Keilani M, Crevenna R
Support Care Cancer 2020 Aug;28(8):3593-3603. Epub 2020 May 15 doi: 10.1007/s00520-020-05521-x. PMID: 32415386Free PMC Article
A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews.
Olsson Möller U, Beck I, Rydén L, Malmström M
BMC Cancer 2019 May 20;19(1):472. doi: 10.1186/s12885-019-5648-7. PMID: 31109309Free PMC Article
Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment.
Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D, Zick SM, Boyce LM, Tripathy D
CA Cancer J Clin 2017 May 6;67(3):194-232. Epub 2017 Apr 24 doi: 10.3322/caac.21397. PMID: 28436999Free PMC Article

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