U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chronic traumatic encephalopathy

MedGen UID:
906070
Concept ID:
C4082769
Disease or Syndrome
Synonyms: Chronic Post Traumatic Encephalopathy; Chronic Post-Traumatic Encephalopathies; Chronic Post-Traumatic Encephalopathy; Chronic Traumatic Encephalopathy; Encephalopathy, Post-Traumatic, Chronic; Traumatic Encephalopathy, Chronic
SNOMED CT: CTE - chronic traumatic encephalopathy (1187004001); Chronic traumatic encephalopathy (1187004001)

Definition

A degenerative brain disease linked to a history of repetitive head impacts such as those experienced in contact and collision sports or combat military service. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic traumatic encephalopathy

Professional guidelines

PubMed

McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, Daneshvar DH
Acta Neuropathol 2023 Apr;145(4):371-394. Epub 2023 Feb 10 doi: 10.1007/s00401-023-02540-w. PMID: 36759368Free PMC Article
Hubertus V, Marklund N, Vajkoczy P
Acta Neurochir (Wien) 2019 Mar;161(3):425-433. Epub 2019 Jan 28 doi: 10.1007/s00701-019-03807-6. PMID: 30687899
Lucke-Wold BP, Logsdon AF, Nguyen L, Eltanahay A, Turner RC, Bonasso P, Knotts C, Moeck A, Maroon JC, Bailes JE, Rosen CL
Nutr Neurosci 2018 Feb;21(2):79-91. Epub 2016 Oct 5 doi: 10.1080/1028415X.2016.1236174. PMID: 27705610Free PMC Article

Recent clinical studies

Etiology

Patricios JS, Schneider KJ, Dvorak J, Ahmed OH, Blauwet C, Cantu RC, Davis GA, Echemendia RJ, Makdissi M, McNamee M, Broglio S, Emery CA, Feddermann-Demont N, Fuller GW, Giza CC, Guskiewicz KM, Hainline B, Iverson GL, Kutcher JS, Leddy JJ, Maddocks D, Manley G, McCrea M, Purcell LK, Putukian M, Sato H, Tuominen MP, Turner M, Yeates KO, Herring SA, Meeuwisse W
Br J Sports Med 2023 Jun;57(11):695-711. doi: 10.1136/bjsports-2023-106898. PMID: 37316210
McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, Daneshvar DH
Acta Neuropathol 2023 Apr;145(4):371-394. Epub 2023 Feb 10 doi: 10.1007/s00401-023-02540-w. PMID: 36759368Free PMC Article
Coulter IC, Forsyth RJ
Curr Opin Pediatr 2019 Dec;31(6):769-774. doi: 10.1097/MOP.0000000000000820. PMID: 31693586
McKee AC, Stein TD, Kiernan PT, Alvarez VE
Brain Pathol 2015 May;25(3):350-64. doi: 10.1111/bpa.12248. PMID: 25904048Free PMC Article
Mckee AC, Daneshvar DH
Handb Clin Neurol 2015;127:45-66. doi: 10.1016/B978-0-444-52892-6.00004-0. PMID: 25702209Free PMC Article

Diagnosis

McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, Daneshvar DH
Acta Neuropathol 2023 Apr;145(4):371-394. Epub 2023 Feb 10 doi: 10.1007/s00401-023-02540-w. PMID: 36759368Free PMC Article
Trejo-Lopez JA, Yachnis AT, Prokop S
Neurotherapeutics 2022 Jan;19(1):173-185. Epub 2021 Nov 2 doi: 10.1007/s13311-021-01146-y. PMID: 34729690Free PMC Article
Mez J, Stern RA, McKee AC
Semin Neurol 2020 Aug;40(4):351-352. Epub 2020 Sep 9 doi: 10.1055/s-0040-1715824. PMID: 32906179
Smith DH, Johnson VE, Trojanowski JQ, Stewart W
Nat Rev Neurol 2019 Mar;15(3):179-183. doi: 10.1038/s41582-018-0114-8. PMID: 30664683Free PMC Article
McKee AC, Stein TD, Kiernan PT, Alvarez VE
Brain Pathol 2015 May;25(3):350-64. doi: 10.1111/bpa.12248. PMID: 25904048Free PMC Article

Therapy

Alosco ML, Mariani ML, Adler CH, Balcer LJ, Bernick C, Au R, Banks SJ, Barr WB, Bouix S, Cantu RC, Coleman MJ, Dodick DW, Farrer LA, Geda YE, Katz DI, Koerte IK, Kowall NW, Lin AP, Marcus DS, Marek KL, McClean MD, McKee AC, Mez J, Palmisano JN, Peskind ER, Tripodis Y, Turner RW 2nd, Wethe JV, Cummings JL, Reiman EM, Shenton ME, Stern RA; DIAGNOSE CTE Research Project Investigators
Alzheimers Res Ther 2021 Aug 12;13(1):136. doi: 10.1186/s13195-021-00872-x. PMID: 34384490Free PMC Article
Pasternak JJ, Abcejo AS
Curr Opin Anaesthesiol 2020 Oct;33(5):639-645. doi: 10.1097/ACO.0000000000000906. PMID: 32796169
Graham NS, Sharp DJ
J Neurol Neurosurg Psychiatry 2019 Nov;90(11):1221-1233. Epub 2019 Sep 21 doi: 10.1136/jnnp-2017-317557. PMID: 31542723Free PMC Article
Lucke-Wold BP, Logsdon AF, Nguyen L, Eltanahay A, Turner RC, Bonasso P, Knotts C, Moeck A, Maroon JC, Bailes JE, Rosen CL
Nutr Neurosci 2018 Feb;21(2):79-91. Epub 2016 Oct 5 doi: 10.1080/1028415X.2016.1236174. PMID: 27705610Free PMC Article
Perry DC, Sturm VE, Peterson MJ, Pieper CF, Bullock T, Boeve BF, Miller BL, Guskiewicz KM, Berger MS, Kramer JH, Welsh-Bohmer KA
J Neurosurg 2016 Feb;124(2):511-26. Epub 2015 Aug 28 doi: 10.3171/2015.2.JNS14503. PMID: 26315003Free PMC Article

Prognosis

McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, Daneshvar DH
Acta Neuropathol 2023 Apr;145(4):371-394. Epub 2023 Feb 10 doi: 10.1007/s00401-023-02540-w. PMID: 36759368Free PMC Article
Trejo-Lopez JA, Yachnis AT, Prokop S
Neurotherapeutics 2022 Jan;19(1):173-185. Epub 2021 Nov 2 doi: 10.1007/s13311-021-01146-y. PMID: 34729690Free PMC Article
Sweeney MD, Sagare AP, Zlokovic BV
Nat Rev Neurol 2018 Mar;14(3):133-150. Epub 2018 Jan 29 doi: 10.1038/nrneurol.2017.188. PMID: 29377008Free PMC Article
Wang KK, Yang Z, Zhu T, Shi Y, Rubenstein R, Tyndall JA, Manley GT
Expert Rev Mol Diagn 2018 Feb;18(2):165-180. Epub 2018 Jan 23 doi: 10.1080/14737159.2018.1428089. PMID: 29338452Free PMC Article
Mckee AC, Daneshvar DH
Handb Clin Neurol 2015;127:45-66. doi: 10.1016/B978-0-444-52892-6.00004-0. PMID: 25702209Free PMC Article

Clinical prediction guides

McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, Daneshvar DH
Acta Neuropathol 2023 Apr;145(4):371-394. Epub 2023 Feb 10 doi: 10.1007/s00401-023-02540-w. PMID: 36759368Free PMC Article
Trejo-Lopez JA, Yachnis AT, Prokop S
Neurotherapeutics 2022 Jan;19(1):173-185. Epub 2021 Nov 2 doi: 10.1007/s13311-021-01146-y. PMID: 34729690Free PMC Article
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DMA, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SHW
Nature 2021 Oct;598(7880):359-363. Epub 2021 Sep 29 doi: 10.1038/s41586-021-03911-7. PMID: 34588692Free PMC Article
Hubertus V, Marklund N, Vajkoczy P
Acta Neurochir (Wien) 2019 Mar;161(3):425-433. Epub 2019 Jan 28 doi: 10.1007/s00701-019-03807-6. PMID: 30687899
Wang KK, Yang Z, Zhu T, Shi Y, Rubenstein R, Tyndall JA, Manley GT
Expert Rev Mol Diagn 2018 Feb;18(2):165-180. Epub 2018 Jan 23 doi: 10.1080/14737159.2018.1428089. PMID: 29338452Free PMC Article

Recent systematic reviews

Murray HC, Osterman C, Bell P, Vinnell L, Curtis MA
Acta Neuropathol Commun 2022 Aug 6;10(1):108. doi: 10.1186/s40478-022-01413-9. PMID: 35933388Free PMC Article
Manley G, Gardner AJ, Schneider KJ, Guskiewicz KM, Bailes J, Cantu RC, Castellani RJ, Turner M, Jordan BD, Randolph C, Dvořák J, Hayden KA, Tator CH, McCrory P, Iverson GL
Br J Sports Med 2017 Jun;51(12):969-977. Epub 2017 Apr 28 doi: 10.1136/bjsports-2017-097791. PMID: 28455362Free PMC Article
Maroon JC, Winkelman R, Bost J, Amos A, Mathyssek C, Miele V
PLoS One 2015;10(2):e0117338. Epub 2015 Feb 11 doi: 10.1371/journal.pone.0117338. PMID: 25671598Free PMC Article
Gardner A, Iverson GL, McCrory P
Br J Sports Med 2014 Jan;48(2):84-90. Epub 2013 Jun 26 doi: 10.1136/bjsports-2013-092646. PMID: 23803602
Wortzel HS, Shura RD, Brenner LA
Biomed Res Int 2013;2013:424280. Epub 2013 Nov 17 doi: 10.1155/2013/424280. PMID: 24328030Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...