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Primary non-gestational choriocarcinoma of ovary

MedGen UID:
906353
•Concept ID:
C4274424
•
Neoplastic Process
Synonyms: NGCO; primary non-gestational choriocarcinoma of ovary; Primary non-gestational ovarian choriocarcinoma; primary non-gestational ovarian choriocarcinoma
SNOMED CT: Primary non-gestational choriocarcinoma of ovary (716588005); Primary non-gestational ovarian choriocarcinoma (716588005)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0017327
Orphanet: ORPHA289356

Definition

A rare ovarian germ cell malignant tumor arising from primordial germ cells, usually presenting with nausea, vomiting, abdominal pain, menstrual irregularities, and characterized by fast growth pattern, metastasis to lung, liver and brain and production of human chorionic gonadotrophin. It is apparently chemoresistant and has a worse prognosis than gestational choriocarcinoma. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary non-gestational choriocarcinoma of ovary

Recent clinical studies

Etiology

Clinical features of a Chinese female nongestational choriocarcinoma cohort: a retrospective study of 37 patients.
Shao Y, Xiang Y, Jiang F, Pan B, Wan X, Yang J, Feng F, Ren T, Zhao J
Orphanet J Rare Dis 2020 Nov 18;15(1):325. doi: 10.1186/s13023-020-01610-6. PMID: 33208175Free PMC Article
Primary non-gestational choriocarcinoma of the uterine cervix: a case report.
Maestá I, Michelin OC, Traiman P, Hokama P, Rudge MV
Gynecol Oncol 2005 Jul;98(1):146-50. doi: 10.1016/j.ygyno.2005.03.045. PMID: 15925400
Ovarian neoplasms in children and adolescents in Papua New Guinea.
Sengupta SK, Everett VJ
Aust N Z J Obstet Gynaecol 1987 Nov;27(4):335-8. doi: 10.1111/j.1479-828x.1987.tb01021.x. PMID: 3453674

Diagnosis

A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927
Short tandem repeat polymorphism analysis for primary peritoneal choriocarcinoma: A case report and literature review.
Yamauchi K, Sato Y, Usui H, Sakurai A, Harada R, Goto M
J Obstet Gynaecol Res 2022 Oct;48(10):2640-2646. Epub 2022 Jul 1 doi: 10.1111/jog.15347. PMID: 35775317
Clinical features of a Chinese female nongestational choriocarcinoma cohort: a retrospective study of 37 patients.
Shao Y, Xiang Y, Jiang F, Pan B, Wan X, Yang J, Feng F, Ren T, Zhao J
Orphanet J Rare Dis 2020 Nov 18;15(1):325. doi: 10.1186/s13023-020-01610-6. PMID: 33208175Free PMC Article
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis.
Koo HL, Choi J, Kim KR, Kim JH
Pathol Int 2006 Oct;56(10):613-6. doi: 10.1111/j.1440-1827.2006.02016.x. PMID: 16984618

Therapy

Successful Treatment of Nongestational Choriocarcinoma in a 15-Year-Old Girl: A Case Report.
Lee AJ, Im YJ, Shim SH, Lee SJ, Kim TJ, So KA
J Pediatr Adolesc Gynecol 2021 Apr;34(2):231-233. Epub 2020 Nov 13 doi: 10.1016/j.jpag.2020.11.004. PMID: 33189896
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083
Laparoscopic Fertility-preserving Treatment of a Pure Nongestational Choriocarcinoma of the Ovary: Case Report and Review of Current Literature.
Xin L, Beier A, Tiede S, Pfiffer T, Köhler C, Favero G
J Minim Invasive Gynecol 2015 Sep-Oct;22(6):1095-9. Epub 2015 May 1 doi: 10.1016/j.jmig.2015.04.025. PMID: 25939824
Good prognosis for primary ovarian pure nongestational choriocarcinoma using the EMA/CO regime.
Ozturk E, Ugur MG, Cebesoy FB, Aydin A, Sever T, Balat O
Eur J Gynaecol Oncol 2010;31(1):123-5. PMID: 20349799
Primary non-gestational choriocarinoma of the ovary. Report of a case.
Panayotou PP, Vrettos AS, Papatheodorou B, Kadas K
Int Surg 1971 Feb;55(2):137-41. PMID: 5313248

Prognosis

A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927
Clinical features of a Chinese female nongestational choriocarcinoma cohort: a retrospective study of 37 patients.
Shao Y, Xiang Y, Jiang F, Pan B, Wan X, Yang J, Feng F, Ren T, Zhao J
Orphanet J Rare Dis 2020 Nov 18;15(1):325. doi: 10.1186/s13023-020-01610-6. PMID: 33208175Free PMC Article
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083
Laparoscopic Fertility-preserving Treatment of a Pure Nongestational Choriocarcinoma of the Ovary: Case Report and Review of Current Literature.
Xin L, Beier A, Tiede S, Pfiffer T, Köhler C, Favero G
J Minim Invasive Gynecol 2015 Sep-Oct;22(6):1095-9. Epub 2015 May 1 doi: 10.1016/j.jmig.2015.04.025. PMID: 25939824
Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis.
Koo HL, Choi J, Kim KR, Kim JH
Pathol Int 2006 Oct;56(10):613-6. doi: 10.1111/j.1440-1827.2006.02016.x. PMID: 16984618

Clinical prediction guides

A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927
Clinical features of a Chinese female nongestational choriocarcinoma cohort: a retrospective study of 37 patients.
Shao Y, Xiang Y, Jiang F, Pan B, Wan X, Yang J, Feng F, Ren T, Zhao J
Orphanet J Rare Dis 2020 Nov 18;15(1):325. doi: 10.1186/s13023-020-01610-6. PMID: 33208175Free PMC Article
Ovarian Intermediate Trophoblastic Tumors: Genotyping Defines a Distinct Category of Nongestational Tumors of Germ Cell Type.
Xing D, Zhong M, Ye F, O'Malley MT, Li S, Vang R, Ronnett BM
Am J Surg Pathol 2020 Apr;44(4):516-525. doi: 10.1097/PAS.0000000000001402. PMID: 31688005Free PMC Article
Extraovarian nongestational choriocarcinoma in a postmenopausal woman.
Dilek S, Pata O, Tok E, Polat A
Int J Gynecol Cancer 2004 Sep-Oct;14(5):1033-5. doi: 10.1111/j.1048-891X.2004.014548.x. PMID: 15361221

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