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Vesicoallantoic abdominal wall defect

MedGen UID:
907200
Concept ID:
C4280796
Anatomical Abnormality
HPO: HP:0030733

Definition

An abdominal wall defected related to a developmental anomaly of the allantois, which is an embryonic structure that develops as a diverticulum off the yolk sac at about 16 days post fertilization. During further development, the allantois becomes incorporated into the body of the embryo, connecting the ventral aspect of the urogenital sinus (which will develop into the upper pole of the urinary bladder) to the external portion of the umbilicus. Upon further development, the lumen of the allantois becomes obliterated and forms a thick fibrous cord called the urachus, which connects the apex of the bladder to the umbilicus. In adults, the urachus is known as the median umbilical ligament. Failure of the allantoic cavity to obliterate can result of one of four conditions [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVesicoallantoic abdominal wall defect

Recent clinical studies

Diagnosis

Donnenfeld AE, Mennuti MT, Templeton JM, Gabbe SG
J Ultrasound Med 1989 Jan;8(1):43-5. doi: 10.7863/jum.1989.8.1.43. PMID: 2521673

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