U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lymphoid hyperplasia

MedGen UID:
90735
Concept ID:
C0333997
Disease or Syndrome
Synonym: Lymphoid Hyperplasia
SNOMED CT: Lymphoid hyperplasia (128863005); Lymphoid hyperplasia (43961000)
 
HPO: HP:0034839

Definition

An abnormal bone marrow finding characterized by many poorly circumscribed and occasionally confluent lymphoid nodules. The nodules contain small and uniform lymphocytes with rounded nuclei, clumped chromatin, and without prominent nucleoli. [from HPO]

Conditions with this feature

BENTA disease
MedGen UID:
1641265
Concept ID:
C4551967
Disease or Syndrome
B-cell expansion with NFKB and T-cell anergy is an autosomal dominant disorder characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy (summary by Snow et al., 2012).

Professional guidelines

PubMed

Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Agarwal S, Mayer L
Clin Gastroenterol Hepatol 2013 Sep;11(9):1050-63. Epub 2013 Mar 13 doi: 10.1016/j.cgh.2013.02.024. PMID: 23501398Free PMC Article

Recent clinical studies

Etiology

Nguyen HN, Salman R, Vogel TP, Silva-Carmona M, DeGuzman M, Guillerman RP
Pediatr Radiol 2023 May;53(5):844-853. Epub 2023 Feb 7 doi: 10.1007/s00247-023-05600-1. PMID: 36746811
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Soyer T
Pediatr Surg Int 2020 Apr;36(4):447-455. Epub 2020 Jan 21 doi: 10.1007/s00383-020-04621-3. PMID: 31965250
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320

Diagnosis

Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Yell M, Rosado FG
Arch Pathol Lab Med 2019 Sep;143(9):1149-1153. Epub 2019 Feb 6 doi: 10.5858/arpa.2018-0188-RS. PMID: 30720334
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Yi E, Aubry MC
Arch Pathol Lab Med 2010 Mar;134(3):417-26. doi: 10.5858/134.3.417. PMID: 20196669

Therapy

Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Li EY, Yuen HK, Cheuk W
Asia Pac J Ophthalmol (Phila) 2015 Mar-Apr;4(2):106-11. doi: 10.1097/APO.0000000000000102. PMID: 26065355
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320
Fisher CH, Oh KS, Bayless TM, Siegelman SS
Am J Roentgenol Radium Ther Nucl Med 1975 Sep;125(1):207-17. doi: 10.2214/ajr.125.1.207. PMID: 1106221

Prognosis

Skala SL, Hristov B, Hristov AC
Arch Pathol Lab Med 2018 Nov;142(11):1313-1321. doi: 10.5858/arpa.2018-0215-RA. PMID: 30407851
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Gilliam AC, Wood GS
Semin Cutan Med Surg 2000 Jun;19(2):133-41. doi: 10.1016/s1085-5629(00)80011-5. PMID: 10892716

Clinical prediction guides

Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article
Chalabreysse L, Orsini A, Vial C, Tronc F
Interact Cardiovasc Thorac Surg 2007 Feb;6(1):133-5. Epub 2006 Nov 13 doi: 10.1510/icvts.2006.137414. PMID: 17669792
Gilliam AC, Wood GS
Semin Cutan Med Surg 2000 Jun;19(2):133-41. doi: 10.1016/s1085-5629(00)80011-5. PMID: 10892716

Recent systematic reviews

Seivright JR, Villa NM, De DR, Hsiao JL, Shi VY
Dermatol Ther 2022 Feb;35(2):e15234. Epub 2021 Dec 8 doi: 10.1111/dth.15234. PMID: 34825744
Khan F, Person H, Dekio F, Ogawa M, Ho HE, Dunkin D, Secord E, Cunningham-Rundles C, Ward SC
J Allergy Clin Immunol Pract 2021 Sep;9(9):3466-3478. Epub 2021 May 21 doi: 10.1016/j.jaip.2021.04.070. PMID: 34029777Free PMC Article
Murphrey M, Huy Nguyen A, White KP, Krol A, Bernert R, Yarbrough K
Pediatr Dermatol 2020 Mar;37(2):320-325. Epub 2020 Jan 12 doi: 10.1111/pde.14043. PMID: 31930561
Guimarães AC, de Carvalho GM, Correa CR, Gusmão RJ
Crit Rev Oncol Hematol 2015 Mar;93(3):304-11. Epub 2014 Nov 22 doi: 10.1016/j.critrevonc.2014.11.003. PMID: 25487766
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...