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Lymphoid hyperplasia

MedGen UID:
90735
•Concept ID:
C0333997
•
Disease or Syndrome
Synonym: Lymphoid Hyperplasia
SNOMED CT: Lymphoid hyperplasia (128863005); Lymphoid hyperplasia (43961000)

Definition

A benign or malignant, diffuse and/or follicular lymphocytic proliferation. [from NCI]

Professional guidelines

PubMed

Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm.
Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595
Primary Pulmonary Lymphoid Lesions: Radiologic and Pathologic Findings.
Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency.
Agarwal S, Mayer L
Clin Gastroenterol Hepatol 2013 Sep;11(9):1050-63. Epub 2013 Mar 13 doi: 10.1016/j.cgh.2013.02.024. PMID: 23501398Free PMC Article

Recent clinical studies

Etiology

Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Chronic appendicitis: the process from pre-diagnosis to pathology.
Kanat BH, Solmaz ÖA, Bozdağ P, Doğan S, Kutluer N, Kurt F, Yazar FM, Aydin Y, Öndes B
Eur Rev Med Pharmacol Sci 2021 Dec;25(24):7898-7902. doi: 10.26355/eurrev_202112_27639. PMID: 34982452
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Appendicitis.
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320

Diagnosis

Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Subcutaneous nodules following vaccination.
Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Pulmonary Nodular Lymphoid Hyperplasia.
Yell M, Rosado FG
Arch Pathol Lab Med 2019 Sep;143(9):1149-1153. Epub 2019 Feb 6 doi: 10.5858/arpa.2018-0188-RS. PMID: 30720334
Cutaneous Pseudolymphomas.
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Pulmonary pseudoneoplasms.
Yi E, Aubry MC
Arch Pathol Lab Med 2010 Mar;134(3):417-26. doi: 10.5858/134.3.417. PMID: 20196669

Therapy

Subcutaneous nodules following vaccination.
Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Thymic Hyperplasia Associated with Graves' Disease: Pathophysiology and Proposed Management Algorithm.
Haider U, Richards P, Gianoukakis AG
Thyroid 2017 Aug;27(8):994-1000. Epub 2017 Jul 7 doi: 10.1089/thy.2017.0086. PMID: 28578595
Cutaneous Pseudolymphomas.
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.
Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA, Harvey P, Valentine A, Davies SE, Walker-Smith JA
Lancet 1998 Feb 28;351(9103):637-41. doi: 10.1016/s0140-6736(97)11096-0. PMID: 9500320
Phenytoin-induced lymphadenopathy.
Schwinghammer TL, Howrie DL
Drug Intell Clin Pharm 1983 Jun;17(6):460-2. doi: 10.1177/106002808301700608. PMID: 6861635

Prognosis

Lymphoproliferative Disorders of the Lung.
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
Cutaneous Pseudolymphomas.
Romero-Pérez D, Blanes Martínez M, Encabo-Durán B
Actas Dermosifiliogr 2016 Oct;107(8):640-51. Epub 2016 Jun 8 doi: 10.1016/j.ad.2016.05.003. PMID: 27289134
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Immunoglobulin G4-Related Lymphadenopathy.
Bookhout CE, Rollins-Raval MA
Surg Pathol Clin 2016 Mar;9(1):117-29. doi: 10.1016/j.path.2015.09.005. PMID: 26940272
Cutaneous lymphoid hyperplasias.
Gilliam AC, Wood GS
Semin Cutan Med Surg 2000 Jun;19(2):133-41. doi: 10.1016/s1085-5629(00)80011-5. PMID: 10892716

Clinical prediction guides

Clinical Follow-Up and Postmortem Findings in a Cat That Was Cured of Feline Infectious Peritonitis with an Oral Antiviral Drug Containing GS-441524.
Krentz D, Zwicklbauer K, Felten S, Bergmann M, Dorsch R, Hofmann-Lehmann R, Meli ML, Spiri AM, von Both U, Alberer M, Hönl A, Matiasek K, Hartmann K
Viruses 2022 Sep 14;14(9) doi: 10.3390/v14092040. PMID: 36146845Free PMC Article
Cutaneous reactive B-cell lymphoid proliferations.
Khalil S, Donthi D, Gru AA
J Cutan Pathol 2022 Oct;49(10):898-916. Epub 2022 Aug 4 doi: 10.1111/cup.14264. PMID: 35656820
Subcutaneous nodules following vaccination.
Collinson AC, Moore L, Cheung A, Gold MS, Goh DW
J Paediatr Child Health 2022 Mar;58(3):388-391. Epub 2022 Feb 9 doi: 10.1111/jpc.15900. PMID: 35137488
Appendicitis.
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article
Cutaneous lymphoid hyperplasias.
Gilliam AC, Wood GS
Semin Cutan Med Surg 2000 Jun;19(2):133-41. doi: 10.1016/s1085-5629(00)80011-5. PMID: 10892716

Recent systematic reviews

Intralesional biologics for inflammatory dermatoses: A systematic review.
Seivright JR, Villa NM, De DR, Hsiao JL, Shi VY
Dermatol Ther 2022 Feb;35(2):e15234. Epub 2021 Dec 8 doi: 10.1111/dth.15234. PMID: 34825744
Crohn's-like Enteritis in X-Linked Agammaglobulinemia: A Case Series and Systematic Review.
Khan F, Person H, Dekio F, Ogawa M, Ho HE, Dunkin D, Secord E, Cunningham-Rundles C, Ward SC
J Allergy Clin Immunol Pract 2021 Sep;9(9):3466-3478. Epub 2021 May 21 doi: 10.1016/j.jaip.2021.04.070. PMID: 34029777Free PMC Article
Pediatric cellular neurothekeoma: Seven cases and systematic review of the literature.
Murphrey M, Huy Nguyen A, White KP, Krol A, Bernert R, Yarbrough K
Pediatr Dermatol 2020 Mar;37(2):320-325. Epub 2020 Jan 12 doi: 10.1111/pde.14043. PMID: 31930561
Association between unilateral tonsillar enlargement and lymphoma in children: A systematic review and meta-analysis.
Guimarães AC, de Carvalho GM, Correa CR, Gusmão RJ
Crit Rev Oncol Hematol 2015 Mar;93(3):304-11. Epub 2014 Nov 22 doi: 10.1016/j.critrevonc.2014.11.003. PMID: 25487766
Appendicitis.
Humes D, Speake WJ, Simpson J
BMJ Clin Evid 2007 Jul 1;2007 PMID: 19454096Free PMC Article

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