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Osseous metaplasia

MedGen UID:
90738
•Concept ID:
C0334040
•
Pathologic Function
Synonyms: Bone Metaplasia; Extraskeletal ossification; Metaplastic ossification; Osseous Metaplasia; Osteosis
SNOMED CT: Osseous metaplasia (38109001); Metaplastic ossification (38109001); Extraskeletal ossification (38109001); Osteosis (38109001)

Definition

Heterotopic formation of normal bone within soft tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsseous metaplasia

Professional guidelines

PubMed

Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis.
Yao H, Wang B, Wen L, Jin Q, Li H, Huang G, Yin J, Zou C, Xie X, Shen J
BMC Cancer 2018 Nov 29;18(1):1195. doi: 10.1186/s12885-018-5062-6. PMID: 30497436Free PMC Article
Anti-angiogenic therapy, a new player in the field of sarcoma treatment.
Versleijen-Jonkers YM, Vlenterie M, van de Luijtgaarden AC, van der Graaf WT
Crit Rev Oncol Hematol 2014 Aug;91(2):172-85. Epub 2014 Feb 15 doi: 10.1016/j.critrevonc.2014.02.001. PMID: 24613529
Interventional management of hypervascular osseous metastasis: role of embolotherapy before orthopedic tumor resection and bone stabilization.
Kickuth R, Waldherr C, Hoppe H, Bonel HM, Ludwig K, Beck M, Triller J
AJR Am J Roentgenol 2008 Dec;191(6):W240-7. doi: 10.2214/AJR.07.4037. PMID: 19020210

Recent clinical studies

Etiology

Osseous metaplasia of the endometrium: A multicenter retrospective study.
Garzon S, Laganà AS, Carugno J, Cayuela Font E, Jimenez J, Kar S, Fikri J, Carlos Pons J, Milind T, Medvedied M, Alonso Pacheco L, Salazar E, Montevecchi L, Ochoa CM, De Angelis C
Eur J Obstet Gynecol Reprod Biol 2021 Oct;265:150-155. Epub 2021 Sep 1 doi: 10.1016/j.ejogrb.2021.08.032. PMID: 34500212
Stromal osseous metaplasia in urothelial carcinoma of the bladder: a rare case report and literature review.
Razafimahefa J, Gosset C, Mongiat-Artus P, Andriamampionona TF, Verine J
Diagn Pathol 2019 Jul 13;14(1):75. doi: 10.1186/s13000-019-0851-z. PMID: 31299983Free PMC Article
Osseous and chondromatous metaplasia in calcific aortic valve stenosis.
Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA
Cardiovasc Pathol 2016 Jan-Feb;25(1):18-24. Epub 2015 Aug 29 doi: 10.1016/j.carpath.2015.08.008. PMID: 26386747
Osseous metaplasia of the endometrium and successful hysteroscopic resection: a report of two cases and a review of the literature.
Madaan M, Suman S, Sharma R, Kapoor N, Garg P, Raj SS
Asian J Endosc Surg 2015 Feb;8(1):63-6. doi: 10.1111/ases.12153. PMID: 25598057
Calcifying synovial sarcoma.
Varela-Duran J, Enzinger FM
Cancer 1982 Jul 15;50(2):345-52. doi: 10.1002/1097-0142(19820715)50:2<345::aid-cncr2820500231>3.0.co;2-y. PMID: 6282441

Diagnosis

Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Thoracic psammomatous meningioma with osseous metaplasia: a controversial diagnosis of a case report and literature review.
Wang C, Chen Y, Zhang L, Ma X, Chen B, Li S
World J Surg Oncol 2019 Aug 24;17(1):150. doi: 10.1186/s12957-019-1694-5. PMID: 31445511Free PMC Article
Ultrasound features of osseous metaplasia of the endometrium-Case series and review of the literature.
Grigore M, Pristavu A, Gafitanu D
Clin Imaging 2018 Nov-Dec;52:260-263. Epub 2018 Aug 27 doi: 10.1016/j.clinimag.2018.08.006. PMID: 30172175
Osseous and chondromatous metaplasia in calcific aortic valve stenosis.
Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA
Cardiovasc Pathol 2016 Jan-Feb;25(1):18-24. Epub 2015 Aug 29 doi: 10.1016/j.carpath.2015.08.008. PMID: 26386747
Vaginal osseous metaplasia.
Landim FM, Tavares JM, de Melo Braga DN, da Silva JE Jr, Bastos Filho JB, Feitosa RG
Arch Gynecol Obstet 2009 Mar;279(3):381-4. Epub 2008 Jun 18 doi: 10.1007/s00404-008-0706-4. PMID: 18563423

Therapy

Nephrogenic Systemic Fibrosis with Osseous Metaplasia in a Kidney-Pancreas Transplant Patient.
de Lavillandre JLB, Buron F, Ducroux E, Kanitakis J
Skinmed 2022;20(2):145-148. Epub 2022 Apr 30 PMID: 35532771
Osseus metaplasia in kidney allografts as a paradigm of regenerative medicine principles.
Sanders BP, Orlando G, Peloso A, Katari RS, Iskandar SS, Farney AC, Rogers J, Soker S, Stratta RJ
Exp Clin Transplant 2014 Aug;12(4):371-3. PMID: 25095714
Osseous metaplasia of the cervix and endometrium: a case of secondary infertility.
Polat I, Sahin O, Yildirim G, Karaman E, Erim A, Tekirdag AI
Fertil Steril 2011 Jun;95(7):2434.e1-4. Epub 2011 Mar 5 doi: 10.1016/j.fertnstert.2011.02.001. PMID: 21377672
True osseous metaplasia of the endometrium: the bone is not from a fetus.
Cayuela E, Perez-Medina T, Vilanova J, Alejo M, Cañadas P
Fertil Steril 2009 Apr;91(4):1293.e1-4. Epub 2009 Jan 30 doi: 10.1016/j.fertnstert.2008.12.026. PMID: 19185859
Endometrial ossification.
Ejeckam GC, Haseeb F, Ahamad R, Azadeh B
Trop Geogr Med 1991 Jul;43(3):314-6. PMID: 1816670

Prognosis

Juvenile Polyps with Osseous Metaplasia: Report of Two Pediatric Cases and Review of the Literature.
Azari-Yam A, Alimadadi H, Safavi M
Fetal Pediatr Pathol 2022 Feb;41(1):166-170. Epub 2020 May 14 doi: 10.1080/15513815.2020.1761916. PMID: 32406794
Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
Stromal osseous metaplasia in urothelial carcinoma of the bladder: a rare case report and literature review.
Razafimahefa J, Gosset C, Mongiat-Artus P, Andriamampionona TF, Verine J
Diagn Pathol 2019 Jul 13;14(1):75. doi: 10.1186/s13000-019-0851-z. PMID: 31299983Free PMC Article
Osseous metaplasia of the endometrium and successful hysteroscopic resection: a report of two cases and a review of the literature.
Madaan M, Suman S, Sharma R, Kapoor N, Garg P, Raj SS
Asian J Endosc Surg 2015 Feb;8(1):63-6. doi: 10.1111/ases.12153. PMID: 25598057
Calcifying synovial sarcoma.
Varela-Duran J, Enzinger FM
Cancer 1982 Jul 15;50(2):345-52. doi: 10.1002/1097-0142(19820715)50:2<345::aid-cncr2820500231>3.0.co;2-y. PMID: 6282441

Clinical prediction guides

Incidental morphological findings in colorectal adenomas.
Dabir PD, van der Post RS, Nagtegaal ID
Histopathology 2021 Feb;78(3):348-357. Epub 2020 Nov 17 doi: 10.1111/his.14263. PMID: 32981102Free PMC Article
So-called massive retinal gliosis: A critical review and reappraisal.
Jakobiec FA, Thanos A, Stagner AM, Grossniklaus HE, Proia AD
Surv Ophthalmol 2016 May-Jun;61(3):339-56. Epub 2015 Dec 15 doi: 10.1016/j.survophthal.2015.12.002. PMID: 26703887
Osseous and chondromatous metaplasia in calcific aortic valve stenosis.
Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA
Cardiovasc Pathol 2016 Jan-Feb;25(1):18-24. Epub 2015 Aug 29 doi: 10.1016/j.carpath.2015.08.008. PMID: 26386747
Fibrous dysplasia of the sinonasal tract and adjacent skull base.
Schreiber A, Villaret AB, Maroldi R, Nicolai P
Curr Opin Otolaryngol Head Neck Surg 2012 Feb;20(1):45-52. doi: 10.1097/MOO.0b013e32834e901c. PMID: 22157166
Ossifying trichilemmal cyst.
Pusiol T, Morichetti D, Zorzi MG, Piscioli F
Am J Dermatopathol 2011 Dec;33(8):867-8. doi: 10.1097/DAD.0b013e31821b0abd. PMID: 22042263

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