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Adenocarcinoma in Multiple Adenomatous Polyps

MedGen UID:
90757
•Concept ID:
C0334295
•
Neoplastic Process
Synonym: Adenocarcinoma in multiple adenomatous polyps
SNOMED CT: Adenocarcinoma in multiple adenomatous polyps (47299001)

Definition

Adenocarcinomas developing in gastrointestinal tract adenomas in patients with multiple adenomatous polyps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma in Multiple Adenomatous Polyps

Professional guidelines

PubMed

Endoscopic management of duodenal adenomas in familial adenomatous polyposis--a single-center experience.
Jaganmohan S, Lynch PM, Raju RP, Ross WA, Lee JE, Raju GS, Bhutani MS, Fleming JB, Lee JH
Dig Dis Sci 2012 Mar;57(3):732-7. Epub 2011 Sep 30 doi: 10.1007/s10620-011-1917-2. PMID: 21960285
Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients.
Ito Y, Miyauchi A, Ishikawa H, Hirokawa M, Kudo T, Tomoda C, Miya A
Endocr J 2011;58(8):685-9. Epub 2011 Jun 14 doi: 10.1507/endocrj.ej11-0022. PMID: 21670544
Nonampullary duodenal polyps: characteristics and endoscopic management.
Abbass R, Rigaux J, Al-Kawas FH
Gastrointest Endosc 2010 Apr;71(4):754-9. doi: 10.1016/j.gie.2009.11.043. PMID: 20363416

Recent clinical studies

Etiology

Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Heritable Gastrointestinal Cancer Syndromes.
Stoffel EM
Gastroenterol Clin North Am 2016 Sep;45(3):509-27. doi: 10.1016/j.gtc.2016.04.008. PMID: 27546846
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article
Familial polyposis.
DeCosse JJ, Adams MB, Condon RE
Cancer 1977 Jan;39(1):267-73. doi: 10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x. PMID: 832240
Colonoscopic polypectomy.
Leaverton GH, Haun TM, Meihoff WE
Am Surg 1976 Jul;42(7):449-54. PMID: 937851

Diagnosis

Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Heritable Gastrointestinal Cancer Syndromes.
Stoffel EM
Gastroenterol Clin North Am 2016 Sep;45(3):509-27. doi: 10.1016/j.gtc.2016.04.008. PMID: 27546846
Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article
Familial polyposis.
DeCosse JJ, Adams MB, Condon RE
Cancer 1977 Jan;39(1):267-73. doi: 10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x. PMID: 832240
Colonoscopic polypectomy.
Leaverton GH, Haun TM, Meihoff WE
Am Surg 1976 Jul;42(7):449-54. PMID: 937851

Therapy

Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article
Management of malignant colon polyps: current status and controversies.
Aarons CB, Shanmugan S, Bleier JI
World J Gastroenterol 2014 Nov 21;20(43):16178-83. doi: 10.3748/wjg.v20.i43.16178. PMID: 25473171Free PMC Article
Surgical treatment of familial adenomatous polyposis: dilemmas and current recommendations.
Campos FG
World J Gastroenterol 2014 Nov 28;20(44):16620-9. doi: 10.3748/wjg.v20.i44.16620. PMID: 25469031Free PMC Article
Adenocarcinoma after ileoanal anastomosis for familial adenomatous polyposis: review of risk factors and current surveillance apropos of a case.
Campos FG, Habr-Gama A, Kiss DR, da Silva EV, Rawet V, Imperiale AR, Perez R, da Silva JH, Sousa AH Jr, Gama-Rodrigues J
J Gastrointest Surg 2005 May-Jun;9(5):695-702. doi: 10.1016/j.gassur.2004.10.017. PMID: 15862266
Sulindac therapy of colorectal polyps in familial adenomatous polyposis.
Tonelli F, Valanzano R, Dolara P
Dig Dis 1994 Sep-Oct;12(5):259-64. doi: 10.1159/000171461. PMID: 7882547

Prognosis

A Rare Case of Multiple Gastrointestinal Stromal Tumors Coexisting with a Rectal Adenocarcinoma in a Patient with Attenuated Familial Adenomatous Polyposis Syndrome and a Mini Review of the Literature.
Paramythiotis D, Kyriakidis F, Karlafti E, Koletsa T, Tsakona A, Papalexis P, Ioannidis A, Malliou P, Netta S, Michalopoulos A
Medicina (Kaunas) 2022 Aug 18;58(8) doi: 10.3390/medicina58081116. PMID: 36013583Free PMC Article
Familial Adenomatous Polyposis Syndrome: An Update and Review of Extraintestinal Manifestations.
Dinarvand P, Davaro EP, Doan JV, Ising ME, Evans NR, Phillips NJ, Lai J, Guzman MA
Arch Pathol Lab Med 2019 Nov;143(11):1382-1398. Epub 2019 May 9 doi: 10.5858/arpa.2018-0570-RA. PMID: 31070935
Genetic Syndromes with Pancreatic Manifestations.
Pittman ME, Brosens LA, Wood LD
Surg Pathol Clin 2016 Dec;9(4):705-715. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.012. PMID: 27926368
Management of malignant colon polyps: current status and controversies.
Aarons CB, Shanmugan S, Bleier JI
World J Gastroenterol 2014 Nov 21;20(43):16178-83. doi: 10.3748/wjg.v20.i43.16178. PMID: 25473171Free PMC Article
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article

Clinical prediction guides

Optimal processing of ESD specimens to avoid pathological artifacts.
Reggiani Bonetti L, Manta R, Manno M, Conigliaro R, Missale G, Bassotti G, Villanacci V
Tech Coloproctol 2018 Nov;22(11):857-866. Epub 2018 Dec 17 doi: 10.1007/s10151-018-1887-x. PMID: 30560321
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Clinical characteristics of gastric cancer in patients with familial adenomatous polyposis.
Shibata C, Ogawa H, Miura K, Naitoh T, Yamauchi J, Unno M
Tohoku J Exp Med 2013 Feb;229(2):143-6. doi: 10.1620/tjem.229.143. PMID: 23343691
The case for a genetic predisposition to serrated neoplasia in the colorectum: hypothesis and review of the literature.
Young J, Jass JR
Cancer Epidemiol Biomarkers Prev 2006 Oct;15(10):1778-84. doi: 10.1158/1055-9965.EPI-06-0164. PMID: 17035382
Sulindac therapy of colorectal polyps in familial adenomatous polyposis.
Tonelli F, Valanzano R, Dolara P
Dig Dis 1994 Sep-Oct;12(5):259-64. doi: 10.1159/000171461. PMID: 7882547

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