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Thyroid cancer, nonmedullary, 4(NMTC4)

MedGen UID:
907624
Concept ID:
C4225293
Neoplastic Process
Synonym: NMTC4
 
Gene (location): FOXE1 (9q22.33)
 
Monarch Initiative: MONDO:0014681
OMIM®: 616534

Definition

Nonmedullary thyroid cancer (NMTC) refers to neoplasms originating from the thyroid follicular cells and represents 80 to 95% of all thyroid cancers. Approximately 5% of NMTC occurs on the background of a familial predisposition. Although papillary thyroid carcinoma (PTC) is usually the most frequent thyroid lesion in NMTC families, multinodular goiter (MNG) and follicular thyroid adenoma also occur (summary by Pereira et al., 2015). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550). [from OMIM]

Clinical features

From HPO
Papillary thyroid carcinoma
MedGen UID:
66773
Concept ID:
C0238463
Neoplastic Process
The presence of a papillary adenocarcinoma of the thyroid gland.
Malignant tumor of prostate
MedGen UID:
138169
Concept ID:
C0376358
Neoplastic Process
A cancer of the prostate.
Neoplasm of ovary
MedGen UID:
181539
Concept ID:
C0919267
Neoplastic Process
A tumor (abnormal growth of tissue) of the ovary.
Skin basal cell carcinoma
MedGen UID:
1648304
Concept ID:
C4721806
Neoplastic Process
The presence of a basal cell carcinoma of the skin.
Goiter
MedGen UID:
42270
Concept ID:
C0018021
Disease or Syndrome
An enlargement of the thyroid gland.

Professional guidelines

PubMed

Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Klubo-Gwiezdzinska J, Wartofsky L
Pol Arch Intern Med 2022 Mar 30;132(3) Epub 2022 Mar 3 doi: 10.20452/pamw.16222. PMID: 35243857Free PMC Article
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Curated

UK NICE Guideline NG230, Thyroid cancer: assessment and management

Recent clinical studies

Etiology

de Carlos Artajo J, Irigaray Echarri A, García Torres J, Pineda Arribas JJ, Ernaga Lorea A, Eguílaz Esparza N, Zubiría Gortázar JM, Anda Apiñániz E
Endocrinol Diabetes Nutr (Engl Ed) 2022 Apr;69(4):262-270. Epub 2022 Mar 16 doi: 10.1016/j.endien.2022.03.003. PMID: 35353680
Xu S, Huang H, Qian J, Liu Y, Huang Y, Wang X, Liu S, Xu Z, Liu J
JAMA Netw Open 2021 Jul 1;4(7):e2118526. doi: 10.1001/jamanetworkopen.2021.18526. PMID: 34313737Free PMC Article
Muallem Kalmovich L, Jabarin B, Koren S, Or K, Marcus E, Tkacheva I, Benbassat C, Steinschneider M
Laryngoscope 2021 Feb;131(2):E677-E681. Epub 2020 Aug 6 doi: 10.1002/lary.28989. PMID: 32761812
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296

Diagnosis

Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
de Carlos Artajo J, Irigaray Echarri A, García Torres J, Pineda Arribas JJ, Ernaga Lorea A, Eguílaz Esparza N, Zubiría Gortázar JM, Anda Apiñániz E
Endocrinol Diabetes Nutr (Engl Ed) 2022 Apr;69(4):262-270. Epub 2022 Mar 16 doi: 10.1016/j.endien.2022.03.003. PMID: 35353680
Lee KS, Park H
Front Biosci (Landmark Ed) 2022 Mar 16;27(3):101. doi: 10.31083/j.fbl2703101. PMID: 35345333
Muallem Kalmovich L, Jabarin B, Koren S, Or K, Marcus E, Tkacheva I, Benbassat C, Steinschneider M
Laryngoscope 2021 Feb;131(2):E677-E681. Epub 2020 Aug 6 doi: 10.1002/lary.28989. PMID: 32761812
Bauer AJ
Endocrinol Metab Clin North Am 2020 Dec;49(4):589-611. Epub 2020 Oct 14 doi: 10.1016/j.ecl.2020.08.001. PMID: 33153669

Therapy

Okubo Y, Toda S, Sato S, Yoshioka E, Ono K, Hasegawa C, Washimi K, Yokose T, Miyagi Y, Iwasaki H, Hayashi H
Histopathology 2023 Oct;83(4):657-663. Epub 2023 Jul 28 doi: 10.1111/his.15013. PMID: 37501641
Xu S, Huang H, Huang Y, Qian J, Wang X, Xu Z, Liu S, Liu J
JAMA Surg 2023 Jan 1;158(1):73-79. doi: 10.1001/jamasurg.2022.5781. PMID: 36449303Free PMC Article
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Waguespack SG, Drilon A, Lin JJ, Brose MS, McDermott R, Almubarak M, Bauman J, Casanova M, Krishnamurthy A, Kummar S, Leyvraz S, Oh DY, Park K, Sohal D, Sherman E, Norenberg R, Silvertown JD, Brega N, Hong DS, Cabanillas ME
Eur J Endocrinol 2022 Apr 29;186(6):631-643. doi: 10.1530/EJE-21-1259. PMID: 35333737Free PMC Article
Lee YA, Lee H, Im SW, Song YS, Oh DY, Kang HJ, Won JK, Jung KC, Kwon D, Chung EJ, Hah JH, Paeng JC, Kim JH, Choi J, Kim OH, Oh JM, Ahn BC, Wirth LJ, Shin CH, Kim JI, Park YJ
J Clin Invest 2021 Sep 15;131(18) doi: 10.1172/JCI144847. PMID: 34237031Free PMC Article

Prognosis

de Carlos Artajo J, Irigaray Echarri A, García Torres J, Pineda Arribas JJ, Ernaga Lorea A, Eguílaz Esparza N, Zubiría Gortázar JM, Anda Apiñániz E
Endocrinol Diabetes Nutr (Engl Ed) 2022 Apr;69(4):262-270. Epub 2022 Mar 16 doi: 10.1016/j.endien.2022.03.003. PMID: 35353680
Megwalu UC, Moon PK
Thyroid 2022 May;32(5):560-570. Epub 2022 Mar 15 doi: 10.1089/thy.2021.0662. PMID: 35132899
Muallem Kalmovich L, Jabarin B, Koren S, Or K, Marcus E, Tkacheva I, Benbassat C, Steinschneider M
Laryngoscope 2021 Feb;131(2):E677-E681. Epub 2020 Aug 6 doi: 10.1002/lary.28989. PMID: 32761812
Bauer AJ
Endocrinol Metab Clin North Am 2020 Dec;49(4):589-611. Epub 2020 Oct 14 doi: 10.1016/j.ecl.2020.08.001. PMID: 33153669
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article

Clinical prediction guides

Fallahi P, Patrizio A, Stoppini G, Elia G, Ragusa F, Paparo SR, Balestri E, Mazzi V, Botrini C, Varricchi G, Ulisse S, Ghionzoli M, Antonelli A, Ferrari SM
Curr Oncol 2023 Nov 30;30(12):10237-10248. doi: 10.3390/curroncol30120745. PMID: 38132379Free PMC Article
Xu S, Huang H, Huang Y, Qian J, Wang X, Xu Z, Liu S, Liu J
JAMA Surg 2023 Jan 1;158(1):73-79. doi: 10.1001/jamasurg.2022.5781. PMID: 36449303Free PMC Article
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Cipriani NA
Surg Pathol Clin 2019 Dec;12(4):883-900. Epub 2019 Sep 18 doi: 10.1016/j.path.2019.07.001. PMID: 31672296

Recent systematic reviews

Zeyghami W, Hansen MU, Jakobsen KK, Groenhøj C, Feldt-Rasmussen U, von Buchwald C, Hahn CH
Endocr Relat Cancer 2023 Dec 1;30(12) Epub 2023 Oct 26 doi: 10.1530/ERC-23-0002. PMID: 37882489
Geropoulos G, Psarras K, Papaioannou M, Giannis D, Meitanidou M, Kapriniotis K, Symeonidis N, Pavlidis ET, Pavlidis TE, Sapalidis K, Ahmed NM, Abdel-Aziz TE, Eddama MMR
In Vivo 2022 Jul-Aug;36(4):1551-1569. doi: 10.21873/invivo.12866. PMID: 35738604Free PMC Article
van Dijk SPJ, Coerts HI, Gunput STG, van Velsen EFS, Medici M, Moelker A, Peeters RP, Verhoef C, van Ginhoven TM
JAMA Otolaryngol Head Neck Surg 2022 Apr 1;148(4):317-325. doi: 10.1001/jamaoto.2021.4381. PMID: 35142816Free PMC Article
Chou R, Dana T, Haymart M, Leung AM, Tufano RP, Sosa JA, Ringel MD
Thyroid 2022 Apr;32(4):351-367. Epub 2022 Mar 17 doi: 10.1089/thy.2021.0539. PMID: 35081743
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG230, Thyroid cancer: assessment and management

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