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Apocrine adenoma

MedGen UID:
90767
•Concept ID:
C0334345
•
Neoplastic Process
Synonyms: Apocrine Adenoma; apocrine adenoma; Tubular apocrine adenoma; Tubular Apocrine Adenoma
SNOMED CT: Apocrine adenoma (307596009); Tubular apocrine adenoma (307596009); Apocrine adenoma (36318001)
 
Monarch Initiative: MONDO:0002804

Definition

A benign dermal adnexal neoplasm with apocrine differentiation. It usually occurs in the scalp and has a female predilection. It presents as an asymptomatic solitary nodule. It is characterized by a lobular architecture. The lobules are composed by tubular structures lined by epithelial cells. There is no cytologic atypia or mitotic figures present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVApocrine adenoma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Recent clinical studies

Etiology

Cutaneous Neuroendocrine Mucinous Carcinomas Are Low-grade But May Be Associated With Other Cancers.
Adkins KE, Busam K, Pulitzer M
Am J Surg Pathol 2023 Oct 1;47(10):1186-1191. Epub 2023 Aug 3 doi: 10.1097/PAS.0000000000002107. PMID: 37530225Free PMC Article
Umbilical Lesions: Clinicopathologic Features of 99 Tumors.
Yan L, Sethi S, Bitterman P, Reddy V, Gattuso P
Int J Surg Pathol 2018 Aug;26(5):417-422. Epub 2018 Feb 27 doi: 10.1177/1066896918758916. PMID: 29484912
Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia.
Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D
Acta Dermatovenerol Croat 2007;15(3):148-51. PMID: 17868540
Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
Kazakov DV, Mukensnabl P, Michal M
Am J Dermatopathol 2006 Apr;28(2):142-6. doi: 10.1097/01.dad.0000171602.63433.51. PMID: 16625077
Three-millimeter apocrine adenoma in a man: a case report and review of the literature.
Pasquale-Styles MA, Milikowski C
Arch Pathol Lab Med 2003 Nov;127(11):1498-500. doi: 10.5858/2003-127-1498-TAAIAM. PMID: 14567753

Diagnosis

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Primary cutaneous apocrine carcinoma, arising in tubular apocrine adenoma.
Griffith M, Singh R, Alabkaa A, Reddy V, Ahmed A
J Cutan Pathol 2023 Dec;50(12):1042-1047. Epub 2023 Sep 17 doi: 10.1111/cup.14509. PMID: 37718479
Cutaneous Neuroendocrine Mucinous Carcinomas Are Low-grade But May Be Associated With Other Cancers.
Adkins KE, Busam K, Pulitzer M
Am J Surg Pathol 2023 Oct 1;47(10):1186-1191. Epub 2023 Aug 3 doi: 10.1097/PAS.0000000000002107. PMID: 37530225Free PMC Article
Umbilical Lesions: Clinicopathologic Features of 99 Tumors.
Yan L, Sethi S, Bitterman P, Reddy V, Gattuso P
Int J Surg Pathol 2018 Aug;26(5):417-422. Epub 2018 Feb 27 doi: 10.1177/1066896918758916. PMID: 29484912
Tubular apocrine adenoma.
Fisher TL
Arch Dermatol 1973 Jan;107(1):137. PMID: 4345346

Prognosis

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Cutaneous Neuroendocrine Mucinous Carcinomas Are Low-grade But May Be Associated With Other Cancers.
Adkins KE, Busam K, Pulitzer M
Am J Surg Pathol 2023 Oct 1;47(10):1186-1191. Epub 2023 Aug 3 doi: 10.1097/PAS.0000000000002107. PMID: 37530225Free PMC Article
Tubular adenoma of the skin with follicular and sebaceous differentiation: A report of two cases.
Kazakov DV, Mukensnabl P, Michal M
Am J Dermatopathol 2006 Apr;28(2):142-6. doi: 10.1097/01.dad.0000171602.63433.51. PMID: 16625077
Apocrine gland adenoma and adenocarcinoma of the axilla.
Warkel RL, Helwig EB
Arch Dermatol 1978 Feb;114(2):198-203. PMID: 629545

Clinical prediction guides

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
Papillary hidradenoma of the eyelid margin: clinical and immunohistochemical observations further supporting an apocrine rather than an eccrine origin.
Jakobiec FA, Rai R, Lefebvre DR
Surv Ophthalmol 2014 Sep-Oct;59(5):540-7. Epub 2014 Jan 28 doi: 10.1016/j.survophthal.2014.01.002. PMID: 24661803
Axillary apocrine carcinoma associated with apocrine adenoma and apocrine gland hyperplasia.
Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D
Acta Dermatovenerol Croat 2007;15(3):148-51. PMID: 17868540
Tubular adenoma and syringocystadenoma papilliferum: a reappraisal of their relationship. An interobserver study of a series, by a panel of dermatopathologists.
Kazakov DV, Bisceglia M, Calonje E, Hantschke M, Kutzner H, Mentzel T, Michal M, Mukensnabl P, Spagnolo DV, Rütten A, Rose C, Urso C, Vazmitel M, Zelger B
Am J Dermatopathol 2007 Jun;29(3):256-63. doi: 10.1097/DAD.0b013e3180576fd9. PMID: 17519623
Tubular apocrine adenoma.
Umbert P, Winkelmann RK
J Cutan Pathol 1976;3(2):75-87. doi: 10.1111/j.1600-0560.1976.tb00850.x. PMID: 993400

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