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Apocrine adenoma

MedGen UID:
90767
Concept ID:
C0334345
Neoplastic Process
Synonyms: Apocrine Adenoma; apocrine adenoma; Tubular apocrine adenoma; Tubular Apocrine Adenoma
SNOMED CT: Apocrine adenoma (307596009); Tubular apocrine adenoma (307596009); Apocrine adenoma (36318001)
 
Monarch Initiative: MONDO:0002804

Definition

A benign dermal adnexal neoplasm with apocrine differentiation. It usually occurs in the scalp and has a female predilection. It presents as an asymptomatic solitary nodule. It is characterized by a lobular architecture. The lobules are composed by tubular structures lined by epithelial cells. There is no cytologic atypia or mitotic figures present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVApocrine adenoma

Professional guidelines

PubMed

Gunduz E, Alçin OF, Kizilay A, Yildirim IO
Eur Arch Otorhinolaryngol 2022 Nov;279(11):5389-5399. Epub 2022 May 21 doi: 10.1007/s00405-022-07455-y. PMID: 35596805
Rzepakowska A, Osuch-Wójcikiewicz E, Sobol M, Cruz R, Sielska-Badurek E, Niemczyk K
Eur Arch Otorhinolaryngol 2017 Aug;274(8):3231-3240. Epub 2017 Jun 13 doi: 10.1007/s00405-017-4636-2. PMID: 28612315Free PMC Article
Roberts WW
Curr Opin Urol 2016 May;26(3):254-8. doi: 10.1097/MOU.0000000000000277. PMID: 26859557

Recent clinical studies

Etiology

Adkins KE, Busam K, Pulitzer M
Am J Surg Pathol 2023 Oct 1;47(10):1186-1191. Epub 2023 Aug 3 doi: 10.1097/PAS.0000000000002107. PMID: 37530225Free PMC Article
Yan L, Sethi S, Bitterman P, Reddy V, Gattuso P
Int J Surg Pathol 2018 Aug;26(5):417-422. Epub 2018 Feb 27 doi: 10.1177/1066896918758916. PMID: 29484912
Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D
Acta Dermatovenerol Croat 2007;15(3):148-51. PMID: 17868540
Kazakov DV, Mukensnabl P, Michal M
Am J Dermatopathol 2006 Apr;28(2):142-6. doi: 10.1097/01.dad.0000171602.63433.51. PMID: 16625077
Pasquale-Styles MA, Milikowski C
Arch Pathol Lab Med 2003 Nov;127(11):1498-500. doi: 10.5858/2003-127-1498-TAAIAM. PMID: 14567753

Diagnosis

Naseri DS, Shukla S, Acharya DS, Vagha S
F1000Res 2023;12:803. Epub 2023 Nov 8 doi: 10.12688/f1000research.135154.3. PMID: 38882714Free PMC Article
Griffith M, Singh R, Alabkaa A, Reddy V, Ahmed A
J Cutan Pathol 2023 Dec;50(12):1042-1047. Epub 2023 Sep 17 doi: 10.1111/cup.14509. PMID: 37718479
Adkins KE, Busam K, Pulitzer M
Am J Surg Pathol 2023 Oct 1;47(10):1186-1191. Epub 2023 Aug 3 doi: 10.1097/PAS.0000000000002107. PMID: 37530225Free PMC Article
Yan L, Sethi S, Bitterman P, Reddy V, Gattuso P
Int J Surg Pathol 2018 Aug;26(5):417-422. Epub 2018 Feb 27 doi: 10.1177/1066896918758916. PMID: 29484912
Fisher TL
Arch Dermatol 1973 Jan;107(1):137. PMID: 4345346

Prognosis

Adkins KE, Busam K, Pulitzer M
Am J Surg Pathol 2023 Oct 1;47(10):1186-1191. Epub 2023 Aug 3 doi: 10.1097/PAS.0000000000002107. PMID: 37530225Free PMC Article
Kazakov DV, Mukensnabl P, Michal M
Am J Dermatopathol 2006 Apr;28(2):142-6. doi: 10.1097/01.dad.0000171602.63433.51. PMID: 16625077
Warkel RL, Helwig EB
Arch Dermatol 1978 Feb;114(2):198-203. PMID: 629545

Clinical prediction guides

Jakobiec FA, Rai R, Lefebvre DR
Surv Ophthalmol 2014 Sep-Oct;59(5):540-7. Epub 2014 Jan 28 doi: 10.1016/j.survophthal.2014.01.002. PMID: 24661803
Bujas T, Pavić I, Lenicek T, Mijić A, Kruslin B, Tomas D
Acta Dermatovenerol Croat 2007;15(3):148-51. PMID: 17868540
Kazakov DV, Bisceglia M, Calonje E, Hantschke M, Kutzner H, Mentzel T, Michal M, Mukensnabl P, Spagnolo DV, Rütten A, Rose C, Urso C, Vazmitel M, Zelger B
Am J Dermatopathol 2007 Jun;29(3):256-63. doi: 10.1097/DAD.0b013e3180576fd9. PMID: 17519623
Michal M
Pathol Res Pract 1996 Nov;192(11):1135-9; discussion 1140-1. doi: 10.1016/S0344-0338(96)80032-X. PMID: 9122033
Umbert P, Winkelmann RK
J Cutan Pathol 1976;3(2):75-87. doi: 10.1111/j.1600-0560.1976.tb00850.x. PMID: 993400

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