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Epithelial-myoepithelial carcinoma

MedGen UID:
90776
Concept ID:
C0334392
Neoplastic Process
Synonyms: EMYOCA; Epithelial-Myoepithelial Carcinoma; epithelial-myoepithelial carcinoma
SNOMED CT: Epithelial-myoepithelial carcinoma (9618003)
 
Monarch Initiative: MONDO:0003389

Definition

A malignant neoplasm which occurs mostly in the major salivary glands (most frequently in the parotid gland), but also in the minor salivary glands of the oral mucosa and the tracheobronchial tree. It is characterized by the presence of ductal structures which are lined by an inner layer of cuboidal epithelial-type cells and an outer layer of myoepithelial cells with clear or eosinophilic cytoplasm. [from NCI]

Professional guidelines

PubMed

Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Wockner RS, Seethala RR, Emeto TI, McCaul JA, Subramaniam SS
Int J Oral Maxillofac Surg 2023 Jan;52(1):1-12. Epub 2022 Jun 3 doi: 10.1016/j.ijom.2022.05.005. PMID: 35667947Free PMC Article
Kim BG, Lee K, Um SW, Han J, Cho JH, Kim J, Kim H, Jeong BH
Lung Cancer 2020 Aug;146:58-65. Epub 2020 May 22 doi: 10.1016/j.lungcan.2020.05.016. PMID: 32512274

Recent clinical studies

Etiology

Ramas A, Kasumovic M, Uscupsic S, Mujic M, Tokic L
Med Arch 2024;78(1):68-70. doi: 10.5455/medarh.2024.78.68-70. PMID: 38481587Free PMC Article
Wockner RS, Seethala RR, Emeto TI, McCaul JA, Subramaniam SS
Int J Oral Maxillofac Surg 2023 Jan;52(1):1-12. Epub 2022 Jun 3 doi: 10.1016/j.ijom.2022.05.005. PMID: 35667947Free PMC Article
Skalova A, Leivo I, Hellquist H, Simpson RHW, Vander Poorten V, Willems SM, Mosaieby E, Slouka D, Ferlito A
Adv Anat Pathol 2022 Jul 1;29(4):217-226. Epub 2022 Mar 7 doi: 10.1097/PAP.0000000000000339. PMID: 35249992
Suto T, Kato H, Kawaguchi M, Kobayashi K, Miyazaki T, Ando T, Noda Y, Hyodo F, Matsuo M, Ishihara H, Ogawa T
Jpn J Radiol 2022 Jun;40(6):578-585. Epub 2022 Jan 4 doi: 10.1007/s11604-021-01243-0. PMID: 34982376Free PMC Article
Dimitrijevic MV, Tomanovic NR, Jesic SD, Arsovic NA, Mircic AL, Krstic AM
Arch Iran Med 2015 Apr;18(4):218-22. PMID: 25841941

Diagnosis

Ramas A, Kasumovic M, Uscupsic S, Mujic M, Tokic L
Med Arch 2024;78(1):68-70. doi: 10.5455/medarh.2024.78.68-70. PMID: 38481587Free PMC Article
Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226
Seethala RR
Mod Pathol 2017 Jan;30(s1):S84-S95. doi: 10.1038/modpathol.2016.190. PMID: 28060371
Dimitrijevic MV, Tomanovic NR, Jesic SD, Arsovic NA, Mircic AL, Krstic AM
Arch Iran Med 2015 Apr;18(4):218-22. PMID: 25841941
Ru K, Srivastava A, Tischler AS
Arch Pathol Lab Med 2004 Jan;128(1):92-4. doi: 10.5858/2004-128-92-BEC. PMID: 14692803

Therapy

Mäkelä R, Arjonen A, Suryo Rahmanto A, Härmä V, Lehtiö J, Kuopio T, Helleday T, Sangfelt O, Kononen J, Rantala JK
Neoplasia 2020 Sep;22(9):390-398. Epub 2020 Jul 6 doi: 10.1016/j.neo.2020.06.007. PMID: 32645560Free PMC Article
Zhu J, Li K, Dong X, Zhou P, Li P, Bi J
Medicine (Baltimore) 2018 Apr;97(15):e0364. doi: 10.1097/MD.0000000000010364. PMID: 29642184Free PMC Article
Kim CH, Jeong JS, Kim SR, Lee YC
Thorax 2018 Jun;73(6):593-594. Epub 2017 Dec 1 doi: 10.1136/thoraxjnl-2017-211155. PMID: 29196470Free PMC Article
Gudmundsson JK, Ajan A, Abtahi J
J Appl Oral Sci 2016 Nov-Dec;24(6):561-567. doi: 10.1590/1678-775720160214. PMID: 28076460Free PMC Article
Mann JM, Kellman RM, Hahn SS, de la Roza GL, Gajra A
Head Neck 2015 Aug;37(8):E96-8. Epub 2015 May 26 doi: 10.1002/hed.23873. PMID: 25242451

Prognosis

Naso JR, Roden AC
Histopathology 2024 Jan;84(1):102-123. Epub 2023 Sep 11 doi: 10.1111/his.15039. PMID: 37694812
Nakaguro M, Nagao T
Surg Pathol Clin 2021 Mar;14(1):97-109. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.10.002. PMID: 33526226
Robinson RA
Surg Pathol Clin 2021 Mar;14(1):25-42. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.005. PMID: 33526221
De Cecio R, Cantile M, Fulciniti F, Botti G, Foschini MP, Losito NS
Pathologica 2017 Mar;109(1):1-8. PMID: 28635988
Dimitrijevic MV, Tomanovic NR, Jesic SD, Arsovic NA, Mircic AL, Krstic AM
Arch Iran Med 2015 Apr;18(4):218-22. PMID: 25841941

Clinical prediction guides

Ma C, Yang C, Peng A, Sun T, Ji X, Mi J, Wei L, Shen S, Feng Q
Mol Cancer 2023 Oct 13;22(1):170. doi: 10.1186/s12943-023-01876-x. PMID: 37833788Free PMC Article
Suto T, Kato H, Kawaguchi M, Kobayashi K, Miyazaki T, Ando T, Noda Y, Hyodo F, Matsuo M, Ishihara H, Ogawa T
Jpn J Radiol 2022 Jun;40(6):578-585. Epub 2022 Jan 4 doi: 10.1007/s11604-021-01243-0. PMID: 34982376Free PMC Article
Roden AC
Semin Diagn Pathol 2021 Sep;38(5):98-108. Epub 2021 Mar 11 doi: 10.1053/j.semdp.2021.03.001. PMID: 33744018
Nakaguro M, Tanigawa M, Hirai H, Yamamoto Y, Urano M, Takahashi RH, Sukeda A, Okumura Y, Honda S, Tasaki K, Shimizu A, Tsukahara K, Tada Y, Matsubayashi J, Faquin WC, Sadow PM, Nagao T
Am J Surg Pathol 2021 Jul 1;45(7):885-894. doi: 10.1097/PAS.0000000000001673. PMID: 33481388Free PMC Article
Cheuk W, Chan JK
Histopathology 2007 Jul;51(1):1-20. Epub 2007 May 31 doi: 10.1111/j.1365-2559.2007.02719.x. PMID: 17539914

Recent systematic reviews

Wockner RS, Seethala RR, Emeto TI, McCaul JA, Subramaniam SS
Int J Oral Maxillofac Surg 2023 Jan;52(1):1-12. Epub 2022 Jun 3 doi: 10.1016/j.ijom.2022.05.005. PMID: 35667947Free PMC Article

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