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Melanoma in Junctional Nevus

MedGen UID:
90782
•Concept ID:
C0334434
•
Neoplastic Process
Synonyms: Malignant melanoma in junctional nevus; Malignant Melanoma in Junctional Nevus; Malignant Melanoma of Skin in Junctional Nevus; Malignant Melanoma of the Skin in Junctional Nevus; Malignant Skin Melanoma in Junctional Nevus
SNOMED CT: Malignant melanoma in junctional nevus (915007)

Definition

A melanoma arising from a melanocytic nevus which involves the dermal-epidermal junction of the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanoma in Junctional Nevus

Professional guidelines

PubMed

Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414
Acral junctional nevus versus acral lentiginous melanoma in situ: a differential diagnosis that should be based on clinicopathologic correlation.
Bravo Puccio F, Chian C
Arch Pathol Lab Med 2011 Jul;135(7):847-52. doi: 10.5858/2010-0323-RAR.1. PMID: 21732773

Recent clinical studies

Etiology

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Clinical and histological characteristics of melanocytic nevus in external auditory canals and auricles.
Lim HJ, Kim YT, Choo OS, Park K, Park HY, Choung YH
Eur Arch Otorhinolaryngol 2013 Nov;270(12):3035-42. Epub 2013 Jan 31 doi: 10.1007/s00405-013-2368-5. PMID: 23371542
Pitfalls in the evaluation of melanocytic lesions.
Brenn T
Histopathology 2012 Apr;60(5):690-705. Epub 2011 Dec 16 doi: 10.1111/j.1365-2559.2011.04042.x. PMID: 22176022
Pigmented penile macules.
Mahto M, Woolley PD, Ashworth J
Int J STD AIDS 2004 Nov;15(11):717-9. doi: 10.1258/0956462042395276. PMID: 15537454
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Diagnosis

Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.
Mansour B, Vanecek T, Kastnerova L, Nosek D, Kazakov DV, Donati M
Am J Dermatopathol 2023 May 1;45(5):306-310. Epub 2023 Mar 20 doi: 10.1097/DAD.0000000000002410. PMID: 36939120
PRAME Expression in Melanocytic Tumors.
Lezcano C, Jungbluth AA, Nehal KS, Hollmann TJ, Busam KJ
Am J Surg Pathol 2018 Nov;42(11):1456-1465. doi: 10.1097/PAS.0000000000001134. PMID: 30045064Free PMC Article
Acral lentiginous melanoma.
Piliang MP
Clin Lab Med 2011 Jun;31(2):281-8. doi: 10.1016/j.cll.2011.03.005. PMID: 21549241
Pigmented penile macules.
Mahto M, Woolley PD, Ashworth J
Int J STD AIDS 2004 Nov;15(11):717-9. doi: 10.1258/0956462042395276. PMID: 15537454
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Therapy

Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.
Yang S, Shu C, Hu H, Ma G, Yang M
Comput Math Methods Med 2022;2022:9726181. Epub 2022 May 28 doi: 10.1155/2022/9726181. PMID: 35669372Free PMC Article
In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions.
Elagin V, Gubarkova E, Garanina O, Davydova D, Orlinskaya N, Matveev L, Klemenova I, Shlivko I, Shirmanova M, Zagaynova E
Sci Rep 2021 Jan 14;11(1):1405. doi: 10.1038/s41598-020-80744-w. PMID: 33446823Free PMC Article
A quantitative comparison between SOX10 and MART-1 immunostaining to detect melanocytic hyperplasia in chronically sun-damaged skin.
Muzumdar S, Argraves M, Kristjansson A, Ferenczi K, Dadras SS
J Cutan Pathol 2018 Apr;45(4):263-268. Epub 2018 Feb 15 doi: 10.1111/cup.13115. PMID: 29377259
Dermabrasion in acquired melanocytic nevi: a histopathological and immunohistochemical study.
Dal'Forno T, Cartell A, Bakos L
Am J Dermatopathol 2011 Feb;33(1):40-6. doi: 10.1097/DAD.0b013e3181eb3eb1. PMID: 21178582
Epidermotropism in melanoma.
Warner TF, Gilbert EF, Ramirez G
J Cutan Pathol 1980 Feb;7(1):50-4. doi: 10.1111/j.1600-0560.1980.tb00977.x. PMID: 7358882

Prognosis

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Histologic Screening of Malignant Melanoma, Spitz, Dermal and Junctional Melanocytic Nevi Using a Deep Learning Model.
Snyder AN, Zhang D, Dreesen SL, Baltimore CA, Lopez-Garcia DR, Akers JY, Metts CL, Madory JE, Chang PD, Doan LT, Elston DM, Valdebran MA, Luo F, Forcucci JA
Am J Dermatopathol 2022 Sep 1;44(9):650-657. Epub 2022 Jul 19 doi: 10.1097/DAD.0000000000002232. PMID: 35925282
Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
Acral lentiginous melanoma.
Piliang MP
Clin Lab Med 2011 Jun;31(2):281-8. doi: 10.1016/j.cll.2011.03.005. PMID: 21549241
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Clinical prediction guides

Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.
Mansour B, Vanecek T, Kastnerova L, Nosek D, Kazakov DV, Donati M
Am J Dermatopathol 2023 May 1;45(5):306-310. Epub 2023 Mar 20 doi: 10.1097/DAD.0000000000002410. PMID: 36939120
Histologic Screening of Malignant Melanoma, Spitz, Dermal and Junctional Melanocytic Nevi Using a Deep Learning Model.
Snyder AN, Zhang D, Dreesen SL, Baltimore CA, Lopez-Garcia DR, Akers JY, Metts CL, Madory JE, Chang PD, Doan LT, Elston DM, Valdebran MA, Luo F, Forcucci JA
Am J Dermatopathol 2022 Sep 1;44(9):650-657. Epub 2022 Jul 19 doi: 10.1097/DAD.0000000000002232. PMID: 35925282
Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Dermoscopic Criteria, Histopathological Correlates and Genetic Findings of Thin Melanoma on Non-Volar Skin.
Massone C, Hofman-Wellenhof R, Chiodi S, Sola S
Genes (Basel) 2021 Aug 23;12(8) doi: 10.3390/genes12081288. PMID: 34440462Free PMC Article
Pointillist nevi.
Huynh PM, Glusac EJ, Bolognia JL
J Am Acad Dermatol 2001 Sep;45(3):397-400. doi: 10.1067/mjd.2001.116343. PMID: 11511837

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