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Round cell liposarcoma

MedGen UID:
90787
Concept ID:
C0334471
Neoplastic Process
Synonyms: cellular myxoid liposarcoma; Round Cell Liposarcoma; round cell liposarcoma; round cell liposarcoma (morphologic abnormality)
 
Monarch Initiative: MONDO:0005238

Definition

A poorly differentiated liposarcoma, characterized by the presence of solid sheets of primitive round mesenchymal cells and the absence of myxoid stroma. [from NCI]

Professional guidelines

PubMed

Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Recent clinical studies

Etiology

Hatina J, Kripnerova M, Houfkova K, Pesta M, Kuncova J, Sana J, Slaby O, Rodríguez R
Adv Exp Med Biol 2019;1123:95-118. doi: 10.1007/978-3-030-11096-3_7. PMID: 31016597
Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H
Pathol Int 2017 Sep;67(9):435-446. Epub 2017 Jul 31 doi: 10.1111/pin.12565. PMID: 28759137
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Hoffman A, Ghadimi MP, Demicco EG, Creighton CJ, Torres K, Colombo C, Peng T, Lusby K, Ingram D, Hornick JL, Wang WL, Ravi V, Lazar AJ, Lev D, Pollock RE
Cancer 2013 May 15;119(10):1868-77. Epub 2013 Feb 7 doi: 10.1002/cncr.27847. PMID: 23401071
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

Dermawan JK
Surg Pathol Clin 2024 Mar;17(1):25-29. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.005. PMID: 38278605
Ho TP
Curr Treat Options Oncol 2023 Apr;24(4):292-299. Epub 2023 Mar 3 doi: 10.1007/s11864-023-01064-5. PMID: 36867390
Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Therapy

D'Angelo SP, Araujo DM, Abdul Razak AR, Agulnik M, Attia S, Blay JY, Carrasco Garcia I, Charlson JA, Choy E, Demetri GD, Druta M, Forcade E, Ganjoo KN, Glod J, Keedy VL, Le Cesne A, Liebner DA, Moreno V, Pollack SM, Schuetze SM, Schwartz GK, Strauss SJ, Tap WD, Thistlethwaite F, Valverde Morales CM, Wagner MJ, Wilky BA, McAlpine C, Hudson L, Navenot JM, Wang T, Bai J, Rafail S, Wang R, Sun A, Fernandes L, Van Winkle E, Elefant E, Lunt C, Norry E, Williams D, Biswas S, Van Tine BA
Lancet 2024 Apr 13;403(10435):1460-1471. Epub 2024 Mar 27 doi: 10.1016/S0140-6736(24)00319-2. PMID: 38554725
Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163

Prognosis

Ho TP
Curr Treat Options Oncol 2023 Apr;24(4):292-299. Epub 2023 Mar 3 doi: 10.1007/s11864-023-01064-5. PMID: 36867390
Mujtaba B, Wang F, Taher A, Aslam R, Madewell JE, Nassar S
Curr Probl Diagn Radiol 2021 Jan-Feb;50(1):66-73. Epub 2019 Oct 30 doi: 10.1067/j.cpradiol.2019.10.008. PMID: 31813645
Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H
Pathol Int 2017 Sep;67(9):435-446. Epub 2017 Jul 31 doi: 10.1111/pin.12565. PMID: 28759137
Orvieto E, Furlanetto A, Laurino L, Dei Tos AP
Semin Diagn Pathol 2001 Nov;18(4):267-73. PMID: 11757867
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Clinical prediction guides

Mahalingam P, Julve M, Huang P, Furness AJS, Pollack SM, Jones RL
Curr Opin Oncol 2022 Jul 1;34(4):362-370. doi: 10.1097/CCO.0000000000000843. PMID: 35837706
Mujtaba B, Wang F, Taher A, Aslam R, Madewell JE, Nassar S
Curr Probl Diagn Radiol 2021 Jan-Feb;50(1):66-73. Epub 2019 Oct 30 doi: 10.1067/j.cpradiol.2019.10.008. PMID: 31813645
Yen CC, Chen TW
Chin Clin Oncol 2018 Aug;7(4):43. doi: 10.21037/cco.2018.08.04. PMID: 30173533
Hoffman A, Ghadimi MP, Demicco EG, Creighton CJ, Torres K, Colombo C, Peng T, Lusby K, Ingram D, Hornick JL, Wang WL, Ravi V, Lazar AJ, Lev D, Pollock RE
Cancer 2013 May 15;119(10):1868-77. Epub 2013 Feb 7 doi: 10.1002/cncr.27847. PMID: 23401071
Orvieto E, Furlanetto A, Laurino L, Dei Tos AP
Semin Diagn Pathol 2001 Nov;18(4):267-73. PMID: 11757867

Recent systematic reviews

Kamitani R, Matsumoto K, Takeda T, Mizuno R, Oya M
Int J Clin Oncol 2020 Dec;25(12):2099-2106. Epub 2020 Jul 26 doi: 10.1007/s10147-020-01753-3. PMID: 32715355

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