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Verrucous hemangioma

MedGen UID:
90802
Concept ID:
C0334540
Neoplastic Process
Synonyms: Verrucous Hemangioma; verrucous hemangioma; Verrucous Keratotic Hemangioma; Verrucous keratotic hemangioma; verrucous keratotic hemangioma; verrucous keratotic hemangioma (morphologic abnormality); Verrucous Venous Malformation
SNOMED CT: Verrucous keratotic hemangioma (20985003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018734
Orphanet: ORPHA464318

Definition

A rare vascular anomaly characterized by congenital, solitary or grouped, red-to-purple plaques which may bleed and enlarge over time. The lesions show a predilection for the lower extremities. Histological examination reveals numerous dilated, congested capillaries and venules in the papillary dermis, often with a deep dermal component, and with increased density of variably congested capillaries and venules also in the subcutaneous tissue. The overlying epidermis displays prominent acanthosis, papillomatosis, hyperkeratosis, parakeratosis, and crusting. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Verrucous hemangioma

Professional guidelines

PubMed

Segura Palacios JM, Boixeda P, Rocha J, Alcántara González J, Alonso Castro L, de Daniel Rodríguez C
Lasers Med Sci 2012 May;27(3):681-4. doi: 10.1007/s10103-011-1000-4. PMID: 21975688
Yang CH, Ohara K
Dermatol Surg 2002 Oct;28(10):913-19; discussion 920. doi: 10.1046/j.1524-4725.2002.02061.x. PMID: 12410675

Recent clinical studies

Etiology

Patel PA, Barnacle AM, Stuart S, Amaral JG, John PR
Pediatr Radiol 2017 Sep;47(10):1353-1363. Epub 2017 May 18 doi: 10.1007/s00247-017-3863-4. PMID: 28523345Free PMC Article
Trindade F, Torrelo A, Requena L, Tellechea O, Del Pozo J, Sacristán F, Esteve-Martínez A, de Unamuno B, de Miquel VA, Colmenero I
J Cutan Pathol 2013 May;40(5):472-6. doi: 10.1111/cup.12123. PMID: 23578182
Tennant LB, Mulliken JB, Perez-Atayde AR, Kozakewich HP
Pediatr Dermatol 2006 May-Jun;23(3):208-15. doi: 10.1111/j.1525-1470.2006.00219.x. PMID: 16780464
Wang G, Li C, Gao T
Int J Dermatol 2004 Oct;43(10):745-6. doi: 10.1111/j.1365-4632.2004.02261.x. PMID: 15485532
Klein JA, Barr RJ
Pediatr Dermatol 1985 Mar;2(3):191-3. doi: 10.1111/j.1525-1470.1985.tb01050.x. PMID: 3991374

Diagnosis

Schmidt BAR, El Zein S, Cuoto J, Al-Ibraheemi A, Liang MG, Paltiel HJ, Anderson ME, Labow BI, Upton J, Fishman SJ, Mulliken JB, Greene AK, Warman ML, Kozakewich H
Am J Dermatopathol 2021 Dec 1;43(12):e181-e184. doi: 10.1097/DAD.0000000000001963. PMID: 33899768
Leavens J, Worswick S, Kim GH
Dermatol Online J 2019 Dec 15;25(12) PMID: 32045166
McCuaig CC
Curr Opin Pediatr 2017 Aug;29(4):448-454. doi: 10.1097/MOP.0000000000000518. PMID: 28654575
Tennant LB, Mulliken JB, Perez-Atayde AR, Kozakewich HP
Pediatr Dermatol 2006 May-Jun;23(3):208-15. doi: 10.1111/j.1525-1470.2006.00219.x. PMID: 16780464
Wang G, Li C, Gao T
Int J Dermatol 2004 Oct;43(10):745-6. doi: 10.1111/j.1365-4632.2004.02261.x. PMID: 15485532

Therapy

Baumgartner J, Šimaljaková M, Babál P
J Cosmet Laser Ther 2016 Jun;18(3):134-7. Epub 2016 Mar 8 doi: 10.3109/14764172.2015.1114643. PMID: 26736060
Segura Palacios JM, Boixeda P, Rocha J, Alcántara González J, Alonso Castro L, de Daniel Rodríguez C
Lasers Med Sci 2012 May;27(3):681-4. doi: 10.1007/s10103-011-1000-4. PMID: 21975688

Prognosis

Al Dhaybi R, Powell J, McCuaig C, Kokta V
J Am Acad Dermatol 2010 Dec;63(6):1052-7. doi: 10.1016/j.jaad.2009.12.017. PMID: 21093662
Koc M, Kavala M, Kocatürk E, Zemheri E, Zindanci I, Sudogan S, Kural E
Dermatol Online J 2009 Nov 15;15(11):7. PMID: 19951643
Rossi A, Bozzi M, Barra E
J Dermatol Surg Oncol 1989 Jan;15(1):88-91. doi: 10.1111/j.1524-4725.1989.tb03117.x. PMID: 2910968

Clinical prediction guides

Gong X, Chang SJ, Xiong P, Lin X, Wang L
Dermatol Surg 2023 Nov 1;49(11):1006-1011. Epub 2023 Sep 18 doi: 10.1097/DSS.0000000000003922. PMID: 37738289
Couto JA, Vivero MP, Kozakewich HP, Taghinia AH, Mulliken JB, Warman ML, Greene AK
Am J Hum Genet 2015 Mar 5;96(3):480-6. Epub 2015 Feb 26 doi: 10.1016/j.ajhg.2015.01.007. PMID: 25728774Free PMC Article
Lin YT, Chen CM, Yang CH, Chuang YH
Chang Gung Med J 2012 Mar-Apr;35(2):167-77. doi: 10.4103/2319-4170.106154. PMID: 22537932
Akyol I, Jayanthi VR, Luquette MH
Urology 2008 Jul;72(1):230.e15-6. Epub 2008 Feb 20 doi: 10.1016/j.urology.2007.11.120. PMID: 18280555
Wentscher U, Happle R
J Am Acad Dermatol 2000 Mar;42(3):516-8. doi: 10.1016/s0190-9622(00)90232-9. PMID: 10688730

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