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Malignant giant cell tumor of soft parts

MedGen UID:
90807
•Concept ID:
C0334554
•
Neoplastic Process
Synonyms: giant cell fibrous histiocytoma; giant cell malignant fibrous histiocytoma; malignant giant cell neoplasm of soft parts; malignant giant cell tumor of soft parts; malignant giant cell tumor of soft parts (morphologic abnormality); Malignant giant cell tumor of soft tissue; malignant giant cell tumour of soft parts (morphologic abnormality); malignant Osteoclastoma; Undifferentiated Pleomorphic Sarcoma with Osteoclast-Like Giant Cells; undifferentiated pleomorphic sarcoma with osteoclast-like giant cells
SNOMED CT: Malignant giant cell tumor of soft tissue (48460009); Malignant giant cell tumor of soft parts (48460009)
 
Monarch Initiative: MONDO:0003561

Definition

An undifferentiated pleomorphic sarcoma characterized by the presence of osteoclast-like giant cells and cellular pleomorphism. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant giant cell tumor of soft parts

Professional guidelines

PubMed

RNAscope CSF1 chromogenic in situ hybridization: a potentially useful tool in the differential diagnosis of tenosynovial giant cell tumors.
Thangaiah JJ, Koepplin JW, Folpe AL
Hum Pathol 2021 Sep;115:1-9. Epub 2021 May 28 doi: 10.1016/j.humpath.2021.05.010. PMID: 34058245
Management of tumors and tumor-like lesions of the hand: a review of 191 patients.
Sağlık Y, Atalar H, Armangil M, Başarır K, Yıldız Y, Bilgin S
Eklem Hastalik Cerrahisi 2013;24(3):149-55. doi: 10.5606/ehc.2013.33. PMID: 24191880

Recent clinical studies

Therapy

Metastatic Giant Cell Tumor Causing Small Bowel Intussusception on 18 F-FDG PET/CT.
Walcutt JE, Johnson CM, Ly QP, Downey RT
Clin Nucl Med 2022 Nov 1;47(11):963-964. Epub 2022 Jul 6 doi: 10.1097/RLU.0000000000004287. PMID: 35777978
Giant cell tumor of soft parts. An ultrastructural study.
van Haelst UJ, de Haas van Dorsser AH
Virchows Arch A Pathol Anat Histol 1976 Sep 21;371(3):199-217. doi: 10.1007/BF00433068. PMID: 184582

Prognosis

Soft tissue giant cell tumor of low malignant potential of the neck: a case report and review of the literature.
Callı AO, Tunakan M, Katilmiş H, Kilçiksiz S, Oztürkcan S
Turk Patoloji Derg 2014;30(1):73-7. doi: 10.5146/tjpath.2013.01174. PMID: 24101352
Malignant giant cell tumor of the vulva.
El Demellawy D, Saleh R, Daya D, Alowami S
Int J Gynecol Pathol 2010 Jan;29(1):93-7. doi: 10.1097/PGP.0b013e3181b15010. PMID: 19952930
Disseminated malignant fibrous histiocytoma (giant cell rich): a case report.
Rao S, Arcot R, Pai V, Prathiba D
Indian J Pathol Microbiol 2007 Oct;50(4):795-7. PMID: 18306558
Ovarian mucinous tumors with sarcoma-like mural nodules: a report of seven cases.
Prat J, Scully RE
Cancer 1979 Oct;44(4):1332-44. doi: 10.1002/1097-0142(197910)44:4<1332::aid-cncr2820440426>3.0.co;2-#. PMID: 498014
Malignant giant cell tumor of soft parts. An analysis of 32 cases.
Guccion JG, Enzinger FM
Cancer 1972 Jun;29(6):1518-29. doi: 10.1002/1097-0142(197206)29:6<1518::aid-cncr2820290616>3.0.co;2-#. PMID: 5031245

Clinical prediction guides

Soft tissue giant cell tumor of low malignant potential of the neck: a case report and review of the literature.
Callı AO, Tunakan M, Katilmiş H, Kilçiksiz S, Oztürkcan S
Turk Patoloji Derg 2014;30(1):73-7. doi: 10.5146/tjpath.2013.01174. PMID: 24101352
p63 immunohistochemical staining is limited in soft tissue tumors.
Jo VY, Fletcher CD
Am J Clin Pathol 2011 Nov;136(5):762-6. doi: 10.1309/AJCPXNUC7JZSKWEU. PMID: 22031315
Pleomorphic hyalinizing angiectatic tumor of soft parts: a case report and literature review.
Matsumoto K, Yamamoto T
Pathol Int 2002 Oct;52(10):664-8. doi: 10.1046/j.1440-1827.2002.01406.x. PMID: 12445140
Mucinous ovarian tumors with giant cell mural nodules. A report of two cases.
Russell P, Wills EJ, Schweitzer P, Bannatyne PM
Diagn Gynecol Obstet 1981 Fall;3(3):233-49. PMID: 6276116
Giant cell tumor of soft parts. An ultrastructural study.
van Haelst UJ, de Haas van Dorsser AH
Virchows Arch A Pathol Anat Histol 1976 Sep 21;371(3):199-217. doi: 10.1007/BF00433068. PMID: 184582

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