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Astroblastoma

MedGen UID:
90811
•Concept ID:
C0334587
•
Neoplastic Process
Synonym: Cerebral astroblastoma
SNOMED CT: Astroblastoma (48952003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016707
Orphanet: ORPHA251679

Definition

A very rare glial neoplasm of the central nervous system, most often with an intra-axial peripheral supratentorial location in one hemisphere of the frontal or parietal lobes and usually presenting in infants and young adults with symptoms of vomiting, loss of consciousness, epileptic seizures and headaches. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAstroblastoma
Follow this link to review classifications for Astroblastoma in Orphanet.

Professional guidelines

PubMed

Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.
Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Clinicoradiological and histopathological characteristics and treatment outcomes of cerebral astroblastoma in children: a single-institution experience.
Jeon C, Kim B, Choi JW
J Neurosurg Pediatr 2022 May 1;29(5):513-519. Epub 2022 Feb 18 doi: 10.3171/2022.1.PEDS21389. PMID: 35180693
Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis.
Merfeld EC, Dahiya S, Perkins SM
CNS Oncol 2018 Apr;7(2):CNS13. Epub 2018 Apr 30 doi: 10.2217/cns-2017-0038. PMID: 29708401Free PMC Article

Recent clinical studies

Etiology

Circumscribed astrocytic gliomas: Contribution of molecular analyses to histopathology diagnosis in the WHO CNS5 classification.
Köy Y, Tihan T
Indian J Pathol Microbiol 2022 May;65(Supplement):S33-S41. doi: 10.4103/ijpm.ijpm_1019_21. PMID: 35562132
Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.
Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Neuroimaging of astroblastomas: A case series and systematic review.
Kurokawa R, Baba A, Kurokawa M, Ota Y, Hassan O, Capizzano A, Kim J, Johnson T, Srinivasan A, Moritani T
J Neuroimaging 2022 Mar;32(2):201-212. Epub 2021 Nov 23 doi: 10.1111/jon.12948. PMID: 34816541
Supratentorial ependymoma in childhood: more than just RELA or YAP.
Zschernack V, Jünger ST, Mynarek M, Rutkowski S, Garre ML, Ebinger M, Neu M, Faber J, Erdlenbruch B, Claviez A, Bielack S, Brozou T, Frühwald MC, Dörner E, Dreschmann V, Stock A, Solymosi L, Hench J, Frank S, Vokuhl C, Waha A, Andreiuolo F, Pietsch T
Acta Neuropathol 2021 Mar;141(3):455-466. Epub 2021 Jan 22 doi: 10.1007/s00401-020-02260-5. PMID: 33481105Free PMC Article
Cerebral astroblastoma.
Caroli E, Salvati M, Esposito V, Orlando ER, Giangaspero F
Acta Neurochir (Wien) 2004 Jun;146(6):629-33. Epub 2004 Apr 13 doi: 10.1007/s00701-004-0230-7. PMID: 15168232

Diagnosis

Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.
Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
High-grade glioma with pleomorphic and pseudopapillary features (HPAP): a proposed type of circumscribed glioma in adults harboring frequent TP53 mutations and recurrent monosomy 13.
Pratt D, Abdullaev Z, Papanicolau-Sengos A, Ketchum C, Panneer Selvam P, Chung HJ, Lee I, Raffeld M, Gilbert MR, Armstrong TS, Pytel P, Borys E, Klonoski JM, McCord M, Horbinski C, Brat D, Perry A, Solomon D, Eberhart C, Giannini C, Quezado M, Aldape K
Acta Neuropathol 2022 Mar;143(3):403-414. Epub 2022 Feb 1 doi: 10.1007/s00401-022-02404-9. PMID: 35103816Free PMC Article
Malignant Astroblastoma.
Sarper B, Yaprak Bayrak B, Halis H, Alparslan B, Yeni Bayraktar H
Balkan Med J 2020 Jun 1;37(4):224-225. Epub 2020 Mar 26 doi: 10.4274/balkanmedj.galenos.2020.2019.11.39. PMID: 32212579Free PMC Article
Rare glial tumors.
Soffietti R, Rudà R, Reardon D
Handb Clin Neurol 2016;134:399-415. doi: 10.1016/B978-0-12-802997-8.00024-4. PMID: 26948368
Cerebral astroblastoma.
Caroli E, Salvati M, Esposito V, Orlando ER, Giangaspero F
Acta Neurochir (Wien) 2004 Jun;146(6):629-33. Epub 2004 Apr 13 doi: 10.1007/s00701-004-0230-7. PMID: 15168232

Therapy

Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.
Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Prevalence of BRAFV600 in glioma and use of BRAF Inhibitors in patients with BRAFV600 mutation-positive glioma: systematic review.
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Malignant Astroblastoma.
Sarper B, Yaprak Bayrak B, Halis H, Alparslan B, Yeni Bayraktar H
Balkan Med J 2020 Jun 1;37(4):224-225. Epub 2020 Mar 26 doi: 10.4274/balkanmedj.galenos.2020.2019.11.39. PMID: 32212579Free PMC Article
Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas.
Sarmiento JM, Venteicher AS, Patil CG
Cochrane Database Syst Rev 2015 Jun 29;6(6):CD009229. doi: 10.1002/14651858.CD009229.pub2. PMID: 26118544Free PMC Article
Astroblastoma in a child.
Unal E, Koksal Y, Vajtai I, Toy H, Kocaogullar Y, Paksoy Y
Childs Nerv Syst 2008 Feb;24(2):165-8. Epub 2007 Jul 26 doi: 10.1007/s00381-007-0424-4. PMID: 17653728

Prognosis

Recurrent high-grade astroblastoma with MN1-BEND2 fusion in spinal cord and literature review.
Sun D, Liu J, Xiao L, Guan H
Clin Neuropathol 2023 Jan-Feb;42(1):30-39. doi: 10.5414/NP301497. PMID: 36366964
Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.
Rosenberg T, Yeo KK, Mauguen A, Alexandrescu S, Prabhu SP, Tsai JW, Malinowski S, Joshirao M, Parikh K, Farouk Sait S, Rosenblum MK, Benhamida JK, Michaiel G, Tran HN, Dahiya S, Kachurak K, Friedman GK, Krystal JI, Huang MA, Margol AS, Wright KD, Aguilera D, MacDonald TJ, Chi SN, Karajannis MA
Neuro Oncol 2022 Nov 2;24(11):1964-1975. doi: 10.1093/neuonc/noac096. PMID: 35397478Free PMC Article
Rare glial tumors.
Soffietti R, Rudà R, Reardon D
Handb Clin Neurol 2016;134:399-415. doi: 10.1016/B978-0-12-802997-8.00024-4. PMID: 26948368
Clinical features and post-surgical outcome of patients with astroblastoma.
Sughrue ME, Choi J, Rutkowski MJ, Aranda D, Kane AJ, Barani IJ, Parsa AT
J Clin Neurosci 2011 Jun;18(6):750-4. Epub 2011 Apr 19 doi: 10.1016/j.jocn.2010.11.007. PMID: 21507653
Cerebral astroblastoma.
Caroli E, Salvati M, Esposito V, Orlando ER, Giangaspero F
Acta Neurochir (Wien) 2004 Jun;146(6):629-33. Epub 2004 Apr 13 doi: 10.1007/s00701-004-0230-7. PMID: 15168232

Clinical prediction guides

Recurrent high-grade astroblastoma with MN1-BEND2 fusion in spinal cord and literature review.
Sun D, Liu J, Xiao L, Guan H
Clin Neuropathol 2023 Jan-Feb;42(1):30-39. doi: 10.5414/NP301497. PMID: 36366964
Neuroimaging of astroblastomas: A case series and systematic review.
Kurokawa R, Baba A, Kurokawa M, Ota Y, Hassan O, Capizzano A, Kim J, Johnson T, Srinivasan A, Moritani T
J Neuroimaging 2022 Mar;32(2):201-212. Epub 2021 Nov 23 doi: 10.1111/jon.12948. PMID: 34816541
Supratentorial ependymoma in childhood: more than just RELA or YAP.
Zschernack V, Jünger ST, Mynarek M, Rutkowski S, Garre ML, Ebinger M, Neu M, Faber J, Erdlenbruch B, Claviez A, Bielack S, Brozou T, Frühwald MC, Dörner E, Dreschmann V, Stock A, Solymosi L, Hench J, Frank S, Vokuhl C, Waha A, Andreiuolo F, Pietsch T
Acta Neuropathol 2021 Mar;141(3):455-466. Epub 2021 Jan 22 doi: 10.1007/s00401-020-02260-5. PMID: 33481105Free PMC Article
Posterior fossa astroblastoma in a child: a case report and a review of the literature.
Yapıcıer Ö, Demir MK, Özdamarlar U, Kılıç D, Akakın A, Kılıç T
Childs Nerv Syst 2019 Jul;35(7):1251-1255. Epub 2019 Mar 12 doi: 10.1007/s00381-019-04113-3. PMID: 30859299
Astroblastoma: report of two cases with unexpected clinical behavior and review of the literature.
Janz C, Buhl R
Clin Neurol Neurosurg 2014 Oct;125:114-24. Epub 2014 Jul 21 doi: 10.1016/j.clineuro.2014.07.013. PMID: 25108699

Recent systematic reviews

Neuroimaging of astroblastomas: A case series and systematic review.
Kurokawa R, Baba A, Kurokawa M, Ota Y, Hassan O, Capizzano A, Kim J, Johnson T, Srinivasan A, Moritani T
J Neuroimaging 2022 Mar;32(2):201-212. Epub 2021 Nov 23 doi: 10.1111/jon.12948. PMID: 34816541
Prevalence of BRAFV600 in glioma and use of BRAF Inhibitors in patients with BRAFV600 mutation-positive glioma: systematic review.
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Central nervous system neuroepithelial tumors with MN1-alteration: an individual patient data meta-analysis of 73 cases.
Chen W, Soon YY, Pratiseyo PD, Sutanto R, Hendriansyah L, Kuick CH, Chang KTE, Tan CL
Brain Tumor Pathol 2020 Oct;37(4):145-153. Epub 2020 Jun 29 doi: 10.1007/s10014-020-00372-0. PMID: 32601775
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications.
Cunningham DA, Lowe LH, Shao L, Acosta NR
Pediatr Radiol 2016 Aug;46(9):1301-8. Epub 2016 Apr 5 doi: 10.1007/s00247-016-3607-x. PMID: 27048363
Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas.
Sarmiento JM, Venteicher AS, Patil CG
Cochrane Database Syst Rev 2015 Jun 29;6(6):CD009229. doi: 10.1002/14651858.CD009229.pub2. PMID: 26118544Free PMC Article

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