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Malignant Lymphoma, Large Cell, Cleaved

MedGen UID:
90819
•Concept ID:
C0334641
•
Neoplastic Process
Synonym: Diffuse malignant lymphoma - large cleaved cell
SNOMED CT: Diffuse malignant lymphoma - large cleaved cell (277628000)

Definition

Antiquated term describing non-Hodgkin lymphomas that are usually diffuse and are composed of large cells with irregular nuclei, invisible nucleoli and a small amount of cytoplasm. This morphologic category includes both mature B- and mature T-cell lymphomas. [from NCI]

Professional guidelines

PubMed

Novel targeted mtLivin nanoparticles treatment for disseminated diffuse large B-cell lymphoma.
Abd-Elrahman I, Nassar T, Khairi N, Perlman R, Benita S, Ben Yehuda D
Oncogene 2021 Jan;40(2):334-344. Epub 2020 Oct 30 doi: 10.1038/s41388-020-01529-z. PMID: 33128043
Management of intermediate-grade lymphomas.
Miller TP
Oncology (Williston Park) 1998 Oct;12(10 Suppl 8):35-9. PMID: 9830631
Biology and treatment of small non-cleaved cell lymphoma.
Magrath IT, Shiramizu B
Oncology (Williston Park) 1989 Nov;3(11):41-53; discussion 53-4, 56, 59-60. PMID: 2578020

Recent clinical studies

Etiology

2α-Hydroxyeudesma-4,11(13)-Dien-8β,12-Olide Isolated from Inula britannica Induces Apoptosis in Diffuse Large B-cell Lymphoma Cells.
Jang DK, Lee IS, Shin HS, Yoo HM
Biomolecules 2020 Feb 18;10(2) doi: 10.3390/biom10020324. PMID: 32085513Free PMC Article
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.
Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M
Prog Neurobiol 2013 Jul-Aug;106-107:33-54. Epub 2013 Jul 1 doi: 10.1016/j.pneurobio.2013.06.002. PMID: 23827971
Primary laryngeal lymphoma.
Ansell SM, Habermann TM, Hoyer JD, Strickler JG, Chen MG, McDonald TJ
Laryngoscope 1997 Nov;107(11 Pt 1):1502-6. doi: 10.1097/00005537-199711000-00014. PMID: 9369397
Non-Hodgkin's lymphoma.
Greiner TC, Medeiros LJ, Jaffe ES
Cancer 1995 Jan 1;75(1 Suppl):370-80. doi: 10.1002/1097-0142(19950101)75:1+<370::aid-cncr2820751319>3.0.co;2-q. PMID: 8001008
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138

Diagnosis

Follicular large cleaved cell (centrocytic) lymphoma: an unrecognized variant of follicular lymphoma.
El Behery R, Laurini JA, Weisenburger DD, Smith LM, Dave BJ, Yuan J, Fu K, Chan WC, Nathwani BN, Bierman PJ, Bociek RG, Vose JM, Armitage JO, Greiner TC, Aoun P
Hum Pathol 2018 Feb;72:180-190. Epub 2017 Nov 21 doi: 10.1016/j.humpath.2017.11.002. PMID: 29170017
Primary laryngeal lymphoma.
Ansell SM, Habermann TM, Hoyer JD, Strickler JG, Chen MG, McDonald TJ
Laryngoscope 1997 Nov;107(11 Pt 1):1502-6. doi: 10.1097/00005537-199711000-00014. PMID: 9369397
Kikuchi-Fujimoto disease mimicking malignant lymphoma.
Chamulak GA, Brynes RK, Nathwani BN
Am J Surg Pathol 1990 Jun;14(6):514-23. doi: 10.1097/00000478-199006000-00002. PMID: 2186643
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138
Cutaneous follicular lymphoma.
Garcia CF, Weiss LM, Warnke RA, Wood GS
Am J Surg Pathol 1986 Jul;10(7):454-63. doi: 10.1097/00000478-198607000-00002. PMID: 3524282

Therapy

Novel targeted mtLivin nanoparticles treatment for disseminated diffuse large B-cell lymphoma.
Abd-Elrahman I, Nassar T, Khairi N, Perlman R, Benita S, Ben Yehuda D
Oncogene 2021 Jan;40(2):334-344. Epub 2020 Oct 30 doi: 10.1038/s41388-020-01529-z. PMID: 33128043
Follicular large cleaved cell (centrocytic) lymphoma: an unrecognized variant of follicular lymphoma.
El Behery R, Laurini JA, Weisenburger DD, Smith LM, Dave BJ, Yuan J, Fu K, Chan WC, Nathwani BN, Bierman PJ, Bociek RG, Vose JM, Armitage JO, Greiner TC, Aoun P
Hum Pathol 2018 Feb;72:180-190. Epub 2017 Nov 21 doi: 10.1016/j.humpath.2017.11.002. PMID: 29170017
cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity.
Francisco JA, Cerveny CG, Meyer DL, Mixan BJ, Klussman K, Chace DF, Rejniak SX, Gordon KA, DeBlanc R, Toki BE, Law CL, Doronina SO, Siegall CB, Senter PD, Wahl AF
Blood 2003 Aug 15;102(4):1458-65. Epub 2003 Apr 24 doi: 10.1182/blood-2003-01-0039. PMID: 12714494
AIDS lymphoma.
Sandler AS, Kaplan L
Curr Opin Oncol 1996 Sep;8(5):377-85. doi: 10.1097/00001622-199609000-00008. PMID: 8914804
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138

Prognosis

HOXD3 Up-regulating KDM5C Promotes Malignant Progression of Diffuse Large B-Cell Lymphoma by Decreasing p53 Expression.
Cui Y, Lv C, Wen Y, Zhao D, Yang Y, Qiu H, Wang C
Balkan Med J 2022 Jan 25;39(1):30-38. Epub 2021 Dec 20 doi: 10.5152/balkanmedj.2021.21068. PMID: 34928233Free PMC Article
LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma.
Huang Y, Lin Y, Song X, Wu D
Carcinogenesis 2021 May 28;42(5):733-741. doi: 10.1093/carcin/bgab013. PMID: 33657224
Non-Hodgkin's lymphoma.
Greiner TC, Medeiros LJ, Jaffe ES
Cancer 1995 Jan 1;75(1 Suppl):370-80. doi: 10.1002/1097-0142(19950101)75:1+<370::aid-cncr2820751319>3.0.co;2-q. PMID: 8001008
Mantle-cell lymphoma.
De Wolf-Peeters C, Pittaluga S
Ann Oncol 1994;5 Suppl 1:35-7. doi: 10.1093/annonc/5.suppl_1.s35. PMID: 8172814
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138

Clinical prediction guides

LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma.
Huang Y, Lin Y, Song X, Wu D
Carcinogenesis 2021 May 28;42(5):733-741. doi: 10.1093/carcin/bgab013. PMID: 33657224
Non-Hodgkin's lymphoma.
Greiner TC, Medeiros LJ, Jaffe ES
Cancer 1995 Jan 1;75(1 Suppl):370-80. doi: 10.1002/1097-0142(19950101)75:1+<370::aid-cncr2820751319>3.0.co;2-q. PMID: 8001008
Low-grade lymphoma: clinical and prognostic studies in a series of 143 patients from a single institution.
Lopez-Guillermo A, Montserrat E, Bosch F, Escoda L, Terol MJ, Marin P, Reverter JC, Blade J, Cervantes F, Sierra J
Leuk Lymphoma 1994 Sep;15(1-2):159-65. doi: 10.3109/10428199409051692. PMID: 7858494
AIDS-associated lymphoma.
Kaplan LD
Baillieres Clin Haematol 1990 Jan;3(1):139-51. doi: 10.1016/s0950-3536(05)80085-x. PMID: 2182138
Signet-ring cell lymphoma.
Iossifides I, Mackay B, Butler JJ
Ultrastruct Pathol 1980 Oct-Dec;1(4):511-7. doi: 10.3109/01913128009140558. PMID: 6821485

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