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Pituitary null cell adenoma

MedGen UID:
90850
•Concept ID:
C0338078
•
Neoplastic Process
Synonym: Silent pituitary adenoma
SNOMED CT: Functionless pituitary adenoma (254962005); Non-functioning pituitary adenoma (254962005); Null cell pituitary adenoma (254962005); Null cell pituitary adenoma (1156905002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0011761
Monarch Initiative: MONDO:0017825
Orphanet: ORPHA314786

Definition

A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess. [from HPO]

Professional guidelines

PubMed

Efficacy and safety of temozolomide in the treatment of aggressive pituitary neuroendocrine tumours in Spain.
Lamas C, Cámara R, Fajardo C, Remon-Ruiz P, Biagetti B, Guerrero-Pérez F, Araujo-Castro M, Mora M, Hanzu F, Iglesias P, García-Centeno R, Soto A
Front Endocrinol (Lausanne) 2023;14:1204206. Epub 2023 Aug 31 doi: 10.3389/fendo.2023.1204206. PMID: 37720528Free PMC Article
Long-term follow-up of a large prospective cohort of patients with nonfunctioning pituitary adenomas: The outcome of a conservative management policy.
Levy MJ, Robertson IJ, Khalk N, Vitello S, Reddy N, Bhake R, Howlett TA
Clin Endocrinol (Oxf) 2018 Sep;89(3):354-359. Epub 2018 Jul 11 doi: 10.1111/cen.13791. PMID: 29920729
Classical pituitary apoplexy: clinical features, management and outcome.
Randeva HS, Schoebel J, Byrne J, Esiri M, Adams CB, Wass JA
Clin Endocrinol (Oxf) 1999 Aug;51(2):181-8. doi: 10.1046/j.1365-2265.1999.00754.x. PMID: 10468988

Recent clinical studies

Etiology

Endothelial cell-specific molecule-1 as an invasiveness marker for pituitary null cell adenoma.
Wang S, Wu Z, Wei L, Zhang J
BMC Endocr Disord 2019 Aug 27;19(1):90. doi: 10.1186/s12902-019-0418-8. PMID: 31455321Free PMC Article
Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness.
Yu G, Li C, Xie W, Wang Z, Gao H, Cao L, Hao L, Zhang Y
Oncol Rep 2017 Aug;38(2):1140-1148. Epub 2017 Jun 22 doi: 10.3892/or.2017.5739. PMID: 28656268Free PMC Article

Diagnosis

A pituitary metastasis, an adenoma and potential hypophysitis: A case report of tumour to tumour metastasis in the pituitary.
Castle-Kirszbaum M, Beng Phung T, Luen SJ, Rimmer J, Chandra RV, Goldschlager T
J Clin Neurosci 2020 Nov;81:161-166. Epub 2020 Oct 10 doi: 10.1016/j.jocn.2020.09.033. PMID: 33222908
Null Cell Adenoma of the Pituitary: Pseudo-rosettes Say It Best When Immunohistochemistry Says Nothing At All!
Singh V, Gupta K, Salunke P, Dhandapani SS
Head Neck Pathol 2019 Dec;13(4):677-680. Epub 2018 Sep 24 doi: 10.1007/s12105-018-0972-9. PMID: 30251033Free PMC Article
Coexistence of sporadic cerebellar hemangioblastoma and pituitary null cell adenoma: simultaneous expression of von Hippel-Lindau gene product. Case report.
Shimoda Y, Ogawa Y, Endo H, Watanabe M, Tominaga T
Neurol Med Chir (Tokyo) 2012;52(8):591-4. doi: 10.2176/nmc.52.591. PMID: 22976143
DNA methylation regulates p27kip1 expression in rodent pituitary cell lines.
Qian X, Jin L, Kulig E, Lloyd RV
Am J Pathol 1998 Nov;153(5):1475-82. doi: 10.1016/S0002-9440(10)65735-5. PMID: 9811339Free PMC Article

Prognosis

Endothelial cell-specific molecule-1 as an invasiveness marker for pituitary null cell adenoma.
Wang S, Wu Z, Wei L, Zhang J
BMC Endocr Disord 2019 Aug 27;19(1):90. doi: 10.1186/s12902-019-0418-8. PMID: 31455321Free PMC Article
Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness.
Yu G, Li C, Xie W, Wang Z, Gao H, Cao L, Hao L, Zhang Y
Oncol Rep 2017 Aug;38(2):1140-1148. Epub 2017 Jun 22 doi: 10.3892/or.2017.5739. PMID: 28656268Free PMC Article

Clinical prediction guides

Endothelial cell-specific molecule-1 as an invasiveness marker for pituitary null cell adenoma.
Wang S, Wu Z, Wei L, Zhang J
BMC Endocr Disord 2019 Aug 27;19(1):90. doi: 10.1186/s12902-019-0418-8. PMID: 31455321Free PMC Article
Long non-coding RNA C5orf66-AS1 is downregulated in pituitary null cell adenomas and is associated with their invasiveness.
Yu G, Li C, Xie W, Wang Z, Gao H, Cao L, Hao L, Zhang Y
Oncol Rep 2017 Aug;38(2):1140-1148. Epub 2017 Jun 22 doi: 10.3892/or.2017.5739. PMID: 28656268Free PMC Article
Identification of a subtype-specific ENC1 gene related to invasiveness in human pituitary null cell adenoma and oncocytomas.
Feng J, Hong L, Wu Y, Li C, Wan H, Li G, Sun Y, Yu S, Chittiboina P, Montgomery B, Zhuang Z, Zhang Y
J Neurooncol 2014 Sep;119(2):307-15. Epub 2014 Jun 11 doi: 10.1007/s11060-014-1479-1. PMID: 24916845Free PMC Article
DNA methylation regulates p27kip1 expression in rodent pituitary cell lines.
Qian X, Jin L, Kulig E, Lloyd RV
Am J Pathol 1998 Nov;153(5):1475-82. doi: 10.1016/S0002-9440(10)65735-5. PMID: 9811339Free PMC Article

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