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Silent pituitary adenoma

MedGen UID:
90850
Concept ID:
C0338078
Neoplastic Process
Synonym: Pituitary null cell adenoma
SNOMED CT: Functionless pituitary adenoma (254962005); Non-functioning pituitary adenoma (254962005); Null cell pituitary adenoma (254962005); Null cell pituitary adenoma (1156905002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0011761
Monarch Initiative: MONDO:0017825
Orphanet: ORPHA314786

Definition

A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess. [from HPO]

Professional guidelines

PubMed

Raverot G, Assié G, Cotton F, Cogne M, Boulin A, Dherbomez M, Bonneville JF, Massart C
Ann Endocrinol (Paris) 2015 Jul;76(3):201-9. Epub 2015 Jun 26 doi: 10.1016/j.ando.2015.04.005. PMID: 26122495
Cortet-Rudelli C, Bonneville JF, Borson-Chazot F, Clavier L, Coche Dequéant B, Desailloud R, Maiter D, Rohmer V, Sadoul JL, Sonnet E, Toussaint P, Chanson P
Ann Endocrinol (Paris) 2015 Jul;76(3):228-38. Epub 2015 Jun 23 doi: 10.1016/j.ando.2015.04.003. PMID: 26116412
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284

Recent clinical studies

Etiology

Akkus G, Karagun B, Çetinalp NE, Açıkalın A, Evran M, Sengöz S, Sert M, Zorludemir S, Tetiker T
Curr Med Imaging 2021;17(2):310-317. doi: 10.2174/1573405616666201223125642. PMID: 33357196
Baba N, Kameda H, Nakamura A, Yong Cho K, Nomoto H, Mitsuhashi T, Miyoshi H, Atsumi T
Endocr J 2021 Feb 28;68(2):195-200. Epub 2020 Oct 6 doi: 10.1507/endocrj.EJ20-0185. PMID: 33028757
Raverot G, Assié G, Cotton F, Cogne M, Boulin A, Dherbomez M, Bonneville JF, Massart C
Ann Endocrinol (Paris) 2015 Jul;76(3):201-9. Epub 2015 Jun 26 doi: 10.1016/j.ando.2015.04.005. PMID: 26122495
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732

Diagnosis

Brownlee BP, Mann D, Glenn C, McKinney KA
Otolaryngol Clin North Am 2022 Apr;55(2):343-350. doi: 10.1016/j.otc.2021.12.015. PMID: 35365312
Raverot G, Assié G, Cotton F, Cogne M, Boulin A, Dherbomez M, Bonneville JF, Massart C
Ann Endocrinol (Paris) 2015 Jul;76(3):201-9. Epub 2015 Jun 26 doi: 10.1016/j.ando.2015.04.005. PMID: 26122495
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Castinetti F, Dufour H, Gaillard S, Jouanneau E, Vasiljevic A, Villa C, Trouillas J
Ann Endocrinol (Paris) 2015 Jul;76(3):220-7. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.007. PMID: 26070464
Mayson SE, Snyder PJ
Endocrinol Metab Clin North Am 2015 Mar;44(1):79-87. Epub 2014 Nov 6 doi: 10.1016/j.ecl.2014.11.001. PMID: 25732644

Therapy

Cortet-Rudelli C, Bonneville JF, Borson-Chazot F, Clavier L, Coche Dequéant B, Desailloud R, Maiter D, Rohmer V, Sadoul JL, Sonnet E, Toussaint P, Chanson P
Ann Endocrinol (Paris) 2015 Jul;76(3):228-38. Epub 2015 Jun 23 doi: 10.1016/j.ando.2015.04.003. PMID: 26116412
Błaut K, Wiśniewski P, Syrenicz A, Sworczak K
Neuro Endocrinol Lett 2006 Oct;27(5):569-72. PMID: 17159826
Hedner P, Valdemarsson S
Neurosurgery 1989 Dec;25(6):948-50. doi: 10.1097/00006123-198912000-00015. PMID: 2532309

Prognosis

Gupta S, Hoffman SE, Mehta NH, Hauser B, Altshuler M, Bernstock JD, Smith TR, Arnaout O, Laws ER
Pituitary 2024 Apr;27(2):204-212. Epub 2024 Feb 12 doi: 10.1007/s11102-024-01382-3. PMID: 38345720Free PMC Article
Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, Blevins LS, Aghi MK
Neurosurg Focus 2020 Jun;48(6):E13. doi: 10.3171/2020.3.FOCUS20114. PMID: 32480370
Giordano M, Samii A, Fahlbusch R
Neurosurg Rev 2018 Oct;41(4):999-1005. Epub 2017 Dec 30 doi: 10.1007/s10143-017-0940-y. PMID: 29290044
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732
Katchy KC, Mallik AA, Al-Nashmi NM, Joseph E, Alexander S, Al-Ramadan A
J Neurooncol 2011 Aug;104(1):271-7. Epub 2010 Dec 7 doi: 10.1007/s11060-010-0482-4. PMID: 21136281

Clinical prediction guides

Santiago-Andres Y, Aquiles A, Taniguchi-Ponciano K, Salame L, Guinto G, Mercado M, Fiordelisio T
Int J Mol Sci 2024 Apr 3;25(7) doi: 10.3390/ijms25073968. PMID: 38612778Free PMC Article
Gupta S, Hoffman SE, Mehta NH, Hauser B, Altshuler M, Bernstock JD, Smith TR, Arnaout O, Laws ER
Pituitary 2024 Apr;27(2):204-212. Epub 2024 Feb 12 doi: 10.1007/s11102-024-01382-3. PMID: 38345720Free PMC Article
Akkus G, Karagun B, Çetinalp NE, Açıkalın A, Evran M, Sengöz S, Sert M, Zorludemir S, Tetiker T
Curr Med Imaging 2021;17(2):310-317. doi: 10.2174/1573405616666201223125642. PMID: 33357196
Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, Blevins LS, Aghi MK
Neurosurg Focus 2020 Jun;48(6):E13. doi: 10.3171/2020.3.FOCUS20114. PMID: 32480370
Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732

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