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Increased risk of endometrial cancer

MedGen UID:
908804
•Concept ID:
C4229680
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of endometrial cancer

Professional guidelines

PubMed

Highly Sensitive Microsatellite Instability and Immunohistochemistry Assessment in Endometrial Aspirates as a Tool for Cancer Risk Individualization in Lynch Syndrome.
Canet-Hermida J, Marín F, Dorca E, Dueñas N, Costas L, Salinas M, Velasco À, Peremiquel-Trillas P, Paytubi S, Ponce J, Fernández S, Martínez JM, Cárdenas L, Taltavull A, Alemany L, Meléndez C, Oliveras G, Vidal A, Capellá G, López-Bonet E, Brunet J, Matias-Guiu X, Pineda M
Mod Pathol 2023 Jul;36(7):100158. Epub 2023 Mar 12 doi: 10.1016/j.modpat.2023.100158. PMID: 36918055
Evaluation and management of abnormal uterine bleeding in premenopausal women.
Sweet MG, Schmidt-Dalton TA, Weiss PM, Madsen KP
Am Fam Physician 2012 Jan 1;85(1):35-43. PMID: 22230306
Treatment of Postmenopausal Breast Cancer with Selective Estrogen Receptor Modulators (SERMs).
Lewis-Wambi JS, Jordan VC
Breast Dis 2005-2006;24:93-105. doi: 10.3233/bd-2006-24108. PMID: 16917142

Recent clinical studies

Etiology

Clinical actionability of molecular targets in endometrial cancer.
Urick ME, Bell DW
Nat Rev Cancer 2019 Sep;19(9):510-521. Epub 2019 Aug 6 doi: 10.1038/s41568-019-0177-x. PMID: 31388127Free PMC Article
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.
Talhouk A, McConechy MK, Leung S, Yang W, Lum A, Senz J, Boyd N, Pike J, Anglesio M, Kwon JS, Karnezis AN, Huntsman DG, Gilks CB, McAlpine JN
Cancer 2017 Mar 1;123(5):802-813. Epub 2017 Jan 6 doi: 10.1002/cncr.30496. PMID: 28061006
Diagnosis and Management of Endometrial Cancer.
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Diagnosis

Endometrial Hyperplasia.
Ring KL, Mills AM, Modesitt SC
Obstet Gynecol 2022 Dec 1;140(6):1061-1075. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004989. PMID: 36357974
Endometrial polyps. An evidence-based diagnosis and management guide.
Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339
Clinical actionability of molecular targets in endometrial cancer.
Urick ME, Bell DW
Nat Rev Cancer 2019 Sep;19(9):510-521. Epub 2019 Aug 6 doi: 10.1038/s41568-019-0177-x. PMID: 31388127Free PMC Article
Diagnosis and Management of Endometrial Cancer.
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Therapy

Conservative Management of Atypical Endometrial Hyperplasia and Early Endometrial Cancer in Childbearing Age Women.
Uccella S, Zorzato PC, Dababou S, Bosco M, Torella M, Braga A, Frigerio M, Gardella B, Cianci S, Laganà AS, Franchi MP, Garzon S
Medicina (Kaunas) 2022 Sep 11;58(9) doi: 10.3390/medicina58091256. PMID: 36143933Free PMC Article
Adjuvant therapy for endometrial cancer in the era of molecular classification: radiotherapy, chemoradiation and novel targets for therapy.
van den Heerik ASVM, Horeweg N, de Boer SM, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2021 Apr;31(4):594-604. Epub 2020 Oct 20 doi: 10.1136/ijgc-2020-001822. PMID: 33082238Free PMC Article
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial.
de Boer SM, Powell ME, Mileshkin L, Katsaros D, Bessette P, Haie-Meder C, Ottevanger PB, Ledermann JA, Khaw P, Colombo A, Fyles A, Baron MH, Jürgenliemk-Schulz IM, Kitchener HC, Nijman HW, Wilson G, Brooks S, Carinelli S, Provencher D, Hanzen C, Lutgens LCHW, Smit VTHBM, Singh N, Do V, D'Amico R, Nout RA, Feeney A, Verhoeven-Adema KW, Putter H, Creutzberg CL; PORTEC study group
Lancet Oncol 2018 Mar;19(3):295-309. Epub 2018 Feb 12 doi: 10.1016/S1470-2045(18)30079-2. PMID: 29449189Free PMC Article
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Prognosis

Adjuvant therapy for endometrial cancer in the era of molecular classification: radiotherapy, chemoradiation and novel targets for therapy.
van den Heerik ASVM, Horeweg N, de Boer SM, Bosse T, Creutzberg CL
Int J Gynecol Cancer 2021 Apr;31(4):594-604. Epub 2020 Oct 20 doi: 10.1136/ijgc-2020-001822. PMID: 33082238Free PMC Article
Clinical actionability of molecular targets in endometrial cancer.
Urick ME, Bell DW
Nat Rev Cancer 2019 Sep;19(9):510-521. Epub 2019 Aug 6 doi: 10.1038/s41568-019-0177-x. PMID: 31388127Free PMC Article
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
Diagnosis and Management of Endometrial Cancer.
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831
Endometrial cancer.
Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E
Lancet 2016 Mar 12;387(10023):1094-1108. Epub 2015 Sep 6 doi: 10.1016/S0140-6736(15)00130-0. PMID: 26354523

Clinical prediction guides

Diet, menopause and the risk of ovarian, endometrial and breast cancer.
Dunneram Y, Greenwood DC, Cade JE
Proc Nutr Soc 2019 Aug;78(3):438-448. Epub 2019 Feb 1 doi: 10.1017/S0029665118002884. PMID: 30706844
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis.
Clarke MA, Long BJ, Del Mar Morillo A, Arbyn M, Bakkum-Gamez JN, Wentzensen N
JAMA Intern Med 2018 Sep 1;178(9):1210-1222. doi: 10.1001/jamainternmed.2018.2820. PMID: 30083701Free PMC Article
Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer.
Talhouk A, McConechy MK, Leung S, Yang W, Lum A, Senz J, Boyd N, Pike J, Anglesio M, Kwon JS, Karnezis AN, Huntsman DG, Gilks CB, McAlpine JN
Cancer 2017 Mar 1;123(5):802-813. Epub 2017 Jan 6 doi: 10.1002/cncr.30496. PMID: 28061006
Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis.
Barry JA, Azizia MM, Hardiman PJ
Hum Reprod Update 2014 Sep-Oct;20(5):748-58. Epub 2014 Mar 30 doi: 10.1093/humupd/dmu012. PMID: 24688118Free PMC Article

Recent systematic reviews

Sedentary behavior and cancer-an umbrella review and meta-analysis.
Hermelink R, Leitzmann MF, Markozannes G, Tsilidis K, Pukrop T, Berger F, Baurecht H, Jochem C
Eur J Epidemiol 2022 May;37(5):447-460. Epub 2022 May 25 doi: 10.1007/s10654-022-00873-6. PMID: 35612669Free PMC Article
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Risk factors for endometrial cancer: An umbrella review of the literature.
Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, Gabra H, Paraskevaidis E, Martin-Hirsch P, Tsilidis KK, Kyrgiou M
Int J Cancer 2019 Oct 1;145(7):1719-1730. Epub 2019 Feb 20 doi: 10.1002/ijc.31961. PMID: 30387875
Metabolic syndrome and risk of cancer: a systematic review and meta-analysis.
Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D
Diabetes Care 2012 Nov;35(11):2402-11. doi: 10.2337/dc12-0336. PMID: 23093685Free PMC Article
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies.
Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M
Lancet 2008 Feb 16;371(9612):569-78. doi: 10.1016/S0140-6736(08)60269-X. PMID: 18280327

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