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Eyelid Squamous Papilloma

MedGen UID:
90936
•Concept ID:
C0339108
•
Neoplastic Process
Synonyms: Epidermoid Papilloma of Eyelid; Epidermoid Papilloma of the Eyelid; Eyelid Epidermoid Papilloma; Eyelid Squamous Cell Papilloma; Squamous cell papilloma of eyelid; Squamous Cell Papilloma of Eyelid; Squamous Cell Papilloma of the Eyelid
SNOMED CT: Squamous cell papilloma of eyelid (231825000)

Definition

A papilloma that arises from the eyelid. It is composed of squamous cells and is characterized by the presence of an acanthotic epithelium with hyperkeratosis and papillary projections with an inner fibrovascular core. It is the most common benign epithelial tumor of eyelid. It usually affects middle-aged or older adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEyelid Squamous Papilloma

Professional guidelines

PubMed

Treatment of benign eyelid lesions with Nd:YVO laser: a prospective study.
Sousa-Neves F, Cardoso da Costa J, Braga J, Prazeres S
J Cosmet Laser Ther 2020 Apr 2;22(3):146-149. Epub 2020 Jun 4 doi: 10.1080/14764172.2020.1767787. PMID: 32496946
Multidisciplinary management of lacrimal sac/nasolacrimal duct carcinomas.
El-Sawy T, Frank SJ, Hanna E, Sniegowski M, Lai SY, Nasser QJ, Myers J, Esmaeli B
Ophthalmic Plast Reconstr Surg 2013 Nov-Dec;29(6):454-7. doi: 10.1097/IOP.0b013e31829f3a73. PMID: 24195987Free PMC Article
Peripunctal melanocytic nevi. Distinctive clinical findings and differential diagnosis.
Scott KR, Jakobiec FA, Font RL
Ophthalmology 1989 Jul;96(7):994-8. PMID: 2771365

Recent clinical studies

Etiology

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Clinical and pathological diagnosis and comparison of benign and malignant eyelid tumors.
Sendul SY, Akpolat C, Yilmaz Z, Eryilmaz OT, Guven D, Kabukcuoglu F
J Fr Ophtalmol 2021 Apr;44(4):537-543. Epub 2021 Feb 18 doi: 10.1016/j.jfo.2020.07.019. PMID: 33610396
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article
The role of infectious agents in the etiology of ocular adnexal neoplasia.
Verma V, Shen D, Sieving PC, Chan CC
Surv Ophthalmol 2008 Jul-Aug;53(4):312-31. doi: 10.1016/j.survophthal.2008.04.008. PMID: 18572051Free PMC Article

Diagnosis

Peripunctal Mass Lesions: Clinicopathological Analysis and Surgical Outcomes-A Multicentric Series.
Nair AG, Mukherjee B, Kamal S, Singh S, Alam MS, Nisar SP, Koka K, Gopinathan I
Ophthalmic Plast Reconstr Surg 2022 Mar-Apr 01;38(2):154-159. doi: 10.1097/IOP.0000000000002012. PMID: 34284425
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Clinical and pathological diagnosis and comparison of benign and malignant eyelid tumors.
Sendul SY, Akpolat C, Yilmaz Z, Eryilmaz OT, Guven D, Kabukcuoglu F
J Fr Ophtalmol 2021 Apr;44(4):537-543. Epub 2021 Feb 18 doi: 10.1016/j.jfo.2020.07.019. PMID: 33610396
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature.
Deprez M, Uffer S
Am J Dermatopathol 2009 May;31(3):256-62. doi: 10.1097/DAD.0b013e3181961861. PMID: 19384066

Therapy

Resolution of a Presumed Conjunctival Papilloma After Therapeutic Treatment With the Human Papillomavirus Vaccine.
Sripawadkul W, AlBayyat G, Galor A, Wylegala A, Nichols AJ, Ioannides T, Karp CL
JAMA Ophthalmol 2022 Apr 1;140(4):434-435. doi: 10.1001/jamaophthalmol.2021.6334. PMID: 35175310
Anterior segment and external ocular disorders associated with HIV infections in the era of HAART in Chiang Mai University Hospital, a prospective descriptive cross sectional study.
Singalavanija T, Ausayakhun S, Tangmonkongvoragul C
PLoS One 2018;13(2):e0193161. Epub 2018 Feb 21 doi: 10.1371/journal.pone.0193161. PMID: 29466424Free PMC Article
Interferon alfa-2b in the management of recurrent conjunctival papillomatosis.
Singh M, Gautam N, Gupta A, Kaur M
Indian J Ophthalmol 2016 Oct;64(10):778-780. doi: 10.4103/0301-4738.195013. PMID: 27905345Free PMC Article
Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article
Argon laser therapy of benign tumors of the eyelid.
Wohlrab TM, Rohrbach JM, Erb C, Schlote T, Knorr M, Thiel HJ
Am J Ophthalmol 1998 May;125(5):693-7. doi: 10.1016/s0002-9394(98)00004-x. PMID: 9625554

Prognosis

Clinical features and factors affecting prognosis and partial deterioration of ocular papilloma: a retrospective study of 298 cases.
Jian H, He W
Graefes Arch Clin Exp Ophthalmol 2023 Aug;261(8):2395-2402. Epub 2023 Mar 18 doi: 10.1007/s00417-023-06035-y. PMID: 36933010
Modified argon laser therapy for benign tumor of the eyelid.
Han J, Lee SH, Choi CY, Khoramnia R, Kim J, Shin HJ
BMC Ophthalmol 2022 Sep 24;22(1):383. doi: 10.1186/s12886-022-02601-w. PMID: 36153503Free PMC Article
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article
Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature.
Deprez M, Uffer S
Am J Dermatopathol 2009 May;31(3):256-62. doi: 10.1097/DAD.0b013e3181961861. PMID: 19384066

Clinical prediction guides

Modified argon laser therapy for benign tumor of the eyelid.
Han J, Lee SH, Choi CY, Khoramnia R, Kim J, Shin HJ
BMC Ophthalmol 2022 Sep 24;22(1):383. doi: 10.1186/s12886-022-02601-w. PMID: 36153503Free PMC Article
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Papillary hidradenoma of the eyelid margin: clinical and immunohistochemical observations further supporting an apocrine rather than an eccrine origin.
Jakobiec FA, Rai R, Lefebvre DR
Surv Ophthalmol 2014 Sep-Oct;59(5):540-7. Epub 2014 Jan 28 doi: 10.1016/j.survophthal.2014.01.002. PMID: 24661803
Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature.
Deprez M, Uffer S
Am J Dermatopathol 2009 May;31(3):256-62. doi: 10.1097/DAD.0b013e3181961861. PMID: 19384066

Recent systematic reviews

Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article

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