U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gonococcal conjunctivitis neonatorum

MedGen UID:
90938
•Concept ID:
C0339166
•
Disease or Syndrome
Synonym: Ophthalmia Neonatorum
SNOMED CT: Opthalmia neonatorum caused by Neisseria (28438004); Gonococcal conjunctivitis neonatorum (28438004); Gonococcal ophthalmia neonatorum (28438004); Neonatal gonococcal conjunctivitis (28438004)

Definition

Inflammation of the conjunctiva in a newborn due to Neisseria gonorrhoeae which was acquired during labor and delivery. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGonococcal conjunctivitis neonatorum
Follow this link to review classifications for Gonococcal conjunctivitis neonatorum in Orphanet.

Professional guidelines

PubMed

Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Ophthalmia neonatorum treatment and prophylaxis: IPOSC global study.
Zloto O, Gharaibeh A, Mezer E, Stankovic B, Isenberg S, Wygnanski-Jaffe T
Graefes Arch Clin Exp Ophthalmol 2016 Mar;254(3):577-82. Epub 2016 Jan 26 doi: 10.1007/s00417-016-3274-5. PMID: 26810921
Neonatal chlamydial infections: prevention and treatment.
Zar HJ
Paediatr Drugs 2005;7(2):103-10. doi: 10.2165/00148581-200507020-00003. PMID: 15871630

Recent clinical studies

Etiology

Sexually transmitted infections and HIV in ophthalmology.
Bibb LA, Htet KZ, Waldman CW, Sloan SB
Clin Dermatol 2024 Jan-Feb;42(1):25-37. Epub 2023 Aug 13 doi: 10.1016/j.clindermatol.2023.08.011. PMID: 37582453
Antibiotics for treating gonorrhoea in pregnancy.
Comunián-Carrasco G, Peña-Martí GE, Martí-Carvajal AJ
Cochrane Database Syst Rev 2018 Feb 21;2(2):CD011167. doi: 10.1002/14651858.CD011167.pub2. PMID: 29465747Free PMC Article
Ophthalmia neonatorum: what kind of prophylaxis?
Zuppa AA, D'Andrea V, Catenazzi P, Scorrano A, Romagnoli C
J Matern Fetal Neonatal Med 2011 Jun;24(6):769-73. doi: 10.3109/14767058.2010.531326. PMID: 21534852
Ophthalmia neonatorum.
Gul SS, Jamal M, Khan N
J Coll Physicians Surg Pak 2010 Sep;20(9):595-8. PMID: 20810051
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Diagnosis

Ophthalmia Neonatorum.
Tan AK
N Engl J Med 2019 Jan 10;380(2):e2. doi: 10.1056/NEJMicm1808613. PMID: 30625059
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Conjunctivitis of the newborn.
de Toledo AR, Chandler JW
Infect Dis Clin North Am 1992 Dec;6(4):807-13. PMID: 1460264
Silver nitrate prophylaxis.
Schneider G
Can Med Assoc J 1984 Aug 1;131(3):193-6. PMID: 6378348Free PMC Article
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Therapy

The use of povidone-iodine in ophthalmology.
Grzybowski A, Kanclerz P, Myers WG
Curr Opin Ophthalmol 2018 Jan;29(1):19-32. doi: 10.1097/ICU.0000000000000437. PMID: 28984794
Conjunctivitis of the newborn.
de Toledo AR, Chandler JW
Infect Dis Clin North Am 1992 Dec;6(4):807-13. PMID: 1460264
Silver nitrate prophylaxis.
Schneider G
Can Med Assoc J 1984 Aug 1;131(3):193-6. PMID: 6378348Free PMC Article
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578
Ophthalmia neonatorum.
Friendly DS
Pediatr Clin North Am 1983 Dec;30(6):1033-42. doi: 10.1016/s0031-3955(16)34500-x. PMID: 6359042

Prognosis

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital.
Quirke M, Cullinane A
Int J Infect Dis 2008 Jul;12(4):371-3. Epub 2008 Feb 21 doi: 10.1016/j.ijid.2007.09.013. PMID: 18093859
Ophthalmia neonatorum.
O'Hara MA
Pediatr Clin North Am 1993 Aug;40(4):715-25. PMID: 8345961
Chlamydial infections in infancy.
Gilbert GL
Aust Paediatr J 1986 Feb;22(1):13-7. doi: 10.1111/j.1440-1754.1986.tb00176.x. PMID: 3521572

Clinical prediction guides

Ophthalmia Neonatorum, Helen Keller, and the Social Dimensions of Eye Disease.
Harman LE, Margo CE
Cornea 2023 Dec 1;42(12):1601-1604. Epub 2023 Jul 6 doi: 10.1097/ICO.0000000000003332. PMID: 37410593
Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Prevalence of gonococcal conjunctivitis in adults and neonates.
McAnena L, Knowles SJ, Curry A, Cassidy L
Eye (Lond) 2015 Jul;29(7):875-80. Epub 2015 Apr 24 doi: 10.1038/eye.2015.57. PMID: 25907207Free PMC Article
Ophthalmia neonatorum.
Gul SS, Jamal M, Khan N
J Coll Physicians Surg Pak 2010 Sep;20(9):595-8. PMID: 20810051
A five-year study in Iran of ophthalmia neonatorum: prevalence and etiology.
Amini E, Ghasemi M, Daneshjou K
Med Sci Monit 2008 Feb;14(2):CR90-96. PMID: 18227767

Recent systematic reviews

Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae: systematic review and meta-analysis.
Vallely LM, Egli-Gany D, Wand H, Pomat WS, Homer CSE, Guy R, Silver B, Rumbold AR, Kaldor JM, Vallely AJ, Low N
Sex Transm Infect 2021 Mar;97(2):104-111. Epub 2021 Jan 12 doi: 10.1136/sextrans-2020-054653. PMID: 33436505Free PMC Article
Interventions for preventing ophthalmia neonatorum.
Kapoor VS, Evans JR, Vedula SS
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD001862. doi: 10.1002/14651858.CD001862.pub4. PMID: 32959365Free PMC Article
Antibiotics for treating gonorrhoea in pregnancy.
Comunián-Carrasco G, Peña-Martí GE, Martí-Carvajal AJ
Cochrane Database Syst Rev 2018 Feb 21;2(2):CD011167. doi: 10.1002/14651858.CD011167.pub2. PMID: 29465747Free PMC Article
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum.
Darling EK, McDonald H
J Midwifery Womens Health 2010 Jul-Aug;55(4):319-27. doi: 10.1016/j.jmwh.2009.09.003. PMID: 20630358
Antibiotics for gonorrhoea in pregnancy.
Brocklehurst P
Cochrane Database Syst Rev 2002;(2):CD000098. doi: 10.1002/14651858.CD000098. PMID: 12076381

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...