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Gonococcal conjunctivitis neonatorum

MedGen UID:
90938
•Concept ID:
C0339166
•
Disease or Syndrome
Synonym: Ophthalmia Neonatorum
SNOMED CT: Opthalmia neonatorum caused by Neisseria (28438004); Gonococcal conjunctivitis neonatorum (28438004); Gonococcal ophthalmia neonatorum (28438004); Neonatal gonococcal conjunctivitis (28438004)

Definition

Inflammation of the conjunctiva in a newborn due to Neisseria gonorrhoeae which was acquired during labor and delivery. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGonococcal conjunctivitis neonatorum
Follow this link to review classifications for Gonococcal conjunctivitis neonatorum in Orphanet.

Professional guidelines

PubMed

Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Treatment and prevention of ophthalmia neonatorum.
Matejcek A, Goldman RD
Can Fam Physician 2013 Nov;59(11):1187-90. PMID: 24235191Free PMC Article
Chlamydial ophthalmia neonatorum. The dilemma of diagnosis and treatment.
Harrison HR
Am J Dis Child 1985 Jun;139(6):550-1. doi: 10.1001/archpedi.1985.02140080020022. PMID: 4003356

Recent clinical studies

Etiology

Antibiotics for treating gonorrhoea in pregnancy.
Comunián-Carrasco G, Peña-Martí GE, Martí-Carvajal AJ
Cochrane Database Syst Rev 2018 Feb 21;2(2):CD011167. doi: 10.1002/14651858.CD011167.pub2. PMID: 29465747Free PMC Article
Ophthalmia neonatorum: what kind of prophylaxis?
Zuppa AA, D'Andrea V, Catenazzi P, Scorrano A, Romagnoli C
J Matern Fetal Neonatal Med 2011 Jun;24(6):769-73. doi: 10.3109/14767058.2010.531326. PMID: 21534852
Gonococcal infections in newborns and in adolescents.
MacDonald N, Mailman T, Desai S
Adv Exp Med Biol 2008;609:108-30. doi: 10.1007/978-0-387-73960-1_9. PMID: 18193661
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578
Prophylaxis of neonatal conjunctivitis. An analytic review.
Bernstein GA, Davis JP, Katcher ML
Clin Pediatr (Phila) 1982 Sep;21(9):545-50. doi: 10.1177/000992288202100906. PMID: 7049501

Diagnosis

Ophthalmia Neonatorum.
Tan AK
N Engl J Med 2019 Jan 10;380(2):e2. doi: 10.1056/NEJMicm1808613. PMID: 30625059
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
Conjunctivitis of the newborn.
de Toledo AR, Chandler JW
Infect Dis Clin North Am 1992 Dec;6(4):807-13. PMID: 1460264
Silver nitrate prophylaxis.
Schneider G
Can Med Assoc J 1984 Aug 1;131(3):193-6. PMID: 6378348Free PMC Article
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578

Therapy

Gonococcal infection: An unresolved problem.
Barberá MJ, Serra-Pladevall J
Enferm Infecc Microbiol Clin (Engl Ed) 2019 Aug-Sep;37(7):458-466. Epub 2019 Feb 4 doi: 10.1016/j.eimc.2018.12.008. PMID: 30732970
Conjunctivitis of the newborn.
de Toledo AR, Chandler JW
Infect Dis Clin North Am 1992 Dec;6(4):807-13. PMID: 1460264
Silver nitrate prophylaxis.
Schneider G
Can Med Assoc J 1984 Aug 1;131(3):193-6. PMID: 6378348Free PMC Article
Gonorrhea.
Spence MR
Clin Obstet Gynecol 1983 Mar;26(1):111-24. doi: 10.1097/00003081-198303000-00016. PMID: 6404578
Ophthalmia neonatorum.
Friendly DS
Pediatr Clin North Am 1983 Dec;30(6):1033-42. doi: 10.1016/s0031-3955(16)34500-x. PMID: 6359042

Prognosis

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Management of Extraocular Infections.
Muthiah S, Radhakrishnan N
Indian J Pediatr 2017 Dec;84(12):945-952. Epub 2017 Jul 14 doi: 10.1007/s12098-017-2409-y. PMID: 28707045
What have we learned from sexually transmitted infection research in sub-Saharan Africa?
Mabey D, Ndowa F, Latif A
Sex Transm Infect 2010 Dec;86(7):488-92. doi: 10.1136/sti.2009.041632. PMID: 21113067
Chlamydial infections.
Blanchard TJ, Mabey DC
Br J Clin Pract 1994 Jul-Aug;48(4):201-5. PMID: 7917800
Ophthalmia neonatorum.
O'Hara MA
Pediatr Clin North Am 1993 Aug;40(4):715-25. PMID: 8345961

Clinical prediction guides

Case series and literature review of chlamydial ophthalmia neonatorum in Botswana.
Yang K, Babalola CM, Mussa A, Ryan R, Wynn A, Simon S, Bame B, Morroni C, Klausner JD
Int J STD AIDS 2023 Oct;34(12):860-868. Epub 2023 Jun 20 doi: 10.1177/09564624231173028. PMID: 37338101
Ophthalmia neonatorum as the presenting sign of SARS-CoV-2.
Mechel E, Trinh M, Kodsi S, Hymowitz M, Kainth MK, Lee AM
J AAPOS 2021 Aug;25(4):230-231. Epub 2021 Mar 24 doi: 10.1016/j.jaapos.2021.03.001. PMID: 33774164Free PMC Article
Prevalence of gonococcal conjunctivitis in adults and neonates.
McAnena L, Knowles SJ, Curry A, Cassidy L
Eye (Lond) 2015 Jul;29(7):875-80. Epub 2015 Apr 24 doi: 10.1038/eye.2015.57. PMID: 25907207Free PMC Article
A five-year study in Iran of ophthalmia neonatorum: prevalence and etiology.
Amini E, Ghasemi M, Daneshjou K
Med Sci Monit 2008 Feb;14(2):CR90-96. PMID: 18227767
Diagnosis of ophthalmia neonatorum.
Winceslaus J, Goh BT, Dunlop EM, Mantell J, Woodland RM, Forsey T, Treharne JD
Br Med J (Clin Res Ed) 1987 Nov 28;295(6610):1377-9. doi: 10.1136/bmj.295.6610.1377. PMID: 3121021Free PMC Article

Recent systematic reviews

Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae: systematic review and meta-analysis.
Vallely LM, Egli-Gany D, Wand H, Pomat WS, Homer CSE, Guy R, Silver B, Rumbold AR, Kaldor JM, Vallely AJ, Low N
Sex Transm Infect 2021 Mar;97(2):104-111. Epub 2021 Jan 12 doi: 10.1136/sextrans-2020-054653. PMID: 33436505Free PMC Article
Interventions for preventing ophthalmia neonatorum.
Kapoor VS, Evans JR, Vedula SS
Cochrane Database Syst Rev 2020 Sep 21;9(9):CD001862. doi: 10.1002/14651858.CD001862.pub4. PMID: 32959365Free PMC Article
Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Guirguis-Blake JM, Evans CV, Rushkin M
JAMA 2019 Jan 29;321(4):404-406. doi: 10.1001/jama.2018.17847. PMID: 30694309Free PMC Article
A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmia neonatorum.
Darling EK, McDonald H
J Midwifery Womens Health 2010 Jul-Aug;55(4):319-27. doi: 10.1016/j.jmwh.2009.09.003. PMID: 20630358
Antibiotics for gonorrhoea in pregnancy.
Brocklehurst P
Cochrane Database Syst Rev 2002;(2):CD000098. doi: 10.1002/14651858.CD000098. PMID: 12076381

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