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Cornea neoplasm

MedGen UID:
90940
•Concept ID:
C0339304
•
Neoplastic Process
Synonyms: Cornea Neoplasm; cornea neoplasm; cornea neoplasm (disease); Cornea Tumor; cornea tumor; cornea tumour; Corneal Neoplasm; corneal neoplasm; Corneal Tumor; corneal tumor; corneal tumour; Neoplasm of cornea; Neoplasm of Cornea; neoplasm of cornea; Neoplasm of the Cornea; neoplasm of the cornea; Tumor of cornea; Tumor of Cornea; tumor of cornea; Tumor of the Cornea; tumor of the cornea; tumour of cornea; tumour of the cornea
SNOMED CT: Neoplasm of cornea (126997008); Tumor of cornea (126997008)
 
Monarch Initiative: MONDO:0021238

Definition

A benign or malignant neoplasm that affects the cornea. [from NCI]

Professional guidelines

PubMed

Consensus Recommendations for the Diagnosis of Vitreoretinal Lymphoma.
Carbonell D, Mahajan S, Chee SP, Sobolewska B, Agrawal R, Bülow T, Gupta V, Jones NP, Accorinti M, Agarwal M, Batchelor T, Biswas J, Cimino L, tenDam-van Loon NH, de-la-Torre A, Frenkel S, Pe'er J, Kramer M, Miserocchi E, Mochizuki M, Ness T, Rosenbaum JT, Sen HN, Simion M (VRL patient), Sitter H, Vasconcelos-Santos DV, Habot-Wilner Z, Coupland SE, Pulido JS, Smith J, Thorne JE, Zierhut M; Study Group for Vitreoretinal Lymphoma Diagnostics
Ocul Immunol Inflamm 2021 Apr 3;29(3):507-520. Epub 2021 May 19 doi: 10.1080/09273948.2021.1878233. PMID: 34009095
Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Clinical diagnosis and treatment recommendations for ocular toxicities of targeted therapy and immune checkpoint inhibitor therapy.
Liu X, Wang Z, Zhao C, Wang H, Guo X, Zhou J, Duan L, Si X, Zhang L, Li Y, Wang M, Zhang M, Zhang L
Thorac Cancer 2020 Mar;11(3):810-818. Epub 2020 Feb 4 doi: 10.1111/1759-7714.13327. PMID: 32017399Free PMC Article

Recent clinical studies

Etiology

Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study.
Wainberg ZA, Enzinger PC, Kang YK, Qin S, Yamaguchi K, Kim IH, Saeed A, Oh SC, Li J, Turk HM, Teixeira A, Borg C, Hitre E, Udrea AA, Cardellino GG, Sanchez RG, Collins H, Mitra S, Yang Y, Catenacci DVT, Lee KW
Lancet Oncol 2022 Nov;23(11):1430-1440. Epub 2022 Oct 14 doi: 10.1016/S1470-2045(22)00603-9. PMID: 36244398
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Tumors of the ocular surface: A review.
Honavar SG, Manjandavida FP
Indian J Ophthalmol 2015 Mar;63(3):187-203. doi: 10.4103/0301-4738.156912. PMID: 25971163Free PMC Article
Ocular choristomas.
Mansour AM, Barber JC, Reinecke RD, Wang FM
Surv Ophthalmol 1989 Mar-Apr;33(5):339-58. doi: 10.1016/0039-6257(89)90011-8. PMID: 2655139

Diagnosis

Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Panorama of limbal changes.
Gueudry J, Majo F, Delcampe A, Muraine M
J Fr Ophtalmol 2019 Mar;42(3):e83-e94. Epub 2019 Mar 2 doi: 10.1016/j.jfo.2019.02.001. PMID: 30833005
Congenital uveal melanoma?
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063
Tumors of the ocular surface: A review.
Honavar SG, Manjandavida FP
Indian J Ophthalmol 2015 Mar;63(3):187-203. doi: 10.4103/0301-4738.156912. PMID: 25971163Free PMC Article

Therapy

Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study.
Wainberg ZA, Enzinger PC, Kang YK, Qin S, Yamaguchi K, Kim IH, Saeed A, Oh SC, Li J, Turk HM, Teixeira A, Borg C, Hitre E, Udrea AA, Cardellino GG, Sanchez RG, Collins H, Mitra S, Yang Y, Catenacci DVT, Lee KW
Lancet Oncol 2022 Nov;23(11):1430-1440. Epub 2022 Oct 14 doi: 10.1016/S1470-2045(22)00603-9. PMID: 36244398
HLA-G Neo-Expression on Tumors.
Loustau M, Anna F, Dréan R, Lecomte M, Langlade-Demoyen P, Caumartin J
Front Immunol 2020;11:1685. Epub 2020 Aug 14 doi: 10.3389/fimmu.2020.01685. PMID: 32922387Free PMC Article
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Pharmacotherapy and Immunotherapy of Conjunctival Tumors.
Midena E, Frizziero L, Parrozzani R
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):121-131. doi: 10.22608/APO.201751. PMID: 28399343
Retinoic acid and the ocular surface.
Samarawickrama C, Chew S, Watson S
Surv Ophthalmol 2015 May-Jun;60(3):183-95. Epub 2014 Oct 16 doi: 10.1016/j.survophthal.2014.10.001. PMID: 25890622

Prognosis

HLA-G Neo-Expression on Tumors.
Loustau M, Anna F, Dréan R, Lecomte M, Langlade-Demoyen P, Caumartin J
Front Immunol 2020;11:1685. Epub 2020 Aug 14 doi: 10.3389/fimmu.2020.01685. PMID: 32922387Free PMC Article
Ophthalmology in Critical Care.
Parekh PH, Boente CS, Boente RD, Meeker JW, Carlos WG
Ann Am Thorac Soc 2019 Aug;16(8):957-966. doi: 10.1513/AnnalsATS.201812-848CME. PMID: 31091984
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Mycotic Infections of the Eye.
Słowik M, Biernat MM, Urbaniak-Kujda D, Kapelko-Słowik K, Misiuk-Hojło M
Adv Clin Exp Med 2015 Nov-Dec;24(6):1113-7. doi: 10.17219/acem/50572. PMID: 26771986
Tumors of the cornea and conjunctiva.
Spraul CW, Grossniklaus HE
Curr Opin Ophthalmol 1996 Aug;7(4):28-34. doi: 10.1097/00055735-199608000-00006. PMID: 10163636

Clinical prediction guides

Actinic Granuloma of the Conjunctiva: Case Series and Review of the Literature.
Magan T, Rapuano CJ, Ayres BD, Skeens HM, Goyal V, Heersink S, Meghpara BB, Syed ZA, Eagle RC Jr, Milman T
Am J Ophthalmol 2021 Sep;229:120-126. Epub 2021 Apr 22 doi: 10.1016/j.ajo.2021.04.006. PMID: 33895150
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH; CASSINI Investigators
N Engl J Med 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630. PMID: 30786186
Mycotic Infections of the Eye.
Słowik M, Biernat MM, Urbaniak-Kujda D, Kapelko-Słowik K, Misiuk-Hojło M
Adv Clin Exp Med 2015 Nov-Dec;24(6):1113-7. doi: 10.17219/acem/50572. PMID: 26771986
Gelatinous drop-like corneal dystrophy.
Tsujikawa M
Cornea 2012 Nov;31 Suppl 1:S37-40. doi: 10.1097/ICO.0b013e31826a066a. PMID: 23038033
Corneal myxoma.
Wollensak G, Green WR, Seiler T
Jpn J Ophthalmol 2002 Mar-Apr;46(2):193-7. doi: 10.1016/s0021-5155(01)00493-2. PMID: 12062226

Recent systematic reviews

The risk of glaucoma associated with phacomatosis cesioflammea and phacomatosis cesioflammeo-marmorata.
Huang S, Yang Y, Ouyang Z, Guo X, Zhan Z, Liu X, Chen Z, Xu J, Yu M
Eur J Dermatol 2022 Sep 1;32(5):589-596. doi: 10.1684/ejd.2022.4317. PMID: 36468718
Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119
Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review.
Chinnery HR, Rajan R, Jiao H, Wu M, Zhang AC, De Silva MEH, Makrai E, Stepp MA, Di Girolamo N, Downie LE
Br J Ophthalmol 2022 Jun;106(6):765-771. Epub 2021 Feb 10 doi: 10.1136/bjophthalmol-2020-318156. PMID: 33568390Free PMC Article
Recent progress in biomedical applications of RGD-based ligand: From precise cancer theranostics to biomaterial engineering: A systematic review.
Alipour M, Baneshi M, Hosseinkhani S, Mahmoudi R, Jabari Arabzadeh A, Akrami M, Mehrzad J, Bardania H
J Biomed Mater Res A 2020 Apr;108(4):839-850. Epub 2019 Dec 30 doi: 10.1002/jbm.a.36862. PMID: 31854488
Changes in visual function and ocular morphology in women who have undergone ART treatment and children born as a result of ART treatment: a systematic review.
Toro MD, Reibaldi M, Longo A, Avitabile T, Lionetti ME, Tripodi S, Posarelli C, Palomba S
Reprod Biomed Online 2019 Apr;38(4):621-633. Epub 2018 Dec 7 doi: 10.1016/j.rbmo.2018.11.007. PMID: 30795976

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