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Transient erythroblastopenia

MedGen UID:
909652
Concept ID:
C4082199
Finding
Synonym: Transient decrease in blood erythrocyte number
 
HPO: HP:0005510

Definition

A transient reduction in the number of erythroblasts in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransient erythroblastopenia

Conditions with this feature

Transient erythroblastopenia of childhood
MedGen UID:
68670
Concept ID:
C0238478
Disease or Syndrome
Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most commonly between 6 months and 4 years of age. The course is characterized by a complete recovery, usually within 1 to 2 months after diagnosis. In most cases no therapy is necessary, although some children may need red cell transfusion (summary by Gustavsson et al., 2002).

Professional guidelines

PubMed

Glader BE
Hematol Oncol Clin North Am 1987 Sep;1(3):431-47. PMID: 3129394

Recent clinical studies

Etiology

Hellström Schmidt S, Tedgård U, Pronk CJ
Acta Paediatr 2016 Sep;105(9):1088-93. Epub 2016 Apr 29 doi: 10.1111/apa.13428. PMID: 27060698
van den Akker M, Dror Y, Odame I
Acta Paediatr 2014 Jul;103(7):e288-94. Epub 2014 Apr 29 doi: 10.1111/apa.12634. PMID: 24635829
Chan GC, Kanwar VS, Wilimas J
J Paediatr Child Health 1998 Jun;34(3):299-301. doi: 10.1046/j.1440-1754.1998.00221.x. PMID: 9633983
Heegaard ED, Hornsleth A
Acta Paediatr 1995 Feb;84(2):109-17. doi: 10.1111/j.1651-2227.1995.tb13591.x. PMID: 7756792
Cherrick I, Karayalcin G, Lanzkowsky P
Am J Pediatr Hematol Oncol 1994 Nov;16(4):320-4. PMID: 7978049

Diagnosis

Mejía Sang ME, Mendez M
Pediatr Ann 2024 Jan;53(1):e34-e36. Epub 2024 Jan 1 doi: 10.3928/19382359-20231113-02. PMID: 38194662
Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Burns RA, Woodward GA
Pediatr Emerg Care 2019 Mar;35(3):237-240. doi: 10.1097/PEC.0000000000001760. PMID: 30817707
van den Akker M, Dror Y, Odame I
Acta Paediatr 2014 Jul;103(7):e288-94. Epub 2014 Apr 29 doi: 10.1111/apa.12634. PMID: 24635829
Glader BE
Hematol Oncol Clin North Am 1987 Sep;1(3):431-47. PMID: 3129394

Therapy

Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Marwaha RK, Bansal D, Trehan A, Marwaha N, Varma N
J Trop Pediatr 2002 Apr;48(2):113-6. doi: 10.1093/tropej/48.2.113. PMID: 12022425
Gussetis ES, Peristeri J, Kitra V, Liakopoulou T, Kattamis A, Graphakos S
J Pediatr Hematol Oncol 1998 Mar-Apr;20(2):120-4. doi: 10.1097/00043426-199803000-00006. PMID: 9544161
Glader BE
Hematol Oncol Clin North Am 1987 Sep;1(3):431-47. PMID: 3129394
Wranne L
Scand J Haematol 1970;7(2):76-81. doi: 10.1111/j.1600-0609.1970.tb01872.x. PMID: 5450690

Prognosis

Sibaud V, Beylot-Barry M, Protin C, Vigarios E, Recher C, Ysebaert L
Am J Clin Dermatol 2020 Dec;21(6):799-812. doi: 10.1007/s40257-020-00535-x. PMID: 32613545
Chan GC, Kanwar VS, Wilimas J
J Paediatr Child Health 1998 Jun;34(3):299-301. doi: 10.1046/j.1440-1754.1998.00221.x. PMID: 9633983
Cherrick I, Karayalcin G, Lanzkowsky P
Am J Pediatr Hematol Oncol 1994 Nov;16(4):320-4. PMID: 7978049
Skeppner G, Wranne L
Acta Paediatr 1993 Jun-Jul;82(6-7):574-8. doi: 10.1111/j.1651-2227.1993.tb12757.x. PMID: 8338993
Glader BE
Hematol Oncol Clin North Am 1987 Sep;1(3):431-47. PMID: 3129394

Clinical prediction guides

Roelens M, Dossier C, Fenneteau O, Couque N, Da Costa L
Ann Biol Clin (Paris) 2016 Jun 1;74(3):299-305. doi: 10.1684/abc.2016.1136. PMID: 27101632
Piomelli S, Seaman C
Am J Hematol 1993 Jan;42(1):46-52. doi: 10.1002/ajh.2830420110. PMID: 8416296
Glader BE
Hematol Oncol Clin North Am 1987 Sep;1(3):431-47. PMID: 3129394
Glader BE, Backer K, Diamond LK
N Engl J Med 1983 Dec 15;309(24):1486-90. doi: 10.1056/NEJM198312153092404. PMID: 6646173
Wang WC, Mentzer WC
J Pediatr 1976 May;88(5):784-9. doi: 10.1016/s0022-3476(76)81115-8. PMID: 131849

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