U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Heliotrope rash of eyelid

MedGen UID:
909660
•Concept ID:
C4280745
•
Finding
HPO: HP:0030845

Definition

Heliotrope rash is a violaceous discoloration of the eyelids associated with periorbital edema. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeliotrope rash of eyelid

Recent clinical studies

Etiology

Ophthalmic manifestations in patients with collagen vascular disorders: a hospital-based retrospective observational study.
Sharma SK, Sharma AL, Mahajan VK
Int Ophthalmol 2021 Aug;41(8):2765-2775. Epub 2021 Apr 8 doi: 10.1007/s10792-021-01833-x. PMID: 33830371
Ovarian teratoma mimicking features of juvenile dermatomyositis in a child.
Ibarra M, Chou P, Pachman LM
Pediatrics 2011 Nov;128(5):e1293-6. Epub 2011 Oct 3 doi: 10.1542/peds.2010-2115. PMID: 21969283Free PMC Article
Paraneoplastic dermatomyositis associated with testicular cancer: a case report and literature review.
Dourmishev LA, Popov JM, Rusinova D
Acta Dermatovenerol Alp Pannonica Adriat 2010;19(1):39-43. PMID: 20372774
Juvenile dermatomyositis presenting with periorbital edema.
Taban M, Perry JD
Ophthalmic Plast Reconstr Surg 2006 Sep-Oct;22(5):393-5. doi: 10.1097/01.iop.0000230271.21976.0d. PMID: 16985429
Amyopathic dermatomyositis.
Saoud B, Allali F, Hassouni NH
Joint Bone Spine 2006 May;73(3):318-20. Epub 2005 Sep 16 doi: 10.1016/j.jbspin.2005.05.004. PMID: 16253536

Diagnosis

Allergic shiners in a patient with cough-variant asthma: a case report.
Rekabi M, Raad N, Abedini A, Darougar S, Velayati AA
J Med Case Rep 2022 May 28;16(1):208. doi: 10.1186/s13256-022-03423-6. PMID: 35624503Free PMC Article
Heliotrope-like manifestation of adult-onset Still disease with macrophage activation syndrome: A case-based review.
Ikeda T, Yokoyama K, Kawakami T
J Dermatol 2022 Jul;49(7):736-740. Epub 2022 Apr 19 doi: 10.1111/1346-8138.16373. PMID: 35438204
Anti-Mi-2 and Anti-TIF1-γ Double-Positive Juvenile Dermatomyositis Treated under Diagnosis of Chronic Eczema: A Case Report.
Yoshida S, Matsumoto H, Fujita Y, Yokose K, Temmoku J, Matsuoka N, Yashiro-Furuya M, Asano T, Sato S, Suzuki E, Yago T, Yaguchi T, Aita T, Kusano M, Yamamoto T, Watanabe H, Migita K
Tohoku J Exp Med 2022 Apr 20;256(4):303-308. Epub 2022 Mar 17 doi: 10.1620/tjem.2022.J006. PMID: 35296571
Juvenile dermatomyositis presenting with periorbital edema.
Taban M, Perry JD
Ophthalmic Plast Reconstr Surg 2006 Sep-Oct;22(5):393-5. doi: 10.1097/01.iop.0000230271.21976.0d. PMID: 16985429
Amyopathic dermatomyositis.
Saoud B, Allali F, Hassouni NH
Joint Bone Spine 2006 May;73(3):318-20. Epub 2005 Sep 16 doi: 10.1016/j.jbspin.2005.05.004. PMID: 16253536

Therapy

A case of refractory anti-MDA5-positive amyopathic dermatomyositis successfully treated with upadacitinib.
Huang X, Zhang G, Luo S
J Dermatolog Treat 2024 Dec;35(1):2391445. Epub 2024 Aug 27 doi: 10.1080/09546634.2024.2391445. PMID: 39191432
Clinical utility of anti-Ro52 antibody confirmation in anti-MDA5 antibody-positive dermatomyositis: A case report.
Kodera H, Hirano R, Akiyama M, Matsumoto Y
Mod Rheumatol Case Rep 2024 Jul 8;8(2):291-295. doi: 10.1093/mrcr/rxae027. PMID: 38753322
A Rare Case of Pembrolizumab-Induced Dermatomyositis in a Patient with Cancer of Unknown Primary Origin.
Takatsuki K, Yanagihara T, Egashira A, Ogo N, Yoshizawa S, Sunami S, Asoh T, Maeyama T
Am J Case Rep 2021 Apr 27;22:e930286. doi: 10.12659/AJCR.930286. PMID: 33903584Free PMC Article
Unusual sequelae of adult-onset dermatomyositis.
Naffaa ME, Bishara R, Braun-Moscovici Y, Balbir-Gurman A
BMJ Case Rep 2014 Aug 1;2014:bcr-2014-204521. doi: 10.1136/bcr-2014-204521. PMID: 25085949Free PMC Article
Juvenile dermatomyositis presenting with periorbital edema.
Taban M, Perry JD
Ophthalmic Plast Reconstr Surg 2006 Sep-Oct;22(5):393-5. doi: 10.1097/01.iop.0000230271.21976.0d. PMID: 16985429

Prognosis

Clinical utility of anti-Ro52 antibody confirmation in anti-MDA5 antibody-positive dermatomyositis: A case report.
Kodera H, Hirano R, Akiyama M, Matsumoto Y
Mod Rheumatol Case Rep 2024 Jul 8;8(2):291-295. doi: 10.1093/mrcr/rxae027. PMID: 38753322
Heliotrope-like manifestation of adult-onset Still disease with macrophage activation syndrome: A case-based review.
Ikeda T, Yokoyama K, Kawakami T
J Dermatol 2022 Jul;49(7):736-740. Epub 2022 Apr 19 doi: 10.1111/1346-8138.16373. PMID: 35438204
A Rare Case of Pembrolizumab-Induced Dermatomyositis in a Patient with Cancer of Unknown Primary Origin.
Takatsuki K, Yanagihara T, Egashira A, Ogo N, Yoshizawa S, Sunami S, Asoh T, Maeyama T
Am J Case Rep 2021 Apr 27;22:e930286. doi: 10.12659/AJCR.930286. PMID: 33903584Free PMC Article
Juvenile dermatomyositis presenting with periorbital edema.
Taban M, Perry JD
Ophthalmic Plast Reconstr Surg 2006 Sep-Oct;22(5):393-5. doi: 10.1097/01.iop.0000230271.21976.0d. PMID: 16985429
Amyopathic dermatomyositis.
Saoud B, Allali F, Hassouni NH
Joint Bone Spine 2006 May;73(3):318-20. Epub 2005 Sep 16 doi: 10.1016/j.jbspin.2005.05.004. PMID: 16253536

Clinical prediction guides

Heliotrope-like manifestation of adult-onset Still disease with macrophage activation syndrome: A case-based review.
Ikeda T, Yokoyama K, Kawakami T
J Dermatol 2022 Jul;49(7):736-740. Epub 2022 Apr 19 doi: 10.1111/1346-8138.16373. PMID: 35438204
Anti-Mi-2 and Anti-TIF1-γ Double-Positive Juvenile Dermatomyositis Treated under Diagnosis of Chronic Eczema: A Case Report.
Yoshida S, Matsumoto H, Fujita Y, Yokose K, Temmoku J, Matsuoka N, Yashiro-Furuya M, Asano T, Sato S, Suzuki E, Yago T, Yaguchi T, Aita T, Kusano M, Yamamoto T, Watanabe H, Migita K
Tohoku J Exp Med 2022 Apr 20;256(4):303-308. Epub 2022 Mar 17 doi: 10.1620/tjem.2022.J006. PMID: 35296571
Ophthalmic manifestations in patients with collagen vascular disorders: a hospital-based retrospective observational study.
Sharma SK, Sharma AL, Mahajan VK
Int Ophthalmol 2021 Aug;41(8):2765-2775. Epub 2021 Apr 8 doi: 10.1007/s10792-021-01833-x. PMID: 33830371
A case of juvenile dermatomyositis manifesting inflammatory epidermal nevus-like skin lesions: unrecognized cutaneous manifestation of blaschkitis?
Takahashi Y, Murota H, Tarutani M, Sano S, Okinaga T, Tominaga K, Yano T, Katayama I
Allergol Int 2010 Dec;59(4):425-8. Epub 2010 Oct 25 doi: 10.2332/allergolint.10-CR-0213. PMID: 20962570
Skin involvement and outcome measures in systemic autoimmune diseases.
Albrecht J, Atzeni F, Baldini C, Bombardieri S, Dalakas MC, Demirkesen C, Yazici H, Mat C, Werth VP, Sarzi-Puttini P
Clin Exp Rheumatol 2006 Jan-Feb;24(1 Suppl 40):S52-9. PMID: 16466625

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...