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Heliotrope rash of eyelid

MedGen UID:
909660
•Concept ID:
C4280745
•
Finding
HPO: HP:0030845

Definition

Heliotrope rash is a violaceous discoloration of the eyelids associated with periorbital edema. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeliotrope rash of eyelid

Recent clinical studies

Etiology

Ophthalmic manifestations in patients with collagen vascular disorders: a hospital-based retrospective observational study.
Sharma SK, Sharma AL, Mahajan VK
Int Ophthalmol 2021 Aug;41(8):2765-2775. Epub 2021 Apr 8 doi: 10.1007/s10792-021-01833-x. PMID: 33830371
Ovarian teratoma mimicking features of juvenile dermatomyositis in a child.
Ibarra M, Chou P, Pachman LM
Pediatrics 2011 Nov;128(5):e1293-6. Epub 2011 Oct 3 doi: 10.1542/peds.2010-2115. PMID: 21969283Free PMC Article
Paraneoplastic dermatomyositis associated with testicular cancer: a case report and literature review.
Dourmishev LA, Popov JM, Rusinova D
Acta Dermatovenerol Alp Pannonica Adriat 2010;19(1):39-43. PMID: 20372774
Juvenile dermatomyositis presenting with periorbital edema.
Taban M, Perry JD
Ophthalmic Plast Reconstr Surg 2006 Sep-Oct;22(5):393-5. doi: 10.1097/01.iop.0000230271.21976.0d. PMID: 16985429
Amyopathic dermatomyositis.
Saoud B, Allali F, Hassouni NH
Joint Bone Spine 2006 May;73(3):318-20. Epub 2005 Sep 16 doi: 10.1016/j.jbspin.2005.05.004. PMID: 16253536

Diagnosis

Allergic shiners in a patient with cough-variant asthma: a case report.
Rekabi M, Raad N, Abedini A, Darougar S, Velayati AA
J Med Case Rep 2022 May 28;16(1):208. doi: 10.1186/s13256-022-03423-6. PMID: 35624503Free PMC Article
Heliotrope-like manifestation of adult-onset Still disease with macrophage activation syndrome: A case-based review.
Ikeda T, Yokoyama K, Kawakami T
J Dermatol 2022 Jul;49(7):736-740. Epub 2022 Apr 19 doi: 10.1111/1346-8138.16373. PMID: 35438204
Anti-Mi-2 and Anti-TIF1-γ Double-Positive Juvenile Dermatomyositis Treated under Diagnosis of Chronic Eczema: A Case Report.
Yoshida S, Matsumoto H, Fujita Y, Yokose K, Temmoku J, Matsuoka N, Yashiro-Furuya M, Asano T, Sato S, Suzuki E, Yago T, Yaguchi T, Aita T, Kusano M, Yamamoto T, Watanabe H, Migita K
Tohoku J Exp Med 2022 Apr 20;256(4):303-308. Epub 2022 Mar 17 doi: 10.1620/tjem.2022.J006. PMID: 35296571
Unusual sequelae of adult-onset dermatomyositis.
Naffaa ME, Bishara R, Braun-Moscovici Y, Balbir-Gurman A
BMJ Case Rep 2014 Aug 1;2014:bcr-2014-204521. doi: 10.1136/bcr-2014-204521. PMID: 25085949Free PMC Article
Amyopathic dermatomyositis.
Saoud B, Allali F, Hassouni NH
Joint Bone Spine 2006 May;73(3):318-20. Epub 2005 Sep 16 doi: 10.1016/j.jbspin.2005.05.004. PMID: 16253536

Therapy

A Rare Case of Pembrolizumab-Induced Dermatomyositis in a Patient with Cancer of Unknown Primary Origin.
Takatsuki K, Yanagihara T, Egashira A, Ogo N, Yoshizawa S, Sunami S, Asoh T, Maeyama T
Am J Case Rep 2021 Apr 27;22:e930286. doi: 10.12659/AJCR.930286. PMID: 33903584Free PMC Article
Unusual sequelae of adult-onset dermatomyositis.
Naffaa ME, Bishara R, Braun-Moscovici Y, Balbir-Gurman A
BMJ Case Rep 2014 Aug 1;2014:bcr-2014-204521. doi: 10.1136/bcr-2014-204521. PMID: 25085949Free PMC Article
A case of juvenile dermatomyositis manifesting inflammatory epidermal nevus-like skin lesions: unrecognized cutaneous manifestation of blaschkitis?
Takahashi Y, Murota H, Tarutani M, Sano S, Okinaga T, Tominaga K, Yano T, Katayama I
Allergol Int 2010 Dec;59(4):425-8. Epub 2010 Oct 25 doi: 10.2332/allergolint.10-CR-0213. PMID: 20962570
Juvenile dermatomyositis presenting with periorbital edema.
Taban M, Perry JD
Ophthalmic Plast Reconstr Surg 2006 Sep-Oct;22(5):393-5. doi: 10.1097/01.iop.0000230271.21976.0d. PMID: 16985429
Periorbital edema as the presenting sign of dermatomyositis.
Hall VC, Keeling JH, Davis MD
Int J Dermatol 2003 Jun;42(6):466-7. doi: 10.1046/j.1365-4362.2003.01696.x. PMID: 12786876

Prognosis

Heliotrope-like manifestation of adult-onset Still disease with macrophage activation syndrome: A case-based review.
Ikeda T, Yokoyama K, Kawakami T
J Dermatol 2022 Jul;49(7):736-740. Epub 2022 Apr 19 doi: 10.1111/1346-8138.16373. PMID: 35438204
A Rare Case of Pembrolizumab-Induced Dermatomyositis in a Patient with Cancer of Unknown Primary Origin.
Takatsuki K, Yanagihara T, Egashira A, Ogo N, Yoshizawa S, Sunami S, Asoh T, Maeyama T
Am J Case Rep 2021 Apr 27;22:e930286. doi: 10.12659/AJCR.930286. PMID: 33903584Free PMC Article
Anti-SAE autoantibody-positive Japanese patient with juvenile dermatomyositis complicated with interstitial lung disease - a case report.
Kishi T, Tani Y, Okiyama N, Mizuochi K, Ichimura Y, Harigai M, Nagata S, Miyamae T
Pediatr Rheumatol Online J 2021 Mar 19;19(1):34. doi: 10.1186/s12969-021-00532-2. PMID: 33740993Free PMC Article
Ovarian teratoma mimicking features of juvenile dermatomyositis in a child.
Ibarra M, Chou P, Pachman LM
Pediatrics 2011 Nov;128(5):e1293-6. Epub 2011 Oct 3 doi: 10.1542/peds.2010-2115. PMID: 21969283Free PMC Article
Amyopathic dermatomyositis.
Saoud B, Allali F, Hassouni NH
Joint Bone Spine 2006 May;73(3):318-20. Epub 2005 Sep 16 doi: 10.1016/j.jbspin.2005.05.004. PMID: 16253536

Clinical prediction guides

Heliotrope-like manifestation of adult-onset Still disease with macrophage activation syndrome: A case-based review.
Ikeda T, Yokoyama K, Kawakami T
J Dermatol 2022 Jul;49(7):736-740. Epub 2022 Apr 19 doi: 10.1111/1346-8138.16373. PMID: 35438204
Anti-Mi-2 and Anti-TIF1-γ Double-Positive Juvenile Dermatomyositis Treated under Diagnosis of Chronic Eczema: A Case Report.
Yoshida S, Matsumoto H, Fujita Y, Yokose K, Temmoku J, Matsuoka N, Yashiro-Furuya M, Asano T, Sato S, Suzuki E, Yago T, Yaguchi T, Aita T, Kusano M, Yamamoto T, Watanabe H, Migita K
Tohoku J Exp Med 2022 Apr 20;256(4):303-308. Epub 2022 Mar 17 doi: 10.1620/tjem.2022.J006. PMID: 35296571
Ophthalmic manifestations in patients with collagen vascular disorders: a hospital-based retrospective observational study.
Sharma SK, Sharma AL, Mahajan VK
Int Ophthalmol 2021 Aug;41(8):2765-2775. Epub 2021 Apr 8 doi: 10.1007/s10792-021-01833-x. PMID: 33830371
A case of juvenile dermatomyositis manifesting inflammatory epidermal nevus-like skin lesions: unrecognized cutaneous manifestation of blaschkitis?
Takahashi Y, Murota H, Tarutani M, Sano S, Okinaga T, Tominaga K, Yano T, Katayama I
Allergol Int 2010 Dec;59(4):425-8. Epub 2010 Oct 25 doi: 10.2332/allergolint.10-CR-0213. PMID: 20962570
Skin involvement and outcome measures in systemic autoimmune diseases.
Albrecht J, Atzeni F, Baldini C, Bombardieri S, Dalakas MC, Demirkesen C, Yazici H, Mat C, Werth VP, Sarzi-Puttini P
Clin Exp Rheumatol 2006 Jan-Feb;24(1 Suppl 40):S52-9. PMID: 16466625

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