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Condyloma acuminata of vulva

MedGen UID:
90970
•Concept ID:
C0341851
•
Disease or Syndrome
Synonyms: Condylomata Acuminata of the Vulva; Condylomata Acuminata of Vulva; Vulvar Condyloma; Vulvar Condyloma Acuminatum
SNOMED CT: Condyloma acuminata of vulva (237110007)

Definition

A benign human papillomavirus-related neoplasm that arises from the vulva. It is characterized by the presence of papillary structures with fibrovascular cores covered by stratified squamous epithelium showing koilocytotic changes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCondyloma acuminata of vulva

Professional guidelines

PubMed

Recurrence of genitals warts in pre-HPV vaccine era after laser treatment.
Widschwendter A, Böttcher B, Riedl D, Coban S, Mutz-Dehbalaie I, Matteucci Gothe R, Ciresa-König A, Marth C, Fessler S
Arch Gynecol Obstet 2019 Sep;300(3):661-668. Epub 2019 Jul 8 doi: 10.1007/s00404-019-05242-5. PMID: 31286210Free PMC Article
Treatment of multi-position condyloma acuminatum using topical CO(2) laser combined with photodynamic therapy - Report of 6 cases.
Zhang L, Li X, Liu X, Gao Y, Tang Q
Photodiagnosis Photodyn Ther 2019 Mar;25:436-439. Epub 2019 Jan 29 doi: 10.1016/j.pdpdt.2019.01.030. PMID: 30703534
Nursing care and treatment of the patient with human papillomavirus.
Peate I
Br J Nurs 2006 Oct 26-Nov 8;15(19):1063-9. doi: 10.12968/bjon.2006.15.19.22107. PMID: 17167367

Recent clinical studies

Etiology

HPV vaccination in boys and men.
Stanley M
Hum Vaccin Immunother 2014;10(7):2109-11. doi: 10.4161/hv.29137. PMID: 25424825Free PMC Article
Green and black tea in relation to gynecologic cancers.
Butler LM, Wu AH
Mol Nutr Food Res 2011 Jun;55(6):931-40. Epub 2011 May 19 doi: 10.1002/mnfr.201100058. PMID: 21595018Free PMC Article
Pigmented lesions of the vulva.
Venkatesan A
Dermatol Clin 2010 Oct;28(4):795-805. doi: 10.1016/j.det.2010.08.007. PMID: 20883921
Human papillomavirus-related disease in men: not just a women's issue.
Palefsky JM
J Adolesc Health 2010 Apr;46(4 Suppl):S12-9. doi: 10.1016/j.jadohealth.2010.01.010. PMID: 20307839Free PMC Article
Human papillomavirus, smoking, and cancer.
Moore TO, Moore AY, Carrasco D, Vander Straten M, Arany I, Au W, Tyring SK
J Cutan Med Surg 2001 Jul-Aug;5(4):323-8. Epub 2001 Jul 18 doi: 10.1007/s102270000029. PMID: 11907844

Diagnosis

Reproductive system infections in women: lower genital tract syndromes.
Brunham RC, Paavonen J
Pathog Dis 2020 Jul 1;78(5) doi: 10.1093/femspd/ftaa022. PMID: 32463432
Clinical features of external genital warts.
Lynde C, Vender R, Bourcier M, Bhatia N
J Cutan Med Surg 2013 Dec;17 Suppl 2:S55-60. PMID: 24388559
Pigmented lesions of the vulva.
Venkatesan A
Dermatol Clin 2010 Oct;28(4):795-805. doi: 10.1016/j.det.2010.08.007. PMID: 20883921
Nursing care and treatment of the patient with human papillomavirus.
Peate I
Br J Nurs 2006 Oct 26-Nov 8;15(19):1063-9. doi: 10.12968/bjon.2006.15.19.22107. PMID: 17167367
Prepubertal vulvovaginopathies.
Pokorny SF
Obstet Gynecol Clin North Am 1992 Mar;19(1):39-58. PMID: 1584544

Therapy

HPV vaccination in boys and men.
Stanley M
Hum Vaccin Immunother 2014;10(7):2109-11. doi: 10.4161/hv.29137. PMID: 25424825Free PMC Article
Clinical features of external genital warts.
Lynde C, Vender R, Bourcier M, Bhatia N
J Cutan Med Surg 2013 Dec;17 Suppl 2:S55-60. PMID: 24388559
Green and black tea in relation to gynecologic cancers.
Butler LM, Wu AH
Mol Nutr Food Res 2011 Jun;55(6):931-40. Epub 2011 May 19 doi: 10.1002/mnfr.201100058. PMID: 21595018Free PMC Article
Monitoring of human papillomavirus vaccination.
Dillner J, Arbyn M, Unger E, Dillner L
Clin Exp Immunol 2011 Jan;163(1):17-25. Epub 2010 Nov 9 doi: 10.1111/j.1365-2249.2010.04268.x. PMID: 21062269Free PMC Article
Human papillomavirus-related disease in men: not just a women's issue.
Palefsky JM
J Adolesc Health 2010 Apr;46(4 Suppl):S12-9. doi: 10.1016/j.jadohealth.2010.01.010. PMID: 20307839Free PMC Article

Prognosis

The burden of human papillomavirus infections and related diseases in sub-saharan Africa.
De Vuyst H, Alemany L, Lacey C, Chibwesha CJ, Sahasrabuddhe V, Banura C, Denny L, Parham GP
Vaccine 2013 Dec 29;31 Suppl 5(0 5):F32-46. doi: 10.1016/j.vaccine.2012.07.092. PMID: 24331746Free PMC Article
Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma.
Del Pino M, Rodriguez-Carunchio L, Ordi J
Histopathology 2013 Jan;62(1):161-75. Epub 2012 Nov 27 doi: 10.1111/his.12034. PMID: 23190170
Global burden of human papillomavirus and related diseases.
Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, Vignat J, Ferlay J, Bray F, Plummer M, Franceschi S
Vaccine 2012 Nov 20;30 Suppl 5:F12-23. doi: 10.1016/j.vaccine.2012.07.055. PMID: 23199955
Human papillomavirus, smoking, and cancer.
Moore TO, Moore AY, Carrasco D, Vander Straten M, Arany I, Au W, Tyring SK
J Cutan Med Surg 2001 Jul-Aug;5(4):323-8. Epub 2001 Jul 18 doi: 10.1007/s102270000029. PMID: 11907844
Genital papillomavirus infections: current knowledge and future prospects.
Koutsky LA, Wølner-Hanssen P
Obstet Gynecol Clin North Am 1989 Sep;16(3):541-64. PMID: 2556673

Clinical prediction guides

Clinical observation of laser combined with 5-aminolevulinic acid photodynamic therapy for female vulva condyloma acuminatum.
Zhao Z, Jama AA, Gao H, Lu Y
J Obstet Gynaecol Res 2023 Aug;49(8):2010-2014. Epub 2023 May 25 doi: 10.1111/jog.15679. PMID: 37230948
Study on the application and imaging characteristics of optical coherence tomography in vulva lesions.
Xu L, Ma Q, Lin S, Ju J, Feng S, Shi Z, Bai Y, Song J, Du J, Wang B
Sci Rep 2022 Mar 7;12(1):3659. doi: 10.1038/s41598-022-07634-1. PMID: 35256649Free PMC Article
Real-world impact and effectiveness assessment of the quadrivalent HPV vaccine: a systematic review of study designs and data sources.
Wang W, Kothari S, Baay M, Garland SM, Giuliano AR, Nygård M, Velicer C, Tota J, Sinha A, Skufca J, Verstraeten T, Sundström K
Expert Rev Vaccines 2022 Feb;21(2):227-240. Epub 2021 Dec 13 doi: 10.1080/14760584.2022.2008243. PMID: 34845951
Pathogenicity of high risk HPV infection in pseudocondyloma of vulvae and its carcinogenicity in inducing cervical lesions.
Song PF, Chen JY, He Q, Wang J, Xu J
Eur Rev Med Pharmacol Sci 2018 Mar;22(6):1541-1548. doi: 10.26355/eurrev_201803_14558. PMID: 29630095
Green and black tea in relation to gynecologic cancers.
Butler LM, Wu AH
Mol Nutr Food Res 2011 Jun;55(6):931-40. Epub 2011 May 19 doi: 10.1002/mnfr.201100058. PMID: 21595018Free PMC Article

Recent systematic reviews

Real-world impact and effectiveness assessment of the quadrivalent HPV vaccine: a systematic review of study designs and data sources.
Wang W, Kothari S, Baay M, Garland SM, Giuliano AR, Nygård M, Velicer C, Tota J, Sinha A, Skufca J, Verstraeten T, Sundström K
Expert Rev Vaccines 2022 Feb;21(2):227-240. Epub 2021 Dec 13 doi: 10.1080/14760584.2022.2008243. PMID: 34845951
Anogenital warts and relationship to child sexual abuse: Systematic review and meta-analysis.
Awasthi S, Ornelas J, Armstrong A, Johnson JA, Eisen DB
Pediatr Dermatol 2021 Jul;38(4):842-850. Epub 2021 Jun 1 doi: 10.1111/pde.14650. PMID: 34060139

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