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Central precocious puberty

MedGen UID:
90985
•Concept ID:
C0342543
•
Disease or Syndrome
Synonyms: Central Precocious Puberties; Central Precocious Puberty; Precocious Puberties, Central; Precocious Puberty, Central; Puberties, Central Precocious; Puberty, Central Precocious
SNOMED CT: Central precocious puberty (237816004)
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
•Concept ID:
C0443147
•
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Autosomal dominant inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019165
OMIM® Phenotypic series: PS176400
Orphanet: ORPHA759

Definition

Central precocious puberty (CPP), also referred to as gonadotropin dependent precocious puberty, is an endocrine-related developmental disease characterized by the onset of pubertal changes, with development of secondary sexual characteristics and accelerated growth and bone maturation, before the normal age of puberty (8 years in girls and 9 years in boys). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral precocious puberty
Follow this link to review classifications for Central precocious puberty in Orphanet.

Professional guidelines

PubMed

Diagnosis and management of precocious sexual maturation: an updated review.
Cheuiche AV, da Silveira LG, de Paula LCP, Lucena IRS, Silveiro SP
Eur J Pediatr 2021 Oct;180(10):3073-3087. Epub 2021 Mar 21 doi: 10.1007/s00431-021-04022-1. PMID: 33745030
Central precocious puberty: From genetics to treatment.
Aguirre RS, Eugster EA
Best Pract Res Clin Endocrinol Metab 2018 Aug;32(4):343-354. Epub 2018 May 26 doi: 10.1016/j.beem.2018.05.008. PMID: 30086862
Causes, diagnosis, and treatment of central precocious puberty.
Latronico AC, Brito VN, Carel JC
Lancet Diabetes Endocrinol 2016 Mar;4(3):265-274. Epub 2016 Feb 4 doi: 10.1016/S2213-8587(15)00380-0. PMID: 26852255

Recent clinical studies

Etiology

Central precocious puberty: a review of diagnosis, treatment, and outcomes.
Zevin EL, Eugster EA
Lancet Child Adolesc Health 2023 Dec;7(12):886-896. doi: 10.1016/S2352-4642(23)00237-7. PMID: 37973253
Approach to the Patient: Central Precocious Puberty.
Kilberg MJ, Vogiatzi MG
J Clin Endocrinol Metab 2023 Jul 14;108(8):2115-2123. doi: 10.1210/clinem/dgad081. PMID: 36916130
Obesity is a risk factor for central precocious puberty: a case-control study.
Liu G, Guo J, Zhang X, Lu Y, Miao J, Xue H
BMC Pediatr 2021 Nov 16;21(1):509. doi: 10.1186/s12887-021-02936-1. PMID: 34784914Free PMC Article
Central precocious puberty, functional and tumor-related.
Soriano-Guillén L, Argente J
Best Pract Res Clin Endocrinol Metab 2019 Jun;33(3):101262. Epub 2019 Jan 22 doi: 10.1016/j.beem.2019.01.003. PMID: 30733078
Consensus statement on the use of gonadotropin-releasing hormone analogs in children.
Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR; ESPE-LWPES GnRH Analogs Consensus Conference Group, Antoniazzi F, Berenbaum S, Bourguignon JP, Chrousos GP, Coste J, Deal S, de Vries L, Foster C, Heger S, Holland J, Jahnukainen K, Juul A, Kaplowitz P, Lahlou N, Lee MM, Lee P, Merke DP, Neely EK, Oostdijk W, Phillip M, Rosenfield RL, Shulman D, Styne D, Tauber M, Wit JM
Pediatrics 2009 Apr;123(4):e752-62. Epub 2009 Mar 30 doi: 10.1542/peds.2008-1783. PMID: 19332438

Diagnosis

Central precocious puberty: a review of diagnosis, treatment, and outcomes.
Zevin EL, Eugster EA
Lancet Child Adolesc Health 2023 Dec;7(12):886-896. doi: 10.1016/S2352-4642(23)00237-7. PMID: 37973253
Precocious Puberty.
Banerjee S, Bajpai A
Indian J Pediatr 2023 Jun;90(6):582-589. Epub 2023 Apr 19 doi: 10.1007/s12098-023-04554-4. PMID: 37074536
Diagnosis and management of precocious sexual maturation: an updated review.
Cheuiche AV, da Silveira LG, de Paula LCP, Lucena IRS, Silveiro SP
Eur J Pediatr 2021 Oct;180(10):3073-3087. Epub 2021 Mar 21 doi: 10.1007/s00431-021-04022-1. PMID: 33745030
Central precocious puberty: From genetics to treatment.
Aguirre RS, Eugster EA
Best Pract Res Clin Endocrinol Metab 2018 Aug;32(4):343-354. Epub 2018 May 26 doi: 10.1016/j.beem.2018.05.008. PMID: 30086862
Causes, diagnosis, and treatment of central precocious puberty.
Latronico AC, Brito VN, Carel JC
Lancet Diabetes Endocrinol 2016 Mar;4(3):265-274. Epub 2016 Feb 4 doi: 10.1016/S2213-8587(15)00380-0. PMID: 26852255

Therapy

Central precocious puberty: a review of diagnosis, treatment, and outcomes.
Zevin EL, Eugster EA
Lancet Child Adolesc Health 2023 Dec;7(12):886-896. doi: 10.1016/S2352-4642(23)00237-7. PMID: 37973253
Precocious Puberty.
Banerjee S, Bajpai A
Indian J Pediatr 2023 Jun;90(6):582-589. Epub 2023 Apr 19 doi: 10.1007/s12098-023-04554-4. PMID: 37074536
Should Skeletal Maturation Be Manipulated for Extra Height Gain?
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
Obesity is a risk factor for central precocious puberty: a case-control study.
Liu G, Guo J, Zhang X, Lu Y, Miao J, Xue H
BMC Pediatr 2021 Nov 16;21(1):509. doi: 10.1186/s12887-021-02936-1. PMID: 34784914Free PMC Article
Leuprolide acetate: a drug of diverse clinical applications.
Wilson AC, Meethal SV, Bowen RL, Atwood CS
Expert Opin Investig Drugs 2007 Nov;16(11):1851-63. doi: 10.1517/13543784.16.11.1851. PMID: 17970643

Prognosis

Leptin/adiponectin ratio as a prognostic factor for increased weight gain in girls with central precocious puberty.
Zurita-Cruz JN, Villasís-Keever MA, Manuel-Apolinar L, Damasio-Santana L, Garrido-Magaña E, Rivera-Hernández AJ
Front Endocrinol (Lausanne) 2023;14:1101399. Epub 2023 Mar 10 doi: 10.3389/fendo.2023.1101399. PMID: 36967781Free PMC Article
Precocious puberty and microbiota: The role of the sex hormone-gut microbiome axis.
Calcaterra V, Rossi V, Massini G, Regalbuto C, Hruby C, Panelli S, Bandi C, Zuccotti G
Front Endocrinol (Lausanne) 2022;13:1000919. Epub 2022 Oct 21 doi: 10.3389/fendo.2022.1000919. PMID: 36339428Free PMC Article
Should Skeletal Maturation Be Manipulated for Extra Height Gain?
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
Update on Precocious Puberty: Who Should Be Treated?
Kaplowitz PB
Adv Pediatr 2020 Aug;67:93-104. Epub 2020 May 26 doi: 10.1016/j.yapd.2020.04.003. PMID: 32591066
Premature Thelarche.
Khokhar A, Mojica A
Pediatr Ann 2018 Jan 1;47(1):e12-e15. doi: 10.3928/19382359-20171214-01. PMID: 29323691

Clinical prediction guides

Precocious puberty and microbiota: The role of the sex hormone-gut microbiome axis.
Calcaterra V, Rossi V, Massini G, Regalbuto C, Hruby C, Panelli S, Bandi C, Zuccotti G
Front Endocrinol (Lausanne) 2022;13:1000919. Epub 2022 Oct 21 doi: 10.3389/fendo.2022.1000919. PMID: 36339428Free PMC Article
Should Skeletal Maturation Be Manipulated for Extra Height Gain?
Wit JM
Front Endocrinol (Lausanne) 2021;12:812196. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.812196. PMID: 34975773Free PMC Article
Obesity is a risk factor for central precocious puberty: a case-control study.
Liu G, Guo J, Zhang X, Lu Y, Miao J, Xue H
BMC Pediatr 2021 Nov 16;21(1):509. doi: 10.1186/s12887-021-02936-1. PMID: 34784914Free PMC Article
Long-term effects and significant Adverse Drug Reactions (ADRs) associated with the use of Gonadotropin-Releasing Hormone analogs (GnRHa) for central precocious puberty: a brief review of literature.
De Sanctis V, Soliman AT, Di Maio S, Soliman N, Elsedfy H
Acta Biomed 2019 Sep 6;90(3):345-359. doi: 10.23750/abm.v90i3.8736. PMID: 31580327Free PMC Article
Leuprolide acetate: a drug of diverse clinical applications.
Wilson AC, Meethal SV, Bowen RL, Atwood CS
Expert Opin Investig Drugs 2007 Nov;16(11):1851-63. doi: 10.1517/13543784.16.11.1851. PMID: 17970643

Recent systematic reviews

An updated meta-analysis of the relationship between vitamin D levels and precocious puberty.
Cheng H, Chen D, Gao H
Front Endocrinol (Lausanne) 2023;14:1298374. Epub 2023 Dec 5 doi: 10.3389/fendo.2023.1298374. PMID: 38116317Free PMC Article
Is surgery effective for treating hypothalamic hamartoma causing isolated central precocious puberty? A systematic review.
Agrawal M, Samala R, Doddamani RS, Goyal A, Tripathi M, Chandra PS
Neurosurg Rev 2021 Dec;44(6):3087-3105. Epub 2021 Feb 28 doi: 10.1007/s10143-021-01512-6. PMID: 33641048
Kisspeptin Levels in Girls with Precocious Puberty: A Systematic Review and Meta-Analysis.
Cintra RG, Wajnsztejn R, Trevisan CM, Zaia V, Laganà AS, Bianco B, Montagna E
Horm Res Paediatr 2020;93(11-12):589-598. Epub 2021 Apr 22 doi: 10.1159/000515660. PMID: 33887744
Herbal Medicine for Idiopathic Central Precocious Puberty: A Systematic Review and Meta-Analysis.
Lee YB, Lee JA, Lee HL
J Altern Complement Med 2020 Nov;26(11):976-999. Epub 2020 Jul 10 doi: 10.1089/acm.2019.0312. PMID: 32654496
Prevalence of cranial MRI findings in girls with central precocious puberty: a systematic review and meta-analysis.
Cantas-Orsdemir S, Garb JL, Allen HF
J Pediatr Endocrinol Metab 2018 Jul 26;31(7):701-710. doi: 10.1515/jpem-2018-0052. PMID: 29902155

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