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Eosinophilic cellulitis

MedGen UID:
91008
•Concept ID:
C0343101
•
Disease or Syndrome
Synonyms: Bullous cellulitis with eosinophilia; Wells syndrome; Wells' syndrome
SNOMED CT: Wells' syndrome (238931006); Eosinophilic cellulitis (238931006)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0019547
Orphanet: ORPHA901

Definition

Wells syndrome is characterised by the presence of recurrent cellulitis-like eruptions with eosinophilia. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEosinophilic cellulitis
Follow this link to review classifications for Eosinophilic cellulitis in Orphanet.

Professional guidelines

PubMed

Treatment of Eosinophilic Annular Erythema: Retrospective multicenter study and literature review.
Chastagner M, Shourik J, Jachiet M, Battistella M, Lefevre G, Gibier JB, Aubert H, Musquer M, Descamps V, Deschamps L, Chosidow O, Ortonne N, Groh M, Bernier M, Jullien D, Chasset F, Staumont-Salle D, Bouaziz JD, Kanitakis J, Villani AP
Ann Dermatol Venereol 2022 Jun;149(2):123-127. Epub 2021 Oct 27 doi: 10.1016/j.annder.2021.07.007. PMID: 34716028
Eosinophilic Dermatoses: Recognition and Management.
Marzano AV, Genovese G
Am J Clin Dermatol 2020 Aug;21(4):525-539. doi: 10.1007/s40257-020-00520-4. PMID: 32394361
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.
Räßler F, Lukács J, Elsner P
J Eur Acad Dermatol Venereol 2016 Sep;30(9):1465-79. Epub 2016 Jun 29 doi: 10.1111/jdv.13706. PMID: 27357601

Recent clinical studies

Etiology

Paradoxical and bimodal immune-mediated dermatological side effects of TNF-α inhibitors: A comprehensive review.
Behrangi E, Moodi F, Jafarzadeh A, Goodarzi A
Skin Res Technol 2024 May;30(5):e13718. doi: 10.1111/srt.13718. PMID: 38700458Free PMC Article
Eosinophilic Dermatoses: Recognition and Management.
Marzano AV, Genovese G
Am J Clin Dermatol 2020 Aug;21(4):525-539. doi: 10.1007/s40257-020-00520-4. PMID: 32394361
Eosinophilic dermatoses.
Peckruhn M, Elsner P, Tittelbach J
J Dtsch Dermatol Ges 2019 Oct;17(10):1039-1051. Epub 2019 Sep 27 doi: 10.1111/ddg.13943. PMID: 31562692
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.
Räßler F, Lukács J, Elsner P
J Eur Acad Dermatol Venereol 2016 Sep;30(9):1465-79. Epub 2016 Jun 29 doi: 10.1111/jdv.13706. PMID: 27357601
Eosinophilic Skin Diseases: A Comprehensive Review.
Long H, Zhang G, Wang L, Lu Q
Clin Rev Allergy Immunol 2016 Apr;50(2):189-213. doi: 10.1007/s12016-015-8485-8. PMID: 25876839

Diagnosis

Eosinophilic Dermatoses: Recognition and Management.
Marzano AV, Genovese G
Am J Clin Dermatol 2020 Aug;21(4):525-539. doi: 10.1007/s40257-020-00520-4. PMID: 32394361
Wells syndrome.
Weins AB, Biedermann T, Weiss T, Weiss JM
J Dtsch Dermatol Ges 2016 Oct;14(10):989-993. doi: 10.1111/ddg.13132. PMID: 27767278
Eosinophilic Skin Diseases: A Comprehensive Review.
Long H, Zhang G, Wang L, Lu Q
Clin Rev Allergy Immunol 2016 Apr;50(2):189-213. doi: 10.1007/s12016-015-8485-8. PMID: 25876839
Distinguishing cellulitis from its mimics.
Keller EC, Tomecki KJ, Alraies MC
Cleve Clin J Med 2012 Aug;79(8):547-52. doi: 10.3949/ccjm.79a.11121. PMID: 22854433
Wells syndrome.
Afsahi V, Kassabian C
Cutis 2003 Sep;72(3):209-12; quiz 208. PMID: 14533832

Therapy

Paradoxical and bimodal immune-mediated dermatological side effects of TNF-α inhibitors: A comprehensive review.
Behrangi E, Moodi F, Jafarzadeh A, Goodarzi A
Skin Res Technol 2024 May;30(5):e13718. doi: 10.1111/srt.13718. PMID: 38700458Free PMC Article
Eosinophilic Dermatoses: Recognition and Management.
Marzano AV, Genovese G
Am J Clin Dermatol 2020 Aug;21(4):525-539. doi: 10.1007/s40257-020-00520-4. PMID: 32394361
Wells syndrome.
Weins AB, Biedermann T, Weiss T, Weiss JM
J Dtsch Dermatol Ges 2016 Oct;14(10):989-993. doi: 10.1111/ddg.13132. PMID: 27767278
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.
Räßler F, Lukács J, Elsner P
J Eur Acad Dermatol Venereol 2016 Sep;30(9):1465-79. Epub 2016 Jun 29 doi: 10.1111/jdv.13706. PMID: 27357601
Wells syndrome.
Afsahi V, Kassabian C
Cutis 2003 Sep;72(3):209-12; quiz 208. PMID: 14533832

Prognosis

Dimethyl fumarate induced Wells syndrome. A case report.
Candeliere-Merlicco A, Villaverde-González R, Hidalgo-Pérez PV, Escobar-Arias FH, Aparicio-Castro E, Lastres-Arias MC
Rev Neurol 2023 May 16;76(10):337-339. doi: 10.33588/rn.7610.2022323. PMID: 37165530Free PMC Article
Wells syndrome.
Weins AB, Biedermann T, Weiss T, Weiss JM
J Dtsch Dermatol Ges 2016 Oct;14(10):989-993. doi: 10.1111/ddg.13132. PMID: 27767278
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.
Räßler F, Lukács J, Elsner P
J Eur Acad Dermatol Venereol 2016 Sep;30(9):1465-79. Epub 2016 Jun 29 doi: 10.1111/jdv.13706. PMID: 27357601
Eosinophilic Skin Diseases: A Comprehensive Review.
Long H, Zhang G, Wang L, Lu Q
Clin Rev Allergy Immunol 2016 Apr;50(2):189-213. doi: 10.1007/s12016-015-8485-8. PMID: 25876839
Wells' syndrome, insect bites, and eosinophils.
Melski JW
Dermatol Clin 1990 Apr;8(2):287-93. PMID: 2191801

Clinical prediction guides

Hyperactivation of the JAK2/STAT5 Signaling Pathway and Evaluation of Baricitinib Treatment Among Patients With Eosinophilic Cellulitis.
Morot J, Del Duca E, Chastagner M, Fernandes M, Estrada Y, Lefevre MA, Kanitakis J, Harou O, Jullien D, Nicolas JF, Krueger JG, Vocanson M, Guttman-Yassky E, Villani AP
JAMA Dermatol 2023 Aug 1;159(8):820-829. doi: 10.1001/jamadermatol.2023.1651. PMID: 37342057Free PMC Article
Centipede envenomation: Clinical importance and the underlying molecular mechanisms.
Ombati R, Luo L, Yang S, Lai R
Toxicon 2018 Nov;154:60-68. Epub 2018 Sep 29 doi: 10.1016/j.toxicon.2018.09.008. PMID: 30273703
Wells syndrome.
Weins AB, Biedermann T, Weiss T, Weiss JM
J Dtsch Dermatol Ges 2016 Oct;14(10):989-993. doi: 10.1111/ddg.13132. PMID: 27767278
Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon alfa.
French LE, Shapiro M, Junkins-Hopkins JM, Wolfe JT, Rook AH
J Am Acad Dermatol 2003 Dec;49(6):1170-4. doi: 10.1016/s0190-9622(03)00447-x. PMID: 14639411
Eosinophilic cellulitis.
Wells GC, Smith NP
Br J Dermatol 1979 Jan;100(1):101-9. doi: 10.1111/j.1365-2133.1979.tb03574.x. PMID: 427009

Recent systematic reviews

Treatment of Eosinophilic Annular Erythema: Retrospective multicenter study and literature review.
Chastagner M, Shourik J, Jachiet M, Battistella M, Lefevre G, Gibier JB, Aubert H, Musquer M, Descamps V, Deschamps L, Chosidow O, Ortonne N, Groh M, Bernier M, Jullien D, Chasset F, Staumont-Salle D, Bouaziz JD, Kanitakis J, Villani AP
Ann Dermatol Venereol 2022 Jun;149(2):123-127. Epub 2021 Oct 27 doi: 10.1016/j.annder.2021.07.007. PMID: 34716028
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.
Räßler F, Lukács J, Elsner P
J Eur Acad Dermatol Venereol 2016 Sep;30(9):1465-79. Epub 2016 Jun 29 doi: 10.1111/jdv.13706. PMID: 27357601

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