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Trachea squamous cell carcinoma

MedGen UID:
91059
•Concept ID:
C0345946
•
Neoplastic Process
Synonyms: Epidermoid Carcinoma of the Trachea; epidermoid carcinoma of the trachea; Epidermoid Carcinoma of Trachea; epidermoid carcinoma of trachea; Squamous Cell Carcinoma of the Trachea; squamous cell carcinoma of the trachea; Squamous cell carcinoma of trachea; Squamous Cell Carcinoma of Trachea; squamous cell carcinoma of trachea; Trachea Epidermoid Carcinoma; trachea epidermoid carcinoma; Trachea Squamous Cell Carcinoma; trachea squamous cell carcinoma; Tracheal Epidermoid Carcinoma; tracheal epidermoid carcinoma; Tracheal Squamous Cell Carcinoma; tracheal squamous cell carcinoma
SNOMED CT: Squamous cell carcinoma of trachea (254620000)
 
Monarch Initiative: MONDO:0001419

Definition

A rare squamous cell carcinoma that arises from the mucosal lining of the trachea. It usually grows as an intraluminal mass and later invades extraluminal structures. The majority of patients present with hemoptysis, coughing, dyspnea, or stridor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrachea squamous cell carcinoma

Professional guidelines

PubMed

Patterns of Care and Outcomes of Primary Adenoid Cystic Carcinoma of the Trachea.
Behbahani S, Barinsky GL, Wassef D, Paskhover B, Kaye R
Ann Otol Rhinol Laryngol 2022 Jan;131(1):78-85. Epub 2021 Apr 19 doi: 10.1177/00034894211008101. PMID: 33870720
Clinical manifestation and management of primary malignant tumors of the cervical trachea.
Li Y, Peng A, Yang X, Xiao Z, Wu W, Wang Q
Eur Arch Otorhinolaryngol 2014 Feb;271(2):225-35. Epub 2013 Mar 20 doi: 10.1007/s00405-013-2429-9. PMID: 23512430
Clinical aspects and treatment of primary tracheal malignancies.
Honings J, Gaissert HA, van der Heijden HF, Verhagen AF, Kaanders JH, Marres HA
Acta Otolaryngol 2010 Jul;130(7):763-72. doi: 10.3109/00016480903403005. PMID: 20569185

Recent clinical studies

Etiology

Patterns of Care and Outcomes of Primary Adenoid Cystic Carcinoma of the Trachea.
Behbahani S, Barinsky GL, Wassef D, Paskhover B, Kaye R
Ann Otol Rhinol Laryngol 2022 Jan;131(1):78-85. Epub 2021 Apr 19 doi: 10.1177/00034894211008101. PMID: 33870720
Comparison between Primary and Secondary Tracheoesophageal Puncture Prosthesis: A Systematic Review.
Barauna Neto JC, Dedivitis RA, Aires FT, Pfann RZ, Matos LL, Cernea CR
ORL J Otorhinolaryngol Relat Spec 2017;79(4):222-229. Epub 2017 Jul 29 doi: 10.1159/000477970. PMID: 28768272
The importance of stem cell engineering in head and neck oncology.
Barczak W, Golusiński P, Luczewski L, Suchorska WM, Masternak MM, Golusiński W
Biotechnol Lett 2016 Oct;38(10):1665-72. Epub 2016 Jun 24 doi: 10.1007/s10529-016-2163-7. PMID: 27341837Free PMC Article
Cervical esophageal cancer: a gap in cancer knowledge.
Hoeben A, Polak J, Van De Voorde L, Hoebers F, Grabsch HI, de Vos-Geelen J
Ann Oncol 2016 Sep;27(9):1664-74. Epub 2016 Apr 26 doi: 10.1093/annonc/mdw183. PMID: 27117535
Gastroesophageal reflux disease and non-esophageal cancer.
Herbella FA, Neto SP, Santoro IL, Figueiredo LC
World J Gastroenterol 2015 Jan 21;21(3):815-9. doi: 10.3748/wjg.v21.i3.815. PMID: 25624714Free PMC Article

Diagnosis

Mucous Gland Adenoma of the Lung: A Neoplastic Counterpart of Mucinous Bronchial Glands.
Sasaki E, Masago K, Kogure Y, Fujita S, Iwakoshi A, Kuroda H, Tsuzuki T, Tsuta K, Matsushita H, Oki M
Mod Pathol 2023 Jun;36(6):100182. Epub 2023 Apr 5 doi: 10.1016/j.modpat.2023.100182. PMID: 37028599
Tracheal resection and anastomosis for squamous cell carcinoma.
Faccioli E, Comacchio G, Mammana M, Zambello G, Zuin A, Rea F
Multimed Man Cardiothorac Surg 2022 Apr 1;2022 doi: 10.1510/mmcts.2022.012. PMID: 35377973
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Tracheal tumors.
Mathisen DJ
Chest Surg Clin N Am 1996 Nov;6(4):875-98. PMID: 8934015
Malignant tracheal tumors.
Allen MS
Mayo Clin Proc 1993 Jul;68(7):680-4. doi: 10.1016/s0025-6196(12)60604-1. PMID: 8394484

Therapy

Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma.
Habu T, Kumanishi R, Ogata T, Fujisawa T, Mishima S, Kotani D, Kadowaki S, Nakamura M, Hojo H, Fujiwara H, Kumagai S, Koyama S, Fujita T, Kinoshita T, Nishikawa H, Yano T, Tajika M, Muro K, Mitsunaga S, Kojima T, Bando H
Esophagus 2023 Jul;20(3):533-540. Epub 2023 Feb 8 doi: 10.1007/s10388-023-00987-0. PMID: 36750480
Docetaxel, Cisplatin, and 5-FU Triplet Therapy as Conversion Therapy for Locoregionally Advanced Unresectable Esophageal Squamous Cell Carcinoma.
Chan WL, Choi CW, Wong IY, Tsang TH, Lam AT, Tse RP, Chan KK, Wong C, Law BT, Cheung EE, Chan SY, Lam KO, Kwong D, Law S
Ann Surg Oncol 2023 Feb;30(2):861-870. Epub 2022 Oct 28 doi: 10.1245/s10434-022-12694-8. PMID: 36307666
Pathology of tracheal tumors.
Junker K
Thorac Surg Clin 2014 Feb;24(1):7-11. doi: 10.1016/j.thorsurg.2013.09.008. PMID: 24295655
Teflon haemoptysis.
Aboudara M, Krimsky W, Harley D
BMJ Case Rep 2012 Mar 20;2012 doi: 10.1136/bcr.12.2011.5279. PMID: 22605709Free PMC Article
Tracheal tumors.
Mathisen DJ
Chest Surg Clin N Am 1996 Nov;6(4):875-98. PMID: 8934015

Prognosis

Clinical and prognostic features of multiple primary cancers with oral squamous cell carcinoma.
Cai X, Zhang J, Jing F, Zhou X, Zhang H, Li T
Arch Oral Biol 2023 May;149:105661. Epub 2023 Feb 23 doi: 10.1016/j.archoralbio.2023.105661. PMID: 36857878
Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma.
Habu T, Kumanishi R, Ogata T, Fujisawa T, Mishima S, Kotani D, Kadowaki S, Nakamura M, Hojo H, Fujiwara H, Kumagai S, Koyama S, Fujita T, Kinoshita T, Nishikawa H, Yano T, Tajika M, Muro K, Mitsunaga S, Kojima T, Bando H
Esophagus 2023 Jul;20(3):533-540. Epub 2023 Feb 8 doi: 10.1007/s10388-023-00987-0. PMID: 36750480
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Pathology of tracheal tumors.
Junker K
Thorac Surg Clin 2014 Feb;24(1):7-11. doi: 10.1016/j.thorsurg.2013.09.008. PMID: 24295655
Malignant tracheal tumors.
Allen MS
Mayo Clin Proc 1993 Jul;68(7):680-4. doi: 10.1016/s0025-6196(12)60604-1. PMID: 8394484

Clinical prediction guides

Clinical and molecular features of pulmonary NUT carcinoma characterizes diverse responses to immunotherapy, with a pathologic complete response case.
Chen M, Chen X, Zhang Y, Wang W, Jiang L
J Cancer Res Clin Oncol 2023 Aug;149(9):6361-6370. Epub 2023 Feb 8 doi: 10.1007/s00432-023-04621-5. PMID: 36752907
Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma.
Habu T, Kumanishi R, Ogata T, Fujisawa T, Mishima S, Kotani D, Kadowaki S, Nakamura M, Hojo H, Fujiwara H, Kumagai S, Koyama S, Fujita T, Kinoshita T, Nishikawa H, Yano T, Tajika M, Muro K, Mitsunaga S, Kojima T, Bando H
Esophagus 2023 Jul;20(3):533-540. Epub 2023 Feb 8 doi: 10.1007/s10388-023-00987-0. PMID: 36750480
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
The usefulness of the IMAP propeller flap for trachea and tracheostome reconstruction after resection of parastomal recurrence of squamous cell carcinoma following salvage total laryngectomy.
Almadori G, Di Cintio G, De Corso E, Mele DA, Settimi S, Almadori A, Cina A, Visconti G, Paludetti G, Salgarello M
Eur Arch Otorhinolaryngol 2021 Feb;278(2):499-507. Epub 2020 Jul 1 doi: 10.1007/s00405-020-06168-4. PMID: 32613354
Cervical esophageal cancer: a gap in cancer knowledge.
Hoeben A, Polak J, Van De Voorde L, Hoebers F, Grabsch HI, de Vos-Geelen J
Ann Oncol 2016 Sep;27(9):1664-74. Epub 2016 Apr 26 doi: 10.1093/annonc/mdw183. PMID: 27117535

Recent systematic reviews

Demography, patterns of care and survival outcomes in patients with malignant tumors of trachea: A systematic review and individual patient data analysis of 733 patients.
Mallick S, Benson R, Giridhar P, Rajan Singh A, Rath GK
Lung Cancer 2019 Jun;132:87-93. Epub 2019 Apr 10 doi: 10.1016/j.lungcan.2019.04.017. PMID: 31097099
Comparison between Primary and Secondary Tracheoesophageal Puncture Prosthesis: A Systematic Review.
Barauna Neto JC, Dedivitis RA, Aires FT, Pfann RZ, Matos LL, Cernea CR
ORL J Otorhinolaryngol Relat Spec 2017;79(4):222-229. Epub 2017 Jul 29 doi: 10.1159/000477970. PMID: 28768272
Cervical esophageal cancer: a gap in cancer knowledge.
Hoeben A, Polak J, Van De Voorde L, Hoebers F, Grabsch HI, de Vos-Geelen J
Ann Oncol 2016 Sep;27(9):1664-74. Epub 2016 Apr 26 doi: 10.1093/annonc/mdw183. PMID: 27117535

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