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Clear cell squamous cell skin carcinoma

MedGen UID:
91064
•Concept ID:
C0345978
•
Neoplastic Process
Synonyms: Clear cell squamous cell carcinoma of skin; Clear Cell Squamous Cell Carcinoma of Skin; clear cell squamous cell carcinoma of skin; Clear Cell Squamous Cell Carcinoma of the Skin; clear cell squamous cell carcinoma of the skin; Clear Cell Squamous Cell Skin Carcinoma; clear cell squamous cell skin carcinoma; SCC - Clear cell squamous cell carcinoma of skin; Skin Clear Cell Squamous Cell Carcinoma
SNOMED CT: SCC - Clear cell squamous cell carcinoma of skin (254652000); Clear cell squamous cell carcinoma of skin (254652000)
 
Monarch Initiative: MONDO:0004523

Definition

A squamous cell carcinoma of the skin with a prominent clear cell component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell squamous cell skin carcinoma

Professional guidelines

PubMed

Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Treatment considerations in actinic keratosis.
Goldenberg G
J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:12-16. doi: 10.1111/jdv.14152. PMID: 28263018
Diagnosis and treatment of Basal cell and squamous cell carcinoma.
Firnhaber JM
Am Fam Physician 2012 Jul 15;86(2):161-8. PMID: 22962928

Recent clinical studies

Etiology

Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Adverse effects of voriconazole: Over a decade of use.
Levine MT, Chandrasekar PH
Clin Transplant 2016 Nov;30(11):1377-1386. Epub 2016 Oct 14 doi: 10.1111/ctr.12834. PMID: 27581783
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559
Skin precancer.
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Diagnosis

Epidemiology of advanced cutaneous squamous cell carcinoma.
Dessinioti C, Pitoulias M, Stratigos AJ
J Eur Acad Dermatol Venereol 2022 Jan;36(1):39-50. Epub 2021 Oct 11 doi: 10.1111/jdv.17709. PMID: 34592000
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Immunotherapy for skin cancer.
Paulson KG, Lahman MC, Chapuis AG, Brownell I
Int Immunol 2019 Jul 13;31(7):465-475. doi: 10.1093/intimm/dxz012. PMID: 30753483Free PMC Article
Diagnosis and treatment of Basal cell and squamous cell carcinoma.
Firnhaber JM
Am Fam Physician 2012 Jul 15;86(2):161-8. PMID: 22962928

Therapy

Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Adverse effects of voriconazole: Over a decade of use.
Levine MT, Chandrasekar PH
Clin Transplant 2016 Nov;30(11):1377-1386. Epub 2016 Oct 14 doi: 10.1111/ctr.12834. PMID: 27581783
Sun protection for preventing basal cell and squamous cell skin cancers.
Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, Olmos M, Godfrey K, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2016 Jul 25;7(7):CD011161. doi: 10.1002/14651858.CD011161.pub2. PMID: 27455163Free PMC Article
Chemotherapy of squamous cell carcinoma of the skin.
DeConti RC
Semin Oncol 2012 Apr;39(2):145-9. doi: 10.1053/j.seminoncol.2012.01.002. PMID: 22484186

Prognosis

Tumor-associated macrophage-derived chemokine CCL5 facilitates the progression and immunosuppressive tumor microenvironment of clear cell renal cell carcinoma.
Xu W, Wu Y, Liu W, Anwaier A, Tian X, Su J, Huang H, Wei G, Qu Y, Zhang H, Ye D
Int J Biol Sci 2022;18(13):4884-4900. Epub 2022 Jul 18 doi: 10.7150/ijbs.74647. PMID: 35982911Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker.
Cheng X, Wang X, Nie K, Cheng L, Zhang Z, Hu Y, Peng W
Front Immunol 2021;12:646523. Epub 2021 Feb 17 doi: 10.3389/fimmu.2021.646523. PMID: 33679809Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Pilomatrix carcinoma.
Sau P, Lupton GP, Graham JH
Cancer 1993 Apr 15;71(8):2491-8. doi: 10.1002/1097-0142(19930415)71:8<2491::aid-cncr2820710811>3.0.co;2-i. PMID: 8453573

Clinical prediction guides

The BRCAness Landscape of Cancer.
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
Tumor-associated macrophage-derived chemokine CCL5 facilitates the progression and immunosuppressive tumor microenvironment of clear cell renal cell carcinoma.
Xu W, Wu Y, Liu W, Anwaier A, Tian X, Su J, Huang H, Wei G, Qu Y, Zhang H, Ye D
Int J Biol Sci 2022;18(13):4884-4900. Epub 2022 Jul 18 doi: 10.7150/ijbs.74647. PMID: 35982911Free PMC Article
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Skin precancer.
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Recent systematic reviews

Efficacy and prognostic factors of adjuvant radiotherapy for cutaneous squamous cell carcinoma: A systematic review and meta-analysis.
Zhang J, Wang Y, Wijaya WA, Liang Z, Chen J
J Eur Acad Dermatol Venereol 2021 Sep;35(9):1777-1787. Epub 2021 May 27 doi: 10.1111/jdv.17330. PMID: 33930213
Sun protection for preventing basal cell and squamous cell skin cancers.
Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, Olmos M, Godfrey K, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2016 Jul 25;7(7):CD011161. doi: 10.1002/14651858.CD011161.pub2. PMID: 27455163Free PMC Article
Keratoacanthoma clinical behavior: a systematic review.
Savage JA, Maize JC Sr
Am J Dermatopathol 2014 May;36(5):422-9. doi: 10.1097/DAD.0000000000000031. PMID: 24366198
Dermatologic adverse events: golimumab, friend or foe?
Zidi I, Bartegi A, Ben AN
Pharmazie 2011 Jan;66(1):5-10. PMID: 21391428
Interventions for non-metastatic squamous cell carcinoma of the skin.
Lansbury L, Leonardi-Bee J, Perkins W, Goodacre T, Tweed JA, Bath-Hextall FJ
Cochrane Database Syst Rev 2010 Apr 14;(4):CD007869. doi: 10.1002/14651858.CD007869.pub2. PMID: 20393962

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