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Verruciform xanthoma

MedGen UID:
91076
•Concept ID:
C0346054
•
Neoplastic Process
Synonyms: Cutaneous Verruciform Xanthoma; cutaneous verruciform xanthoma; Histiocytosis Y; Skin Verruciform Xanthoma; skin verruciform xanthoma; Verruciform Xanthoma; verruciform xanthoma; verruciform xanthoma (morphologic abnormality); Verruciform xanthoma of skin; Verruciform Xanthoma of Skin; verruciform xanthoma of skin; Verruciform Xanthoma of the Skin; verruciform xanthoma of the skin
SNOMED CT: Verruciform xanthoma (66174008); Histiocytosis Y (66174008); Verruciform xanthoma of skin (254756007)
 
HPO: HP:0031517
Monarch Initiative: MONDO:0003640

Definition

A papillary or cauliflower-like growth characterized by the presence of foamy histiocytes within the elongated dermal papillae forms. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVerruciform xanthoma

Recent clinical studies

Etiology

Verruciform Xanthoma: Clinical and Morphologic Spectrum Across Oral, Genital, and Cutaneous Sites.
Javadi T, Saeed F, Parker DC, Magliocca KR
Head Neck Pathol 2023 Sep;17(3):673-678. Epub 2023 Jul 7 doi: 10.1007/s12105-023-01568-4. PMID: 37420145Free PMC Article
Oral verruciform xanthoma in chronic graft-versus-host disease patients.
Bar O, Elad S, Avni B, Abu-Tair J, Zaharia B, Hanut A, Zadik Y
Support Care Cancer 2021 Jan;29(1):79-84. Epub 2020 Aug 15 doi: 10.1007/s00520-020-05681-w. PMID: 32803727
HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
A Guide to Yellow Oral Mucosal Entities: Etiology and Pathology.
Schafer DR, Glass SH
Head Neck Pathol 2019 Mar;13(1):33-46. Epub 2019 Jan 31 doi: 10.1007/s12105-018-0977-4. PMID: 30693453Free PMC Article
Oral verruciform xanthoma: Report of 13 new cases and review of the literature.
Tamiolakis P, Theofilou VI, Tosios KI, Sklavounou-Andrikopoulou A
Med Oral Patol Oral Cir Bucal 2018 Jul 1;23(4):e429-e435. doi: 10.4317/medoral.22342. PMID: 29924759Free PMC Article

Diagnosis

Verruciform Xanthoma: Clinical and Morphologic Spectrum Across Oral, Genital, and Cutaneous Sites.
Javadi T, Saeed F, Parker DC, Magliocca KR
Head Neck Pathol 2023 Sep;17(3):673-678. Epub 2023 Jul 7 doi: 10.1007/s12105-023-01568-4. PMID: 37420145Free PMC Article
Subungual Verruciform Xanthoma.
Haneke E
Dermatol Surg 2021 May 1;47(5):722-724. doi: 10.1097/DSS.0000000000002640. PMID: 33481453
HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
Verruciform xanthoma.
Gill BJ, Chan AJ, Hsu S
Dermatol Online J 2014 Jan 15;20(1):21253. PMID: 24456956
Verruciform xanthoma.
Robinson MR, Meehan SA
Cutis 2013 Jun;91(6):272, 285-6. PMID: 23837157

Therapy

Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform xanthoma of the scrotum and literature review.
Beutler BD, Cohen PR
Dermatol Online J 2015 Aug 15;21(8) PMID: 26437158
Disseminated verruciform xanthoma: a case report.
Tang R, Kopp SA, Cobb C, Halpern AV
Cutis 2014 Jun;93(6):307-10. PMID: 24999643
Verruciform xanthoma: report of two cases.
Teixeira V, Reis JP, Tellechea Ó, Vieira R, Figueiredo A
Dermatol Online J 2012 May 15;18(5):10. PMID: 22630580
Esophageal verruciform xanthoma following radiotherapy.
Salamanca J, Alemany I, Sosa G, Pinedo F, Hernando S, Martín-Acosta P
Gastroenterol Hepatol 2012 May;35(5):317-20. Epub 2012 Jan 28 doi: 10.1016/j.gastrohep.2011.12.009. PMID: 22285788
Verruciform xanthoma in a psoriatic patient under PUVA therapy.
Yamamoto T, Katayama I, Nishioka K
Dermatology 1995;191(3):254-6. doi: 10.1159/000246557. PMID: 8534948

Prognosis

Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature.
Capocasale G, Panzarella V, Tozzo P, Mauceri R, Rodolico V, Lauritano D, Campisi G
BMC Res Notes 2017 Nov 28;10(1):631. doi: 10.1186/s13104-017-2952-7. PMID: 29183344Free PMC Article
Verruciform xanthoma and neurofibromatosis: a case report.
Anbinder AL, Quirino MR, Brandão AA
Br J Oral Maxillofac Surg 2011 Jun;49(4):e6-7. Epub 2010 Jul 16 doi: 10.1016/j.bjoms.2010.06.013. PMID: 20638163
Oral verruciform xanthoma: a clinicopathologic study of 15 cases.
Yu CH, Tsai TC, Wang JT, Liu BY, Wang YP, Sun A, Chiang CP
J Formos Med Assoc 2007 Feb;106(2):141-7. doi: 10.1016/S0929-6646(09)60230-8. PMID: 17339158
Verruciform xanthoma in close association with isolated epidermolytic acanthoma: a case report and review of the Japanese dermatological literature.
Fukuda H, Saito R
J Dermatol 2005 Jun;32(6):464-8. doi: 10.1111/j.1346-8138.2005.tb00781.x. PMID: 16043921
Verruciform xanthoma--biological profile of 282 oral lesions based on a literature survey with nine new cases from Japan.
Philipsen HP, Reichart PA, Takata T, Ogawa I
Oral Oncol 2003 Jun;39(4):325-36. doi: 10.1016/s1368-8375(02)00088-x. PMID: 12676251

Clinical prediction guides

Verruciform xanthoma accompanying a cystic growth: A case report.
Hara M, Kato Y, Kaku Y, Tsujioka K
J Cutan Pathol 2020 May;47(5):475-478. Epub 2019 Dec 23 doi: 10.1111/cup.13629. PMID: 31845384
Verruciform Xanthoma with Equivocal Exfoliative Cytological Diagnosis.
Onda T, Hayashi K, Shiraishi N, Takano N, Shibahara T
Bull Tokyo Dent Coll 2018;59(3):193-200. doi: 10.2209/tdcpublication.2017-0034. PMID: 30224613
Oral verruciform xanthoma and erythroplakia associated with chronic graft-versus-host disease: a rare case report and review of the literature.
Capocasale G, Panzarella V, Tozzo P, Mauceri R, Rodolico V, Lauritano D, Campisi G
BMC Res Notes 2017 Nov 28;10(1):631. doi: 10.1186/s13104-017-2952-7. PMID: 29183344Free PMC Article
Verruciform Genital-Associated (Vegas) Xanthoma: report of a patient with verruciform xanthoma of the scrotum and literature review.
Beutler BD, Cohen PR
Dermatol Online J 2015 Aug 15;21(8) PMID: 26437158
Verruciform xanthoma of the esophagus.
Herrera-Goepfert R, Lizano-Soberón M, García-Perales M
Hum Pathol 2003 Aug;34(8):814-5. doi: 10.1016/s0046-8177(03)00236-3. PMID: 14506645

Recent systematic reviews

Zebras in Foreskin Dermatopathology: A Review.
Alhatem A, Patel N, Lambert WC, Heller DS
J Low Genit Tract Dis 2019 Jul;23(3):235-240. doi: 10.1097/LGT.0000000000000478. PMID: 31149956

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