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Skin Hemangioendothelioma

MedGen UID:
91082
•Concept ID:
C0346086
•
Neoplastic Process
Synonyms: Angioendothelioma of Skin; Angioendothelioma of the Skin; Hemangioendothelioma of skin; Hemangioendothelioma of Skin; Hemangioendothelioma of the Skin; Skin Angioendothelioma
SNOMED CT: Hemangioendothelioma of skin (254798005)

Definition

A vascular proliferation arising from the skin. It is characterized by the presence of prominent endothelial cells and formation of vascular channels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Hemangioendothelioma

Professional guidelines

PubMed

Infantile hemangioma. Part 2: Management.
Sebaratnam DF, Rodríguez Bandera AL, Wong LF, Wargon O
J Am Acad Dermatol 2021 Dec;85(6):1395-1404. Epub 2021 Aug 19 doi: 10.1016/j.jaad.2021.08.020. PMID: 34419523
Consensus Statement for the Management and Treatment of Port-Wine Birthmarks in Sturge-Weber Syndrome.
Sabeti S, Ball KL, Burkhart C, Eichenfield L, Fernandez Faith E, Frieden IJ, Geronemus R, Gupta D, Krakowski AC, Levy ML, Metry D, Nelson JS, Tollefson MM, Kelly KM
JAMA Dermatol 2021 Jan 1;157(1):98-104. doi: 10.1001/jamadermatol.2020.4226. PMID: 33175124Free PMC Article
Clinical Practice Guideline for the Management of Infantile Hemangiomas.
Krowchuk DP, Frieden IJ, Mancini AJ, Darrow DH, Blei F, Greene AK, Annam A, Baker CN, Frommelt PC, Hodak A, Pate BM, Pelletier JL, Sandrock D, Weinberg ST, Whelan MA; SUBCOMMITTEE ON THE MANAGEMENT OF INFANTILE HEMANGIOMAS
Pediatrics 2019 Jan;143(1) doi: 10.1542/peds.2018-3475. PMID: 30584062

Recent clinical studies

Etiology

Benign Neonatal Hemangiomatosis.
Miller AC, Gordon ES, Peterson CR, Cohen DJ, Bowe AC
Adv Neonatal Care 2022 Oct 1;22(5):408-412. Epub 2022 Mar 29 doi: 10.1097/ANC.0000000000000982. PMID: 35749711
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Clinical Practice Guideline for the Management of Infantile Hemangiomas.
Krowchuk DP, Frieden IJ, Mancini AJ, Darrow DH, Blei F, Greene AK, Annam A, Baker CN, Frommelt PC, Hodak A, Pate BM, Pelletier JL, Sandrock D, Weinberg ST, Whelan MA; SUBCOMMITTEE ON THE MANAGEMENT OF INFANTILE HEMANGIOMAS
Pediatrics 2019 Jan;143(1) doi: 10.1542/peds.2018-3475. PMID: 30584062
Infantile haemangioma.
Léauté-Labrèze C, Harper JI, Hoeger PH
Lancet 2017 Jul 1;390(10089):85-94. Epub 2017 Jan 13 doi: 10.1016/S0140-6736(16)00645-0. PMID: 28089471
PELVIS Syndrome.
Girard C, Bigorre M, Guillot B, Bessis D
Arch Dermatol 2006 Jul;142(7):884-8. doi: 10.1001/archderm.142.7.884. PMID: 16847205

Diagnosis

Vascular Lesions.
Urban MJ, Williams EF 3rd
Facial Plast Surg Clin North Am 2024 Feb;32(1):13-25. Epub 2023 Oct 21 doi: 10.1016/j.fsc.2023.09.003. PMID: 37981409
Infantile haemangiomas.
Surlis T, De Sa Reilly H, Sadlier M, Nelson J
BMJ 2022 Jul 6;378:e068734. doi: 10.1136/bmj-2021-068734. PMID: 35793832
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
What is new in endothelial neoplasia?
Papke DJ Jr, Hornick JL
Virchows Arch 2020 Jan;476(1):17-28. Epub 2019 Aug 28 doi: 10.1007/s00428-019-02651-4. PMID: 31463731
Cutaneous Malignant Vascular Neoplasms.
Shon W, Billings SD
Clin Lab Med 2017 Sep;37(3):633-646. Epub 2017 Jul 13 doi: 10.1016/j.cll.2017.06.004. PMID: 28802504

Therapy

Infantile Hemangiomas.
Hasbani DJ, Hamie L
Dermatol Clin 2022 Oct;40(4):383-392. Epub 2022 Sep 16 doi: 10.1016/j.det.2022.06.004. PMID: 36243426
Infantile Hemangioma: A Current Review.
Pahl KS, McLean TW
J Pediatr Hematol Oncol 2022 Mar 1;44(2):31-39. doi: 10.1097/MPH.0000000000002384. PMID: 34966091
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Infantile haemangioma.
Léauté-Labrèze C, Harper JI, Hoeger PH
Lancet 2017 Jul 1;390(10089):85-94. Epub 2017 Jan 13 doi: 10.1016/S0140-6736(16)00645-0. PMID: 28089471
Vascular Lesions.
Slaughter KA, Chen T, Williams E 3rd
Facial Plast Surg Clin North Am 2016 Nov;24(4):559-571. doi: 10.1016/j.fsc.2016.06.009. PMID: 27712821

Prognosis

Incidence, demographics, and survival of malignant hemangioendothelioma in the United States.
Paulson KG, Ravi V, Rubin BP, Park M, Loggers ET, Cranmer LD, Wagner MJ
Cancer Med 2023 Jul;12(14):15101-15106. Epub 2023 Jun 1 doi: 10.1002/cam4.6181. PMID: 37260142Free PMC Article
Laser treatment of infantile hemangioma.
Ziad K, Badi J, Roaa Z, Emily AH
J Cosmet Dermatol 2023 Jun;22 Suppl 2:1-7. Epub 2023 Feb 12 doi: 10.1111/jocd.15671. PMID: 36774645
Infantile Hemangioma: A Current Review.
Pahl KS, McLean TW
J Pediatr Hematol Oncol 2022 Mar 1;44(2):31-39. doi: 10.1097/MPH.0000000000002384. PMID: 34966091
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Cutaneous Malignant Vascular Neoplasms.
Shon W, Billings SD
Clin Lab Med 2017 Sep;37(3):633-646. Epub 2017 Jul 13 doi: 10.1016/j.cll.2017.06.004. PMID: 28802504

Clinical prediction guides

Benign Neonatal Hemangiomatosis.
Miller AC, Gordon ES, Peterson CR, Cohen DJ, Bowe AC
Adv Neonatal Care 2022 Oct 1;22(5):408-412. Epub 2022 Mar 29 doi: 10.1097/ANC.0000000000000982. PMID: 35749711
Efficacy and Safety of Topical Timolol for the Treatment of Infantile Hemangioma in the Early Proliferative Stage: A Randomized Clinical Trial.
Muñoz-Garza FZ, Ríos M, Roé-Crespo E, Bernabeu-Wittel J, Montserrat-García MT, Puig L, Gich I, Baselga E
JAMA Dermatol 2021 May 1;157(5):583-587. doi: 10.1001/jamadermatol.2021.0596. PMID: 33825828Free PMC Article
Infantile Hemangioma: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL
Curr Pediatr Rev 2021;17(1):55-69. doi: 10.2174/1573396316666200508100038. PMID: 32384034
Infantile haemangioma.
Léauté-Labrèze C, Harper JI, Hoeger PH
Lancet 2017 Jul 1;390(10089):85-94. Epub 2017 Jan 13 doi: 10.1016/S0140-6736(16)00645-0. PMID: 28089471
PELVIS Syndrome.
Girard C, Bigorre M, Guillot B, Bessis D
Arch Dermatol 2006 Jul;142(7):884-8. doi: 10.1001/archderm.142.7.884. PMID: 16847205

Recent systematic reviews

Skin sequelae in patients with infantile hemangioma: a systematic review.
Li W, Kang J, Bai S, Yuan L, Liu J, Bi Y, Sun J, He Y
Eur J Pediatr 2023 Feb;182(2):479-488. Epub 2022 Nov 24 doi: 10.1007/s00431-022-04688-1. PMID: 36434402
Interventions for infantile haemangiomas of the skin.
Novoa M, Baselga E, Beltran S, Giraldo L, Shahbaz A, Pardo-Hernandez H, Arevalo-Rodriguez I
Cochrane Database Syst Rev 2018 Apr 18;4(4):CD006545. doi: 10.1002/14651858.CD006545.pub3. PMID: 29667726Free PMC Article
Treatment of kaposiform hemangioendothelioma and tufted angioma.
Liu XH, Li JY, Qu XH, Yan WL, Zhang L, Yang C, Zheng JW
Int J Cancer 2016 Oct 1;139(7):1658-66. Epub 2016 Jun 28 doi: 10.1002/ijc.30216. PMID: 27252149
Laser treatment of infantile hemangioma: A systematic review.
Chinnadurai S, Sathe NA, Surawicz T
Lasers Surg Med 2016 Mar;48(3):221-33. Epub 2015 Dec 29 doi: 10.1002/lsm.22455. PMID: 26711436
Interventions for infantile haemangiomas (strawberry birthmarks) of the skin.
Leonardi-Bee J, Batta K, O'Brien C, Bath-Hextall FJ
Cochrane Database Syst Rev 2011 May 11;(5):CD006545. doi: 10.1002/14651858.CD006545.pub2. PMID: 21563155

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