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Pineal parenchymal cell neoplasm

MedGen UID:
910833
•Concept ID:
CN241427
•
Finding
Synonyms: neoplasm of pineal gland; neoplasm of the pineal gland; pineal gland neoplasm; pineal gland tumor; pineal gland tumour; pineal parenchymal cell neoplasm; pineal parenchymal cell tumor; pineal parenchymal cell tumour; pineal parenchymal neoplasm; pineal parenchymal tumor; pineal parenchymal tumour; pineocytic neoplasm; pineocytic tumor; pineocytic tumour; tumor of pineal gland; tumor of the pineal gland; tumour of pineal gland; tumour of the pineal gland
 
HPO: HP:0030694
Monarch Initiative: MONDO:0024890

Definition

A neoplasm arising from the pineocyte, a cell with photosensory and neuroendocrine functions. It may be composed of mature elements or primitive, immature cells. The cellular composition determines the biological behavior and clinical outcome. Three types are recognized: pineoblastoma, pineocytoma, and pineal parenchymal tumor of intermediate differentiation (Adapted from WHO.) [from MONDO]

Professional guidelines

PubMed

Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090
The management of pineal tumors as a model for a multidisciplinary approach in neuro-oncology.
Frappaz D, Conter CF, Szathmari A, Valsijevic A, Mottolese C
Neurochirurgie 2015 Apr-Jun;61(2-3):208-11. Epub 2014 May 24 doi: 10.1016/j.neuchi.2014.03.003. PMID: 24863688

Recent clinical studies

Etiology

Pineal/germ cell tumors and pineal parenchymal tumors.
Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
In and around the pineal gland: a neuroimaging review.
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Pineal Parenchymal Tumor of Intermediate Differentiation (PPTID) and Papillary Tumor of Pineal Region (PTPR): A Review.
Sadashiva N, Deora H, Arumalla K, Rao S, Saini J, Shukla D, Santosh V
Neurol India 2021 Sep-Oct;69(5):1153-1164. doi: 10.4103/0028-3886.329550. PMID: 34747779
Stereotactic Radiosurgery for Pineal Region Tumors.
Mathieu D, Iorio-Morin C
Prog Neurol Surg 2019;34:173-183. Epub 2019 May 16 doi: 10.1159/000493062. PMID: 31096261
Pineal tumors.
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647

Diagnosis

Pineal/germ cell tumors and pineal parenchymal tumors.
Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Imagery of pineal tumors.
Deiana G, Mottolese C, Hermier M, Louis-Tisserand G, Berthezene Y
Neurochirurgie 2015 Apr-Jun;61(2-3):113-22. Epub 2015 Feb 9 doi: 10.1016/j.neuchi.2014.10.111. PMID: 25676911
Pineal tumors.
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Pineal tumors.
Baumgartner JE, Edwards MS
Neurosurg Clin N Am 1992 Oct;3(4):853-62. PMID: 1392580

Therapy

Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study.
Liu APY, Li BK, Pfaff E, Gudenas B, Vasiljevic A, Orr BA, Dufour C, Snuderl M, Karajannis MA, Rosenblum MK, Hwang EI, Ng HK, Hansford JR, Szathmari A, Faure-Conter C, Merchant TE, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson GW, Gajjar A, Pfister SM, Bouffet E, Northcott PA, Jones DTW, Huang A
Acta Neuropathol 2021 May;141(5):771-785. Epub 2021 Feb 22 doi: 10.1007/s00401-021-02284-5. PMID: 33619588Free PMC Article
Microsurgical resection of pineal region tumors.
Sonabend AM, Bowden S, Bruce JN
J Neurooncol 2016 Nov;130(2):351-366. Epub 2016 May 19 doi: 10.1007/s11060-016-2138-5. PMID: 27193692
Pineal germ cell tumors.
Matsutani M
Prog Neurol Surg 2009;23:76-85. Epub 2009 Mar 23 doi: 10.1159/000210054. PMID: 19329862
Trilateral retinoblastoma.
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402
Pinealoblastomas in children.
Cuccia V, Rodríguez F, Palma F, Zuccaro G
Childs Nerv Syst 2006 Jun;22(6):577-85. Epub 2006 Mar 23 doi: 10.1007/s00381-006-0095-6. PMID: 16555075

Prognosis

Histopathology and molecular pathology of pediatric pineal parenchymal tumors.
Vasiljevic A
Childs Nerv Syst 2023 Sep;39(9):2273-2284. Epub 2022 Aug 16 doi: 10.1007/s00381-022-05637-x. PMID: 35972537
Pineal Parenchymal Tumor of Intermediate Differentiation (PPTID) and Papillary Tumor of Pineal Region (PTPR): A Review.
Sadashiva N, Deora H, Arumalla K, Rao S, Saini J, Shukla D, Santosh V
Neurol India 2021 Sep-Oct;69(5):1153-1164. doi: 10.4103/0028-3886.329550. PMID: 34747779
Incidence of pineal tumours. A review of the literature.
Mottolese C, Szathmari A, Beuriat PA
Neurochirurgie 2015 Apr-Jun;61(2-3):65-9. Epub 2014 Aug 10 doi: 10.1016/j.neuchi.2014.01.005. PMID: 25113513
Pineal germinoma.
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Pineal tumors.
Baumgartner JE, Edwards MS
Neurosurg Clin N Am 1992 Oct;3(4):853-62. PMID: 1392580

Clinical prediction guides

Pineal cysts in children: a paediatric series treated over the last twenty years in Lyon.
Szathmari A, Vasiljevic A, Di Rocco F, Beuriat PA, Mottolese C
Childs Nerv Syst 2023 Dec;39(12):3467-3474. Epub 2023 Oct 29 doi: 10.1007/s00381-023-06181-y. PMID: 37898987
Concomitant, Single Burr Hole Endoscopic Third Ventriculostomy and Tumor Biopsy for Pineal Lesions: Feasibility, Safety, and Benefits.
Leone A, Colamaria A, Fochi NP, Di Napoli V, Blagia M, Sacco M, Winkler G, Spetzger U, Almerayed W, Carbone F
World Neurosurg 2023 May;173:5-11. Epub 2023 Feb 9 doi: 10.1016/j.wneu.2023.01.082. PMID: 36764448
Differentiation between germinoma and other pineal region tumors using diffusion-and susceptibility-weighted MRI.
Phuttharak W, Wannasarnmetha M, Lueangingkasut P, Waraasawapati S, Mukherji SK
Eur J Radiol 2023 Feb;159:110663. Epub 2022 Dec 20 doi: 10.1016/j.ejrad.2022.110663. PMID: 36584565
Clinical Efficacy of Endoscopic Infratentorial Supracerebellar Approach for Pineal Region Tumors: A Retrospective Case-Control Study.
Zhu Y, Li Z, Xiong Z, Zhang T, Chen J
Contrast Media Mol Imaging 2022;2022:5702309. Epub 2022 Aug 10 doi: 10.1155/2022/5702309. PMID: 36017015Free PMC Article
Pineal germ cell tumors: review.
Miškovská V, Usakova V, Vertakova-Krakovska B, Mrinakova B, Lehotská V, Chorváth M, Rychlý B, Steno J, Ondruš D
Klin Onkol 2013;26(1):19-24. doi: 10.14735/amko201319. PMID: 23528168

Recent systematic reviews

Primary Gamma Knife Radiosurgery for pineal region tumors: A systematic review and pooled analysis of available literature with histological stratification.
Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090
Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors.
Yamaki VN, Solla DJF, Ribeiro RR, da Silva SA, Teixeira MJ, Figueiredo EG
Neurosurgery 2019 Sep 1;85(3):E420-E429. doi: 10.1093/neuros/nyz062. PMID: 30989225
Regression of Pineal Lesions: Spontaneous or Iatrogenic? A Case Report and Systematic Literature Review.
Schipmann S, Keurhorst D, Köchling M, Schwake M, Heß K, Sundermann B, Stummer W, Brentrup A
World Neurosurg 2017 Dec;108:939-947.e1. Epub 2017 Aug 24 doi: 10.1016/j.wneu.2017.08.106. PMID: 28844909

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