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Breast benign neoplasm

MedGen UID:
91085
•Concept ID:
C0346156
•
Neoplastic Process
Synonyms: Benign Breast Neoplasm; benign breast neoplasm; Benign Breast Tumor; benign breast tumor; benign breast tumour; Benign neoplasm of breast; Benign Neoplasm of Breast; benign neoplasm of breast; Benign Neoplasm of the Breast; benign neoplasm of the breast; Benign tumor of breast; Benign Tumor of Breast; benign tumor of breast; Benign Tumor of the Breast; benign tumor of the breast; benign tumour of breast; benign tumour of the breast; breast benign neoplasm
SNOMED CT: Benign neoplasm of breast (269485000); Benign tumor of breast (269485000)
 
Monarch Initiative: MONDO:0000620

Definition

A neoplasm that arises from the breast and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Early breast cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Loibl S, André F, Bachelot T, Barrios CH, Bergh J, Burstein HJ, Cardoso MJ, Carey LA, Dawood S, Del Mastro L, Denkert C, Fallenberg EM, Francis PA, Gamal-Eldin H, Gelmon K, Geyer CE, Gnant M, Guarneri V, Gupta S, Kim SB, Krug D, Martin M, Meattini I, Morrow M, Janni W, Paluch-Shimon S, Partridge A, Poortmans P, Pusztai L, Regan MM, Sparano J, Spanic T, Swain S, Tjulandin S, Toi M, Trapani D, Tutt A, Xu B, Curigliano G, Harbeck N; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2024 Feb;35(2):159-182. Epub 2023 Dec 13 doi: 10.1016/j.annonc.2023.11.016. PMID: 38101773
Pretransplant solid organ malignancy and organ transplant candidacy: A consensus expert opinion statement.
Al-Adra DP, Hammel L, Roberts J, Woodle ES, Levine D, Mandelbrot D, Verna E, Locke J, D'Cunha J, Farr M, Sawinski D, Agarwal PK, Plichta J, Pruthi S, Farr D, Carvajal R, Walker J, Zwald F, Habermann T, Gertz M, Bierman P, Dizon DS, Langstraat C, Al-Qaoud T, Eggener S, Richgels JP, Chang GJ, Geltzeiler C, Sapisochin G, Ricciardi R, Krupnick AS, Kennedy C, Mohindra N, Foley DP, Watt KD
Am J Transplant 2021 Feb;21(2):460-474. Epub 2020 Oct 23 doi: 10.1111/ajt.16318. PMID: 32969590Free PMC Article
Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment.
Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D, Zick SM, Boyce LM, Tripathy D
CA Cancer J Clin 2017 May 6;67(3):194-232. Epub 2017 Apr 24 doi: 10.3322/caac.21397. PMID: 28436999Free PMC Article

Recent clinical studies

Etiology

Idiopathic Granulomatous Mastitis.
Dilaveri C, Degnim A, Lee C, DeSimone D, Moldoveanu D, Ghosh K
Breast J 2024;2024:6693720. Epub 2024 Jan 25 doi: 10.1155/2024/6693720. PMID: 38304866Free PMC Article
Contrast-enhanced mammography in breast cancer screening.
Coffey K, Jochelson MS
Eur J Radiol 2022 Nov;156:110513. Epub 2022 Sep 10 doi: 10.1016/j.ejrad.2022.110513. PMID: 36108478Free PMC Article
Benign Breast Disease.
Pleasant V
Clin Obstet Gynecol 2022 Sep 1;65(3):448-460. Epub 2022 Jun 16 doi: 10.1097/GRF.0000000000000719. PMID: 35708970
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Fibrocystic Breast Changes.
Faguy K
Radiol Technol 2022 Jan;93(3):303M-315M. PMID: 35017277

Diagnosis

Idiopathic Granulomatous Mastitis.
Dilaveri C, Degnim A, Lee C, DeSimone D, Moldoveanu D, Ghosh K
Breast J 2024;2024:6693720. Epub 2024 Jan 25 doi: 10.1155/2024/6693720. PMID: 38304866Free PMC Article
Contrast-enhanced mammography in breast cancer screening.
Coffey K, Jochelson MS
Eur J Radiol 2022 Nov;156:110513. Epub 2022 Sep 10 doi: 10.1016/j.ejrad.2022.110513. PMID: 36108478Free PMC Article
Benign Breast Disease.
Pleasant V
Clin Obstet Gynecol 2022 Sep 1;65(3):448-460. Epub 2022 Jun 16 doi: 10.1097/GRF.0000000000000719. PMID: 35708970
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Breast Biomechanics: What Do We Really Know?
McGhee DE, Steele JR
Physiology (Bethesda) 2020 Mar 1;35(2):144-156. doi: 10.1152/physiol.00024.2019. PMID: 32027563

Therapy

Combining causal and correlative approaches to discover biomarkers of response to paclitaxel.
Moscona-Nissan A, Habashy KJ, Arrieta VA, Sonabend AM, Dmello C
Oncotarget 2024 Feb 8;15:117-122. doi: 10.18632/oncotarget.28549. PMID: 38329732Free PMC Article
Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
4th ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)†.
Cardoso F, Senkus E, Costa A, Papadopoulos E, Aapro M, André F, Harbeck N, Aguilar Lopez B, Barrios CH, Bergh J, Biganzoli L, Boers-Doets CB, Cardoso MJ, Carey LA, Cortés J, Curigliano G, Diéras V, El Saghir NS, Eniu A, Fallowfield L, Francis PA, Gelmon K, Johnston SRD, Kaufman B, Koppikar S, Krop IE, Mayer M, Nakigudde G, Offersen BV, Ohno S, Pagani O, Paluch-Shimon S, Penault-Llorca F, Prat A, Rugo HS, Sledge GW, Spence D, Thomssen C, Vorobiof DA, Xu B, Norton L, Winer EP
Ann Oncol 2018 Aug 1;29(8):1634-1657. doi: 10.1093/annonc/mdy192. PMID: 30032243Free PMC Article
Breast Cancer Screening, Mammography, and Other Modalities.
Fiorica JV
Clin Obstet Gynecol 2016 Dec;59(4):688-709. doi: 10.1097/GRF.0000000000000246. PMID: 27741212
Long-term results of hypofractionated radiation therapy for breast cancer.
Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, Shelley W, Grimard L, Bowen J, Lukka H, Perera F, Fyles A, Schneider K, Gulavita S, Freeman C
N Engl J Med 2010 Feb 11;362(6):513-20. doi: 10.1056/NEJMoa0906260. PMID: 20147717

Prognosis

Analysis of Breast Cancer Mortality in the US-1975 to 2019.
Caswell-Jin JL, Sun LP, Munoz D, Lu Y, Li Y, Huang H, Hampton JM, Song J, Jayasekera J, Schechter C, Alagoz O, Stout NK, Trentham-Dietz A, Lee SJ, Huang X, Mandelblatt JS, Berry DA, Kurian AW, Plevritis SK
JAMA 2024 Jan 16;331(3):233-241. doi: 10.1001/jama.2023.25881. PMID: 38227031Free PMC Article
Breast cancer immunotherapy: Current and novel approaches.
Barzaman K, Moradi-Kalbolandi S, Hosseinzadeh A, Kazemi MH, Khorramdelazad H, Safari E, Farahmand L
Int Immunopharmacol 2021 Sep;98:107886. Epub 2021 Jun 19 doi: 10.1016/j.intimp.2021.107886. PMID: 34153663
Comparison of Abbreviated Breast MRI vs Digital Breast Tomosynthesis for Breast Cancer Detection Among Women With Dense Breasts Undergoing Screening.
Comstock CE, Gatsonis C, Newstead GM, Snyder BS, Gareen IF, Bergin JT, Rahbar H, Sung JS, Jacobs C, Harvey JA, Nicholson MH, Ward RC, Holt J, Prather A, Miller KD, Schnall MD, Kuhl CK
JAMA 2020 Feb 25;323(8):746-756. doi: 10.1001/jama.2020.0572. PMID: 32096852Free PMC Article
Supplemental MRI Screening for Women with Extremely Dense Breast Tissue.
Bakker MF, de Lange SV, Pijnappel RM, Mann RM, Peeters PHM, Monninkhof EM, Emaus MJ, Loo CE, Bisschops RHC, Lobbes MBI, de Jong MDF, Duvivier KM, Veltman J, Karssemeijer N, de Koning HJ, van Diest PJ, Mali WPTM, van den Bosch MAAJ, Veldhuis WB, van Gils CH; DENSE Trial Study Group
N Engl J Med 2019 Nov 28;381(22):2091-2102. doi: 10.1056/NEJMoa1903986. PMID: 31774954
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

Clinical prediction guides

Inter- and intra-observer variability of qualitative visual breast-composition assessment in mammography among Japanese physicians: a first multi-institutional observer performance study in Japan.
Koyama Y, Nakashima K, Orihara S, Tsunoda H, Kimura F, Uenaka N, Ban K, Michishita Y, Kanemaki Y, Kurihara A, Tawaraya K, Taguri M, Ishikawa T, Uematsu T
Breast Cancer 2024 Jul;31(4):671-683. Epub 2024 Apr 15 doi: 10.1007/s12282-024-01580-8. PMID: 38619787
Radial scar appearances on contrast-enhanced mammography.
Pienaar WE, Taylor DB, Wylie E
J Med Imaging Radiat Oncol 2023 Aug;67(5):514-518. Epub 2023 Jul 3 doi: 10.1111/1754-9485.13554. PMID: 37401164
Interobserver Variability in Ductal Carcinoma In Situ of the Breast.
Van Bockstal MR, Berlière M, Duhoux FP, Galant C
Am J Clin Pathol 2020 Oct 13;154(5):596-609. doi: 10.1093/ajcp/aqaa077. PMID: 32566938
Low-Grade Ductal Carcinoma In Situ.
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Ductoscopy-assisted microdochectomy.
Escobar PF, Baynes D, Crowe JP
Int J Fertil Womens Med 2004 Sep-Oct;49(5):222-4. PMID: 15633479

Recent systematic reviews

Global Stage Distribution of Breast Cancer at Diagnosis: A Systematic Review and Meta-Analysis.
Benitez Fuentes JD, Morgan E, de Luna Aguilar A, Mafra A, Shah R, Giusti F, Vignat J, Znaor A, Musetti C, Yip CH, Van Eycken L, Jedy-Agba E, Piñeros M, Soerjomataram I
JAMA Oncol 2024 Jan 1;10(1):71-78. doi: 10.1001/jamaoncol.2023.4837. PMID: 37943547Free PMC Article
Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.
Bodewes FTH, van Asselt AA, Dorrius MD, Greuter MJW, de Bock GH
Breast 2022 Dec;66:62-68. Epub 2022 Sep 26 doi: 10.1016/j.breast.2022.09.007. PMID: 36183671Free PMC Article
Global guidelines for breast cancer screening: A systematic review.
Ren W, Chen M, Qiao Y, Zhao F
Breast 2022 Aug;64:85-99. Epub 2022 Apr 19 doi: 10.1016/j.breast.2022.04.003. PMID: 35636342Free PMC Article
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Soy Isoflavones and Breast Cancer Risk: A Meta-analysis.
Boutas I, Kontogeorgi A, Dimitrakakis C, Kalantaridou SN
In Vivo 2022 Mar-Apr;36(2):556-562. doi: 10.21873/invivo.12737. PMID: 35241506Free PMC Article

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