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Breast benign neoplasm

MedGen UID:
91085
•Concept ID:
C0346156
•
Neoplastic Process
Synonyms: Benign Breast Neoplasm; benign breast neoplasm; Benign Breast Tumor; benign breast tumor; benign breast tumour; Benign neoplasm of breast; Benign Neoplasm of Breast; benign neoplasm of breast; Benign Neoplasm of the Breast; benign neoplasm of the breast; Benign tumor of breast; Benign Tumor of Breast; benign tumor of breast; Benign Tumor of the Breast; benign tumor of the breast; benign tumour of breast; benign tumour of the breast; breast benign neoplasm
SNOMED CT: Benign neoplasm of breast (269485000); Benign tumor of breast (269485000)
 
Monarch Initiative: MONDO:0000620

Definition

A neoplasm that arises from the breast and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Early breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2019 Aug 1;30(8):1194-1220. doi: 10.1093/annonc/mdz173. PMID: 31161190
Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment.
Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, Johnson JA, Mumber M, Seely D, Zick SM, Boyce LM, Tripathy D
CA Cancer J Clin 2017 May 6;67(3):194-232. Epub 2017 Apr 24 doi: 10.3322/caac.21397. PMID: 28436999Free PMC Article
Breast cancer biomarkers: risk assessment, diagnosis, prognosis, prediction of treatment efficacy and toxicity, and recurrence.
M Braden A, V Stankowski R, M Engel J, A Onitilo A
Curr Pharm Des 2014;20(30):4879-98. doi: 10.2174/1381612819666131125145517. PMID: 24283956

Recent clinical studies

Etiology

Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Benign Breast Disease.
Pleasant V
Clin Obstet Gynecol 2022 Sep 1;65(3):448-460. Epub 2022 Jun 16 doi: 10.1097/GRF.0000000000000719. PMID: 35708970
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Fibrocystic Breast Changes.
Faguy K
Radiol Technol 2022 Jan;93(3):303M-315M. PMID: 35017277
An overview of mammographic density and its association with breast cancer.
Nazari SS, Mukherjee P
Breast Cancer 2018 May;25(3):259-267. Epub 2018 Apr 12 doi: 10.1007/s12282-018-0857-5. PMID: 29651637Free PMC Article

Diagnosis

Benign Breast Disease.
Pleasant V
Clin Obstet Gynecol 2022 Sep 1;65(3):448-460. Epub 2022 Jun 16 doi: 10.1097/GRF.0000000000000719. PMID: 35708970
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Fibrocystic Breast Changes.
Faguy K
Radiol Technol 2022 Jan;93(3):303M-315M. PMID: 35017277
Breast Biomechanics: What Do We Really Know?
McGhee DE, Steele JR
Physiology (Bethesda) 2020 Mar 1;35(2):144-156. doi: 10.1152/physiol.00024.2019. PMID: 32027563
An overview of mammographic density and its association with breast cancer.
Nazari SS, Mukherjee P
Breast Cancer 2018 May;25(3):259-267. Epub 2018 Apr 12 doi: 10.1007/s12282-018-0857-5. PMID: 29651637Free PMC Article

Therapy

Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.
Hussein H, Abbas E, Keshavarzi S, Fazelzad R, Bukhanov K, Kulkarni S, Au F, Ghai S, Alabousi A, Freitas V
Radiology 2023 Mar;306(3):e221785. Epub 2023 Jan 31 doi: 10.1148/radiol.221785. PMID: 36719288
Comparison of Abbreviated Breast MRI vs Digital Breast Tomosynthesis for Breast Cancer Detection Among Women With Dense Breasts Undergoing Screening.
Comstock CE, Gatsonis C, Newstead GM, Snyder BS, Gareen IF, Bergin JT, Rahbar H, Sung JS, Jacobs C, Harvey JA, Nicholson MH, Ward RC, Holt J, Prather A, Miller KD, Schnall MD, Kuhl CK
JAMA 2020 Feb 25;323(8):746-756. doi: 10.1001/jama.2020.0572. PMID: 32096852Free PMC Article
Breast Cancer Screening, Mammography, and Other Modalities.
Fiorica JV
Clin Obstet Gynecol 2016 Dec;59(4):688-709. doi: 10.1097/GRF.0000000000000246. PMID: 27741212
Long-term results of hypofractionated radiation therapy for breast cancer.
Whelan TJ, Pignol JP, Levine MN, Julian JA, MacKenzie R, Parpia S, Shelley W, Grimard L, Bowen J, Lukka H, Perera F, Fyles A, Schneider K, Gulavita S, Freeman C
N Engl J Med 2010 Feb 11;362(6):513-20. doi: 10.1056/NEJMoa0906260. PMID: 20147717
Androgens and the breast.
von Schoultz B
Maturitas 2007 May 20;57(1):47-9. Epub 2007 Mar 26 doi: 10.1016/j.maturitas.2007.02.012. PMID: 17386984

Prognosis

Analysis of Breast Cancer Mortality in the US-1975 to 2019.
Caswell-Jin JL, Sun LP, Munoz D, Lu Y, Li Y, Huang H, Hampton JM, Song J, Jayasekera J, Schechter C, Alagoz O, Stout NK, Trentham-Dietz A, Lee SJ, Huang X, Mandelblatt JS, Berry DA, Kurian AW, Plevritis SK
JAMA 2024 Jan 16;331(3):233-241. doi: 10.1001/jama.2023.25881. PMID: 38227031Free PMC Article
Breast cancer immunotherapy: Current and novel approaches.
Barzaman K, Moradi-Kalbolandi S, Hosseinzadeh A, Kazemi MH, Khorramdelazad H, Safari E, Farahmand L
Int Immunopharmacol 2021 Sep;98:107886. Epub 2021 Jun 19 doi: 10.1016/j.intimp.2021.107886. PMID: 34153663
Comparison of Abbreviated Breast MRI vs Digital Breast Tomosynthesis for Breast Cancer Detection Among Women With Dense Breasts Undergoing Screening.
Comstock CE, Gatsonis C, Newstead GM, Snyder BS, Gareen IF, Bergin JT, Rahbar H, Sung JS, Jacobs C, Harvey JA, Nicholson MH, Ward RC, Holt J, Prather A, Miller KD, Schnall MD, Kuhl CK
JAMA 2020 Feb 25;323(8):746-756. doi: 10.1001/jama.2020.0572. PMID: 32096852Free PMC Article
Global Trend of Breast Cancer Mortality Rate: A 25-Year Study.
Azamjah N, Soltan-Zadeh Y, Zayeri F
Asian Pac J Cancer Prev 2019 Jul 1;20(7):2015-2020. doi: 10.31557/APJCP.2019.20.7.2015. PMID: 31350959Free PMC Article
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F
Int J Cancer 2015 Mar 1;136(5):E359-86. Epub 2014 Oct 9 doi: 10.1002/ijc.29210. PMID: 25220842

Clinical prediction guides

WSI validation studies in breast and gynecological pathology.
Mastrosimini MG, Eccher A, Nottegar A, Montin U, Scarpa A, Pantanowitz L, Girolami I
Pathol Res Pract 2022 Dec;240:154191. Epub 2022 Oct 28 doi: 10.1016/j.prp.2022.154191. PMID: 36356336
Meta-analysis: Architectural distortion and breast MRI.
Ferre R, Kuzmiak CM
Breast Dis 2022;41(1):205-214. doi: 10.3233/BD-210045. PMID: 35094984
An immune cell infiltration-based immune score model predicts prognosis and chemotherapy effects in breast cancer.
Sui S, An X, Xu C, Li Z, Hua Y, Huang G, Sui S, Long Q, Sui Y, Xiong Y, Ntim M, Guo W, Chen M, Deng W, Xiao X, Li M
Theranostics 2020;10(26):11938-11949. Epub 2020 Oct 25 doi: 10.7150/thno.49451. PMID: 33204321Free PMC Article
Three-dimensional automated breast ultrasound: Technical aspects and first results.
Vourtsis A
Diagn Interv Imaging 2019 Oct;100(10):579-592. Epub 2019 Apr 5 doi: 10.1016/j.diii.2019.03.012. PMID: 30962169
Role of breast density measurement in screening for breast cancer.
McLean KE, Stone J
Climacteric 2018 Jun;21(3):214-220. Epub 2018 Feb 15 doi: 10.1080/13697137.2018.1424816. PMID: 29447010

Recent systematic reviews

Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.
Bodewes FTH, van Asselt AA, Dorrius MD, Greuter MJW, de Bock GH
Breast 2022 Dec;66:62-68. Epub 2022 Sep 26 doi: 10.1016/j.breast.2022.09.007. PMID: 36183671Free PMC Article
Global guidelines for breast cancer screening: A systematic review.
Ren W, Chen M, Qiao Y, Zhao F
Breast 2022 Aug;64:85-99. Epub 2022 Apr 19 doi: 10.1016/j.breast.2022.04.003. PMID: 35636342Free PMC Article
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Soy Isoflavones and Breast Cancer Risk: A Meta-analysis.
Boutas I, Kontogeorgi A, Dimitrakakis C, Kalantaridou SN
In Vivo 2022 Mar-Apr;36(2):556-562. doi: 10.21873/invivo.12737. PMID: 35241506Free PMC Article
Breast surgery for metastatic breast cancer.
Tosello G, Torloni MR, Mota BS, Neeman T, Riera R
Cochrane Database Syst Rev 2018 Mar 15;3(3):CD011276. doi: 10.1002/14651858.CD011276.pub2. PMID: 29542106Free PMC Article

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