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Vulvar intraepithelial neoplasia

MedGen UID:
91093
Concept ID:
C0346210
Neoplastic Process
Synonyms: Dysplasia of vulva; Intraepithelial Neoplasia of the Vulva; intraepithelial neoplasia of the vulva; Intraepithelial Neoplasia of Vulva; intraepithelial neoplasia of vulva; Squamous Vulvar Intraepithelial Neoplasia; squamous vulvar intraepithelial neoplasia; VIN; Vulva Intraepithelial Neoplasia; vulva intraepithelial neoplasia; Vulval intraepithelial neoplasia; Vulval Intraepithelial Neoplasia; vulval intraepithelial neoplasia; Vulval intraepithelial neoplasia (VIN); Vulvar Intraepithelial Neoplasia; vulvar intraepithelial neoplasia; Vulvar intraepithelial tumor; vulvar intraepithelial tumor; vulvar intraepithelial tumour
SNOMED CT: Dysplasia of vulva (399382009); Vulval intraepithelial neoplasia (VIN) (399933001); Vulval intraepithelial neoplasia (399933001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0032202
Monarch Initiative: MONDO:0005198
Orphanet: ORPHA137583

Definition

Vulvar intraepithelial neoplasia (VIN) is widely accepted as the precursor lesion of vulvar squamous cell carcinoma (VSCC). VSCC arises via either a human papilloma virus (HPV)-associated pathway, or more commonly, via a mechanism independent of HPV, often being linked to chronic inflammatory conditions such as lichen sclerosus (LS). Accordingly, two distinct subtypes of VIN are recognised [from HPO]

Professional guidelines

PubMed

Dockery LE, Soper JT
Obstet Gynecol Surv 2021 Jan;76(1):55-62. doi: 10.1097/OGX.0000000000000857. PMID: 33506879
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2020 Jul;136(1):e1-e14. doi: 10.1097/AOG.0000000000003944. PMID: 32590724
Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455

Recent clinical studies

Etiology

Trutnovsky G, Reich O, Joura EA, Holter M, Ciresa-König A, Widschwendter A, Schauer C, Bogner G, Jan Z, Boandl A, Kalteis MS, Regauer S, Tamussino K
Lancet 2022 May 7;399(10337):1790-1798. Epub 2022 Apr 25 doi: 10.1016/S0140-6736(22)00469-X. PMID: 35483400
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Pérez-López FR, Vieira-Baptista P
Climacteric 2017 Aug;20(4):339-347. Epub 2017 Jun 29 doi: 10.1080/13697137.2017.1343295. PMID: 28661705
Preti M, Scurry J, Marchitelli CE, Micheletti L
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):1051-62. Epub 2014 Jul 18 doi: 10.1016/j.bpobgyn.2014.07.010. PMID: 25106700

Diagnosis

Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2020 Jul;136(1):e1-e14. doi: 10.1097/AOG.0000000000003944. PMID: 32590724
Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Woelber L, Prieske K, Mendling W, Schmalfeldt B, Tietz HJ, Jaeger A
Dtsch Arztebl Int 2020 Feb 21;116(8):126-133. doi: 10.3238/arztebl.2020.0126. PMID: 32181734Free PMC Article
Pérez-López FR, Vieira-Baptista P
Climacteric 2017 Aug;20(4):339-347. Epub 2017 Jun 29 doi: 10.1080/13697137.2017.1343295. PMID: 28661705

Therapy

Li Z, Liu P, Wang Z, Zhang Z, Chen Z, Chu R, Li G, Han Q, Zhao Y, Li L, Miao J, Kong B, Song K
Lancet Oncol 2023 Apr;24(4):403-414. Epub 2023 Mar 15 doi: 10.1016/S1470-2045(23)00066-9. PMID: 36933562
Trutnovsky G, Reich O, Joura EA, Holter M, Ciresa-König A, Widschwendter A, Schauer C, Bogner G, Jan Z, Boandl A, Kalteis MS, Regauer S, Tamussino K
Lancet 2022 May 7;399(10337):1790-1798. Epub 2022 Apr 25 doi: 10.1016/S0140-6736(22)00469-X. PMID: 35483400
Nelson EL, Bogliatto F, Stockdale CK
Clin Obstet Gynecol 2015 Sep;58(3):512-25. doi: 10.1097/GRF.0000000000000132. PMID: 26133495
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article
Garland SM
Curr Opin Infect Dis 2003 Apr;16(2):85-9. doi: 10.1097/00001432-200304000-00004. PMID: 12734440

Prognosis

Lebreton M, Carton I, Brousse S, Lavoué V, Body G, Levêque J, Nyangoh-Timoh K
J Gynecol Obstet Hum Reprod 2020 Nov;49(9):101801. Epub 2020 May 14 doi: 10.1016/j.jogoh.2020.101801. PMID: 32417455
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Wohlmuth C, Wohlmuth-Wieser I
J Dtsch Dermatol Ges 2019 Dec;17(12):1257-1276. Epub 2019 Dec 12 doi: 10.1111/ddg.13995. PMID: 31829526Free PMC Article
Williams A, Syed S, Velangi S, Ganesan R
Curr Oncol Rep 2019 Aug 15;21(10):88. doi: 10.1007/s11912-019-0833-z. PMID: 31418120
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907

Clinical prediction guides

Trutnovsky G, Reich O, Joura EA, Holter M, Ciresa-König A, Widschwendter A, Schauer C, Bogner G, Jan Z, Boandl A, Kalteis MS, Regauer S, Tamussino K
Lancet 2022 May 7;399(10337):1790-1798. Epub 2022 Apr 25 doi: 10.1016/S0140-6736(22)00469-X. PMID: 35483400
Lyra J, Melo C, Figueiredo R, Polonia-Valente R, Falcão V, Beires J, Vieira-Baptista P
J Low Genit Tract Dis 2021 Jan 1;25(1):71-75. doi: 10.1097/LGT.0000000000000581. PMID: 33214502
Day T, Marzol A, Pagano R, Jaaback K, Scurry J
J Low Genit Tract Dis 2020 Oct;24(4):392-398. doi: 10.1097/LGT.0000000000000569. PMID: 32976294Free PMC Article
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Smith JS, Backes DM, Hoots BE, Kurman RJ, Pimenta JM
Obstet Gynecol 2009 Apr;113(4):917-924. doi: 10.1097/AOG.0b013e31819bd6e0. PMID: 19305339

Recent systematic reviews

Li Z, Liu P, Wang Z, Zhang Z, Chen Z, Chu R, Li G, Han Q, Zhao Y, Li L, Miao J, Kong B, Song K
Lancet Oncol 2023 Apr;24(4):403-414. Epub 2023 Mar 15 doi: 10.1016/S1470-2045(23)00066-9. PMID: 36933562
Jamieson A, Tse SS, Brar H, Sadownik LA, Proctor L
J Low Genit Tract Dis 2022 Apr 1;26(2):140-146. doi: 10.1097/LGT.0000000000000662. PMID: 35249976
Faber MT, Sand FL, Albieri V, Norrild B, Kjaer SK, Verdoodt F
Int J Cancer 2017 Sep 15;141(6):1161-1169. Epub 2017 Jun 21 doi: 10.1002/ijc.30821. PMID: 28577297
Smith JS, Backes DM, Hoots BE, Kurman RJ, Pimenta JM
Obstet Gynecol 2009 Apr;113(4):917-924. doi: 10.1097/AOG.0b013e31819bd6e0. PMID: 19305339
Insinga RP, Liaw KL, Johnson LG, Madeleine MM
Cancer Epidemiol Biomarkers Prev 2008 Jul;17(7):1611-22. doi: 10.1158/1055-9965.EPI-07-2922. PMID: 18628412Free PMC Article

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