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Oncocytoma of kidney

MedGen UID:
91094
Concept ID:
C0346255
Neoplastic Process
Synonyms: Oncocytoma kidney; Renal oncocytoma
SNOMED CT: Oncocytoma of kidney (254922006)
 
HPO: HP:0011798
Monarch Initiative: MONDO:0003825

Definition

A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. [from HPO]

Conditions with this feature

Oxyphilic adenoma
MedGen UID:
307150
Concept ID:
C1510502
Neoplastic Process
Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely packed cells with mitochondria, which show morphologic differences from those in normal cells. On the average they are larger than those in renal carcinoma cells and their shape is abnormal (summary by Welter et al., 1989).

Professional guidelines

PubMed

Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Abdessater M, Kanbar A, Comperat E, Dupont-Athenor A, Alechinsky L, Mouton M, Sebe P
Urology 2020 Sep;143:173-180. Epub 2020 Jun 5 doi: 10.1016/j.urology.2020.05.047. PMID: 32512107
Massari F, Di Nunno V, Santoni M, Gatto L, Caserta C, Morelli F, Zafarana E, Carrozza F, Mosca A, Mollica V, Iacovelli R, Sabbatini R, Porta C, Bracarda S
Crit Rev Oncol Hematol 2019 Oct;142:141-152. Epub 2019 Aug 2 doi: 10.1016/j.critrevonc.2019.07.020. PMID: 31401421

Recent clinical studies

Diagnosis

Johnson JR, Thurman AE, Metter JB, Bannayan GA
Urology 1979 Aug;14(2):181-5. doi: 10.1016/0090-4295(79)90157-2. PMID: 473471

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