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Pituitary carcinoma

MedGen UID:: 91096
•Concept ID:: C0346300
•: Neoplastic Process

Synonyms:	Cancer of Pituitary; Cancer of the Pituitary; Cancer, Pituitary; Cancers, Pituitary; Carcinoma, Pituitary; Carcinomas, Pituitary; Pituitary Cancer; Pituitary Cancers; Pituitary Carcinoma; Pituitary Carcinomas
SNOMED CT:	Pituitary carcinoma (128665000); Pituitary carcinoma (254955001)
Modes of inheritance:	Unknown inheritance MedGen UID: 989040 •Concept ID: CN307042 • Finding Source: Orphanet Hereditary clinical entity whose mode of inheritance is unknown. See: This record Unknown inheritance (Orphanet)

HPO:	HP:0011763
Monarch Initiative:	MONDO:0017582
Orphanet:	ORPHA300385

Definition

A pituitary tumor with subarachnoid, brain, or systemic metastasis. The diagnosis of a pituitary carcinoma requires evidence of metastatic disease, either outside the central nervous system (CNS) or as separate noncontiguous foci within the CNS. [from HPO]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

Pituitary carcinoma

Pathological process
- Disease
  - Neoplasm
    - Epithelial neoplasm
      - Carcinoma
        Adenocarcinoma
        Pituitary carcinoma
        ACTH-producing pituitary gland carcinoma
        Growth hormone-producing pituitary gland carcinoma
        Malignant thyroid stimulating hormone producing neoplasm of pituitary gland
        Metastatic Unresectable Pituitary Neuroendocrine Tumor
        Prolactin-producing pituitary gland carcinoma

Follow this link to review classifications for Pituitary carcinoma in Orphanet.

Professional guidelines

PubMed

European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas.

Raverot G, Burman P, McCormack A, Heaney A, Petersenn S, Popovic V, Trouillas J, Dekkers OM; European Society of Endocrinology
Eur J Endocrinol 2018 Jan;178(1):G1-G24. Epub 2017 Oct 18 doi: 10.1530/EJE-17-0796. PMID: 29046323

Clinical review: Pituitary carcinoma: difficult diagnosis and treatment.

Heaney AP
J Clin Endocrinol Metab 2011 Dec;96(12):3649-60. Epub 2011 Sep 28 doi: 10.1210/jc.2011-2031. PMID: 21956419 Free PMC Article

Pituitary carcinoma: diagnosis and treatment.

Lopes MB, Scheithauer BW, Schiff D
Endocrine 2005 Oct;28(1):115-21. doi: 10.1385/ENDO:28:1:115. PMID: 16311418

See all (11)

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Pituitary Tumors.

Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028

Stereotactic Radiosurgery for Pituitary Carcinoma.

Mehta GU, McCutcheon IE
Acta Neurochir Suppl 2021;128:43-49. doi: 10.1007/978-3-030-69217-9_5. PMID: 34191060

Malignant transformation in non-functioning pituitary adenomas (pituitary carcinoma).

Lenders N, McCormack A
Pituitary 2018 Apr;21(2):217-229. doi: 10.1007/s11102-017-0857-z. PMID: 29299820

Invasive, atypical and aggressive pituitary adenomas and carcinomas.

Sav A, Rotondo F, Syro LV, Di Ieva A, Cusimano MD, Kovacs K
Endocrinol Metab Clin North Am 2015 Mar;44(1):99-104. Epub 2014 Nov 4 doi: 10.1016/j.ecl.2014.10.008. PMID: 25732646

Non-functioning pituitary tumors: 2012 update.

Cámara Gómez R
Endocrinol Nutr 2014 Mar;61(3):160-70. Epub 2013 Sep 12 doi: 10.1016/j.endonu.2013.04.009. PMID: 24035732

See all (47)

Diagnosis

Aggressive corticotroph tumors and carcinomas.

Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732 Free PMC Article

Overview of the 2022 WHO Classification of Pituitary Tumors.

Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028

Aggressive Pituitary Adenomas and Carcinomas.

Ilie MD, Jouanneau E, Raverot G
Endocrinol Metab Clin North Am 2020 Sep;49(3):505-515. Epub 2020 Jul 8 doi: 10.1016/j.ecl.2020.05.008. PMID: 32741485

European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas.

Pituitary carcinoma.

Sansur CA, Oldfield EH
Semin Oncol 2010 Dec;37(6):591-3. doi: 10.1053/j.seminoncol.2010.10.012. PMID: 21167378

See all (147)

Therapy

Temozolomide in aggressive pituitary tumours and pituitary carcinomas.

McCormack A
Best Pract Res Clin Endocrinol Metab 2022 Dec;36(6):101713. Epub 2022 Oct 13 doi: 10.1016/j.beem.2022.101713. PMID: 36274026

Pituitary carcinoma - case series and review of the literature.

Du Four S, Van Der Veken J, Duerinck J, Vermeulen E, Andreescu CE, Bruneau M, Neyns B, Velthoven V, Velkeniers B
Front Endocrinol (Lausanne) 2022;13:968692. Epub 2022 Sep 8 doi: 10.3389/fendo.2022.968692. PMID: 36157469 Free PMC Article

Aggressive corticotroph tumors and carcinomas.

Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732 Free PMC Article

Aggressive pituitary tumours and pituitary carcinomas.

Raverot G, Ilie MD, Lasolle H, Amodru V, Trouillas J, Castinetti F, Brue T
Nat Rev Endocrinol 2021 Nov;17(11):671-684. Epub 2021 Sep 7 doi: 10.1038/s41574-021-00550-w. PMID: 34493834

Aggressive prolactinomas: how to manage?

Lasolle H, Ilie MD, Raverot G
Pituitary 2020 Feb;23(1):70-77. doi: 10.1007/s11102-019-01000-7. PMID: 31617128

See all (71)

Prognosis

Aggressive corticotroph tumors and carcinomas.

Lasolle H, Vasiljevic A, Jouanneau E, Ilie MD, Raverot G
J Neuroendocrinol 2022 Aug;34(8):e13169. Epub 2022 Aug 18 doi: 10.1111/jne.13169. PMID: 35979732 Free PMC Article

Aggressive pituitary tumours and pituitary carcinomas.

Raverot G, Ilie MD, Lasolle H, Amodru V, Trouillas J, Castinetti F, Brue T
Nat Rev Endocrinol 2021 Nov;17(11):671-684. Epub 2021 Sep 7 doi: 10.1038/s41574-021-00550-w. PMID: 34493834

Aggressive Pituitary Adenomas and Carcinomas.

Ilie MD, Jouanneau E, Raverot G
Endocrinol Metab Clin North Am 2020 Sep;49(3):505-515. Epub 2020 Jul 8 doi: 10.1016/j.ecl.2020.05.008. PMID: 32741485

Multimodal therapy in aggressive pituitary tumors.

Iglesias P, Magallón R, Mitjavila M, Rodríguez Berrocal V, Pian H, Díez JJ
Endocrinol Diabetes Nutr (Engl Ed) 2020 Aug-Sep;67(7):469-485. Epub 2019 Nov 15 doi: 10.1016/j.endinu.2019.08.004. PMID: 31740190

Pituitary carcinomas.

Colao A, Ochoa AS, Auriemma RS, Faggiano A, Pivonello R, Lombardi G
Front Horm Res 2010;38:94-108. Epub 2010 Jul 5 doi: 10.1159/000318499. PMID: 20616500

See all (106)

Clinical prediction guides

Pituitary carcinoma - case series and review of the literature.

Aggressive pituitary tumours and pituitary carcinomas.

Raverot G, Ilie MD, Lasolle H, Amodru V, Trouillas J, Castinetti F, Brue T
Nat Rev Endocrinol 2021 Nov;17(11):671-684. Epub 2021 Sep 7 doi: 10.1038/s41574-021-00550-w. PMID: 34493834

Aggressive Pituitary Adenomas and Carcinomas.

Ilie MD, Jouanneau E, Raverot G
Endocrinol Metab Clin North Am 2020 Sep;49(3):505-515. Epub 2020 Jul 8 doi: 10.1016/j.ecl.2020.05.008. PMID: 32741485

MicroRNAs and Target Genes in Pituitary Adenomas.

Feng Y, Mao ZG, Wang X, Du Q, Jian M, Zhu D, Xiao Z, Wang HJ, Zhu YH
Horm Metab Res 2018 Mar;50(3):179-192. Epub 2018 Jan 19 doi: 10.1055/s-0043-123763. PMID: 29351706

Invasive, atypical and aggressive pituitary adenomas and carcinomas.

Sav A, Rotondo F, Syro LV, Di Ieva A, Cusimano MD, Kovacs K
Endocrinol Metab Clin North Am 2015 Mar;44(1):99-104. Epub 2014 Nov 4 doi: 10.1016/j.ecl.2014.10.008. PMID: 25732646

See all (57)

Recent systematic reviews

Metastatic pituitary tumors: an institutional case series.

Yearley AG, Chalif EJ, Gupta S, Chalif JI, Bernstock JD, Nawabi N, Arnaout O, Smith TR, Reardon DA, Laws ER
Pituitary 2023 Oct;26(5):561-572. Epub 2023 Jul 31 doi: 10.1007/s11102-023-01341-4. PMID: 37523025

Immunotherapy in aggressive pituitary tumors and carcinomas: a systematic review.

Ilie MD, Vasiljevic A, Jouanneau E, Raverot G
Endocr Relat Cancer 2022 May 27;29(7):415-426. doi: 10.1530/ERC-22-0037. PMID: 35521777

Distant Pituitary Adenoma Spread: A Systematic Review and Report of 2 Cases.

Azizkhanian I, El Ahmadieh TY, Palmisciano P, Abou-Mrad Z, Daoud EV, Essibayi MA, Connors S, Aoun SG, Kim J, Hatanpaa KJ, Garzon-Muvdi T, Barnett SL, Patel T, Raisanen JM, Mickey BE
Oper Neurosurg (Hagerstown) 2022 Mar 1;22(3):131-143. doi: 10.1227/ONS.0000000000000089. PMID: 35030115

Immune-checkpoint inhibitors in pituitary malignancies.

Di Nunno V, Franceschi E, Tosoni A, Gatto L, Maggio I, Lodi R, Bartolini S, Brandes AA
Anticancer Drugs 2022 Jan 1;33(1):e28-e35. doi: 10.1097/CAD.0000000000001157. PMID: 34348358

Genetic aspects of pituitary carcinoma: A systematic review.

Yang Z, Zhang T, Gao H
Medicine (Baltimore) 2016 Nov;95(47):e5268. doi: 10.1097/MD.0000000000005268. PMID: 27893664 Free PMC Article

See all (8)

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Pituitary carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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