Somatotroph Pituitary Neuroendocrine Tumor

MedGen UID:: 91097
•Concept ID:: C0346302
•: Neoplastic Process

Synonyms:

Acromegaly Due To Pituitary Adenoma; Adenoma, Somatotroph; Adenomas, Somatotroph; GH Secreting Pituitary Adenoma; GH-Secreting Pituitary Adenoma; GH-Secreting Pituitary Adenomas; Growth Hormone-Secreting Pituitary Adenoma; Pituitary Adenoma, GH Secreting; Pituitary Adenoma, GH-Secreting; Pituitary Adenoma, Growth Hormone Secreting; Pituitary Adenoma, Growth Hormone-Secreting; Pituitary Adenomas, GH-Secreting; Pituitary Growth Hormone Secreting Adenoma; Pituitary Growth Hormone-Secreting Adenoma; Somatotroph Adenoma; Somatotroph Adenomas

SNOMED CT:

Somatotroph adenoma (254957009); Growth hormone-secreting pituitary adenoma (254957009); Somatotroph pituitary adenoma (1156906001)

Definition

A pituitary neuroendocrine tumor that produces growth hormone. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSomatotroph Pituitary Neuroendocrine Tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Adenoma
        Somatotroph Pituitary Neuroendocrine Tumor
        Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor
        Sparsely Granulated Somatotroph Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.

Tomasik A, Stelmachowska-Banaś M, Maksymowicz M, Czajka-Oraniec I, Raczkiewicz D, Zieliński G, Kunicki J, Zgliczyński W
Front Endocrinol (Lausanne) 2022;13:957301. Epub 2022 Sep 16 doi: 10.3389/fendo.2022.957301. PMID: 36187106 Free PMC Article

See all (1)

Recent clinical studies

Etiology

Transcriptomic Classification of Pituitary Neuroendocrine Tumors Causing Acromegaly.

Rymuza J, Kober P, Rusetska N, Mossakowska BJ, Maksymowicz M, Nyc A, Baluszek S, Zieliński G, Kunicki J, Bujko M
Cells 2022 Nov 30;11(23) doi: 10.3390/cells11233846. PMID: 36497102 Free PMC Article

Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.

See all (2)

Diagnosis

Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.

Mixed Sparsely Granulated Lactotroph and Densely Granulated Somatotroph Pituitary Neuroendocrine Tumor Expands the Spectrum of Neuroendocrine Neoplasms in Ovarian Teratomas: the Role of Pituitary Neuroendocrine Cell Lineage Biomarkers.

Hodgson A, Pakbaz S, Shenouda C, Francis JA, Mete O
Endocr Pathol 2020 Sep;31(3):315-319. Epub 2020 Jul 6 doi: 10.1007/s12022-020-09639-w. PMID: 32632841

See all (2)

Therapy

Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.

See all (1)

Prognosis

MiR-320a Acts as a Tumor Suppressor in Somatotroph Pituitary Neuroendocrine Tumors by Targeting BCAT1.

Zhao S, Li B, Gao H, Zhang Y
Neuroendocrinology 2024;114(1):14-24. Epub 2023 Aug 17 doi: 10.1159/000533549. PMID: 37591221

Transcriptomic Classification of Pituitary Neuroendocrine Tumors Causing Acromegaly.

Rymuza J, Kober P, Rusetska N, Mossakowska BJ, Maksymowicz M, Nyc A, Baluszek S, Zieliński G, Kunicki J, Bujko M
Cells 2022 Nov 30;11(23) doi: 10.3390/cells11233846. PMID: 36497102 Free PMC Article

Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly.

See all (3)