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Cornea squamous cell carcinoma

MedGen UID:
91102
•Concept ID:
C0346366
•
Neoplastic Process
Synonyms: Cornea Epidermoid Carcinoma; cornea epidermoid carcinoma; Cornea Squamous Cell Carcinoma; cornea squamous cell carcinoma; Corneal Epidermoid Carcinoma; corneal epidermoid carcinoma; Corneal Squamous Cell Carcinoma; corneal squamous cell carcinoma; Epidermoid Carcinoma of Cornea; epidermoid carcinoma of cornea; Epidermoid Carcinoma of the Cornea; epidermoid carcinoma of the cornea; Squamous cell carcinoma of cornea; Squamous Cell Carcinoma of Cornea; squamous cell carcinoma of cornea; Squamous Cell Carcinoma of the Cornea; squamous cell carcinoma of the cornea
SNOMED CT: Squamous cell carcinoma of cornea (255008003)
 
Monarch Initiative: MONDO:0001740

Definition

A rare squamous cell carcinoma that arises from the cornea. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCornea squamous cell carcinoma

Professional guidelines

PubMed

Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Management of Ocular Surface Squamous Neoplasia with Topical and Intralesional Interferon Alpha 2B in Mexicans.
Nava-Castañeda Á, Hernández-Orgaz J, Garnica-Hayashi L, Ansart A, Matus G, Tovilla-Canales JL
Nepal J Ophthalmol 2018 Jul;10(20):143-150. doi: 10.3126/nepjoph.v10i2.18574. PMID: 31056557
Conjunctival Squamous Neoplasia: Staging and Initial Treatment.
Bellerive C, Berry JL, Polski A, Singh AD
Cornea 2018 Oct;37(10):1287-1291. doi: 10.1097/ICO.0000000000001651. PMID: 29863543Free PMC Article

Recent clinical studies

Etiology

Corneal Involvement in HIV-infected Individuals.
Radhakrishnan N, Smit D, Venkatesh Prajna N, S R R
Ocul Immunol Inflamm 2021 Aug 18;29(6):1177-1182. Epub 2021 Jul 7 doi: 10.1080/09273948.2021.1887283. PMID: 34232799
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Matrix metalloproteinases and their inhibitors in squamous cell carcinoma of the conjunctiva.
Di Girolamo N, Atik A, McCluskey PJ, Wakefield D
Ocul Surf 2013 Jul;11(3):193-205. Epub 2013 Mar 28 doi: 10.1016/j.jtos.2013.01.006. PMID: 23838020
Squamous carcinoma and dysplasia of the conjunctiva and cornea: an analysis of 101 cases.
Yousef YA, Finger PT
Ophthalmology 2012 Feb;119(2):233-40. Epub 2011 Dec 20 doi: 10.1016/j.ophtha.2011.08.005. PMID: 22189448
Health risks.
Longstreth J, de Gruijl FR, Kripke ML, Abseck S, Arnold F, Slaper HI, Velders G, Takizawa Y, van der Leun JC
J Photochem Photobiol B 1998 Oct;46(1-3):20-39. doi: 10.1016/s1011-1344(98)00183-3. PMID: 9894351

Diagnosis

Actinic Granuloma of the Conjunctiva: Case Series and Review of the Literature.
Magan T, Rapuano CJ, Ayres BD, Skeens HM, Goyal V, Heersink S, Meghpara BB, Syed ZA, Eagle RC Jr, Milman T
Am J Ophthalmol 2021 Sep;229:120-126. Epub 2021 Apr 22 doi: 10.1016/j.ajo.2021.04.006. PMID: 33895150
Ocular surface squamous neoplasia: management and outcomes.
Hӧllhumer R, Williams S, Michelow P
Eye (Lond) 2021 Jun;35(6):1562-1573. Epub 2021 Feb 9 doi: 10.1038/s41433-021-01422-3. PMID: 33564137Free PMC Article
Tumors of the conjunctiva and cornea.
Shields CL, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1930-1948. doi: 10.4103/ijo.IJO_2040_19. PMID: 31755426Free PMC Article
Conjunctival keratoacanthoma.
Oellers P, Karp CL, Shah RR, Winnick M, Matthews J, Dubovy S
Br J Ophthalmol 2014 Feb;98(2):275-6, 285. Epub 2013 Nov 28 doi: 10.1136/bjophthalmol-2013-303999. PMID: 24288390
Squamous carcinoma and dysplasia of the conjunctiva and cornea: an analysis of 101 cases.
Yousef YA, Finger PT
Ophthalmology 2012 Feb;119(2):233-40. Epub 2011 Dec 20 doi: 10.1016/j.ophtha.2011.08.005. PMID: 22189448

Therapy

Retinoic acid and the ocular surface.
Samarawickrama C, Chew S, Watson S
Surv Ophthalmol 2015 May-Jun;60(3):183-95. Epub 2014 Oct 16 doi: 10.1016/j.survophthal.2014.10.001. PMID: 25890622
Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article
Squamous carcinoma and dysplasia of the conjunctiva and cornea: an analysis of 101 cases.
Yousef YA, Finger PT
Ophthalmology 2012 Feb;119(2):233-40. Epub 2011 Dec 20 doi: 10.1016/j.ophtha.2011.08.005. PMID: 22189448
Refractory squamous cell carcinoma of the conjunctiva treated with subconjunctival ranibizumab (Lucentis): a two-year study.
Finger PT, Chin KJ
Ophthalmic Plast Reconstr Surg 2012 Mar-Apr;28(2):85-9. doi: 10.1097/IOP.0b013e3182392f29. PMID: 22186988
Phototoxicity and the cornea.
Schein OD
J Natl Med Assoc 1992 Jul;84(7):579-83. PMID: 1629921Free PMC Article

Prognosis

Loss of pRB in Conjunctival Squamous Cell Carcinoma: A Predictor of Poor Prognosis.
Chauhan S, Sen S, Sharma A, Kashyap S, Tandon R, Pushker N, Vanathi M, Chauhan SS
Appl Immunohistochem Mol Morphol 2018 Jul;26(6):e70-e76. doi: 10.1097/PAI.0000000000000592. PMID: 29489511
Matrix metalloproteinases and their inhibitors in squamous cell carcinoma of the conjunctiva.
Di Girolamo N, Atik A, McCluskey PJ, Wakefield D
Ocul Surf 2013 Jul;11(3):193-205. Epub 2013 Mar 28 doi: 10.1016/j.jtos.2013.01.006. PMID: 23838020
Health risks.
Longstreth J, de Gruijl FR, Kripke ML, Abseck S, Arnold F, Slaper HI, Velders G, Takizawa Y, van der Leun JC
J Photochem Photobiol B 1998 Oct;46(1-3):20-39. doi: 10.1016/s1011-1344(98)00183-3. PMID: 9894351
Tumors of the cornea and conjunctiva.
Yoon YD, Grossniklaus H
Curr Opin Ophthalmol 1997 Aug;8(4):55-8. doi: 10.1097/00055735-199708000-00008. PMID: 10170445
Tumors of the cornea and conjunctiva.
Spraul CW, Grossniklaus HE
Curr Opin Ophthalmol 1996 Aug;7(4):28-34. doi: 10.1097/00055735-199608000-00006. PMID: 10163636

Clinical prediction guides

Actinic Granuloma of the Conjunctiva: Case Series and Review of the Literature.
Magan T, Rapuano CJ, Ayres BD, Skeens HM, Goyal V, Heersink S, Meghpara BB, Syed ZA, Eagle RC Jr, Milman T
Am J Ophthalmol 2021 Sep;229:120-126. Epub 2021 Apr 22 doi: 10.1016/j.ajo.2021.04.006. PMID: 33895150
Stratifin in ocular surface squamous neoplasia and its association with p53.
Chauhan S, Sen S, Chauhan SS, Pushker N, Tandon R, Kashyap S, Vanathi M, Bajaj MS
Acta Ophthalmol 2021 Dec;99(8):e1483-e1491. Epub 2021 Mar 26 doi: 10.1111/aos.14844. PMID: 33769712
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Loss of pRB in Conjunctival Squamous Cell Carcinoma: A Predictor of Poor Prognosis.
Chauhan S, Sen S, Sharma A, Kashyap S, Tandon R, Pushker N, Vanathi M, Chauhan SS
Appl Immunohistochem Mol Morphol 2018 Jul;26(6):e70-e76. doi: 10.1097/PAI.0000000000000592. PMID: 29489511
Neoplasms of the limbus.
Sunderraj PP, Viswanathan RK, Balachander R
Indian J Ophthalmol 1991 Oct-Dec;39(4):168-9. PMID: 1810878

Recent systematic reviews

Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article

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