U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant exocrine pancreas neoplasm

MedGen UID:
91108
Concept ID:
C0346648
Neoplastic Process
Synonyms: cancer of exocrine pancreas; exocrine pancreas cancer; Malignant Exocrine Pancreas Neoplasm; malignant exocrine pancreas neoplasm; Malignant Exocrine Pancreas Tumor; malignant exocrine pancreas tumor; malignant exocrine pancreas tumour; Malignant Neoplasm of Exocrine Pancreas; malignant neoplasm of exocrine pancreas; Malignant Neoplasm of the Exocrine Pancreas; malignant neoplasm of the exocrine pancreas; Malignant tumor of exocrine pancreas; Malignant Tumor of Exocrine Pancreas; malignant tumor of exocrine pancreas; Malignant Tumor of the Exocrine Pancreas; malignant tumor of the exocrine pancreas; malignant tumour of exocrine pancreas; malignant tumour of the exocrine pancreas; Pancreatic exocrine cancer; tumor of exocrine pancreas; tumour of exocrine pancreas
SNOMED CT: Malignant tumor of exocrine pancreas (255088001); Pancreatic exocrine cancer (255088001)
 
Monarch Initiative: MONDO:0002116

Definition

A malignant neoplasm that arises from the epithelial cells of the exocrine pancreatic tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant exocrine pancreas neoplasm

Professional guidelines

PubMed

De Luca R, Gianotti L, Pedrazzoli P, Brunetti O, Rizzo A, Sandini M, Paiella S, Pecorelli N, Pugliese L, Pietrabissa A, Zerbi A, Salvia R, Boggi U, Casirati A, Falconi M, Caccialanza R
Eur J Surg Oncol 2023 Mar;49(3):542-549. Epub 2022 Dec 22 doi: 10.1016/j.ejso.2022.12.006. PMID: 36577556
Seufferlein T, Porzner M, Heinemann V, Tannapfel A, Stuschke M, Uhl W
Dtsch Arztebl Int 2014 May 30;111(22):396-402. doi: 10.3238/arztebl.2014.0396. PMID: 24980565Free PMC Article
Benavides M, Abad A, Ales I, Carrato A, Díaz Rubio E, Gallego J, García-Foncillas J, Grávalos C, Laquente B, Pericay C, Rivera F, Tabernero J, Aranda E
Clin Transl Oncol 2014 Oct;16(10):865-78. Epub 2014 Apr 12 doi: 10.1007/s12094-014-1177-7. PMID: 24728654

Recent clinical studies

Etiology

Vlavcheski F, O'Neill EJ, Gagacev F, Tsiani E
Molecules 2022 Dec 6;27(23) doi: 10.3390/molecules27238630. PMID: 36500723Free PMC Article
Kumaran S, Unnikrishnan AG
J Diabetes Complications 2021 Jan;35(1):107627. Epub 2020 May 22 doi: 10.1016/j.jdiacomp.2020.107627. PMID: 32553576
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Hart PA, Bellin MD, Andersen DK, Bradley D, Cruz-Monserrate Z, Forsmark CE, Goodarzi MO, Habtezion A, Korc M, Kudva YC, Pandol SJ, Yadav D, Chari ST; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer(CPDPC)
Lancet Gastroenterol Hepatol 2016 Nov;1(3):226-237. Epub 2016 Oct 12 doi: 10.1016/S2468-1253(16)30106-6. PMID: 28404095Free PMC Article
Stram M, Liu S, Singhi AD
Surg Pathol Clin 2016 Dec;9(4):643-659. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.008. PMID: 27926364

Diagnosis

Kumaran S, Unnikrishnan AG
J Diabetes Complications 2021 Jan;35(1):107627. Epub 2020 May 22 doi: 10.1016/j.jdiacomp.2020.107627. PMID: 32553576
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Gilliland TM, Villafane-Ferriol N, Shah KP, Shah RM, Tran Cao HS, Massarweh NN, Silberfein EJ, Choi EA, Hsu C, McElhany AL, Barakat O, Fisher W, Van Buren G
Nutrients 2017 Mar 7;9(3) doi: 10.3390/nu9030243. PMID: 28272344Free PMC Article
Hart PA, Bellin MD, Andersen DK, Bradley D, Cruz-Monserrate Z, Forsmark CE, Goodarzi MO, Habtezion A, Korc M, Kudva YC, Pandol SJ, Yadav D, Chari ST; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer(CPDPC)
Lancet Gastroenterol Hepatol 2016 Nov;1(3):226-237. Epub 2016 Oct 12 doi: 10.1016/S2468-1253(16)30106-6. PMID: 28404095Free PMC Article
Stram M, Liu S, Singhi AD
Surg Pathol Clin 2016 Dec;9(4):643-659. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.008. PMID: 27926364

Therapy

De Luca R, Gianotti L, Pedrazzoli P, Brunetti O, Rizzo A, Sandini M, Paiella S, Pecorelli N, Pugliese L, Pietrabissa A, Zerbi A, Salvia R, Boggi U, Casirati A, Falconi M, Caccialanza R
Eur J Surg Oncol 2023 Mar;49(3):542-549. Epub 2022 Dec 22 doi: 10.1016/j.ejso.2022.12.006. PMID: 36577556
Vlavcheski F, O'Neill EJ, Gagacev F, Tsiani E
Molecules 2022 Dec 6;27(23) doi: 10.3390/molecules27238630. PMID: 36500723Free PMC Article
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Gilliland TM, Villafane-Ferriol N, Shah KP, Shah RM, Tran Cao HS, Massarweh NN, Silberfein EJ, Choi EA, Hsu C, McElhany AL, Barakat O, Fisher W, Van Buren G
Nutrients 2017 Mar 7;9(3) doi: 10.3390/nu9030243. PMID: 28272344Free PMC Article
Romiti A, Falcone R, Roberto M, Marchetti P
Cancer Lett 2017 May 28;394:88-95. Epub 2017 Feb 20 doi: 10.1016/j.canlet.2017.02.017. PMID: 28232048

Prognosis

Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Gilliland TM, Villafane-Ferriol N, Shah KP, Shah RM, Tran Cao HS, Massarweh NN, Silberfein EJ, Choi EA, Hsu C, McElhany AL, Barakat O, Fisher W, Van Buren G
Nutrients 2017 Mar 7;9(3) doi: 10.3390/nu9030243. PMID: 28272344Free PMC Article
Grant TJ, Hua K, Singh A
Prog Mol Biol Transl Sci 2016;144:241-275. Epub 2016 Oct 15 doi: 10.1016/bs.pmbts.2016.09.008. PMID: 27865459Free PMC Article
Amundadottir LT
Int J Biol Sci 2016;12(3):314-25. Epub 2016 Jan 28 doi: 10.7150/ijbs.15001. PMID: 26929738Free PMC Article
Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, Miller DK, Christ AN, Bruxner TJ, Quinn MC, Nourse C, Murtaugh LC, Harliwong I, Idrisoglu S, Manning S, Nourbakhsh E, Wani S, Fink L, Holmes O, Chin V, Anderson MJ, Kazakoff S, Leonard C, Newell F, Waddell N, Wood S, Xu Q, Wilson PJ, Cloonan N, Kassahn KS, Taylor D, Quek K, Robertson A, Pantano L, Mincarelli L, Sanchez LN, Evers L, Wu J, Pinese M, Cowley MJ, Jones MD, Colvin EK, Nagrial AM, Humphrey ES, Chantrill LA, Mawson A, Humphris J, Chou A, Pajic M, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Lovell JA, Merrett ND, Toon CW, Epari K, Nguyen NQ, Barbour A, Zeps N, Moran-Jones K, Jamieson NB, Graham JS, Duthie F, Oien K, Hair J, Grützmann R, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Rusev B, Capelli P, Salvia R, Tortora G, Mukhopadhyay D, Petersen GM; Australian Pancreatic Cancer Genome Initiative, Munzy DM, Fisher WE, Karim SA, Eshleman JR, Hruban RH, Pilarsky C, Morton JP, Sansom OJ, Scarpa A, Musgrove EA, Bailey UM, Hofmann O, Sutherland RL, Wheeler DA, Gill AJ, Gibbs RA, Pearson JV, Waddell N, Biankin AV, Grimmond SM
Nature 2016 Mar 3;531(7592):47-52. Epub 2016 Feb 24 doi: 10.1038/nature16965. PMID: 26909576

Clinical prediction guides

Hosein AN, Dangol G, Okumura T, Roszik J, Rajapakshe K, Siemann M, Zaid M, Ghosh B, Monberg M, Guerrero PA, Singhi A, Haymaker CL, Clevers H, Abou-Elkacem L, Woermann SM, Maitra A
Gastroenterology 2022 Apr;162(4):1303-1318.e18. Epub 2021 Dec 30 doi: 10.1053/j.gastro.2021.12.273. PMID: 34973294Free PMC Article
Puleo F, Nicolle R, Blum Y, Cros J, Marisa L, Demetter P, Quertinmont E, Svrcek M, Elarouci N, Iovanna J, Franchimont D, Verset L, Galdon MG, Devière J, de Reyniès A, Laurent-Puig P, Van Laethem JL, Bachet JB, Maréchal R
Gastroenterology 2018 Dec;155(6):1999-2013.e3. Epub 2018 Aug 27 doi: 10.1053/j.gastro.2018.08.033. PMID: 30165049
Amundadottir LT
Int J Biol Sci 2016;12(3):314-25. Epub 2016 Jan 28 doi: 10.7150/ijbs.15001. PMID: 26929738Free PMC Article
Lomberk G
Pancreatology 2009;9(3):200-2. Epub 2009 Mar 20 doi: 10.1159/000187722. PMID: 19299909
Shi C, Hruban RH, Klein AP
Arch Pathol Lab Med 2009 Mar;133(3):365-74. doi: 10.5858/133.3.365. PMID: 19260742Free PMC Article

Recent systematic reviews

Farrarons SS, van Bodegraven EA, Sauvanet A, Hilal MA, Besselink MG, Dokmak S
Surgery 2022 Nov;172(5):1490-1501. Epub 2022 Aug 18 doi: 10.1016/j.surg.2022.06.024. PMID: 35987787
Manuel-Vazquez A, Ramia JM, Latorre-Fragua R, Valle-Rubio A, Arteaga-Peralta V, Ramiro-Pérez C, de la Plaza-Llamas R
Pancreas 2018 May/Jun;47(5):551-555. doi: 10.1097/MPA.0000000000001048. PMID: 29683974
Zhou Y, Zhao M, Wu L, Ye F, Si X
Pancreatology 2016 Nov-Dec;16(6):1092-1098. Epub 2016 Jul 9 doi: 10.1016/j.pan.2016.07.006. PMID: 27423534
Beger HG, Nakao A, Mayer B, Poch B
Pancreatology 2015 Mar-Apr;15(2):167-78. Epub 2015 Feb 7 doi: 10.1016/j.pan.2015.01.009. PMID: 25732271
Epstein AS, O'Reilly EM
J Natl Compr Canc Netw 2012 Jul 1;10(7):835-46. doi: 10.6004/jnccn.2012.0087. PMID: 22773799

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...