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Metastatic Malignant Neoplasm in the Uterine Cervix

MedGen UID:
91112
Concept ID:
C0346996
Neoplastic Process
Synonyms: Cancer metastatic to cervix; Metastasis to the Cervix; Metastasis to the Cervix Uteri; Metastasis to the Uterine Cervix; Metastatic malignant neoplasm of cervix uteri; Metastatic malignant neoplasm to cervix uteri; Metastatic Malignant Neoplasm to the Cervix; Metastatic Malignant Neoplasm to the Uterine Cervix; Metastatic malignant neoplasm to uterine cervix; Metastatic Malignant Tumor to the Cervix; Metastatic Malignant Tumor to the Uterine Cervix; Secondary cancer of the cervix; Secondary malignant neoplasm of cervix uteri; Secondary malignant neoplasm of uterine cervix
SNOMED CT: Metastatic malignant neoplasm to uterine cervix (188469005); Metastatic malignant neoplasm to cervix uteri (188469005); Secondary malignant neoplasm of uterine cervix (188469005); Secondary malignant neoplasm of cervix uteri (188469005); Secondary cancer of the cervix (188469005); Cancer metastatic to cervix (188469005); Metastatic malignant neoplasm of cervix uteri (188469005)

Definition

A malignant neoplasm that has spread to the cervix from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Uterine Cervix

Professional guidelines

PubMed

Wei F, Georges D, Man I, Baussano I, Clifford GM
Lancet 2024 Aug 3;404(10451):435-444. doi: 10.1016/S0140-6736(24)01097-3. PMID: 39097395
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
FIGO Committee on Gynecologic Oncology
Int J Gynaecol Obstet 2014 May;125(2):97-8. Epub 2014 Feb 22 doi: 10.1016/j.ijgo.2014.02.003. PMID: 24630859

Recent clinical studies

Etiology

Viveros-Carreño D, Fernandes A, Pareja R
Int J Gynecol Cancer 2023 Mar 6;33(3):394-402. doi: 10.1136/ijgc-2022-003703. PMID: 36878567
Schmeler KM, Pareja R, Lopez Blanco A, Humberto Fregnani J, Lopes A, Perrotta M, Tsunoda AT, Cantú-de-León DF, Ramondetta LM, Manchana T, Crotzer DR, McNally OM, Riege M, Scambia G, Carvajal JM, Di Guilmi J, Rendon GJ, Ramalingam P, Fellman BM, Coleman RL, Frumovitz M, Ramirez PT
Int J Gynecol Cancer 2021 Oct;31(10):1317-1325. Epub 2021 Sep 7 doi: 10.1136/ijgc-2021-002921. PMID: 34493587
Pors J, Segura S, Chiu DS, Almadani N, Ren H, Fix DJ, Howitt BE, Kolin D, McCluggage WG, Mirkovic J, Gilks B, Park KJ, Hoang L
Am J Surg Pathol 2021 Apr 1;45(4):498-506. doi: 10.1097/PAS.0000000000001612. PMID: 33165093Free PMC Article
Kremer WW, Steenbergen R, Heideman D, Kenter GG, Meijer C
BJOG 2021 Feb;128(3):504-514. Epub 2020 Aug 9 doi: 10.1111/1471-0528.16395. PMID: 32619334Free PMC Article
Bhatla N, Berek JS, Cuello Fredes M, Denny LA, Grenman S, Karunaratne K, Kehoe ST, Konishi I, Olawaiye AB, Prat J, Sankaranarayanan R, Brierley J, Mutch D, Querleu D, Cibula D, Quinn M, Botha H, Sigurd L, Rice L, Ryu HS, Ngan H, Mäenpää J, Andrijono A, Purwoto G, Maheshwari A, Bafna UD, Plante M, Natarajan J
Int J Gynaecol Obstet 2019 Apr;145(1):129-135. Epub 2019 Jan 17 doi: 10.1002/ijgo.12749. PMID: 30656645

Diagnosis

Gociman S, Florell SR, Clarke JT
Dermatol Online J 2023 Oct 15;29(5) doi: 10.5070/D329562409. PMID: 38478645
Viveros-Carreño D, Fernandes A, Pareja R
Int J Gynecol Cancer 2023 Mar 6;33(3):394-402. doi: 10.1136/ijgc-2022-003703. PMID: 36878567
Lee JE, Chung Y, Rhee S, Kim TH
BMB Rep 2022 Sep;55(9):429-438. doi: 10.5483/BMBRep.2022.55.9.042. PMID: 35725012Free PMC Article
Kremer WW, Steenbergen R, Heideman D, Kenter GG, Meijer C
BJOG 2021 Feb;128(3):504-514. Epub 2020 Aug 9 doi: 10.1111/1471-0528.16395. PMID: 32619334Free PMC Article
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131

Therapy

Tewari KS, Colombo N, Monk BJ, Dubot C, Cáceres MV, Hasegawa K, Shapira-Frommer R, Salman P, Yañez E, Gümüs M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Tekin C, Li K, Toker S, Keefe SM, Lorusso D
JAMA Oncol 2024 Feb 1;10(2):185-192. doi: 10.1001/jamaoncol.2023.5410. PMID: 38095881Free PMC Article
Huang H, Nie CP, Liu XF, Song B, Yue JH, Xu JX, He J, Li K, Feng YL, Wan T, Zheng M, Zhang YN, Ye WJ, Li JD, Li YF, Li JY, Cao XP, Liu ZM, Zhang XS, Liu Q, Zhang X, Liu JH, Li J
J Clin Invest 2022 Aug 1;132(15) doi: 10.1172/JCI157726. PMID: 35727633Free PMC Article
Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, Chon HS, Chu C, Clark R, Cohn D, Crispens MA, Damast S, Dorigo O, Eifel PJ, Fisher CM, Frederick P, Gaffney DK, Han E, Huh WK, Lurain JR, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Fader AN, Remmenga SW, Reynolds RK, Tillmanns T, Ueda S, Wyse E, Yashar CM, McMillian NR, Scavone JL
J Natl Compr Canc Netw 2019 Jan;17(1):64-84. doi: 10.6004/jnccn.2019.0001. PMID: 30659131
Jin BY, Campbell TE, Draper LM, Stevanović S, Weissbrich B, Yu Z, Restifo NP, Rosenberg SA, Trimble CL, Hinrichs CS
JCI Insight 2018 Apr 19;3(8) doi: 10.1172/jci.insight.99488. PMID: 29669936Free PMC Article
Tangjitgamol S, Manusirivithaya S, Hanprasertpong J
Gynecol Obstet Invest 2009;67(4):250-68. Epub 2009 Mar 24 doi: 10.1159/000209324. PMID: 19321982

Prognosis

Simms KT, Steinberg J, Caruana M, Smith MA, Lew JB, Soerjomataram I, Castle PE, Bray F, Canfell K
Lancet Oncol 2019 Mar;20(3):394-407. Epub 2019 Feb 19 doi: 10.1016/S1470-2045(18)30836-2. PMID: 30795950
Ogilvie GS, van Niekerk D, Krajden M, Smith LW, Cook D, Gondara L, Ceballos K, Quinlan D, Lee M, Martin RE, Gentile L, Peacock S, Stuart GCE, Franco EL, Coldman AJ
JAMA 2018 Jul 3;320(1):43-52. doi: 10.1001/jama.2018.7464. PMID: 29971397Free PMC Article
Kapoor R, Khosla D, Gupta R, Srinivasan R, Bahl A, Kumar R, Sharma SC
J Gastrointest Cancer 2013 Jun;44(2):231-3. doi: 10.1007/s12029-012-9437-7. PMID: 22961708
Tangjitgamol S, Manusirivithaya S, Hanprasertpong J
Gynecol Obstet Invest 2009;67(4):250-68. Epub 2009 Mar 24 doi: 10.1159/000209324. PMID: 19321982
Feys A, Herregods MC, Ector H
Acta Cardiol 2005 Feb;60(1):73-5. doi: 10.2143/AC.60.1.2005055. PMID: 15779858

Clinical prediction guides

Tewari KS, Colombo N, Monk BJ, Dubot C, Cáceres MV, Hasegawa K, Shapira-Frommer R, Salman P, Yañez E, Gümüs M, Olivera Hurtado de Mendoza M, Samouëlian V, Castonguay V, Arkhipov A, Tekin C, Li K, Toker S, Keefe SM, Lorusso D
JAMA Oncol 2024 Feb 1;10(2):185-192. doi: 10.1001/jamaoncol.2023.5410. PMID: 38095881Free PMC Article
Bizzarri N, Russo L, Dolciami M, Zormpas-Petridis K, Boldrini L, Querleu D, Ferrandina G, Pedone Anchora L, Gui B, Sala E, Scambia G
Int J Gynecol Cancer 2023 Oct 2;33(10):1522-1541. doi: 10.1136/ijgc-2023-004589. PMID: 37714669
Chiva L, Zanagnolo V, Querleu D, Martin-Calvo N, Arévalo-Serrano J, Căpîlna ME, Fagotti A, Kucukmetin A, Mom C, Chakalova G, Aliyev S, Malzoni M, Narducci F, Arencibia O, Raspagliesi F, Toptas T, Cibula D, Kaidarova D, Meydanli MM, Tavares M, Golub D, Perrone AM, Poka R, Tsolakidis D, Vujić G, Jedryka MA, Zusterzeel PLM, Beltman JJ, Goffin F, Haidopoulos D, Haller H, Jach R, Yezhova I, Berlev I, Bernardino M, Bharathan R, Lanner M, Maenpaa MM, Sukhin V, Feron JG, Fruscio R, Kukk K, Ponce J, Minguez JA, Vázquez-Vicente D, Castellanos T, Chacon E, Alcazar JL; SUCCOR study Group
Int J Gynecol Cancer 2020 Sep;30(9):1269-1277. Epub 2020 Aug 11 doi: 10.1136/ijgc-2020-001506. PMID: 32788262
Simms KT, Steinberg J, Caruana M, Smith MA, Lew JB, Soerjomataram I, Castle PE, Bray F, Canfell K
Lancet Oncol 2019 Mar;20(3):394-407. Epub 2019 Feb 19 doi: 10.1016/S1470-2045(18)30836-2. PMID: 30795950
Raab SS, Grzybicki DM
Cancer Cytopathol 2011 Oct 25;119(5):293-309. Epub 2011 Jul 5 doi: 10.1002/cncy.20165. PMID: 21732549

Recent systematic reviews

Wei F, Georges D, Man I, Baussano I, Clifford GM
Lancet 2024 Aug 3;404(10451):435-444. doi: 10.1016/S0140-6736(24)01097-3. PMID: 39097395
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354
Adelman MR
J Low Genit Tract Dis 2014 Jul;18(3):246-60. doi: 10.1097/LGT.0b013e3182a72170. PMID: 24633164
Guitarte C, Alagkiozidis I, Mize B, Stevens E, Salame G, Lee YC
Gynecol Oncol 2014 May;133(2):186-91. Epub 2014 Feb 4 doi: 10.1016/j.ygyno.2014.01.048. PMID: 24503463
Pérez-Montiel D, Serrano-Olvera A, Salazar LC, Cetina-Pérez L, Candelaria M, Coronel J, Montalvo LA, de León DC
J Obstet Gynaecol Res 2012 Mar;38(3):541-9. Epub 2012 Feb 22 doi: 10.1111/j.1447-0756.2011.01747.x. PMID: 22353422

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