U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anal intraepithelial neoplasia

MedGen UID:
91117
Concept ID:
C0347129
Neoplastic Process
Synonyms: AIN - Anal intraepithelial neoplasia; Anal Canal and Anal Margin Squamous Intraepithelial Neoplasia; Anal Canal and Perianal Squamous Intraepithelial Neoplasia; Anal Dysplasia; Anal Intraepithelial Neoplasia; Anal Squamous Dysplasia; Anal Squamous Intraepithelial Neoplasia; Dysplasia of anus; Intraepithelial Neoplasia of Anus; Intraepithelial Neoplasia of the Anus
SNOMED CT: Dysplasia of anus (399563001); Anal intraepithelial neoplasia (255143004); AIN - Anal intraepithelial neoplasia (255143004)
 
HPO: HP:0032187

Definition

Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. [from HPO]

Professional guidelines

PubMed

Vyas M, Gonzalez RS
Hum Pathol 2023 Feb;132:56-64. Epub 2022 Jul 16 doi: 10.1016/j.humpath.2022.07.005. PMID: 35843339
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Chittleborough T, Tapper R, Eglinton T, Frizelle F
Tech Coloproctol 2020 Feb;24(2):95-103. Epub 2019 Dec 13 doi: 10.1007/s10151-019-02133-4. PMID: 31834554

Recent clinical studies

Etiology

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, Stier EA, Wentzensen N
Int J Cancer 2022 Dec 1;151(11):1889-1901. Epub 2022 Aug 6 doi: 10.1002/ijc.34199. PMID: 35793241Free PMC Article
Goldstone SE, Giuliano AR, Palefsky JM, Lazcano-Ponce E, Penny ME, Cabello RE, Moreira ED Jr, Baraldi E, Jessen H, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Bautista O, Das R, Group T, Luxembourg A, Zhou HJ, Saah A
Lancet Infect Dis 2022 Mar;22(3):413-425. Epub 2021 Nov 12 doi: 10.1016/S1473-3099(21)00327-3. PMID: 34780705
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article
Limoges-Gonzalez M, Al-Juburi A
J Clin Gastroenterol 2017 Mar;51(3):203-207. doi: 10.1097/MCG.0000000000000721. PMID: 27749636

Diagnosis

Vyas M, Gonzalez RS
Hum Pathol 2023 Feb;132:56-64. Epub 2022 Jul 16 doi: 10.1016/j.humpath.2022.07.005. PMID: 35843339
Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, Stier EA, Wentzensen N
Int J Cancer 2022 Dec 1;151(11):1889-1901. Epub 2022 Aug 6 doi: 10.1002/ijc.34199. PMID: 35793241Free PMC Article
Wieland U, Oellig F, Kreuter A
Hautarzt 2020 Dec;71(Suppl 2):74-81. doi: 10.1007/s00105-020-04562-x. PMID: 32303769
Yang EJ, Kong CS, Longacre TA
Adv Anat Pathol 2017 May;24(3):136-150. doi: 10.1097/PAP.0000000000000149. PMID: 28398952
Abbasakoor F, Boulos PB
Br J Surg 2005 Mar;92(3):277-90. doi: 10.1002/bjs.4967. PMID: 15736144

Therapy

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Goldstone SE, Giuliano AR, Palefsky JM, Lazcano-Ponce E, Penny ME, Cabello RE, Moreira ED Jr, Baraldi E, Jessen H, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Bautista O, Das R, Group T, Luxembourg A, Zhou HJ, Saah A
Lancet Infect Dis 2022 Mar;22(3):413-425. Epub 2021 Nov 12 doi: 10.1016/S1473-3099(21)00327-3. PMID: 34780705
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article
Oette M, Mosthaf FA, Sautter-Bihl ML, Esser S
Oncol Res Treat 2017;40(3):100-105. Epub 2017 Feb 24 doi: 10.1159/000456715. PMID: 28253522
Bejarano PA, Boutros M, Berho M
Gastroenterol Clin North Am 2013 Dec;42(4):893-912. doi: 10.1016/j.gtc.2013.09.005. PMID: 24280406

Prognosis

Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, Stier EA, Wentzensen N
Int J Cancer 2022 Dec 1;151(11):1889-1901. Epub 2022 Aug 6 doi: 10.1002/ijc.34199. PMID: 35793241Free PMC Article
Goldstone SE, Giuliano AR, Palefsky JM, Lazcano-Ponce E, Penny ME, Cabello RE, Moreira ED Jr, Baraldi E, Jessen H, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Bautista O, Das R, Group T, Luxembourg A, Zhou HJ, Saah A
Lancet Infect Dis 2022 Mar;22(3):413-425. Epub 2021 Nov 12 doi: 10.1016/S1473-3099(21)00327-3. PMID: 34780705
Rider P, Hunter J, Grimm L
Curr Gastroenterol Rep 2018 Jul 5;20(8):38. doi: 10.1007/s11894-018-0640-y. PMID: 29974261
Palefsky JM
Sex Health 2012 Dec;9(6):580-6. doi: 10.1071/SH12045. PMID: 23380236
Coutlée F, de Pokomandy A, Franco EL
Sex Health 2012 Dec;9(6):547-55. doi: 10.1071/SH11167. PMID: 22954036

Clinical prediction guides

Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, Stier EA, Wentzensen N
Int J Cancer 2022 Dec 1;151(11):1889-1901. Epub 2022 Aug 6 doi: 10.1002/ijc.34199. PMID: 35793241Free PMC Article
Wieland U, Oellig F, Kreuter A
Hautarzt 2020 Dec;71(Suppl 2):74-81. doi: 10.1007/s00105-020-04562-x. PMID: 32303769
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article
Rider P, Hunter J, Grimm L
Curr Gastroenterol Rep 2018 Jul 5;20(8):38. doi: 10.1007/s11894-018-0640-y. PMID: 29974261

Recent systematic reviews

Wei F, Alberts CJ, Albuquerque A, Clifford GM
J Infect Dis 2023 Nov 28;228(11):1496-1504. doi: 10.1093/infdis/jiad183. PMID: 37257044
Kechagias KS, Kalliala I, Bowden SJ, Athanasiou A, Paraskevaidi M, Paraskevaidis E, Dillner J, Nieminen P, Strander B, Sasieni P, Veroniki AA, Kyrgiou M
BMJ 2022 Aug 3;378:e070135. doi: 10.1136/bmj-2022-070135. PMID: 35922074Free PMC Article
Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, Stier EA, Wentzensen N
Int J Cancer 2022 Dec 1;151(11):1889-1901. Epub 2022 Aug 6 doi: 10.1002/ijc.34199. PMID: 35793241Free PMC Article
Brogden DRL, Lupi MEE, Warren OJ, Kontovounisios C, Mills SC
Updates Surg 2021 Dec;73(6):2047-2058. Epub 2021 Sep 4 doi: 10.1007/s13304-021-01156-7. PMID: 34482519Free PMC Article
Harder T, Wichmann O, Klug SJ, van der Sande MAB, Wiese-Posselt M
BMC Med 2018 Jul 18;16(1):110. doi: 10.1186/s12916-018-1098-3. PMID: 30016957Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...